P75106 (KTHY_MYCPN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thymidylate kinase
EC=2.7.4.9

Alternative name(s):
dTMP kinase

Gene names

Name:	tmk
Ordered Locus Names:	MPN_006
ORF Names:	MP148

Organism

Mycoplasma pneumoniae (strain ATCC 29342 / M129)

Taxonomic identifier

272634 [NCBI]

Taxonomic lineage

Bacteria › Tenericutes › Mollicutes › Mycoplasmataceae › Mycoplasma

Protein attributes

Sequence length	210 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis By similarity. HAMAP MF_00165
Catalytic activity	ATP + dTMP = ADP + dTDP. HAMAP MF_00165
Sequence similarities	Belongs to the thymidylate kinase family.

Ontologies

Keywords
Biological process	Nucleotide biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	dTDP biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW thymidylate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 210	210	Thymidylate kinase HAMAP MF_00165		PRO_0000155307
Regions
	Nucleotide binding	11 – 18	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	P75106 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: 911F50922BA06FB0	FASTA	210	23,711
	10 20 30 40 50 60 MKQGVFVAIE GVDGAGKTVL LEAFKQRFPQ SFLGFKTLFS REPGGTPLAE KIRALLLHEA 70 80 90 100 110 120 MEPLTEAYLF AASRTEHVRQ LIQPALQQKQ LVIVDRFVWS SYAYQGLIKK VGLDVVKKLN 130 140 150 160 170 180 ADAVGDSMPD FTFIVDCDFE TALNRMAKRG QDNLLDNTVK KQADFNTMRQ YYHSLVDNKR 190 200 210 VFLLDGQNQT GCLEQFIEQL SQCLTQPTLS

References

[1]	"Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae." Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R. Nucleic Acids Res. 24:4420-4449(1996) [PubMed: 8948633] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 29342 / M129.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U00089 Genomic DNA. Translation: AAB95796.1.
PIR	S73474.
RefSeq	NP_109694.1. NC_000912.1.
3D structure databases
ProteinModelPortal	P75106.
ModBase	Search...
Protein-protein interaction databases
IntAct	P75106. 4 interactions.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	877298.
GenomeReviews	Gene locus MPN_006 in contig U00089_GR.
KEGG	mpn:MPN006.
PATRIC	20021285. VBIMycPne110_0006.
Phylogenomic databases
HOGENOM	HBG626009.
OMA	EAYLFAA.
PhylomeDB	P75106.
ProtClustDB	CLSK542092.
Enzyme and pathway databases
BioCyc	MetaCyc:MONOMER-567. MPNE272634:MPN006-MONOMER.
Family and domain databases
HAMAP	MF_00165. Thymidylate_kinase. [Tree]
InterPro	IPR018095. Thymidylate_kin_CS. IPR018094. Thymidylate_kinase. [Graphical view]
KO	K00943.
PANTHER	PTHR10344. Thymidylate_kin. 1 hit.
Pfam	PF02223. Thymidylate_kin. 1 hit. [Graphical view]
TIGRFAMs	TIGR00041. DTMP_kinase. 1 hit.
PROSITE	PS01331. THYMIDYLATE_KINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KTHY_MYCPN

Accession

Primary (citable) accession number: P75106

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	February 1, 1997
Last modified:	January 25, 2012
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program