P75090 (RPOE_MYCPN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable DNA-directed RNA polymerase subunit delta

Alternative name(s):
RNAP delta factor

Gene names

Name:	rpoE
Ordered Locus Names:	MPN_024
ORF Names:	MP130

Organism

Mycoplasma pneumoniae (strain ATCC 29342 / M129)

Taxonomic identifier

272634 [NCBI]

Taxonomic lineage

Bacteria › Tenericutes › Mollicutes › Mycoplasmataceae › Mycoplasma

Protein attributes

Sequence length	144 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling By similarity. HAMAP MF_00357
Subunit structure	RNAP is composed of a core of 2 alpha, a beta and a beta' subunits. The core is associated with a delta subunit and one of several sigma factors By similarity.
Sequence similarities	Belongs to the rpoE family.
Sequence caution	The sequence AAB95778.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Transcription
Cellular component	DNA-directed RNA polymerase
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	DNA binding Inferred from electronic annotation. Source: InterPro DNA-directed RNA polymerase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 144	144	Probable DNA-directed RNA polymerase subunit delta HAMAP MF_00357		PRO_0000204319
Regions
	Compositional bias	93 – 144	52	Asp/Glu-rich (acidic) HAMAP MF_00357

Sequences

	Sequence		Length	Mass (Da)
	P75090 [UniParc]. Last modified May 4, 2001. Version 2. Checksum: 0157775EAD9E25A9	FASTA	144	17,174
	10 20 30 40 50 60 MQVEYLDLIS QAKEIAETQF KAEPFSFDAI WKEVVKHFKI SKQDEPNLIS RFYQDFLEDP 70 80 90 100 110 120 NFVYLGERNW KLRDFMKFDE WNKISQAMFV TKEIFEEGYE DLSNKKKENE EEVNDFIMGN 130 140 DGDDNSTGDE IVQGLINDFR DDNQ

References

[1]

"Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae." Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R. Nucleic Acids Res. 24:4420-4449(1996) [PubMed: 8948633] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 29342 / M129.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U00089 Genomic DNA. Translation: AAB95778.1. Different initiation.
PIR	S73456.
RefSeq	NP_109712.1. NC_000912.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	P75090. 1 interaction.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	876869.
GenomeReviews	Gene locus MPN_024 in contig U00089_GR.
KEGG	mpn:MPN024.
PATRIC	20021323. VBIMycPne110_0023.
Phylogenomic databases
HOGENOM	HBG572042.
OMA	ISKQDEP.
PhylomeDB	P75090.
ProtClustDB	PRK02363.
Enzyme and pathway databases
BioCyc	MPNE272634:MPN024-MONOMER.
Family and domain databases
HAMAP	MF_00357. RNApol_bact_RpoE. [Tree]
InterPro	IPR007759. DNA-dir_RNA_pol_delta. [Graphical view]
KO	K03048.
Pfam	PF05066. RNA_pol_delta. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RPOE_MYCPN

Accession

Primary (citable) accession number: P75090

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	May 4, 2001
Last modified:	January 25, 2012
This is version 57 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program