Reviewed, UniProtKB/Swiss-Prot P75050 (MANB_MYCPN)

Names and origin

Protein names

Recommended name:
    Phosphomannomutase
      Short name=PMM
    EC=5.4.2.8

Gene names

Name:	manB
Synonyms:	cpsG
Ordered Locus Names:	MPN_066
ORF Names:	MP088

Organism

Mycoplasma pneumoniae [Complete proteome] [HAMAP]

Taxonomic identifier

2104 [NCBI]

Taxonomic lineage

Bacteria › Tenericutes › Mollicutes › Mycoplasmataceae › Mycoplasma

Protein attributes

Sequence length	554 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.
Cofactor	Binds 1 magnesium ion per subunit By similarity.
Sequence similarities	Belongs to the phosphohexose mutase family.

Ontologies

Keywords
Ligand	Magnesium Metal-binding
Molecular function	Isomerase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW phosphomannomutase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 554	554	Phosphomannomutase		PRO_0000147830
Sites
	Active site	149	1	Phosphoserine intermediate By similarity
	Metal binding	149	1	Magnesium; via phosphate group By similarity
	Metal binding	301	1	Magnesium By similarity
	Metal binding	303	1	Magnesium By similarity
	Metal binding	305	1	Magnesium By similarity

Sequences

	Sequence		Length	Mass (Da)
	P75050-1 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: 9993A52B3D5E6C0B	FASTA	554	63,215
	10 20 30 40 50 60 MNSNAYLEAQ RWLSHPRVKP NLKEVITAMS AEEIEHFFSL KKPSFGTAGV RGKMAPGYHG 70 80 90 100 110 120 MNVFSYAYLT QGYVNYIQSL NPTKKPLRFL VARDTRKHGA LFNGIVCDVI TSMGHVVYMF 130 140 150 160 170 180 DNNEPTPTPL VSYVIKKYHF DGGVNVTASH NPKTDNGFKI YDGHGAQLLD FQTDQLIAML 190 200 210 220 230 240 PPVVTMLDFE PRGNNELLHF LDNEVVYKNY FDDLKESLVV DNDSFKNLPV VFTGLHGTSV 250 260 270 280 290 300 KLLPRFLTYL GYSNIISVQP QNVFDANFAN ADHLNPESKD TWELARQYAS NTKAKLMMAI 310 320 330 340 350 360 DPDADRFAIA EWNPQTQDWH YFSGNESGVM VAYYKLKHKQ FKRQPYIVTT VVSTDLVDKI 370 380 390 400 410 420 AKKYGAFVKR TNVGFKFIGQ AVNHFSKDNE LVVAFEEAIG MMASDGLNRE KDSFQAAAIM 430 440 450 460 470 480 LEIARYCHNK GISLLEFYRG EIFGEFGDYY NWTVPHTIHG VNWKEKMEQV LHQLTTATIK 490 500 510 520 530 540 EVVGHKITKI KNYVDINLVE YVLENGNWIK FRISGTEPKL KLYFNLSNGY LAALKHEAKK 550 MHEFLVRLLN LDKA

References

[1]

"Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae." Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R. Nucleic Acids Res. 24:4420-4449(1996) [PubMed: 8948633] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 29342 / M129.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U00089 Genomic DNA. Translation: AAB95736.1.
PIR	S73414.
RefSeq	NP_109754.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	876721.
GenomeReviews	Gene locus MPN_066 in contig U00089_GR.
KEGG	mpn:MPN066.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P75050.
OMA	IGEDVDM
Enzyme and pathway databases
BioCyc	MetaCyc:MONOMER-621. MPNE272634:MPN066-MON.
BRENDA	5.4.2.8. 39500.
Family and domain databases
InterPro	IPR005844. A-D-PHexomutase_a/b/a-I. IPR016055. A-D-PHexomutase_a/b/a-I/II/III. IPR005845. A-D-PHexomutase_a/b/a-II. IPR016066. A-D-PHexomutase_CS. [Graphical view]
Gene3D	G3DSA:3.40.120.10. A-D-PHexomutase_a/b/a-I/II/III. 2 hits.
Pfam	PF02878. PGM_PMM_I. 1 hit. PF02879. PGM_PMM_II. 1 hit. [Graphical view]
PROSITE	PS00710. PGM_PMM. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MANB_MYCPN

Accession

Primary (citable) accession number: P75050

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	February 1, 1997
Last modified:	November 24, 2009
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)