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P75089

- ALF_MYCPN

UniProt

P75089 - ALF_MYCPN

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Protein

Fructose-bisphosphate aldolase

Gene

fba

Organism
Mycoplasma pneumoniae (strain ATCC 29342 / M129)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.By similarity

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Cofactori

Zn2+By similarityNote: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei49 – 491Glyceraldehyde 3-phosphateBy similarity
Active sitei84 – 841Proton donorBy similarity
Metal bindingi85 – 851Zinc 1; catalyticBy similarity
Metal bindingi105 – 1051Zinc 2By similarity
Metal bindingi135 – 1351Zinc 2By similarity
Metal bindingi177 – 1771Zinc 1; catalyticBy similarity
Binding sitei178 – 1781Dihydroxyacetone phosphate; via amide nitrogenBy similarity
Metal bindingi206 – 2061Zinc 1; catalyticBy similarity

GO - Molecular functioni

  1. fructose-bisphosphate aldolase activity Source: UniProtKB-EC
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. fructose 1,6-bisphosphate metabolic process Source: InterPro
  2. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-546.
MPNE272634:GJ6Z-27-MONOMER.
UniPathwayiUPA00109; UER00183.

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase (EC:4.1.2.13)
Short name:
FBP aldolase
Short name:
FBPA
Alternative name(s):
Fructose-1,6-bisphosphate aldolase
Gene namesi
Name:fba
Synonyms:tsr
Ordered Locus Names:MPN_025
ORF Names:MP129
OrganismiMycoplasma pneumoniae (strain ATCC 29342 / M129)
Taxonomic identifieri272634 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000000808: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 288288Fructose-bisphosphate aldolasePRO_0000178720Add
BLAST

Proteomic databases

PaxDbiP75089.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

IntActiP75089. 7 interactions.
STRINGi272634.MPN025.

Structurei

3D structure databases

ProteinModelPortaliP75089.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni207 – 2093Dihydroxyacetone phosphate bindingBy similarity
Regioni228 – 2314Dihydroxyacetone phosphate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0191.
KOiK01624.
OMAiCTTRYEA.
OrthoDBiEOG6HXJ7B.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR011289. Fruc_bis_ald_class-2.
IPR000771. Ketose_bisP_aldolase_II.
[Graphical view]
PfamiPF01116. F_bP_aldolase. 1 hit.
[Graphical view]
PIRSFiPIRSF001359. F_bP_aldolase_II. 1 hit.
TIGRFAMsiTIGR00167. cbbA. 1 hit.
TIGR01859. fruc_bis_ald_. 1 hit.
PROSITEiPS00806. ALDOLASE_CLASS_II_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P75089-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLVNIKQMLQ HAKQHHYAVP HININNYEWA KAVLTAAQQA KSPIIVSTSE
60 70 80 90 100
GALKYISGHQ VVVPMVKGLV DALKITVPVA LHLDHGSYEG CKAALQAGFS
110 120 130 140 150
SIMFDGSHLP FQENFTKSKE LIELAKQTNA SVELEVGTLG GEEDGIVGQG
160 170 180 190 200
ELANIEECKQ IATLKPDALA AGIGNIHGLY PDNWKGLNYE LIEAIAKATN
210 220 230 240 250
LPLVLHGGSG IPEADVKKAI GLGISKLNIN TECQLAFAKA IREYVEAKKD
260 270 280
LDTHNKGYDP RKLLKSPTQA IVDCCLEKMQ LCGSTNKA
Length:288
Mass (Da):31,069
Last modified:February 1, 1997 - v1
Checksum:i174A7F2E4E215FD8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00089 Genomic DNA. Translation: AAB95777.1.
PIRiS73455.
RefSeqiNP_109713.1. NC_000912.1.

Genome annotation databases

EnsemblBacteriaiAAB95777; AAB95777; MPN_025.
GeneIDi876888.
KEGGimpn:MPN025.
PATRICi20021325. VBIMycPne110_0024.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00089 Genomic DNA. Translation: AAB95777.1 .
PIRi S73455.
RefSeqi NP_109713.1. NC_000912.1.

3D structure databases

ProteinModelPortali P75089.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P75089. 7 interactions.
STRINGi 272634.MPN025.

Proteomic databases

PaxDbi P75089.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB95777 ; AAB95777 ; MPN_025 .
GeneIDi 876888.
KEGGi mpn:MPN025.
PATRICi 20021325. VBIMycPne110_0024.

Phylogenomic databases

eggNOGi COG0191.
KOi K01624.
OMAi CTTRYEA.
OrthoDBi EOG6HXJ7B.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00183 .
BioCyci MetaCyc:MONOMER-546.
MPNE272634:GJ6Z-27-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR011289. Fruc_bis_ald_class-2.
IPR000771. Ketose_bisP_aldolase_II.
[Graphical view ]
Pfami PF01116. F_bP_aldolase. 1 hit.
[Graphical view ]
PIRSFi PIRSF001359. F_bP_aldolase_II. 1 hit.
TIGRFAMsi TIGR00167. cbbA. 1 hit.
TIGR01859. fruc_bis_ald_. 1 hit.
PROSITEi PS00806. ALDOLASE_CLASS_II_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae."
    Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.
    Nucleic Acids Res. 24:4420-4449(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29342 / M129.

Entry informationi

Entry nameiALF_MYCPN
AccessioniPrimary (citable) accession number: P75089
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: November 26, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycoplasma pneumoniae
    Mycoplasma pneumoniae (strain M129): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3