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P75070

- KITH_MYCPN

UniProt

P75070 - KITH_MYCPN

Protein

Thymidine kinase

Gene

tdk

Organism
Mycoplasma pneumoniae (strain ATCC 29342 / M129)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei94 – 941Proton acceptorUniRule annotation
    Metal bindingi150 – 1501ZincUniRule annotation
    Metal bindingi153 – 1531ZincUniRule annotation
    Metal bindingi183 – 1831ZincUniRule annotation
    Metal bindingi186 – 1861ZincUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi20 – 278ATPUniRule annotation
    Nucleotide bindingi93 – 964ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. thymidine kinase activity Source: UniProtKB-HAMAP
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    DNA synthesis

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding, Zinc

    Enzyme and pathway databases

    BioCyciMPNE272634:GJ6Z-46-MONOMER.
    BRENDAi2.7.1.21. 3534.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
    Gene namesi
    Name:tdkUniRule annotation
    Ordered Locus Names:MPN_044
    ORF Names:MP110
    OrganismiMycoplasma pneumoniae (strain ATCC 29342 / M129)
    Taxonomic identifieri272634 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
    ProteomesiUP000000808: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 191191Thymidine kinasePRO_0000174999Add
    BLAST

    Proteomic databases

    PaxDbiP75070.

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    IntActiP75070. 1 interaction.
    STRINGi272634.MPN044.

    Structurei

    3D structure databases

    ProteinModelPortaliP75070.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidine kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1435.
    KOiK00857.
    OMAiDHISEST.
    OrthoDBiEOG69D3J2.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    HAMAPiMF_00124. Thymidine_kinase.
    InterProiIPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view]
    PANTHERiPTHR11441. PTHR11441. 1 hit.
    PfamiPF00265. TK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF035805. TK_cell. 1 hit.
    SUPFAMiSSF52540. SSF52540. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P75070-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSFSQVFHQS PRGWIEVICG PMFSGKTEEL LRKIKRWKLA KIPVIIFKPK    50
    IDTRQQHLVK SRNGHSDEAI EINSPLEIYD YLTKDRFDVV AIDEAQFFSS 100
    EIVEVVKSLN DLGINVIVSG LDTDFRAEPF GSIPQLLAIA DKICKLDAVC 150
    NVCGQLAQRT QRIVSKSNET VLIGDIEAYE PRCKLHQPSA G 191
    Length:191
    Mass (Da):21,500
    Last modified:February 1, 1997 - v1
    Checksum:iC333AF82EFC21F15
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00089 Genomic DNA. Translation: AAB95758.1.
    PIRiS73436.
    RefSeqiNP_109732.1. NC_000912.1.
    WP_010874401.1. NC_000912.1.

    Genome annotation databases

    EnsemblBacteriaiAAB95758; AAB95758; MPN_044.
    GeneIDi877408.
    KEGGimpn:MPN044.
    PATRICi20021365. VBIMycPne110_0044.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00089 Genomic DNA. Translation: AAB95758.1 .
    PIRi S73436.
    RefSeqi NP_109732.1. NC_000912.1.
    WP_010874401.1. NC_000912.1.

    3D structure databases

    ProteinModelPortali P75070.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P75070. 1 interaction.
    STRINGi 272634.MPN044.

    Proteomic databases

    PaxDbi P75070.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAB95758 ; AAB95758 ; MPN_044 .
    GeneIDi 877408.
    KEGGi mpn:MPN044.
    PATRICi 20021365. VBIMycPne110_0044.

    Phylogenomic databases

    eggNOGi COG1435.
    KOi K00857.
    OMAi DHISEST.
    OrthoDBi EOG69D3J2.

    Enzyme and pathway databases

    BioCyci MPNE272634:GJ6Z-46-MONOMER.
    BRENDAi 2.7.1.21. 3534.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    HAMAPi MF_00124. Thymidine_kinase.
    InterProi IPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view ]
    PANTHERi PTHR11441. PTHR11441. 1 hit.
    Pfami PF00265. TK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF035805. TK_cell. 1 hit.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae."
      Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.
      Nucleic Acids Res. 24:4420-4449(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 29342 / M129.
    2. "Towards a two-dimensional proteome map of Mycoplasma pneumoniae."
      Regula J.T., Ueberle B., Boguth G., Goerg A., Schnoelzer M., Herrmann R., Frank R.
      Electrophoresis 21:3765-3780(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: ATCC 29342 / M129.

    Entry informationi

    Entry nameiKITH_MYCPN
    AccessioniPrimary (citable) accession number: P75070
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Mycoplasma pneumoniae
      Mycoplasma pneumoniae (strain M129): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3