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P75051 (CDD_MYCPN) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytidine deaminase

Short name=CDA
EC=3.5.4.5
Alternative name(s):
Cytidine aminohydrolase
Gene names
Name:cdd
Ordered Locus Names:MPN_065
ORF Names:MP089
OrganismMycoplasma pneumoniae (strain ATCC 29342 / M129) [Reference proteome] [HAMAP]
Taxonomic identifier272634 [NCBI]
Taxonomic lineageBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma

Protein attributes

Sequence length133 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis By similarity.

Catalytic activity

Cytidine + H2O = uridine + NH3.

2'deoxycytidine + H2O = 2'-deoxyuridine + NH3.

Cofactor

Binds 1 zinc ion By similarity.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the cytidine and deoxycytidylate deaminase family.

Contains 1 CMP/dCMP deaminase zinc-binding domain.

Ontologies

Keywords
   LigandMetal-binding
Zinc
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functioncytidine deaminase activity

Inferred from electronic annotation. Source: UniProtKB-EC

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 133133Cytidine deaminase
PRO_0000171681

Regions

Domain7 – 10498CMP/dCMP deaminase zinc-binding
Region43 – 453Substrate binding By similarity

Sites

Active site561Proton donor By similarity
Metal binding541Zinc; catalytic By similarity
Metal binding891Zinc; catalytic By similarity
Metal binding921Zinc; catalytic By similarity

Sequences

Sequence LengthMass (Da)Tools
P75051 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: EC87E73810DEA9C7

FASTA13315,185
        10         20         30         40         50         60 
MKVDLDWVHH KLQEVVNHAY TPFSKFKVAC MLVANNQAFY GVNIENASYP VTLCAERSAI 

        70         80         90        100        110        120 
ANMVTSIGKA TIDYVFVYFD TKTPTNSPCG MCRQNIFEFA TDKTQLFCIE KDKSFKQFTI 

       130 
PEILKGGFRS YEQ 

« Hide

References

[1]"Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae."
Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.
Nucleic Acids Res. 24:4420-4449(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 29342 / M129.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U00089 Genomic DNA. Translation: AAB95737.1.
PIRS73415.
RefSeqNP_109753.1. NC_000912.1.

3D structure databases

ProteinModelPortalP75051.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP75051. 1 interaction.
STRING272634.MPN065.

Proteomic databases

PaxDbP75051.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAB95737; AAB95737; MPN_065.
GeneID877155.
KEGGmpn:MPN065.
PATRIC20021409. VBIMycPne110_0066.

Phylogenomic databases

eggNOGCOG0295.
OMAIDYVFVY.
OrthoDBEOG6XDH25.
ProtClustDBCLSK542120.

Enzyme and pathway databases

BioCycMPNE272634:GJ6Z-67-MONOMER.

Family and domain databases

InterProIPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR002125. CMP_dCMP_Zn-bd.
IPR006262. Cyt_deam_tetra.
IPR016193. Cytidine_deaminase-like.
[Graphical view]
PfamPF00383. dCMP_cyt_deam_1. 1 hit.
[Graphical view]
SUPFAMSSF53927. SSF53927. 1 hit.
TIGRFAMsTIGR01354. cyt_deam_tetra. 1 hit.
PROSITEPS00903. CYT_DCMP_DEAMINASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCDD_MYCPN
AccessionPrimary (citable) accession number: P75051
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: November 13, 2013
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Mycoplasma pneumoniae

Mycoplasma pneumoniae (strain M129): entries and gene names