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P75167

- GPMI_MYCPN

UniProt

P75167 - GPMI_MYCPN

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Protein

2,3-bisphosphoglycerate-independent phosphoglycerate mutase

Gene

gpmI

Organism
Mycoplasma pneumoniae (strain ATCC 29342 / M129)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.By similarity

Catalytic activityi

2-phospho-D-glycerate = 3-phospho-D-glycerate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi11 – 111Manganese 2By similarity
Active sitei61 – 611Phosphoserine intermediateBy similarity
Metal bindingi61 – 611Manganese 2By similarity
Metal bindingi397 – 3971Manganese 1By similarity
Metal bindingi401 – 4011Manganese 1By similarity
Metal bindingi438 – 4381Manganese 2By similarity
Metal bindingi439 – 4391Manganese 2By similarity
Metal bindingi456 – 4561Manganese 1By similarity

GO - Molecular functioni

  1. 2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity Source: UniProtKB-HAMAP
  2. manganese ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. glucose catabolic process Source: InterPro
  2. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-550.
MPNE272634:GJ6Z-674-MONOMER.
UniPathwayiUPA00109; UER00186.

Names & Taxonomyi

Protein namesi
Recommended name:
2,3-bisphosphoglycerate-independent phosphoglycerate mutase (EC:5.4.2.12)
Short name:
BPG-independent PGAM
Short name:
Phosphoglyceromutase
Short name:
iPGM
Gene namesi
Name:gpmI
Synonyms:pgm
Ordered Locus Names:MPN_628
ORF Names:MP214
OrganismiMycoplasma pneumoniae (strain ATCC 29342 / M129)
Taxonomic identifieri272634 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000000808: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 5085082,3-bisphosphoglycerate-independent phosphoglycerate mutasePRO_0000212175Add
BLAST

Proteomic databases

PaxDbiP75167.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

IntActiP75167. 4 interactions.
STRINGi272634.MPN628.

Structurei

3D structure databases

ProteinModelPortaliP75167.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0696.
KOiK15633.
OMAiDACIGRV.
OrthoDBiEOG6HJ22X.

Family and domain databases

Gene3Di3.40.1450.10. 1 hit.
3.40.720.10. 2 hits.
HAMAPiMF_01038. GpmI.
InterProiIPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core.
IPR011258. BPG-indep_PGM_N.
IPR006124. Metalloenzyme.
IPR005995. Pgm_bpd_ind.
[Graphical view]
PfamiPF06415. iPGM_N. 1 hit.
PF01676. Metalloenzyme. 1 hit.
[Graphical view]
PIRSFiPIRSF001492. IPGAM. 1 hit.
SUPFAMiSSF53649. SSF53649. 2 hits.
SSF64158. SSF64158. 1 hit.
TIGRFAMsiTIGR01307. pgm_bpd_ind. 1 hit.

Sequencei

Sequence statusi: Complete.

P75167-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHKKVLLAIL DGYGISNKQH GNAVYHAKTP ALDSLIKDYP CVMLEASGEA
60 70 80 90 100
VGLPQGQIGN SEVGHLNIGA GRIVYTGLSL INQNIKTGAF HHNQVLLEAI
110 120 130 140 150
ARAKANNAKL HLIGLFSHGG VHSHMDHLYA LIKLAAPQVK MVLHLFGDGR
160 170 180 190 200
DVAPCTMKSD LEAFMVFLKD YHNVIIGTLG GRYYGMDRDQ RWDREEIAYN
210 220 230 240 250
AILGNSKASF TDPVAYVQSA YDQKVTDEFL YPAVNGNVDK EQFALKDHDS
260 270 280 290 300
VIFFNFRPDR ARQMSHMLFQ TDYYDYTPKA GRKYNLFFVT MMNYEGIKPS
310 320 330 340 350
AVVFPPETIP NTFGEVIAHN KLKQLRIAET EKYAHVTFFF DGGVEVDLPN
360 370 380 390 400
ETKCMVPSLK VATYDLAPEM ACKGITDQLL NQINQFDLTV LNFANPDMVG
410 420 430 440 450
HTGNYAACVQ GLEALDVQIQ RIIDFCKANH ITLFLTADHG NAEEMIDSNN
460 470 480 490 500
NPVTKHTVNK VPFVCTDTNI DLQQDSASLA NIAPTILAYL GLKQPAEMTA

NSLLISKK
Length:508
Mass (Da):56,375
Last modified:February 1, 1997 - v1
Checksum:iA856375375B09F5E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00089 Genomic DNA. Translation: AAB95862.1.
PIRiS73540.
RefSeqiNP_110317.1. NC_000912.1.

Genome annotation databases

EnsemblBacteriaiAAB95862; AAB95862; MPN_628.
GeneIDi877355.
KEGGimpn:MPN628.
PATRICi20022739. VBIMycPne110_0692.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00089 Genomic DNA. Translation: AAB95862.1 .
PIRi S73540.
RefSeqi NP_110317.1. NC_000912.1.

3D structure databases

ProteinModelPortali P75167.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P75167. 4 interactions.
STRINGi 272634.MPN628.

Proteomic databases

PaxDbi P75167.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB95862 ; AAB95862 ; MPN_628 .
GeneIDi 877355.
KEGGi mpn:MPN628.
PATRICi 20022739. VBIMycPne110_0692.

Phylogenomic databases

eggNOGi COG0696.
KOi K15633.
OMAi DACIGRV.
OrthoDBi EOG6HJ22X.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00186 .
BioCyci MetaCyc:MONOMER-550.
MPNE272634:GJ6Z-674-MONOMER.

Family and domain databases

Gene3Di 3.40.1450.10. 1 hit.
3.40.720.10. 2 hits.
HAMAPi MF_01038. GpmI.
InterProi IPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core.
IPR011258. BPG-indep_PGM_N.
IPR006124. Metalloenzyme.
IPR005995. Pgm_bpd_ind.
[Graphical view ]
Pfami PF06415. iPGM_N. 1 hit.
PF01676. Metalloenzyme. 1 hit.
[Graphical view ]
PIRSFi PIRSF001492. IPGAM. 1 hit.
SUPFAMi SSF53649. SSF53649. 2 hits.
SSF64158. SSF64158. 1 hit.
TIGRFAMsi TIGR01307. pgm_bpd_ind. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae."
    Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.
    Nucleic Acids Res. 24:4420-4449(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29342 / M129.

Entry informationi

Entry nameiGPMI_MYCPN
AccessioniPrimary (citable) accession number: P75167
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: November 26, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycoplasma pneumoniae
    Mycoplasma pneumoniae (strain M129): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3