Reviewed, UniProtKB/Swiss-Prot P75071 (GLPF_MYCPN)

Names and origin

Protein names

Recommended name:
    Probable glycerol uptake facilitator protein

Gene names

Name:	glpF
Ordered Locus Names:	MPN_043
ORF Names:	MP111

Organism

Mycoplasma pneumoniae [Complete proteome] [HAMAP]

Taxonomic identifier

2104 [NCBI]

Taxonomic lineage

Bacteria › Tenericutes › Mollicutes › Mycoplasmataceae › Mycoplasma

Protein attributes

Sequence length	264 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Glycerol enters the cell via the glycerol diffusion facilitator protein. This membrane protein facilitates the movement of glycerol across the cytoplasmic membrane By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein Potential.
Domain	Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
Sequence similarities	Belongs to the MIP/aquaporin (TC 1.A.8) family. [View classification]

Ontologies

Keywords
Biological process	Glycerol metabolism Transport
Cellular component	Cell membrane Membrane
Domain	Repeat Transmembrane
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycerol metabolic process Inferred from electronic annotation. Source: UniProtKB-KW transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 264	264	Probable glycerol uptake facilitator protein		PRO_0000064088
Regions
	Transmembrane	13 – 33	21	Potential
	Transmembrane	51 – 71	21	Potential
	Transmembrane	104 – 124	21	Potential
	Transmembrane	162 – 182	21	Potential
	Transmembrane	195 – 215	21	Potential
	Transmembrane	244 – 264	21	Potential
	Motif	78 – 80	3	NPA 1
	Motif	216 – 218	3	NPA 2

Sequences

	Sequence		Length	Mass (Da)
	P75071-1 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: 56A3FBD375A059CC	FASTA	264	28,305
	10 20 30 40 50 60 MFNLSDFSEL PRWIGAEFLG TFFLILSGNG AGSQLTLNKM FAKESKAKLL TAAFAWGIAV 70 80 90 100 110 120 LVGVLIANSL FEGAGNINPA VSLFYAVSGT IQKALYPLHV NFSIPLLWVA LLLAWVAQFA 130 140 150 160 170 180 GAMLAQALLN FLFWKHIEQT DPQSVLVTHC TNPAIFNIPR NFATEFVATS VLIASLLVAG 190 200 210 220 230 240 SFGANRFDQS PRGVVPMLVV TGLIMSFGAA TGTAINPARD LGPRIVYWLS PIKNKDPNLK 250 260 YSWIPVAAPL SASVILGVLV AVIV

References

[1]

"Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae." Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R. Nucleic Acids Res. 24:4420-4449(1996) [PubMed: 8948633] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 29342 / M129.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U00089 Genomic DNA. Translation: AAB95759.1.
PIR	S73437.
RefSeq	NP_109731.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	877407.
GenomeReviews	Gene locus MPN_043 in contig U00089_GR.
KEGG	mpn:MPN043.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG705794.
OMA	FESTEDH.
Enzyme and pathway databases
BioCyc	MPNE272634:MPN043-MON.
Family and domain databases
InterPro	IPR000425. MIP. [Graphical view]
Gene3D	G3DSA:1.20.1080.10. MIP. 1 hit.
PANTHER	PTHR19139. MIP. 1 hit.
Pfam	PF00230. MIP. 1 hit. [Graphical view]
PRINTS	PR00783. MINTRINSICP.
PROSITE	PS00221. MIP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLPF_MYCPN

Accession

Primary (citable) accession number: P75071

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	February 1, 1997
Last modified:	December 15, 2009
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)