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P75052

- TYPH_MYCPN

UniProt

P75052 - TYPH_MYCPN

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Protein

Thymidine phosphorylase

Gene
deoA, MPN_064, MP090
Organism
Mycoplasma pneumoniae (strain ATCC 29342 / M129)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis.

Catalytic activityi

Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate.

GO - Molecular functioni

  1. phosphorylase activity Source: InterPro
  2. pyrimidine-nucleoside phosphorylase activity Source: InterPro
  3. thymidine phosphorylase activity Source: UniProtKB-EC

GO - Biological processi

  1. pyrimidine nucleobase metabolic process Source: InterPro
  2. pyrimidine nucleoside metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciMPNE272634:GJ6Z-66-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine phosphorylase (EC:2.4.2.4)
Alternative name(s):
TdRPase
Gene namesi
Name:deoA
Ordered Locus Names:MPN_064
ORF Names:MP090
OrganismiMycoplasma pneumoniae (strain ATCC 29342 / M129)
Taxonomic identifieri272634 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000000808: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 421421Thymidine phosphorylasePRO_0000059081Add
BLAST

Proteomic databases

PaxDbiP75052.

Interactioni

Subunit structurei

Homodimer By similarity.

Binary interactionsi

WithEntry#Exp.IntActNotes
uppP750811EBI-2258997,EBI-2258987

Protein-protein interaction databases

IntActiP75052. 1 interaction.
STRINGi272634.MPN064.

Structurei

3D structure databases

ProteinModelPortaliP75052.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0213.
KOiK00758.
OMAiITNMNEP.
OrthoDBiEOG61ZTGG.

Family and domain databases

Gene3Di3.40.1030.10. 1 hit.
3.90.1170.30. 1 hit.
InterProiIPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
IPR013102. PYNP_C.
IPR018090. Pyrmidine_PPas_bac/euk.
IPR000053. Pyrmidine_PPase.
IPR017872. Pyrmidine_PPase_CS.
[Graphical view]
PANTHERiPTHR10515. PTHR10515. 1 hit.
PfamiPF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000478. TP_PyNP. 1 hit.
SMARTiSM00941. PYNP_C. 1 hit.
[Graphical view]
SUPFAMiSSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
SSF54680. SSF54680. 1 hit.
TIGRFAMsiTIGR02644. Y_phosphoryl. 1 hit.
PROSITEiPS00647. THYMID_PHOSPHORYLASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P75052-1 [UniParc]FASTAAdd to Basket

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MNIVNLISKK QRGKALTETE INWFVHSVNN KSLADYQVSA FLMAVWFQGM    50
NSKELFCLTK AMVKSGESLH FNHHSKLSVD KHSTGGIGDK VSIALIPILT 100
ALDYSVAKLS GRGLGYTGGT IDKLEAVGVK TDFTPTEAQN LLDQNDCFII 150
GQSEGIAPVD KVLYALRDTT ATVDSLPLIA SSVMSKKLAI NNDYIFIDLK 200
YGKGAFCKTK TMAKELAQYM YSIAKQFKRK LYIKLSDMNQ VLGKTIGNAL 250
EVLEVVHFLK RNWTEVGADF IQLMEQIVTE ILIETKRAPN KRAAVALYHA 300
TLEGEKPWQR FLKFIELQGS SWERFLDLKE LFNPQYKAPV LASQSGTLSY 350
TSPVDLAMVS ISLGAGRMVK TDLIDPMAGI KLVKQANEVV KAGDTVLELY 400
SSKPITPAHI EAAQHTIIIK Q 421
Length:421
Mass (Da):46,628
Last modified:February 1, 1997 - v1
Checksum:iE29DBF93C6D8549F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00089 Genomic DNA. Translation: AAB95738.1.
PIRiS73416.
RefSeqiNP_109752.1. NC_000912.1.

Genome annotation databases

EnsemblBacteriaiAAB95738; AAB95738; MPN_064.
GeneIDi876960.
KEGGimpn:MPN064.
PATRICi20021407. VBIMycPne110_0065.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00089 Genomic DNA. Translation: AAB95738.1 .
PIRi S73416.
RefSeqi NP_109752.1. NC_000912.1.

3D structure databases

ProteinModelPortali P75052.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P75052. 1 interaction.
STRINGi 272634.MPN064.

Proteomic databases

PaxDbi P75052.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB95738 ; AAB95738 ; MPN_064 .
GeneIDi 876960.
KEGGi mpn:MPN064.
PATRICi 20021407. VBIMycPne110_0065.

Phylogenomic databases

eggNOGi COG0213.
KOi K00758.
OMAi ITNMNEP.
OrthoDBi EOG61ZTGG.

Enzyme and pathway databases

BioCyci MPNE272634:GJ6Z-66-MONOMER.

Family and domain databases

Gene3Di 3.40.1030.10. 1 hit.
3.90.1170.30. 1 hit.
InterProi IPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
IPR013102. PYNP_C.
IPR018090. Pyrmidine_PPas_bac/euk.
IPR000053. Pyrmidine_PPase.
IPR017872. Pyrmidine_PPase_CS.
[Graphical view ]
PANTHERi PTHR10515. PTHR10515. 1 hit.
Pfami PF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view ]
PIRSFi PIRSF000478. TP_PyNP. 1 hit.
SMARTi SM00941. PYNP_C. 1 hit.
[Graphical view ]
SUPFAMi SSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
SSF54680. SSF54680. 1 hit.
TIGRFAMsi TIGR02644. Y_phosphoryl. 1 hit.
PROSITEi PS00647. THYMID_PHOSPHORYLASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae."
    Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.
    Nucleic Acids Res. 24:4420-4449(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29342 / M129.

Entry informationi

Entry nameiTYPH_MYCPN
AccessioniPrimary (citable) accession number: P75052
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: May 14, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycoplasma pneumoniae
    Mycoplasma pneumoniae (strain M129): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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