Reviewed,
UniProtKB/Swiss-Prot P75051 (CDD_MYCPN)
Last modified
November 3, 2009.
Version 57.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Cytidine deaminase Short name=CDA EC=3.5.4.5 Alternative name(s): Cytidine aminohydrolase | ||||||
| Gene names |
| ||||||
| Organism | Mycoplasma pneumoniae [Complete proteome] [HAMAP] | ||||||
| Taxonomic identifier | 2104 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Tenericutes › Mollicutes › Mycoplasmataceae › Mycoplasma |
Protein attributes
| Sequence length | 133 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis By similarity. |
| Catalytic activity | Cytidine + H2O = uridine + NH3. |
| Cofactor | Binds 1 zinc ion By similarity. |
| Subunit structure | Homodimer By similarity. |
| Sequence similarities | Belongs to the cytidine and deoxycytidylate deaminase family. |
Ontologies
| Keywords | |
|---|---|
| Ligand | Metal-binding Zinc |
| Molecular function | Hydrolase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | cytidine metabolic process Inferred from electronic annotation. Source: InterPro |
| Molecular function | cytidine deaminase activity Inferred from electronic annotation. Source: EC zinc ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 133 | 133 | Cytidine deaminase | PRO_0000171681 | |||||
Regions | |||||||||
| Region | 43 – 45 | 3 | Substrate binding By similarity | ||||||
Sites | |||||||||
| Active site | 56 | 1 | Proton donor By similarity | ||||||
| Metal binding | 54 | 1 | Zinc; catalytic By similarity | ||||||
| Metal binding | 89 | 1 | Zinc; catalytic By similarity | ||||||
| Metal binding | 92 | 1 | Zinc; catalytic By similarity | ||||||
Sequences
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References
| [1] | "Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae." Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R. Nucleic Acids Res. 24:4420-4449(1996) [PubMed: 8948633] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 29342 / M129. |
Cross-references
Sequence databases | |
|---|---|
| U00089 Genomic DNA. Translation: AAB95737.1. | |
| PIR | S73415. |
| RefSeq | NP_109753.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1JTK based on UniProtKB P19079. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 877155. |
| GenomeReviews | Gene locus MPN_065 in contig U00089_GR. |
| KEGG | mpn:MPN065. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | P75051. |
| OMA | IDYVFVY. |
Enzyme and pathway databases | |
| BioCyc | MetaCyc:MON-572. MPNE272634:MPN065-MON. |
| BRENDA | 3.5.4.5. 39500. |
Family and domain databases | |
| InterPro | IPR016192. APOBEC/CMP_deaminase_Zn-bd. IPR002125. CMP_dCMP_Zn_bd. IPR006262. Cyt_deam_tetra. [Graphical view] |
| PANTHER | PTHR11644:SF2. Cyt_deam_tetra. 1 hit. |
| Pfam | PF00383. dCMP_cyt_deam_1. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR01354. cyt_deam_tetra. 1 hit. |
| PROSITE | PS00903. CYT_DCMP_DEAMINASES. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | CDD_MYCPN | ||||||||
| Accession | Primary (citable) accession number: P75051 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| Mycoplasma pneumoniae Mycoplasma pneumoniae (strain M129): entries and gene names |
| SIMILARITY comments Index of protein domains and families |

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