P75092 (PIP_MYCPN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative proline iminopeptidase
Short name=PIP
EC=3.4.11.5

Alternative name(s):
Prolyl aminopeptidase
Short name=PAP

Gene names

Name:	pip
Ordered Locus Names:	MPN_022
ORF Names:	MP132

Organism

Mycoplasma pneumoniae (strain ATCC 29342 / M129)

Taxonomic identifier

272634 [NCBI]

Taxonomic lineage

Bacteria › Tenericutes › Mollicutes › Mycoplasmataceae › Mycoplasma

Protein attributes

Sequence length	309 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Specifically catalyzes the removal of N-terminal proline residues from peptides By similarity.
Catalytic activity	Release of N-terminal proline from a peptide.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the peptidase S33 family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Aminopeptidase Hydrolase Protease
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	aminopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 309	309	Putative proline iminopeptidase		PRO_0000080840
Sites
	Active site	105	1	Nucleophile By similarity
	Active site	262	1	By similarity
	Active site	290	1	Proton donor By similarity

Sequences

	Sequence		Length	Mass (Da)
	P75092 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: 6E414919FC01E767	FASTA	309	34,690
	10 20 30 40 50 60 MNTSPKQSGY LKVGNGHEVY FWTAGNPQGK SALYVHGGPG SGTDAGCLKY FDLDTTYVIL 70 80 90 100 110 120 LDQRGCGQSK AVNPLLHNTT QDLVGDLEAL RQHLKLERWT LFGGSWGSTL ALVYAITHPQ 130 140 150 160 170 180 VVEQVFLRAL FLGREQDWAE MLLGLGKLFY PYEHQTLLKA IPQACRTDFT KFTNYFYEVL 190 200 210 220 230 240 QGNDSALKTQ LANAWVKWEN TLLSPISYVK DEKAEDANFT FKLALLECHY AKHHSFLKPN 250 260 270 280 290 300 FILENVAVLK DKPVHLIHGR FDLVCPLSQA LELKRALPTL NLYVTNNAGH SGSDPNNLTT IKHLLKTQL

References

[1]	"Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae." Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R. Nucleic Acids Res. 24:4420-4449(1996) [PubMed: 8948633] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 29342 / M129.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U00089 Genomic DNA. Translation: AAB95780.1.
PIR	S73458.
RefSeq	NP_109710.1. NC_000912.1.
3D structure databases
ProteinModelPortal	P75092.
ModBase	Search...
Protein-protein interaction databases
IntAct	P75092. 4 interactions.
Protein family/group databases
MEROPS	S33.001.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	876978.
GenomeReviews	Gene locus MPN_022 in contig U00089_GR.
KEGG	mpn:MPN022.
PATRIC	20021319. VBIMycPne110_0021.
Phylogenomic databases
HOGENOM	HBG677789.
OMA	CAPVMAR.
PhylomeDB	P75092.
ProtClustDB	CLSK542100.
Enzyme and pathway databases
BioCyc	MPNE272634:MPN022-MONOMER.
Family and domain databases
InterPro	IPR000073. AB_hydrolase_1. IPR005944. Pept_S33. IPR002410. Peptidase_S33. [Graphical view]
KO	K01259.
PANTHER	PTHR10992:SF12. PTHR10992:SF12. 1 hit.
Pfam	PF00561. Abhydrolase_1. 1 hit. [Graphical view]
PIRSF	PIRSF006431. Pept_S33. 1 hit.
PRINTS	PR00793. PROAMNOPTASE.
TIGRFAMs	TIGR01249. Pro_imino_pep_1. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PIP_MYCPN

Accession

Primary (citable) accession number: P75092

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	February 1, 1997
Last modified:	January 25, 2012
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program