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Reviewed, UniProtKB/Swiss-Prot P75064 (GLPK_MYCPN)

Last modified November 24, 2009. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Glycerol kinase
    EC=2.7.1.30
Alternative name(s):
    ATP:glycerol 3-phosphotransferase
    Glycerokinase
      Short name=GK
Gene names
Name: glpK
Ordered Locus Names: MPN_050
ORF Names: MP104
OrganismMycoplasma pneumoniae [Complete proteome] [HAMAP]
Taxonomic identifier2104 [NCBI]
Taxonomic lineageBacteria › Tenericutes › Mollicutes › Mycoplasmataceae › Mycoplasma

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Protein attributes

Sequence length508 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Key enzyme in the regulation of glycerol uptake and metabolism. HAMAP MF_00186

Catalytic activity

ATP + glycerol = ADP + sn-glycerol 3-phosphate. HAMAP MF_00186

Pathway

Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1. HAMAP MF_00186

Sequence similarities

Belongs to the FGGY kinase family.

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Ontologies

Keywords
   Biological processGlycerol metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processglycerol-3-phosphate metabolic process

Inferred from electronic annotation. Source: HAMAP

   Molecular functionATP binding

Inferred from electronic annotation. Source: HAMAP

glycerol kinase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 508508Glycerol kinase HAMAP MF_00186
PRO_0000059468

Regions

Nucleotide binding419 – 4235ATP By similarity

Sites

Binding site151Substrate By similarity
Binding site191ATP By similarity
Binding site851Substrate By similarity
Binding site1381Substrate By similarity
Binding site2511Substrate By similarity
Binding site2731ATP By similarity
Binding site3171ATP; via carbonyl oxygen By similarity

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Sequences

Sequence LengthMass (Da)Tools
P75064-1 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: 8C60F0132DFD62A6

FASTA50856,591
        10         20         30         40         50         60 
MDLKQQYILA LDEGTSSCRT IVFDKDLNQV AIAQNEFNQF FPKSGWVEQD PLEIWSVQLA 

        70         80         90        100        110        120 
TMQSAKNKAQ IKSNNIAAVG ITNQRETIVL WNKENGLPVY NAIVWQDQRT ASLCDKLNQD 

       130        140        150        160        170        180 
TKIKEFVKKH TGLPINPYFS ATKIAWILEN VPLAQKMLKE DKLLAGTIDT WLIWKLTGGK 

       190        200        210        220        230        240 
MHVTDVSNAS RTLLFDITTM TWSQELGDIF KVPLSILPKV MPSNAHFGDI VPSHWSTSAT 

       250        260        270        280        290        300 
GMVPIRGVAG DQQAALFGQL CVEPAMVKNT YGTGCFMLMN IGNELKYSQH NLLTTVAWQL 

       310        320        330        340        350        360 
ENQKPVYALE GSVFVAGAAL KWLRDSLKVM YSAAESDFYA KLAQKEEQEV VFVPAFTGLG 

       370        380        390        400        410        420 
APYWDASARG AIFGIEANTK REHLVKATLE AIAFQANDLI KAMASDLNSS IKKIKADGGA 

       430        440        450        460        470        480 
CNSNYLMQFQ ADIANLEVII PKNVETTTMG AAFLAGLAVN YWKDTKQLEK LTGIAKQFKS 

       490        500 
QMNQTVREKK SKRWNEAVKR TLKWASLD

« Hide

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References

[1]"Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae."
Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.
Nucleic Acids Res. 24:4420-4449(1996) [PubMed: 8948633] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 29342 / M129.

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Cross-references

Sequence databases

U00089 Genomic DNA. Translation: AAB95752.1.
PIRS73430.
RefSeqNP_109738.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID876741.
GenomeReviewsGene locus MPN_050 in contig U00089_GR.
KEGGmpn:MPN050.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMP75064.
OMANHEESEI

Enzyme and pathway databases

BioCycMPNE272634:MPN050-MON.
BRENDA2.7.1.30. 39500.

Family and domain databases

HAMAPMF_00186.
[Tree]
InterProIPR000577. Carb_kinase_FGGY.
IPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
IPR005999. Glycerol_kin.
[Graphical view]
PANTHERPTHR10196. FGGY_kin. 1 hit.
PTHR10196:SF9. Glycerol_kin. 1 hit.
PfamPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]
TIGRFAMsTIGR01311. glycerol_kin. 1 hit.
PROSITEPS00933. FGGY_KINASES_1. 1 hit.
PS00445. FGGY_KINASES_2. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameGLPK_MYCPN
AccessionPrimary (citable) accession number: P75064
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: November 24, 2009
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

Mycoplasma pneumoniae

Mycoplasma pneumoniae (strain M129): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents