Reviewed, UniProtKB/Swiss-Prot P75160 (CDSA_MYCPN)

Names and origin

Protein names

Recommended name:
    Putative phosphatidate cytidylyltransferase
    EC=2.7.7.41
Alternative name(s):
    CDP-diglyceride pyrophosphorylase
    CDP-diglyceride synthetase
    CDP-diacylglycerol synthase
      Short name=CDS
    CTP:phosphatidate cytidylyltransferase
    CDP-DG synthetase
    CDP-DAG synthase

Gene names

Name:	cdsA
Ordered Locus Names:	MPN_637
ORF Names:	MP205

Organism

Mycoplasma pneumoniae [Complete proteome] [HAMAP]

Taxonomic identifier

2104 [NCBI]

Taxonomic lineage

Bacteria › Tenericutes › Mollicutes › Mycoplasmataceae › Mycoplasma

Protein attributes

Sequence length	395 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	CTP + phosphatidate = diphosphate + CDP-diacylglycerol.
Pathway	Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the CDS family.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	phospholipid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	phosphatidate cytidylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 395	395	Putative phosphatidate cytidylyltransferase		PRO_0000090740
Regions
	Transmembrane	13 – 33	21	Potential
	Transmembrane	78 – 98	21	Potential
	Transmembrane	115 – 135	21	Potential
	Transmembrane	144 – 164	21	Potential
	Transmembrane	177 – 197	21	Potential
	Transmembrane	201 – 221	21	Potential
	Transmembrane	242 – 262	21	Potential
	Transmembrane	306 – 326	21	Potential
	Transmembrane	358 – 378	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	P75160-1 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: 4AB163423C2E9EFB	FASTA	395	44,644
	10 20 30 40 50 60 MDLKDNSFAK KRSTVFVVLL IVFCFFLMFS AFADGFNFWS PWSTDFNSRV IHIKSDGNIE 70 80 90 100 110 120 TTSIVSHELH PDFKAVRFAF GLVIVLFISV IAVLMNWELS NSIFKNYEKL NLSLSLLSGI 130 140 150 160 170 180 MVSGGMIPTF FVIYFREWNA TVNWIWTASF AGMIVFLWAV YMISTSFIKI RPSLQVIYSL 190 200 210 220 230 240 GAVICFIACI GTIYFSVIRG WTTIFLLIAI GVCTDTFAYL FGKRFGKNPL IKISPSKTWE 250 260 270 280 290 300 GAFFGVTGTV LTISIICVLY SIPNYVRQPS IKDASKTALQ TPQNYDVHNL ITNVFLISFI 310 320 330 340 350 360 SGGSTFYIYW WVSTLALIFT ASIFAIGGDL FFSYIKRLTK IKDFSKLLGK HGGILDRFDS 370 380 390 SSFLISFFFI YHVIAGISSN QRLLMEPNTY FSAVS

References

[1]

"Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae." Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R. Nucleic Acids Res. 24:4420-4449(1996) [PubMed: 8948633] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 29342 / M129.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U00089 Genomic DNA. Translation: AAB95853.1.
PIR	S73531.
RefSeq	NP_110326.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	876996.
GenomeReviews	Gene locus MPN_637 in contig U00089_GR.
KEGG	mpn:MPN637.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P75160.
OMA	LMEPNTY.
Enzyme and pathway databases
BioCyc	MPNE272634:MPN637-MON.
BRENDA	2.7.7.41. 39500.
Family and domain databases
InterPro	IPR000374. PC_trans. [Graphical view]
Pfam	PF01148. CTP_transf_1. 1 hit. [Graphical view]
PROSITE	PS01315. CDS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CDSA_MYCPN

Accession

Primary (citable) accession number: P75160

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	February 1, 1997
Last modified:	November 3, 2009
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)