P75160 (CDSA_MYCPN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative phosphatidate cytidylyltransferase
EC=2.7.7.41

Alternative name(s):
CDP-DAG synthase
CDP-DG synthase
CDP-diacylglycerol synthase
Short name=CDS
CDP-diglyceride pyrophosphorylase
CDP-diglyceride synthase
CTP:phosphatidate cytidylyltransferase

Gene names

Name:	cdsA
Ordered Locus Names:	MPN_637
ORF Names:	MP205

Organism

Mycoplasma pneumoniae (strain ATCC 29342 / M129) [Reference proteome] [HAMAP]

Taxonomic identifier

272634 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Tenericutes › Mollicutes › Mycoplasmatales › Mycoplasmataceae › Mycoplasma › Mycoplasma pneumoniae

Protein attributes

Sequence length	395 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	CTP + phosphatidate = diphosphate + CDP-diacylglycerol.
Pathway	Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the CDS family.

Ontologies

Keywords
Biological process	Lipid biosynthesis Lipid metabolism Phospholipid biosynthesis Phospholipid metabolism
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	CDP-diacylglycerol biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	phosphatidate cytidylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 395	395	Putative phosphatidate cytidylyltransferase		PRO_0000090740
Regions
	Transmembrane	13 – 33	21	Helical; Potential
	Transmembrane	78 – 98	21	Helical; Potential
	Transmembrane	115 – 135	21	Helical; Potential
	Transmembrane	144 – 164	21	Helical; Potential
	Transmembrane	177 – 197	21	Helical; Potential
	Transmembrane	201 – 221	21	Helical; Potential
	Transmembrane	242 – 262	21	Helical; Potential
	Transmembrane	306 – 326	21	Helical; Potential
	Transmembrane	358 – 378	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	P75160 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: 4AB163423C2E9EFB	FASTA	395	44,644
	10 20 30 40 50 60 MDLKDNSFAK KRSTVFVVLL IVFCFFLMFS AFADGFNFWS PWSTDFNSRV IHIKSDGNIE 70 80 90 100 110 120 TTSIVSHELH PDFKAVRFAF GLVIVLFISV IAVLMNWELS NSIFKNYEKL NLSLSLLSGI 130 140 150 160 170 180 MVSGGMIPTF FVIYFREWNA TVNWIWTASF AGMIVFLWAV YMISTSFIKI RPSLQVIYSL 190 200 210 220 230 240 GAVICFIACI GTIYFSVIRG WTTIFLLIAI GVCTDTFAYL FGKRFGKNPL IKISPSKTWE 250 260 270 280 290 300 GAFFGVTGTV LTISIICVLY SIPNYVRQPS IKDASKTALQ TPQNYDVHNL ITNVFLISFI 310 320 330 340 350 360 SGGSTFYIYW WVSTLALIFT ASIFAIGGDL FFSYIKRLTK IKDFSKLLGK HGGILDRFDS 370 380 390 SSFLISFFFI YHVIAGISSN QRLLMEPNTY FSAVS

References

[1]

"Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae." Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R. Nucleic Acids Res. 24:4420-4449(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 29342 / M129.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U00089 Genomic DNA. Translation: AAB95853.1.
PIR	S73531.
RefSeq	NP_110326.1. NC_000912.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	272634.MPN637.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAB95853; AAB95853; MPN_637.
GeneID	876996.
KEGG	mpn:MPN637.
PATRIC	20022755. VBIMycPne110_0700.
Phylogenomic databases
eggNOG	COG0575.
OMA	LMEPNTY.
ProtClustDB	CLSK437132.
Enzyme and pathway databases
BioCyc	MPNE272634:GJ6Z-683-MONOMER.
UniPathway	UPA00557; UER00614.
Family and domain databases
InterPro	IPR000374. PC_trans. [Graphical view]
Pfam	PF01148. CTP_transf_1. 1 hit. [Graphical view]
PROSITE	PS01315. CDS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CDSA_MYCPN

Accession

Primary (citable) accession number: P75160

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	February 1, 1997
Last modified:	May 1, 2013
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program