P75051 (CDD_MYCPN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytidine deaminase
Short name=CDA
EC=3.5.4.5

Alternative name(s):
Cytidine aminohydrolase

Gene names

Name:	cdd
Ordered Locus Names:	MPN_065
ORF Names:	MP089

Organism

Mycoplasma pneumoniae (strain ATCC 29342 / M129)

Taxonomic identifier

272634 [NCBI]

Taxonomic lineage

Bacteria › Tenericutes › Mollicutes › Mycoplasmataceae › Mycoplasma

Protein attributes

Sequence length	133 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis By similarity.
Catalytic activity	Cytidine + H2O = uridine + NH3.
Cofactor	Binds 1 zinc ion By similarity.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the cytidine and deoxycytidylate deaminase family.

Ontologies

Keywords
Ligand	Metal-binding Zinc
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	cytidine deaminase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 133	133	Cytidine deaminase		PRO_0000171681
Regions
	Region	43 – 45	3	Substrate binding By similarity
Sites
	Active site	56	1	Proton donor By similarity
	Metal binding	54	1	Zinc; catalytic By similarity
	Metal binding	89	1	Zinc; catalytic By similarity
	Metal binding	92	1	Zinc; catalytic By similarity

Sequences

	Sequence		Length	Mass (Da)
	P75051 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: EC87E73810DEA9C7	FASTA	133	15,185
	10 20 30 40 50 60 MKVDLDWVHH KLQEVVNHAY TPFSKFKVAC MLVANNQAFY GVNIENASYP VTLCAERSAI 70 80 90 100 110 120 ANMVTSIGKA TIDYVFVYFD TKTPTNSPCG MCRQNIFEFA TDKTQLFCIE KDKSFKQFTI 130 PEILKGGFRS YEQ

References

[1]	"Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae." Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R. Nucleic Acids Res. 24:4420-4449(1996) [PubMed: 8948633] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 29342 / M129.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U00089 Genomic DNA. Translation: AAB95737.1.
PIR	S73415.
RefSeq	NP_109753.1. NC_000912.1.
3D structure databases
ProteinModelPortal	P75051.
ModBase	Search...
Protein-protein interaction databases
IntAct	P75051. 1 interaction.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	877155.
GenomeReviews	Gene locus MPN_065 in contig U00089_GR.
KEGG	mpn:MPN065.
PATRIC	20021409. VBIMycPne110_0066.
Phylogenomic databases
HOGENOM	HBG352939.
OMA	CNIENAT.
PhylomeDB	P75051.
ProtClustDB	CLSK542120.
Enzyme and pathway databases
BioCyc	MetaCyc:MONOMER-572. MPNE272634:MPN065-MONOMER.
Family and domain databases
InterPro	IPR016192. APOBEC/CMP_deaminase_Zn-bd. IPR002125. CMP_dCMP_Zn-bd. IPR006262. Cyt_deam_tetra. IPR016193. Cytidine_deaminase-like. [Graphical view]
Pfam	PF00383. dCMP_cyt_deam_1. 1 hit. [Graphical view]
SUPFAM	SSF53927. Cytidine_deaminase-like. 1 hit.
TIGRFAMs	TIGR01354. Cyt_deam_tetra. 1 hit.
PROSITE	PS00903. CYT_DCMP_DEAMINASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CDD_MYCPN

Accession

Primary (citable) accession number: P75051

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	February 1, 1997
Last modified:	January 25, 2012
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program