Reviewed,
UniProtKB/Swiss-Prot P75052 (TYPH_MYCPN)
Last modified
November 24, 2009.
Version 62.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
Customize display | text xml rdf/xml gff fasta |
Names and origin
| Protein names | Recommended name: Thymidine phosphorylase EC=2.4.2.4 Alternative name(s): TdRPase | ||||||
| Gene names |
| ||||||
| Organism | Mycoplasma pneumoniae [Complete proteome] [HAMAP] | ||||||
| Taxonomic identifier | 2104 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Tenericutes › Mollicutes › Mycoplasmataceae › Mycoplasma |
Protein attributes
| Sequence length | 421 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis. |
| Catalytic activity | Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate. |
| Subunit structure | Homodimer By similarity. |
| Sequence similarities | Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. |
Ontologies
| Keywords | |
|---|---|
| Molecular function | Glycosyltransferase Transferase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | pyrimidine base metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleoside metabolic processInferred from electronic annotation. Source: InterPro |
| Molecular function | thymidine phosphorylase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||
Molecule processing | |||||||
|---|---|---|---|---|---|---|---|
| Chain | 1 – 421 | 421 | Thymidine phosphorylase | PRO_0000059081 | |||
Sequences
| ||||||||||||||||||
References
| [1] | "Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae." Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R. Nucleic Acids Res. 24:4420-4449(1996) [PubMed: 8948633] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 29342 / M129. |
Cross-references
Sequence databases | |
|---|---|
| U00089 Genomic DNA. Translation: AAB95738.1. | |
| PIR | S73416. |
| RefSeq | NP_109752.1. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 876960. |
| GenomeReviews | Gene locus MPN_064 in contig U00089_GR. |
| KEGG | mpn:MPN064. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | P75052. |
| OMA | ILLRGMD |
Enzyme and pathway databases | |
| BioCyc | MetaCyc:MONOMER-565. MPNE272634:MPN064-MON. |
| BRENDA | 2.4.2.4. 39500. |
Family and domain databases | |
| InterPro | IPR000312. Glycosyl_Trfase_fam3. IPR017459. Glycosyl_Trfase_fam3_N. IPR013102. PYNP_C. IPR018090. Pyrmidine_PPas_bac/euk. IPR000053. Pyrmidine_PPase. IPR017872. Pyrmidine_PPase_CS. [Graphical view] |
| Gene3D | G3DSA:3.40.1030.10. Glyco_trans_3. 1 hit. |
| PANTHER | PTHR10515. Pyrmidine_PPase. 1 hit. |
| Pfam | PF02885. Glycos_trans_3N. 1 hit. PF00591. Glycos_transf_3. 1 hit. PF07831. PYNP_C. 1 hit. [Graphical view] |
| PIRSF | PIRSF000478. TP_PyNP. 1 hit. |
| TIGRFAMs | TIGR02644. Y_phosphoryl. 1 hit. |
| PROSITE | PS00647. THYMID_PHOSPHORYLASE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | TYPH_MYCPN | ||||||||
| Accession | Primary (citable) accession number: P75052 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| Mycoplasma pneumoniae Mycoplasma pneumoniae (strain M129): entries and gene names |
| SIMILARITY comments Index of protein domains and families |

Clusters with


