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P75167

- GPMI_MYCPN

UniProt

P75167 - GPMI_MYCPN

Protein

2,3-bisphosphoglycerate-independent phosphoglycerate mutase

Gene

gpmI

Organism
Mycoplasma pneumoniae (strain ATCC 29342 / M129)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.By similarity

    Catalytic activityi

    2-phospho-D-glycerate = 3-phospho-D-glycerate.

    Cofactori

    Binds 2 manganese ions per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi11 – 111Manganese 2By similarity
    Active sitei61 – 611Phosphoserine intermediateBy similarity
    Metal bindingi61 – 611Manganese 2By similarity
    Metal bindingi397 – 3971Manganese 1By similarity
    Metal bindingi401 – 4011Manganese 1By similarity
    Metal bindingi438 – 4381Manganese 2By similarity
    Metal bindingi439 – 4391Manganese 2By similarity
    Metal bindingi456 – 4561Manganese 1By similarity

    GO - Molecular functioni

    1. 2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity Source: UniProtKB-HAMAP
    2. manganese ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. glucose catabolic process Source: InterPro
    2. glycolytic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    Manganese, Metal-binding

    Enzyme and pathway databases

    BioCyciMetaCyc:MONOMER-550.
    MPNE272634:GJ6Z-674-MONOMER.
    UniPathwayiUPA00109; UER00186.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    2,3-bisphosphoglycerate-independent phosphoglycerate mutase (EC:5.4.2.12)
    Short name:
    BPG-independent PGAM
    Short name:
    Phosphoglyceromutase
    Short name:
    iPGM
    Gene namesi
    Name:gpmI
    Synonyms:pgm
    Ordered Locus Names:MPN_628
    ORF Names:MP214
    OrganismiMycoplasma pneumoniae (strain ATCC 29342 / M129)
    Taxonomic identifieri272634 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
    ProteomesiUP000000808: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 5085082,3-bisphosphoglycerate-independent phosphoglycerate mutasePRO_0000212175Add
    BLAST

    Proteomic databases

    PaxDbiP75167.

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    IntActiP75167. 4 interactions.
    STRINGi272634.MPN628.

    Structurei

    3D structure databases

    ProteinModelPortaliP75167.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0696.
    KOiK15633.
    OMAiDACIGRV.
    OrthoDBiEOG6HJ22X.

    Family and domain databases

    Gene3Di3.40.1450.10. 1 hit.
    3.40.720.10. 2 hits.
    HAMAPiMF_01038. GpmI.
    InterProiIPR017849. Alkaline_Pase-like_a/b/a.
    IPR017850. Alkaline_phosphatase_core.
    IPR011258. BPG-indep_PGM_N.
    IPR006124. Metalloenzyme.
    IPR005995. Pgm_bpd_ind.
    [Graphical view]
    PfamiPF06415. iPGM_N. 1 hit.
    PF01676. Metalloenzyme. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001492. IPGAM. 1 hit.
    SUPFAMiSSF53649. SSF53649. 2 hits.
    SSF64158. SSF64158. 1 hit.
    TIGRFAMsiTIGR01307. pgm_bpd_ind. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P75167-1 [UniParc]FASTAAdd to Basket

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    MHKKVLLAIL DGYGISNKQH GNAVYHAKTP ALDSLIKDYP CVMLEASGEA    50
    VGLPQGQIGN SEVGHLNIGA GRIVYTGLSL INQNIKTGAF HHNQVLLEAI 100
    ARAKANNAKL HLIGLFSHGG VHSHMDHLYA LIKLAAPQVK MVLHLFGDGR 150
    DVAPCTMKSD LEAFMVFLKD YHNVIIGTLG GRYYGMDRDQ RWDREEIAYN 200
    AILGNSKASF TDPVAYVQSA YDQKVTDEFL YPAVNGNVDK EQFALKDHDS 250
    VIFFNFRPDR ARQMSHMLFQ TDYYDYTPKA GRKYNLFFVT MMNYEGIKPS 300
    AVVFPPETIP NTFGEVIAHN KLKQLRIAET EKYAHVTFFF DGGVEVDLPN 350
    ETKCMVPSLK VATYDLAPEM ACKGITDQLL NQINQFDLTV LNFANPDMVG 400
    HTGNYAACVQ GLEALDVQIQ RIIDFCKANH ITLFLTADHG NAEEMIDSNN 450
    NPVTKHTVNK VPFVCTDTNI DLQQDSASLA NIAPTILAYL GLKQPAEMTA 500
    NSLLISKK 508
    Length:508
    Mass (Da):56,375
    Last modified:February 1, 1997 - v1
    Checksum:iA856375375B09F5E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00089 Genomic DNA. Translation: AAB95862.1.
    PIRiS73540.
    RefSeqiNP_110317.1. NC_000912.1.

    Genome annotation databases

    EnsemblBacteriaiAAB95862; AAB95862; MPN_628.
    GeneIDi877355.
    KEGGimpn:MPN628.
    PATRICi20022739. VBIMycPne110_0692.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00089 Genomic DNA. Translation: AAB95862.1 .
    PIRi S73540.
    RefSeqi NP_110317.1. NC_000912.1.

    3D structure databases

    ProteinModelPortali P75167.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P75167. 4 interactions.
    STRINGi 272634.MPN628.

    Proteomic databases

    PaxDbi P75167.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAB95862 ; AAB95862 ; MPN_628 .
    GeneIDi 877355.
    KEGGi mpn:MPN628.
    PATRICi 20022739. VBIMycPne110_0692.

    Phylogenomic databases

    eggNOGi COG0696.
    KOi K15633.
    OMAi DACIGRV.
    OrthoDBi EOG6HJ22X.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00186 .
    BioCyci MetaCyc:MONOMER-550.
    MPNE272634:GJ6Z-674-MONOMER.

    Family and domain databases

    Gene3Di 3.40.1450.10. 1 hit.
    3.40.720.10. 2 hits.
    HAMAPi MF_01038. GpmI.
    InterProi IPR017849. Alkaline_Pase-like_a/b/a.
    IPR017850. Alkaline_phosphatase_core.
    IPR011258. BPG-indep_PGM_N.
    IPR006124. Metalloenzyme.
    IPR005995. Pgm_bpd_ind.
    [Graphical view ]
    Pfami PF06415. iPGM_N. 1 hit.
    PF01676. Metalloenzyme. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001492. IPGAM. 1 hit.
    SUPFAMi SSF53649. SSF53649. 2 hits.
    SSF64158. SSF64158. 1 hit.
    TIGRFAMsi TIGR01307. pgm_bpd_ind. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae."
      Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.
      Nucleic Acids Res. 24:4420-4449(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 29342 / M129.

    Entry informationi

    Entry nameiGPMI_MYCPN
    AccessioniPrimary (citable) accession number: P75167
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Mycoplasma pneumoniae
      Mycoplasma pneumoniae (strain M129): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3