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P75096 (FOLD_MYCPN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Bifunctional protein FolD

Including the following 2 domains:

  1. Methylenetetrahydrofolate dehydrogenase
    EC=1.5.1.5
  2. Methenyltetrahydrofolate cyclohydrolase
    EC=3.5.4.9
Gene names
Name:folD
Ordered Locus Names:MPN_017
ORF Names:MP137
OrganismMycoplasma pneumoniae (strain ATCC 29342 / M129)
Taxonomic identifier272634 [NCBI]
Taxonomic lineageBacteria › Tenericutes › Mollicutes › Mycoplasmataceae › Mycoplasma

Protein attributes

Sequence length269 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate By similarity. HAMAP MF_01576

Catalytic activity

5,10-methylenetetrahydrofolate + NADP+ = 5,10-methenyltetrahydrofolate + NADPH. HAMAP MF_01576

5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate. HAMAP MF_01576

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP MF_01576

Subunit structure

Homodimer By similarity. HAMAP MF_01576

Sequence similarities

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 269269Bifunctional protein FolD HAMAP MF_01576
PRO_0000199311

Sequences

Sequence LengthMass (Da)Tools
P75096 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: 2976C0FF51B1FA7D

FASTA26930,204
        10         20         30         40         50         60 
MSFDGKQLAH EILLTYKNRD WSQVKLVILQ TNNDVSSDAF IRQKMNACNT LGAQSELIKY 

        70         80         90        100        110        120 
HESVTEKELL EKIQQLNTDP EVTGIILQLP VYPHLKQNKL LKAIDPYKDV DYLTGNCPLP 

       130        140        150        160        170        180 
IRSCVVEAVL ILKEHFHHDF TNKQIVVVGL GVTGGGPIFH YLKETGHQVV GCDKHTPNTM 

       190        200        210        220        230        240 
ELIKTADVVI TAIGKPHFFK TTNFKPGVIL YDVGVSRNVL NKLCGDIDPN GIEKVAKWWS 

       250        260 
PTPGGVGPFT VLAIMKNLWV LYEAHQRRI

« Hide

References

[1]"Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae."
Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.
Nucleic Acids Res. 24:4420-4449(1996) [PubMed: 8948633] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 29342 / M129.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U00089 Genomic DNA. Translation: AAB95785.1.
PIRS73463.
RefSeqNP_109705.1. NC_000912.1.

3D structure databases

ProteinModelPortalP75096.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID876845.
GenomeReviewsGene locus MPN_017 in contig U00089_GR.
KEGGmpn:MPN017.
PATRIC20021305. VBIMycPne110_0016.

Phylogenomic databases

HOGENOMHBG328751.
OMANQDERVD.
PhylomeDBP75096.
ProtClustDBCLSK437070.

Enzyme and pathway databases

BioCycMetaCyc:MONOMER-580.
MPNE272634:MPN017-MONOMER.

Family and domain databases

HAMAPMF_01576. THF_DHG_CYH.
[Tree]
InterProIPR016040. NAD(P)-bd_dom.
IPR000672. THF_DH/CycHdrlase.
IPR020630. THF_DH/CycHdrlase_cat_dom.
IPR020867. THF_DH/CycHdrlase_CS.
IPR020631. THF_DH/CycHdrlase_NAD-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK01491.
PfamPF00763. THF_DHG_CYH. 1 hit.
PF02882. THF_DHG_CYH_C. 1 hit.
[Graphical view]
PRINTSPR00085. THFDHDRGNASE.
PROSITEPS00766. THF_DHG_CYH_1. 1 hit.
PS00767. THF_DHG_CYH_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFOLD_MYCPN
AccessionPrimary (citable) accession number: P75096
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: January 25, 2012
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Mycoplasma pneumoniae

Mycoplasma pneumoniae (strain M129): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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