P75085 (EFP_MYCPN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Elongation factor P
Short name=EF-P

Gene names

Name:	efp
Ordered Locus Names:	MPN_029
ORF Names:	MP125

Organism

Mycoplasma pneumoniae (strain ATCC 29342 / M129)

Taxonomic identifier

272634 [NCBI]

Taxonomic lineage

Bacteria › Tenericutes › Mollicutes › Mycoplasmataceae › Mycoplasma

Protein attributes

Sequence length	190 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase By similarity. HAMAP MF_00141
Pathway	Protein biosynthesis; polypeptide chain elongation. HAMAP MF_00141
Subcellular location	Cytoplasm HAMAP MF_00141.
Sequence similarities	Belongs to the elongation factor P family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Molecular function	Elongation factor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	peptide biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	translation elongation factor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 190	190	Elongation factor P HAMAP MF_00141		PRO_0000094290

Sequences

	Sequence		Length	Mass (Da)
	P75085 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: 547284880C514BCA	FASTA	190	21,810
	10 20 30 40 50 60 MADMIEAKSL RSGQTIFGPN KEILLVLENT FNKTAMRQGI VKTKVKNLRT GAIVWIEFTG 70 80 90 100 110 120 DKLEQVIIDK KKMTFLYKDG ANYVFMDQQD YSQIEIPEKQ LEWEKNFITE DSEVTIISYQ 130 140 150 160 170 180 SEILGVNLPE LVPIEVEFAE EAVQGNTANM ARKRARLVSG YELDVPQFIR TGDKIVISTI 190 DGSYRERYNK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae." Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R. Nucleic Acids Res. 24:4420-4449(1996) [PubMed: 8948633] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 29342 / M129.
[2]	"Towards a two-dimensional proteome map of Mycoplasma pneumoniae." Regula J.T., Ueberle B., Boguth G., Goerg A., Schnoelzer M., Herrmann R., Frank R. Electrophoresis 21:3765-3780(2000) [PubMed: 11271496] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY. Strain: ATCC 29342 / M129.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U00089 Genomic DNA. Translation: AAB95773.1.
PIR	S73451.
RefSeq	NP_109717.1. NC_000912.1.
3D structure databases
ProteinModelPortal	P75085.
ModBase	Search...
Protein-protein interaction databases
IntAct	P75085. 2 interactions.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	876940.
GenomeReviews	Gene locus MPN_029 in contig U00089_GR.
KEGG	mpn:MPN029.
PATRIC	20021333. VBIMycPne110_0028.
Phylogenomic databases
HOGENOM	HBG303311.
OMA	HQSTSGK.
PhylomeDB	P75085.
ProtClustDB	PRK00529.
Enzyme and pathway databases
BioCyc	MPNE272634:MPN029-MONOMER.
Family and domain databases
HAMAP	MF_00141. EF-P. [Tree]
InterPro	IPR015365. Elong-fact-P_C. IPR012340. NA-bd_OB-fold. IPR016027. NA-bd_OB-fold-like. IPR020599. Transl_elong_fac_P/YeiP. IPR013185. Transl_elong_KOW-like. IPR001059. Transl_elong_P/YeiP_cen. IPR013852. Transl_elong_P/YeiP_CS. IPR011768. Transl_elongation_fac_P. IPR014722. Transl_SH3-like_sub. IPR008991. Translation_prot_SH3-like. [Graphical view]
Gene3D	G3DSA:2.40.50.140. OB_NA_bd_sub. 2 hits. G3DSA:2.30.30.30. Ribosomal_L2. 1 hit.
KO	K02356.
Pfam	PF01132. EFP. 1 hit. PF08207. EFP_N. 1 hit. PF09285. Elong-fact-P_C. 1 hit. [Graphical view]
PIRSF	PIRSF005901. EF-P. 1 hit.
SMART	SM00841. Elong-fact-P_C. 1 hit. [Graphical view]
SUPFAM	SSF50249. Nucleic_acid_OB. 2 hits. SSF50104. Transl_SH3_like. 1 hit.
TIGRFAMs	TIGR00038. Efp. 1 hit.
PROSITE	PS01275. EFP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

EFP_MYCPN

Accession

Primary (citable) accession number: P75085

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	February 1, 1997
Last modified:	January 25, 2012
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program