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Reviewed, UniProtKB/Swiss-Prot P75070 (KITH_MYCPN)

Last modified November 24, 2009. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Thymidine kinase
    EC=2.7.1.21
Gene names
Name: tdk
Ordered Locus Names: MPN_044
ORF Names: MP110
OrganismMycoplasma pneumoniae [Complete proteome] [HAMAP]
Taxonomic identifier2104 [NCBI]
Taxonomic lineageBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma

Protein attributes

Sequence length191 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Catalytic activity

ATP + thymidine = ADP + thymidine 5'-phosphate. HAMAP MF_00124

Subcellular location

Cytoplasm Potential.

Sequence similarities

Belongs to the thymidine kinase family.

Ontologies

Keywords
   Biological processDNA synthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processDNA replication

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionATP binding

Inferred from electronic annotation. Source: HAMAP

thymidine kinase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 191191Thymidine kinase HAMAP MF_00124
PRO_0000174999

Regions

Nucleotide binding20 – 278ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
P75070-1 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: C333AF82EFC21F15

FASTA19121,500
        10         20         30         40         50         60 
MSFSQVFHQS PRGWIEVICG PMFSGKTEEL LRKIKRWKLA KIPVIIFKPK IDTRQQHLVK 

        70         80         90        100        110        120 
SRNGHSDEAI EINSPLEIYD YLTKDRFDVV AIDEAQFFSS EIVEVVKSLN DLGINVIVSG 

       130        140        150        160        170        180 
LDTDFRAEPF GSIPQLLAIA DKICKLDAVC NVCGQLAQRT QRIVSKSNET VLIGDIEAYE 

       190 
PRCKLHQPSA G 

« Hide

References

« Hide 'large scale' references
[1]"Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae."
Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.
Nucleic Acids Res. 24:4420-4449(1996) [PubMed: 8948633] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 29342 / M129.
[2]"Towards a two-dimensional proteome map of Mycoplasma pneumoniae."
Regula J.T., Ueberle B., Boguth G., Goerg A., Schnoelzer M., Herrmann R., Frank R.
Electrophoresis 21:3765-3780(2000) [PubMed: 11271496] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY.
Strain: ATCC 29342 / M129.

Cross-references

Sequence databases

U00089 Genomic DNA. Translation: AAB95758.1.
PIRS73436.
RefSeqNP_109732.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID877408.
GenomeReviewsGene locus MPN_044 in contig U00089_GR.
KEGGmpn:MPN044.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMP75070.
OMATRERGSA

Enzyme and pathway databases

BioCycMetaCyc:MONOMER-566.
MPNE272634:MPN044-MON.
BRENDA2.7.1.21. 39500.

Family and domain databases

HAMAPMF_00124.
[Tree]
InterProIPR001267. Thymidine_kinase.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERPTHR11441. TK_cell. 1 hit.
PfamPF00265. TK. 1 hit.
[Graphical view]
PIRSFPIRSF035805. TK_cell. 1 hit.
PROSITEPS00603. TK_CELLULAR_TYPE. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKITH_MYCPN
AccessionPrimary (citable) accession number: P75070
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: November 24, 2009
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

Mycoplasma pneumoniae

Mycoplasma pneumoniae (strain M129): entries and gene names

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents