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Protein

Phosphomannomutase

Gene

manB

Organism
Mycoplasma pneumoniae (strain ATCC 29342 / M129)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.

Cofactori

Mg2+By similarityNote: Binds 1 Mg2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei149 – 1491Phosphoserine intermediateBy similarity
Metal bindingi149 – 1491Magnesium; via phosphate groupBy similarity
Metal bindingi301 – 3011MagnesiumBy similarity
Metal bindingi303 – 3031MagnesiumBy similarity
Metal bindingi305 – 3051MagnesiumBy similarity

GO - Molecular functioni

  1. magnesium ion binding Source: InterPro
  2. phosphomannomutase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-621.
MPNE272634:GJ6Z-68-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphomannomutase (EC:5.4.2.8)
Short name:
PMM
Gene namesi
Name:manB
Synonyms:cpsG
Ordered Locus Names:MPN_066
ORF Names:MP088
OrganismiMycoplasma pneumoniae (strain ATCC 29342 / M129)
Taxonomic identifieri272634 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000000808: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 554554PhosphomannomutasePRO_0000147830Add
BLAST

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP75050.

Interactioni

Protein-protein interaction databases

IntActiP75050. 3 interactions.
STRINGi272634.MPN066.

Structurei

3D structure databases

ProteinModelPortaliP75050.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the phosphohexose mutase family.Curated

Phylogenomic databases

eggNOGiCOG1109.
KOiK01840.
OMAiNYVYTAM.
OrthoDBiEOG6103ZG.

Family and domain databases

Gene3Di3.30.310.50. 1 hit.
3.40.120.10. 3 hits.
InterProiIPR005844. A-D-PHexomutase_a/b/a-I.
IPR016055. A-D-PHexomutase_a/b/a-I/II/III.
IPR005845. A-D-PHexomutase_a/b/a-II.
IPR005846. A-D-PHexomutase_a/b/a-III.
IPR005843. A-D-PHexomutase_C.
IPR016066. A-D-PHexomutase_CS.
[Graphical view]
PfamiPF02878. PGM_PMM_I. 1 hit.
PF02879. PGM_PMM_II. 1 hit.
PF02880. PGM_PMM_III. 1 hit.
PF00408. PGM_PMM_IV. 1 hit.
[Graphical view]
SUPFAMiSSF53738. SSF53738. 3 hits.
SSF55957. SSF55957. 1 hit.
PROSITEiPS00710. PGM_PMM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P75050-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSNAYLEAQ RWLSHPRVKP NLKEVITAMS AEEIEHFFSL KKPSFGTAGV
60 70 80 90 100
RGKMAPGYHG MNVFSYAYLT QGYVNYIQSL NPTKKPLRFL VARDTRKHGA
110 120 130 140 150
LFNGIVCDVI TSMGHVVYMF DNNEPTPTPL VSYVIKKYHF DGGVNVTASH
160 170 180 190 200
NPKTDNGFKI YDGHGAQLLD FQTDQLIAML PPVVTMLDFE PRGNNELLHF
210 220 230 240 250
LDNEVVYKNY FDDLKESLVV DNDSFKNLPV VFTGLHGTSV KLLPRFLTYL
260 270 280 290 300
GYSNIISVQP QNVFDANFAN ADHLNPESKD TWELARQYAS NTKAKLMMAI
310 320 330 340 350
DPDADRFAIA EWNPQTQDWH YFSGNESGVM VAYYKLKHKQ FKRQPYIVTT
360 370 380 390 400
VVSTDLVDKI AKKYGAFVKR TNVGFKFIGQ AVNHFSKDNE LVVAFEEAIG
410 420 430 440 450
MMASDGLNRE KDSFQAAAIM LEIARYCHNK GISLLEFYRG EIFGEFGDYY
460 470 480 490 500
NWTVPHTIHG VNWKEKMEQV LHQLTTATIK EVVGHKITKI KNYVDINLVE
510 520 530 540 550
YVLENGNWIK FRISGTEPKL KLYFNLSNGY LAALKHEAKK MHEFLVRLLN

LDKA
Length:554
Mass (Da):63,215
Last modified:February 1, 1997 - v1
Checksum:i9993A52B3D5E6C0B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00089 Genomic DNA. Translation: AAB95736.1.
PIRiS73414.
RefSeqiNP_109754.1. NC_000912.1.

Genome annotation databases

EnsemblBacteriaiAAB95736; AAB95736; MPN_066.
GeneIDi876721.
KEGGimpn:MPN066.
PATRICi20021411. VBIMycPne110_0067.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00089 Genomic DNA. Translation: AAB95736.1.
PIRiS73414.
RefSeqiNP_109754.1. NC_000912.1.

3D structure databases

ProteinModelPortaliP75050.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP75050. 3 interactions.
STRINGi272634.MPN066.

Proteomic databases

PaxDbiP75050.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB95736; AAB95736; MPN_066.
GeneIDi876721.
KEGGimpn:MPN066.
PATRICi20021411. VBIMycPne110_0067.

Phylogenomic databases

eggNOGiCOG1109.
KOiK01840.
OMAiNYVYTAM.
OrthoDBiEOG6103ZG.

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-621.
MPNE272634:GJ6Z-68-MONOMER.

Family and domain databases

Gene3Di3.30.310.50. 1 hit.
3.40.120.10. 3 hits.
InterProiIPR005844. A-D-PHexomutase_a/b/a-I.
IPR016055. A-D-PHexomutase_a/b/a-I/II/III.
IPR005845. A-D-PHexomutase_a/b/a-II.
IPR005846. A-D-PHexomutase_a/b/a-III.
IPR005843. A-D-PHexomutase_C.
IPR016066. A-D-PHexomutase_CS.
[Graphical view]
PfamiPF02878. PGM_PMM_I. 1 hit.
PF02879. PGM_PMM_II. 1 hit.
PF02880. PGM_PMM_III. 1 hit.
PF00408. PGM_PMM_IV. 1 hit.
[Graphical view]
SUPFAMiSSF53738. SSF53738. 3 hits.
SSF55957. SSF55957. 1 hit.
PROSITEiPS00710. PGM_PMM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae."
    Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.
    Nucleic Acids Res. 24:4420-4449(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29342 / M129.

Entry informationi

Entry nameiMANB_MYCPN
AccessioniPrimary (citable) accession number: P75050
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: January 7, 2015
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycoplasma pneumoniae
    Mycoplasma pneumoniae (strain M129): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.