P75129 (MSRB_MYCPN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptide methionine sulfoxide reductase MsrB
EC=1.8.4.12

Alternative name(s):
Peptide-methionine (R)-S-oxide reductase

Gene names

Name:	msrB
Ordered Locus Names:	MPN_662
ORF Names:	K05_orf151, MP180

Organism

Mycoplasma pneumoniae (strain ATCC 29342 / M129)

Taxonomic identifier

272634 [NCBI]

Taxonomic lineage

Bacteria › Tenericutes › Mollicutes › Mycoplasmataceae › Mycoplasma

Protein attributes

Sequence length	151 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (R)-S-oxide + thioredoxin. HAMAP MF_01400
Sequence similarities	Belongs to the MsrB Met sulfoxide reductase family.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	peptide-methionine (R)-S-oxide reductase activity Inferred from electronic annotation. Source: EC peptide-methionine-(S)-S-oxide reductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 151	151	Peptide methionine sulfoxide reductase MsrB HAMAP MF_01400		PRO_0000140284
Sites
	Active site	121	1	Nucleophile By similarity

Sequences

	Sequence		Length	Mass (Da)
	P75129 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: 3E6D23F0AC857744	FASTA	151	17,279
	10 20 30 40 50 60 MSKYQKKSDG ELKRTLTKLQ YDVTQNAHTE PPYTNEYNRH YEKGIYVDIT SGEPLFISTD 70 80 90 100 110 120 KFKSGCGWPA FTKPISQDLI ANYRDESHGM IRTEVRAKNS NSHLGHVFRD GPEEHGGLRY 130 140 150 CINSAALKFI PFAEMESAGY GEYLKLFKES N

References

[1]	"Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae." Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R. Nucleic Acids Res. 24:4420-4449(1996) [PubMed: 8948633] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 29342 / M129.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U00089 Genomic DNA. Translation: AAB95828.1.
PIR	S73506.
RefSeq	NP_110351.1. NC_000912.1.
3D structure databases
ProteinModelPortal	P75129.
SMR	P75129. Positions 4-145.
ModBase	Search...
Protein-protein interaction databases
IntAct	P75129. 3 interactions.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	877011.
GenomeReviews	Gene locus MPN_662 in contig U00089_GR.
KEGG	mpn:MPN662.
PATRIC	20022809. VBIMycPne110_0727.
Phylogenomic databases
HOGENOM	HBG715255.
OMA	FTDGPVD.
PhylomeDB	P75129.
ProtClustDB	PRK00222.
Enzyme and pathway databases
BioCyc	MPNE272634:MPN662-MONOMER.
Family and domain databases
HAMAP	MF_01400. MsrB. [Tree]
InterPro	IPR002579. Methionine_sulphoxide_MsrB. IPR011057. Mss4-like. [Graphical view]
Gene3D	G3DSA:2.170.150.20. MsrB. 1 hit.
KO	K07305.
Pfam	PF01641. SelR. 1 hit. [Graphical view]
SUPFAM	SSF51316. Mss4_like. 1 hit.
TIGRFAMs	TIGR00357. TIGR00357. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MSRB_MYCPN

Accession

Primary (citable) accession number: P75129

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	February 1, 1997
Last modified:	January 25, 2012
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program