Reviewed, UniProtKB/Swiss-Prot P75052 (TYPH_MYCPN)

Names and origin

Protein names

Recommended name:
    Thymidine phosphorylase
    EC=2.4.2.4
Alternative name(s):
    TdRPase

Gene names

Name:	deoA
Ordered Locus Names:	MPN_064
ORF Names:	MP090

Organism

Mycoplasma pneumoniae [Complete proteome] [HAMAP]

Taxonomic identifier

2104 [NCBI]

Taxonomic lineage

Bacteria › Tenericutes › Mollicutes › Mycoplasmataceae › Mycoplasma

Protein attributes

Sequence length	421 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis.
Catalytic activity	Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.

Ontologies

Keywords
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	pyrimidine base metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleoside metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	thymidine phosphorylase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 421	421	Thymidine phosphorylase		PRO_0000059081

Sequences

	Sequence		Length	Mass (Da)
	P75052-1 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: E29DBF93C6D8549F	FASTA	421	46,628
	10 20 30 40 50 60 MNIVNLISKK QRGKALTETE INWFVHSVNN KSLADYQVSA FLMAVWFQGM NSKELFCLTK 70 80 90 100 110 120 AMVKSGESLH FNHHSKLSVD KHSTGGIGDK VSIALIPILT ALDYSVAKLS GRGLGYTGGT 130 140 150 160 170 180 IDKLEAVGVK TDFTPTEAQN LLDQNDCFII GQSEGIAPVD KVLYALRDTT ATVDSLPLIA 190 200 210 220 230 240 SSVMSKKLAI NNDYIFIDLK YGKGAFCKTK TMAKELAQYM YSIAKQFKRK LYIKLSDMNQ 250 260 270 280 290 300 VLGKTIGNAL EVLEVVHFLK RNWTEVGADF IQLMEQIVTE ILIETKRAPN KRAAVALYHA 310 320 330 340 350 360 TLEGEKPWQR FLKFIELQGS SWERFLDLKE LFNPQYKAPV LASQSGTLSY TSPVDLAMVS 370 380 390 400 410 420 ISLGAGRMVK TDLIDPMAGI KLVKQANEVV KAGDTVLELY SSKPITPAHI EAAQHTIIIK Q

References

[1]

"Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae." Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R. Nucleic Acids Res. 24:4420-4449(1996) [PubMed: 8948633] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 29342 / M129.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U00089 Genomic DNA. Translation: AAB95738.1.
PIR	S73416.
RefSeq	NP_109752.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	876960.
GenomeReviews	Gene locus MPN_064 in contig U00089_GR.
KEGG	mpn:MPN064.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P75052.
OMA	ILLRGMD
Enzyme and pathway databases
BioCyc	MetaCyc:MONOMER-565. MPNE272634:MPN064-MON.
BRENDA	2.4.2.4. 39500.
Family and domain databases
InterPro	IPR000312. Glycosyl_Trfase_fam3. IPR017459. Glycosyl_Trfase_fam3_N. IPR013102. PYNP_C. IPR018090. Pyrmidine_PPas_bac/euk. IPR000053. Pyrmidine_PPase. IPR017872. Pyrmidine_PPase_CS. [Graphical view]
Gene3D	G3DSA:3.40.1030.10. Glyco_trans_3. 1 hit.
PANTHER	PTHR10515. Pyrmidine_PPase. 1 hit.
Pfam	PF02885. Glycos_trans_3N. 1 hit. PF00591. Glycos_transf_3. 1 hit. PF07831. PYNP_C. 1 hit. [Graphical view]
PIRSF	PIRSF000478. TP_PyNP. 1 hit.
TIGRFAMs	TIGR02644. Y_phosphoryl. 1 hit.
PROSITE	PS00647. THYMID_PHOSPHORYLASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TYPH_MYCPN

Accession

Primary (citable) accession number: P75052

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	February 1, 1997
Last modified:	November 24, 2009
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)