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P75051

- CDD_MYCPN

UniProt

P75051 - CDD_MYCPN

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Protein
Cytidine deaminase
Gene
cdd, MPN_065, MP089
Organism
Mycoplasma pneumoniae (strain ATCC 29342 / M129)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis By similarity.

Catalytic activityi

Cytidine + H2O = uridine + NH3.
2'deoxycytidine + H2O = 2'-deoxyuridine + NH3.

Cofactori

Binds 1 zinc ion By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi54 – 541Zinc; catalytic By similarity
Active sitei56 – 561Proton donor By similarity
Metal bindingi89 – 891Zinc; catalytic By similarity
Metal bindingi92 – 921Zinc; catalytic By similarity

GO - Molecular functioni

  1. cytidine deaminase activity Source: UniProtKB-EC
  2. zinc ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciMPNE272634:GJ6Z-67-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytidine deaminase (EC:3.5.4.5)
    Short name:
    CDA
    Alternative name(s):
    Cytidine aminohydrolase
    Gene namesi
    Name:cdd
    Ordered Locus Names:MPN_065
    ORF Names:MP089
    OrganismiMycoplasma pneumoniae (strain ATCC 29342 / M129)
    Taxonomic identifieri272634 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
    ProteomesiUP000000808: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 133133Cytidine deaminase
    PRO_0000171681Add
    BLAST

    Proteomic databases

    PaxDbiP75051.

    Interactioni

    Subunit structurei

    Homodimer By similarity.

    Protein-protein interaction databases

    IntActiP75051. 1 interaction.
    STRINGi272634.MPN065.

    Structurei

    3D structure databases

    ProteinModelPortaliP75051.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini7 – 10498CMP/dCMP deaminase zinc-binding
    Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni43 – 453Substrate binding By similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0295.
    OMAiFIGANIE.
    OrthoDBiEOG6XDH25.

    Family and domain databases

    InterProiIPR016192. APOBEC/CMP_deaminase_Zn-bd.
    IPR002125. CMP_dCMP_Zn-bd.
    IPR006262. Cyt_deam_tetra.
    IPR016193. Cytidine_deaminase-like.
    [Graphical view]
    PfamiPF00383. dCMP_cyt_deam_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF53927. SSF53927. 1 hit.
    TIGRFAMsiTIGR01354. cyt_deam_tetra. 1 hit.
    PROSITEiPS00903. CYT_DCMP_DEAMINASES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P75051-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKVDLDWVHH KLQEVVNHAY TPFSKFKVAC MLVANNQAFY GVNIENASYP    50
    VTLCAERSAI ANMVTSIGKA TIDYVFVYFD TKTPTNSPCG MCRQNIFEFA 100
    TDKTQLFCIE KDKSFKQFTI PEILKGGFRS YEQ 133
    Length:133
    Mass (Da):15,185
    Last modified:February 1, 1997 - v1
    Checksum:iEC87E73810DEA9C7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00089 Genomic DNA. Translation: AAB95737.1.
    PIRiS73415.
    RefSeqiNP_109753.1. NC_000912.1.

    Genome annotation databases

    EnsemblBacteriaiAAB95737; AAB95737; MPN_065.
    GeneIDi877155.
    KEGGimpn:MPN065.
    PATRICi20021409. VBIMycPne110_0066.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00089 Genomic DNA. Translation: AAB95737.1 .
    PIRi S73415.
    RefSeqi NP_109753.1. NC_000912.1.

    3D structure databases

    ProteinModelPortali P75051.
    ModBasei Search...

    Protein-protein interaction databases

    IntActi P75051. 1 interaction.
    STRINGi 272634.MPN065.

    Proteomic databases

    PaxDbi P75051.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAB95737 ; AAB95737 ; MPN_065 .
    GeneIDi 877155.
    KEGGi mpn:MPN065.
    PATRICi 20021409. VBIMycPne110_0066.

    Phylogenomic databases

    eggNOGi COG0295.
    OMAi FIGANIE.
    OrthoDBi EOG6XDH25.

    Enzyme and pathway databases

    BioCyci MPNE272634:GJ6Z-67-MONOMER.

    Family and domain databases

    InterProi IPR016192. APOBEC/CMP_deaminase_Zn-bd.
    IPR002125. CMP_dCMP_Zn-bd.
    IPR006262. Cyt_deam_tetra.
    IPR016193. Cytidine_deaminase-like.
    [Graphical view ]
    Pfami PF00383. dCMP_cyt_deam_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53927. SSF53927. 1 hit.
    TIGRFAMsi TIGR01354. cyt_deam_tetra. 1 hit.
    PROSITEi PS00903. CYT_DCMP_DEAMINASES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae."
      Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.
      Nucleic Acids Res. 24:4420-4449(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 29342 / M129.

    Entry informationi

    Entry nameiCDD_MYCPN
    AccessioniPrimary (citable) accession number: P75051
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: February 1, 1997
    Last modified: May 14, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Mycoplasma pneumoniae
      Mycoplasma pneumoniae (strain M129): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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