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P75089

- ALF_MYCPN

UniProt

P75089 - ALF_MYCPN

Protein

Fructose-bisphosphate aldolase

Gene

fba

Organism
Mycoplasma pneumoniae (strain ATCC 29342 / M129)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.By similarity

    Catalytic activityi

    D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

    Cofactori

    Binds 2 zinc ions per subunit. One is catalytic and the other provides a structural contribution By similarity.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei49 – 491Glyceraldehyde 3-phosphateBy similarity
    Active sitei84 – 841Proton donorBy similarity
    Metal bindingi85 – 851Zinc 1; catalyticBy similarity
    Metal bindingi105 – 1051Zinc 2By similarity
    Metal bindingi135 – 1351Zinc 2By similarity
    Metal bindingi177 – 1771Zinc 1; catalyticBy similarity
    Binding sitei178 – 1781Dihydroxyacetone phosphate; via amide nitrogenBy similarity
    Metal bindingi206 – 2061Zinc 1; catalyticBy similarity

    GO - Molecular functioni

    1. fructose-bisphosphate aldolase activity Source: UniProtKB-EC
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. fructose 1,6-bisphosphate metabolic process Source: InterPro
    2. glycolytic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciMetaCyc:MONOMER-546.
    MPNE272634:GJ6Z-27-MONOMER.
    UniPathwayiUPA00109; UER00183.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fructose-bisphosphate aldolase (EC:4.1.2.13)
    Short name:
    FBP aldolase
    Short name:
    FBPA
    Alternative name(s):
    Fructose-1,6-bisphosphate aldolase
    Gene namesi
    Name:fba
    Synonyms:tsr
    Ordered Locus Names:MPN_025
    ORF Names:MP129
    OrganismiMycoplasma pneumoniae (strain ATCC 29342 / M129)
    Taxonomic identifieri272634 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
    ProteomesiUP000000808: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 288288Fructose-bisphosphate aldolasePRO_0000178720Add
    BLAST

    Proteomic databases

    PaxDbiP75089.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    IntActiP75089. 7 interactions.
    STRINGi272634.MPN025.

    Structurei

    3D structure databases

    ProteinModelPortaliP75089.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni207 – 2093Dihydroxyacetone phosphate bindingBy similarity
    Regioni228 – 2314Dihydroxyacetone phosphate bindingBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0191.
    KOiK01624.
    OMAiCTTRYEA.
    OrthoDBiEOG6HXJ7B.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR013785. Aldolase_TIM.
    IPR011289. Fruc_bis_ald_class-2.
    IPR000771. Ketose_bisP_aldolase_II.
    [Graphical view]
    PfamiPF01116. F_bP_aldolase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001359. F_bP_aldolase_II. 1 hit.
    TIGRFAMsiTIGR00167. cbbA. 1 hit.
    TIGR01859. fruc_bis_ald_. 1 hit.
    PROSITEiPS00806. ALDOLASE_CLASS_II_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P75089-1 [UniParc]FASTAAdd to Basket

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    MLVNIKQMLQ HAKQHHYAVP HININNYEWA KAVLTAAQQA KSPIIVSTSE    50
    GALKYISGHQ VVVPMVKGLV DALKITVPVA LHLDHGSYEG CKAALQAGFS 100
    SIMFDGSHLP FQENFTKSKE LIELAKQTNA SVELEVGTLG GEEDGIVGQG 150
    ELANIEECKQ IATLKPDALA AGIGNIHGLY PDNWKGLNYE LIEAIAKATN 200
    LPLVLHGGSG IPEADVKKAI GLGISKLNIN TECQLAFAKA IREYVEAKKD 250
    LDTHNKGYDP RKLLKSPTQA IVDCCLEKMQ LCGSTNKA 288
    Length:288
    Mass (Da):31,069
    Last modified:February 1, 1997 - v1
    Checksum:i174A7F2E4E215FD8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00089 Genomic DNA. Translation: AAB95777.1.
    PIRiS73455.
    RefSeqiNP_109713.1. NC_000912.1.

    Genome annotation databases

    EnsemblBacteriaiAAB95777; AAB95777; MPN_025.
    GeneIDi876888.
    KEGGimpn:MPN025.
    PATRICi20021325. VBIMycPne110_0024.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00089 Genomic DNA. Translation: AAB95777.1 .
    PIRi S73455.
    RefSeqi NP_109713.1. NC_000912.1.

    3D structure databases

    ProteinModelPortali P75089.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P75089. 7 interactions.
    STRINGi 272634.MPN025.

    Proteomic databases

    PaxDbi P75089.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAB95777 ; AAB95777 ; MPN_025 .
    GeneIDi 876888.
    KEGGi mpn:MPN025.
    PATRICi 20021325. VBIMycPne110_0024.

    Phylogenomic databases

    eggNOGi COG0191.
    KOi K01624.
    OMAi CTTRYEA.
    OrthoDBi EOG6HXJ7B.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00183 .
    BioCyci MetaCyc:MONOMER-546.
    MPNE272634:GJ6Z-27-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR013785. Aldolase_TIM.
    IPR011289. Fruc_bis_ald_class-2.
    IPR000771. Ketose_bisP_aldolase_II.
    [Graphical view ]
    Pfami PF01116. F_bP_aldolase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001359. F_bP_aldolase_II. 1 hit.
    TIGRFAMsi TIGR00167. cbbA. 1 hit.
    TIGR01859. fruc_bis_ald_. 1 hit.
    PROSITEi PS00806. ALDOLASE_CLASS_II_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae."
      Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.
      Nucleic Acids Res. 24:4420-4449(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 29342 / M129.

    Entry informationi

    Entry nameiALF_MYCPN
    AccessioniPrimary (citable) accession number: P75089
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Mycoplasma pneumoniae
      Mycoplasma pneumoniae (strain M129): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3