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P75165 (PYRH_MYCPN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Uridylate kinase
Short name=UK
EC=2.7.4.22
Alternative name(s):
Uridine monophosphate kinase
Short name=UMP kinase
Short name=UMPK
Gene names
Name:pyrH
Synonyms:smbA
Ordered Locus Names:MPN_632
ORF Names:MP210
OrganismMycoplasma pneumoniae (strain ATCC 29342 / M129) [Reference proteome] [HAMAP]
Taxonomic identifier272634 [NCBI]
Taxonomic lineageBacteria › Tenericutes › Mollicutes › Mycoplasmataceae › Mycoplasma ›

Protein attributes

Sequence length235 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the reversible phosphorylation of UMP to UDP By similarity. HAMAP-Rule MF_01220

Catalytic activity

ATP + UMP = ADP + UDP. HAMAP-Rule MF_01220

Enzyme regulation

Inhibited by UTP By similarity.

Pathway

Pyrimidine metabolism; CTP biosynthesis via de novo pathway; UDP from UMP (UMPK route): step 1/1. HAMAP-Rule MF_01220

Subunit structure

Homohexamer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the UMP kinase family.

Ontologies

Keywords
   Biological processPyrimidine biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_process'de novo' CTP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

cellular amino acid biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

UMP kinase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 235235Uridylate kinase HAMAP-Rule MF_01220
PRO_0000143860

Regions

Nucleotide binding8 – 114ATP By similarity
Nucleotide binding131 – 1388UMP By similarity

Sites

Binding site491UMP; via amide nitrogen By similarity
Binding site501ATP; via amide nitrogen By similarity
Binding site541ATP By similarity
Binding site1591ATP By similarity
Binding site1651ATP; via amide nitrogen and carbonyl oxygen By similarity
Binding site1681ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
P75165 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: 92A537B4468C2990

FASTA23525,420
        10         20         30         40         50         60 
MRLKILIKLS GAGMSADSSE PFSNQFLETV IAQLKQLVPN YQIGIVIGGG NIMRGKSCSD 

        70         80         90        100        110        120 
YNITEIAGHH LGIMATVING AFLKAKFDSH KLNSTLLSAV SCPSLATHIV SQTTIDDAFK 

       130        140        150        160        170        180 
NHDIVIFAGG TGNPYFSTDT AVALRATQMQ ADIILIGKNG VDGVYTADPK KDKHAKFLAS 

       190        200        210        220        230 
LTYAEAIKND LQIMDITAFT MCKENNLKVI IFNINAEHAI IKALSKQGKY TLIEK

« Hide

References

[1]"Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae."
Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.
Nucleic Acids Res. 24:4420-4449(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 29342 / M129.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U00089 Genomic DNA. Translation: AAB95858.1.
PIRS73536.
RefSeqNP_110321.1. NC_000912.1.

3D structure databases

ProteinModelPortalP75165.
ModBaseSearch...

Protein-protein interaction databases

STRING272634.MPN632.

Proteomic databases

PaxDbP75165.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAB95858; AAB95858; MPN_632.
GeneID877000.
KEGGmpn:MPN632.
PATRIC20022747. VBIMycPne110_0696.

Phylogenomic databases

eggNOGCOG0528.
KOK09903.
OMAEADNIGM.
ProtClustDBCLSK335337.

Enzyme and pathway databases

BioCycMetaCyc:MONOMER-570.
MPNE272634:GJ6Z-678-MONOMER.
UniPathwayUPA00159; UER00275.

Family and domain databases

Gene3D3.40.1160.10. 1 hit.
HAMAPMF_01220_B. PyrH_B.
InterProIPR001048. Asp/Glu/Uridylate_kinase.
IPR011817. Uridylate_kinase.
IPR015963. Uridylate_kinase_bac.
[Graphical view]
PANTHERPTHR26059. PTHR26059. 1 hit.
PfamPF00696. AA_kinase. 1 hit.
[Graphical view]
PIRSFPIRSF005650. Uridylate_kin. 1 hit.
SUPFAMSSF53633. Aa_kinase. 1 hit.
TIGRFAMsTIGR02075. pyrH_bact. 1 hit.
ProtoNetSearch...

Entry information

Entry namePYRH_MYCPN
AccessionPrimary (citable) accession number: P75165
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: May 1, 2013
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Mycoplasma pneumoniae

Mycoplasma pneumoniae (strain M129): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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