Reviewed, UniProtKB/Swiss-Prot P75055 (GCP_MYCPN)

Names and origin

Protein names

Recommended name:
    Probable O-sialoglycoprotein endopeptidase
      Short name=Glycoprotease
    EC=3.4.24.57

Gene names

Name:	gcp
Ordered Locus Names:	MPN_059
ORF Names:	MP095

Organism

Mycoplasma pneumoniae [Complete proteome] [HAMAP]

Taxonomic identifier

2104 [NCBI]

Taxonomic lineage

Bacteria › Tenericutes › Mollicutes › Mycoplasmataceae › Mycoplasma

Protein attributes

Sequence length	319 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Hydrolysis of O-sialoglycoproteins; cleaves 31-Arg-|-Asp-32 bond in glycophorin A. Does not cleave unglycosylated proteins, desialylated glycoproteins or glycoproteins that are only N-glycosylated. HAMAP MF_01445
Cofactor	Zinc Probable.
Sequence similarities	Belongs to the peptidase M22 family.

Ontologies

Keywords
Ligand	Metal-binding Zinc
Molecular function	Hydrolase Metalloprotease Protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: InterPro
Molecular function	metalloendopeptidase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 319	319	Probable O-sialoglycoprotein endopeptidase HAMAP MF_01445		PRO_0000096968
Sites
	Metal binding	110	1	Zinc Potential
	Metal binding	114	1	Zinc Potential

Sequences

	Sequence		Length	Mass (Da)
	P75055-1 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: 39021A8BBC6A95CE	FASTA	319	35,210
	10 20 30 40 50 60 MEQPLCILGI ETTCDDTSIG VITESKVQAH IVLSSAKLHA QTGGVVPEVA ARSHEQNLLK 70 80 90 100 110 120 ALQQSGVVLE QITHIAYAAN PGLPGCLHVG ATFARSLSFL LDKPLLPINH LYAHIFSALI 130 140 150 160 170 180 DQDINQLKLP ALGLVVSGGH TAIYLIKSLF DLELIAETSD DAIGEVYDKV GRAMGFPYPA 190 200 210 220 230 240 GPQLDSLFQP ELVKSHYFFR PSTKWTKFSY SGLKSQCFTK IKQLRERKGF NPQTHDWNEF 250 260 270 280 290 300 ASNFQATIID HYINHVKDAI QQHQPQMLLL GGGVSANKYL REQVTQLQLP YLIAPLKYTS 310 DNGAMIGFYA NLLINGKNN

References

[1]

"Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae." Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R. Nucleic Acids Res. 24:4420-4449(1996) [PubMed: 8948633] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 29342 / M129.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U00089 Genomic DNA. Translation: AAB95743.1.
PIR	S73421.
RefSeq	NP_109747.1.
3D structure databases
ModBase	Search...
Protein family/group databases
MEROPS	M22.001.
Genome annotation databases
GeneID	876963.
GenomeReviews	Gene locus MPN_059 in contig U00089_GR.
KEGG	mpn:MPN059.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P75055.
OMA	MEVIGQT
Enzyme and pathway databases
BioCyc	MPNE272634:MPN059-MON.
BRENDA	3.4.24.57. 39500.
Family and domain databases
HAMAP	MF_01445. [Tree]
InterPro	IPR009180. Pept_M22_O-sialoglycoprot. IPR000905. Peptidase_M22. IPR017860. Peptidase_M22_CS. IPR017861. Peptidase_M22_subgr. [Graphical view]
PANTHER	PTHR11735. Pept_M22_Osialgl. 1 hit.
Pfam	PF00814. Peptidase_M22. 1 hit. [Graphical view]
PRINTS	PR00789. OSIALOPTASE.
TIGRFAMs	TIGR00329. gcp. 1 hit.
PROSITE	PS01016. GLYCOPROTEASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GCP_MYCPN

Accession

Primary (citable) accession number: P75055

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	February 1, 1997
Last modified:	November 24, 2009
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)