Reviewed, UniProtKB/Swiss-Prot P75081 (UPP_MYCPN)

Names and origin

Protein names

Recommended name:
    Uracil phosphoribosyltransferase
    EC=2.4.2.9
Alternative name(s):
    UMP pyrophosphorylase
    UPRTase

Gene names

Name:	upp
Ordered Locus Names:	MPN_033
ORF Names:	MP121

Organism

Mycoplasma pneumoniae [Complete proteome] [HAMAP]

Taxonomic identifier

2104 [NCBI]

Taxonomic lineage

Bacteria › Tenericutes › Mollicutes › Mycoplasmataceae › Mycoplasma

Protein attributes

Sequence length	206 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_01218
Cofactor	Magnesium By similarity.
Pathway	Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1. HAMAP MF_01218
Sequence similarities	Belongs to the UPRTase family.

Ontologies

Keywords
Ligand	Magnesium
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	nucleoside metabolic process Inferred from electronic annotation. Source: InterPro uracil salvage Inferred from electronic annotation. Source: InterPro
Molecular function	magnesium ion binding Inferred from electronic annotation. Source: HAMAP uracil phosphoribosyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 206	206	Uracil phosphoribosyltransferase HAMAP MF_01218		PRO_0000120856
Regions
	Nucleotide binding	190 – 198	9	UMP By similarity
	Region	124 – 136	13	5-phosphoribose 1-diphosphate binding By similarity

Sequences

	Sequence		Length	Mass (Da)
	P75081-1 [UniParc]. Last modified May 30, 2000. Version 2. Checksum: 681506D3C62CC884	FASTA	206	22,750
	10 20 30 40 50 60 MIKKVHHALI ENELTKLRDK SSSSSQFRMA LSQITSLLFF EVTKESPLEE IVVKTPFTKT 70 80 90 100 110 120 KGYKLKNEIV LVPIMRAGLG MVDPIVRYSE KIRVGHLGIY REHEGTNVIS YYKKMPENIG 130 140 150 160 170 180 NSHVIILDPM LATGTTLATA ISSIKKNHPI KISVVAIVAA PEGIKAVEAA HPDVDIYLAA 190 200 IDEKLNKDNY IIPGLGDAGD RLFGTK

References

[1]

"Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae." Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R. Nucleic Acids Res. 24:4420-4449(1996) [PubMed: 8948633] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 29342 / M129.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U00089 Genomic DNA. Translation: AAG34738.1.
PIR	S73447.
RefSeq	NP_109721.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	877341.
GenomeReviews	Gene locus MPN_033 in contig U00089_GR.
KEGG	mpn:MPN033.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P75081.
OMA	PTAEVGF
Enzyme and pathway databases
BioCyc	MetaCyc:MONOMER-569. MPNE272634:MPN033-MON.
BRENDA	2.4.2.9. 39500.
Family and domain databases
HAMAP	MF_01218. [Tree]
InterPro	IPR000836. PRibTrfase. IPR005765. Ura_phspho_trans. [Graphical view]
Pfam	PF00156. Pribosyltran. 1 hit. [Graphical view]
TIGRFAMs	TIGR01091. upp. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UPP_MYCPN

Accession

Primary (citable) accession number: P75081

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	May 30, 2000
Last modified:	November 24, 2009
This is version 53 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)