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P75050

- MANB_MYCPN

UniProt

P75050 - MANB_MYCPN

Protein

Phosphomannomutase

Gene

manB

Organism
Mycoplasma pneumoniae (strain ATCC 29342 / M129)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.

    Cofactori

    Binds 1 magnesium ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei149 – 1491Phosphoserine intermediateBy similarity
    Metal bindingi149 – 1491Magnesium; via phosphate groupBy similarity
    Metal bindingi301 – 3011MagnesiumBy similarity
    Metal bindingi303 – 3031MagnesiumBy similarity
    Metal bindingi305 – 3051MagnesiumBy similarity

    GO - Molecular functioni

    1. magnesium ion binding Source: InterPro
    2. phosphomannomutase activity Source: UniProtKB-EC

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro

    Keywords - Molecular functioni

    Isomerase

    Keywords - Ligandi

    Magnesium, Metal-binding

    Enzyme and pathway databases

    BioCyciMetaCyc:MONOMER-621.
    MPNE272634:GJ6Z-68-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphomannomutase (EC:5.4.2.8)
    Short name:
    PMM
    Gene namesi
    Name:manB
    Synonyms:cpsG
    Ordered Locus Names:MPN_066
    ORF Names:MP088
    OrganismiMycoplasma pneumoniae (strain ATCC 29342 / M129)
    Taxonomic identifieri272634 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
    ProteomesiUP000000808: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 554554PhosphomannomutasePRO_0000147830Add
    BLAST

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiP75050.

    Interactioni

    Protein-protein interaction databases

    IntActiP75050. 3 interactions.
    STRINGi272634.MPN066.

    Structurei

    3D structure databases

    ProteinModelPortaliP75050.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the phosphohexose mutase family.Curated

    Phylogenomic databases

    eggNOGiCOG1109.
    KOiK01840.
    OMAiFACEESH.
    OrthoDBiEOG6103ZG.

    Family and domain databases

    Gene3Di3.30.310.50. 1 hit.
    3.40.120.10. 3 hits.
    InterProiIPR005844. A-D-PHexomutase_a/b/a-I.
    IPR016055. A-D-PHexomutase_a/b/a-I/II/III.
    IPR005845. A-D-PHexomutase_a/b/a-II.
    IPR005846. A-D-PHexomutase_a/b/a-III.
    IPR005843. A-D-PHexomutase_C.
    IPR016066. A-D-PHexomutase_CS.
    [Graphical view]
    PfamiPF02878. PGM_PMM_I. 1 hit.
    PF02879. PGM_PMM_II. 1 hit.
    PF02880. PGM_PMM_III. 1 hit.
    PF00408. PGM_PMM_IV. 1 hit.
    [Graphical view]
    SUPFAMiSSF53738. SSF53738. 3 hits.
    SSF55957. SSF55957. 1 hit.
    PROSITEiPS00710. PGM_PMM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P75050-1 [UniParc]FASTAAdd to Basket

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    MNSNAYLEAQ RWLSHPRVKP NLKEVITAMS AEEIEHFFSL KKPSFGTAGV    50
    RGKMAPGYHG MNVFSYAYLT QGYVNYIQSL NPTKKPLRFL VARDTRKHGA 100
    LFNGIVCDVI TSMGHVVYMF DNNEPTPTPL VSYVIKKYHF DGGVNVTASH 150
    NPKTDNGFKI YDGHGAQLLD FQTDQLIAML PPVVTMLDFE PRGNNELLHF 200
    LDNEVVYKNY FDDLKESLVV DNDSFKNLPV VFTGLHGTSV KLLPRFLTYL 250
    GYSNIISVQP QNVFDANFAN ADHLNPESKD TWELARQYAS NTKAKLMMAI 300
    DPDADRFAIA EWNPQTQDWH YFSGNESGVM VAYYKLKHKQ FKRQPYIVTT 350
    VVSTDLVDKI AKKYGAFVKR TNVGFKFIGQ AVNHFSKDNE LVVAFEEAIG 400
    MMASDGLNRE KDSFQAAAIM LEIARYCHNK GISLLEFYRG EIFGEFGDYY 450
    NWTVPHTIHG VNWKEKMEQV LHQLTTATIK EVVGHKITKI KNYVDINLVE 500
    YVLENGNWIK FRISGTEPKL KLYFNLSNGY LAALKHEAKK MHEFLVRLLN 550
    LDKA 554
    Length:554
    Mass (Da):63,215
    Last modified:February 1, 1997 - v1
    Checksum:i9993A52B3D5E6C0B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00089 Genomic DNA. Translation: AAB95736.1.
    PIRiS73414.
    RefSeqiNP_109754.1. NC_000912.1.

    Genome annotation databases

    EnsemblBacteriaiAAB95736; AAB95736; MPN_066.
    GeneIDi876721.
    KEGGimpn:MPN066.
    PATRICi20021411. VBIMycPne110_0067.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00089 Genomic DNA. Translation: AAB95736.1 .
    PIRi S73414.
    RefSeqi NP_109754.1. NC_000912.1.

    3D structure databases

    ProteinModelPortali P75050.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P75050. 3 interactions.
    STRINGi 272634.MPN066.

    Proteomic databases

    PaxDbi P75050.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAB95736 ; AAB95736 ; MPN_066 .
    GeneIDi 876721.
    KEGGi mpn:MPN066.
    PATRICi 20021411. VBIMycPne110_0067.

    Phylogenomic databases

    eggNOGi COG1109.
    KOi K01840.
    OMAi FACEESH.
    OrthoDBi EOG6103ZG.

    Enzyme and pathway databases

    BioCyci MetaCyc:MONOMER-621.
    MPNE272634:GJ6Z-68-MONOMER.

    Family and domain databases

    Gene3Di 3.30.310.50. 1 hit.
    3.40.120.10. 3 hits.
    InterProi IPR005844. A-D-PHexomutase_a/b/a-I.
    IPR016055. A-D-PHexomutase_a/b/a-I/II/III.
    IPR005845. A-D-PHexomutase_a/b/a-II.
    IPR005846. A-D-PHexomutase_a/b/a-III.
    IPR005843. A-D-PHexomutase_C.
    IPR016066. A-D-PHexomutase_CS.
    [Graphical view ]
    Pfami PF02878. PGM_PMM_I. 1 hit.
    PF02879. PGM_PMM_II. 1 hit.
    PF02880. PGM_PMM_III. 1 hit.
    PF00408. PGM_PMM_IV. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53738. SSF53738. 3 hits.
    SSF55957. SSF55957. 1 hit.
    PROSITEi PS00710. PGM_PMM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae."
      Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.
      Nucleic Acids Res. 24:4420-4449(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 29342 / M129.

    Entry informationi

    Entry nameiMANB_MYCPN
    AccessioniPrimary (citable) accession number: P75050
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Mycoplasma pneumoniae
      Mycoplasma pneumoniae (strain M129): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3