Reviewed, UniProtKB/Swiss-Prot P75059 (POTA_MYCPN)

Names and origin

Protein names

Recommended name:
    Spermidine/putrescine import ATP-binding protein potA
    EC=3.6.3.31

Gene names

Name:	potA
Ordered Locus Names:	MPN_055
ORF Names:	MP099

Organism

Mycoplasma pneumoniae [Complete proteome] [HAMAP]

Taxonomic identifier

2104 [NCBI]

Taxonomic lineage

Bacteria › Tenericutes › Mollicutes › Mycoplasmataceae › Mycoplasma

Protein attributes

Sequence length	560 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Part of the ABC transporter complex potABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system By similarity.
Catalytic activity	ATP + H2O + polyamine(Out) = ADP + phosphate + polyamine(In). HAMAP MF_01726
Subunit structure	The complex is composed of two ATP-binding proteins (potA), two transmembrane proteins (potB and potC) and a solute-binding protein (potD) Probable.
Subcellular location	Cell membrane; Peripheral membrane protein By similarity.
Sequence similarities	Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family. [View classification] Contains 1 ABC transporter domain.

Ontologies

Keywords
Biological process	Transport
Cellular component	Cell membrane Membrane
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	polyamine transport Inferred from electronic annotation. Source: HAMAP
Cellular component	ATP-binding cassette (ABC) transporter complex Inferred from electronic annotation. Source: InterPro extrinsic to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW polyamine-transporting ATPase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 560	560	Spermidine/putrescine import ATP-binding protein potA HAMAP MF_01726		PRO_0000092751
Regions
	Domain	7 – 449	443	ABC transporter
	Nucleotide binding	40 – 47	8	ATP Potential
	Region	108 – 318	211	Insert HAMAP MF_01726

Sequences

	Sequence		Length	Mass (Da)
	P75059-1 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: 8993CAE61A28723D	FASTA	560	65,131
	10 20 30 40 50 60 MNERFLIEIE GLNKTFDDGF VSVRDINLKI KKGEFITILG PSGCGKTTTL RLLAGFEDPT 70 80 90 100 110 120 YGKIKVNGLD IKDLPIHKRP FATVFQDYAL FSHLTVYKNI AYGLKAMYTK LDPIDKLVEQ 130 140 150 160 170 180 YHQSLLDKQH RLHKRIERLE KSNANPQLLE QLKQTVVVQQ KQFKQQTETF KQKENARRDA 190 200 210 220 230 240 IQQRLVQLTK EWESLSKQKL QQLEAEKKLL DKKFEQTERK YQKDAWMATH SEMRLKQFKQ 250 260 270 280 290 300 EVLALKQLIK TKFKQNEPVD KLQLKLQTLK QKYAAKRQID KEYDKLVLAY NKKDYWTSYW 310 320 330 340 350 360 ETYSLQQQEA FEKRYLSRKL TKQEQHQKVC AVIELVGLKG NEDKLPEELS GGMKQRVALA 370 380 390 400 410 420 RSLVIEPDIL LLDEPLSALD AKVRKNLQKE LQKIHQQSGL TFILVTHDQE EALVLSNRIV 430 440 450 460 470 480 VMNEGNILQV GSPADIYDSP KTEWIANFIG QANIFKGTYL GDLKIKLHSG EVIKTDVDNN 490 500 510 520 530 540 YVVGKEYKIL IRPEDFDIVP KNKGFFNVRV IDKTYKGLLW KITTKLVDDT IVDLESVNDI 550 560 EVDKTFGVTF DPIDVHLMEV

References

[1]

"Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae." Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R. Nucleic Acids Res. 24:4420-4449(1996) [PubMed: 8948633] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 29342 / M129.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U00089 Genomic DNA. Translation: AAB95747.1.
PIR	S73425.
RefSeq	NP_109743.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	876902.
GenomeReviews	Gene locus MPN_055 in contig U00089_GR.
KEGG	mpn:MPN055.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P75059.
OMA	TSYWETY
Enzyme and pathway databases
BioCyc	MPNE272634:MPN055-MON.
BRENDA	3.6.3.31. 39500.
Family and domain databases
HAMAP	MF_01726. [Tree]
InterPro	IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR003593. ATPase_AAA+_core. IPR008995. Mo/tungstate-bd. IPR017879. POTA. IPR013611. Transp-assoc_OB_typ2. [Graphical view]
Pfam	PF00005. ABC_tran. 1 hit. PF08402. TOBE_2. 1 hit. [Graphical view]
SMART	SM00382. AAA. 1 hit. [Graphical view]
PROSITE	PS00211. ABC_TRANSPORTER_1. 1 hit. PS50893. ABC_TRANSPORTER_2. 1 hit. PS51305. POTA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

POTA_MYCPN

Accession

Primary (citable) accession number: P75059

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	February 1, 1997
Last modified:	November 24, 2009
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)