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P75159 (T1SX_MYCPN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Putative type I restriction enzyme specificity protein MPN_638
Short name=S protein
Gene names
Ordered Locus Names:MPN_638
ORF Names:E30_orf375, MP204
OrganismMycoplasma pneumoniae (strain ATCC 29342 / M129) [Reference proteome] [HAMAP]
Taxonomic identifier272634 [NCBI]
Taxonomic lineageBacteria › Tenericutes › Mollicutes › Mycoplasmataceae › Mycoplasma ›

Protein attributes

Sequence length375 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

The M and S subunits together form a methyltransferase (MTase) that methylates two adenine residues in complementary strands of a bipartite DNA recognition sequence. Subunit S dictates DNA sequences specificity By similarity.

Subunit structure

The type I restriction/modification system is composed of three polypeptides R, M and S By similarity.

Domain

Contains two DNA recognition domains, each specifying recognition of one of the two defined components of the target sequence By similarity.

Sequence similarities

Belongs to the type-I restriction system S methylase family.

Ontologies

Keywords
   Biological processRestriction system
   LigandDNA-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processDNA restriction-modification system

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

itself1EBI-2259703,EBI-2259703
MPN_474P753101EBI-2259703,EBI-2260075

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 375375Putative type I restriction enzyme specificity protein MPN_638
PRO_0000198043

Sequences

Sequence LengthMass (Da)Tools
P75159 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: 4DBAE8BED64A45FA

FASTA37542,650
        10         20         30         40         50         60 
MTPKLKLNTN SNWTKKTLGS LFELKKGEML EKELLAPDGK YEYFNGGIKA SGRTNEFNTF 

        70         80         90        100        110        120 
KNTISIIIGG SCGYVRLADK DYFCGQSSCT LTVLDPLEID LKFAYYALKS QEEKITSLAS 

       130        140        150        160        170        180 
GTTIKNIRLS DLKDLPIPLV KSIQDQRTIA HALSVFDLRI EHLNELIEVN RKLRDEYAHK 

       190        200        210        220        230        240 
LFTLDPDFLT HWNLHELHEQ MGEISLGEVF HLKSGKYLKA DERFEDGKFP YYGAGIESTS 

       250        260        270        280        290        300 
FVNEPNTKGD TLSMIANGYS IGNIRYHTIP WFNGTGGIAM EALKPNKTYV PFFYCALKYM 

       310        320        330        340        350        360 
QKDLKERFKR DESPFISLKL AGEIKVPFVK SFALQRKAGK IIYLLDKTLE ECKEEAKSLI 

       370 
SIRDNLLGKL FPTLS

« Hide

References

[1]"Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae."
Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.
Nucleic Acids Res. 24:4420-4449(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 29342 / M129.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U00089 Genomic DNA. Translation: AAB95852.1.
PIRS73530.
RefSeqNP_110327.1. NC_000912.1.

3D structure databases

ProteinModelPortalP75159.
SMRP75159. Positions 1-375.
ModBaseSearch...

Protein-protein interaction databases

IntActP75159. 1 interaction.
STRING272634.MPN638.

Protein family/group databases

REBASE6863. S.MpnORF638P.

Proteomic databases

PaxDbP75159.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAB95852; AAB95852; MPN_638.
GeneID876991.
KEGGmpn:MPN638.
PATRIC20022757. VBIMycPne110_0701.

Phylogenomic databases

eggNOGCOG0732.
OMANTFKNTI.
ProtClustDBCLSK335340.

Enzyme and pathway databases

BioCycMPNE272634:GJ6Z-684-MONOMER.

Family and domain databases

InterProIPR000055. Restrct_endonuc_typeI_HsdS.
[Graphical view]
PfamPF01420. Methylase_S. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameT1SX_MYCPN
AccessionPrimary (citable) accession number: P75159
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: May 1, 2013
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Mycoplasma pneumoniae

Mycoplasma pneumoniae (strain M129): entries and gene names

SIMILARITY comments

Index of protein domains and families

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