Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P75050 (MANB_MYCPN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphomannomutase

Short name=PMM
EC=5.4.2.8
Gene names
Name:manB
Synonyms:cpsG
Ordered Locus Names:MPN_066
ORF Names:MP088
OrganismMycoplasma pneumoniae (strain ATCC 29342 / M129) [Reference proteome] [HAMAP]
Taxonomic identifier272634 [NCBI]
Taxonomic lineageBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma

Protein attributes

Sequence length554 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.

Cofactor

Binds 1 magnesium ion per subunit By similarity.

Sequence similarities

Belongs to the phosphohexose mutase family.

Ontologies

Keywords
   LigandMagnesium
Metal-binding
   Molecular functionIsomerase
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcarbohydrate metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionmagnesium ion binding

Inferred from electronic annotation. Source: InterPro

phosphomannomutase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 554554Phosphomannomutase
PRO_0000147830

Sites

Active site1491Phosphoserine intermediate By similarity
Metal binding1491Magnesium; via phosphate group By similarity
Metal binding3011Magnesium By similarity
Metal binding3031Magnesium By similarity
Metal binding3051Magnesium By similarity

Sequences

Sequence LengthMass (Da)Tools
P75050 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: 9993A52B3D5E6C0B

FASTA55463,215
        10         20         30         40         50         60 
MNSNAYLEAQ RWLSHPRVKP NLKEVITAMS AEEIEHFFSL KKPSFGTAGV RGKMAPGYHG 

        70         80         90        100        110        120 
MNVFSYAYLT QGYVNYIQSL NPTKKPLRFL VARDTRKHGA LFNGIVCDVI TSMGHVVYMF 

       130        140        150        160        170        180 
DNNEPTPTPL VSYVIKKYHF DGGVNVTASH NPKTDNGFKI YDGHGAQLLD FQTDQLIAML 

       190        200        210        220        230        240 
PPVVTMLDFE PRGNNELLHF LDNEVVYKNY FDDLKESLVV DNDSFKNLPV VFTGLHGTSV 

       250        260        270        280        290        300 
KLLPRFLTYL GYSNIISVQP QNVFDANFAN ADHLNPESKD TWELARQYAS NTKAKLMMAI 

       310        320        330        340        350        360 
DPDADRFAIA EWNPQTQDWH YFSGNESGVM VAYYKLKHKQ FKRQPYIVTT VVSTDLVDKI 

       370        380        390        400        410        420 
AKKYGAFVKR TNVGFKFIGQ AVNHFSKDNE LVVAFEEAIG MMASDGLNRE KDSFQAAAIM 

       430        440        450        460        470        480 
LEIARYCHNK GISLLEFYRG EIFGEFGDYY NWTVPHTIHG VNWKEKMEQV LHQLTTATIK 

       490        500        510        520        530        540 
EVVGHKITKI KNYVDINLVE YVLENGNWIK FRISGTEPKL KLYFNLSNGY LAALKHEAKK 

       550 
MHEFLVRLLN LDKA 

« Hide

References

[1]"Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae."
Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.
Nucleic Acids Res. 24:4420-4449(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 29342 / M129.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U00089 Genomic DNA. Translation: AAB95736.1.
PIRS73414.
RefSeqNP_109754.1. NC_000912.1.

3D structure databases

ProteinModelPortalP75050.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP75050. 3 interactions.
STRING272634.MPN066.

Proteomic databases

PaxDbP75050.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAB95736; AAB95736; MPN_066.
GeneID876721.
KEGGmpn:MPN066.
PATRIC20021411. VBIMycPne110_0067.

Phylogenomic databases

eggNOGCOG1109.
KOK01840.
OMANYVYTAM.
OrthoDBEOG6103ZG.
ProtClustDBCLSK542121.

Enzyme and pathway databases

BioCycMetaCyc:MONOMER-621.
MPNE272634:GJ6Z-68-MONOMER.

Family and domain databases

Gene3D3.30.310.50. 1 hit.
3.40.120.10. 3 hits.
InterProIPR005844. A-D-PHexomutase_a/b/a-I.
IPR016055. A-D-PHexomutase_a/b/a-I/II/III.
IPR005845. A-D-PHexomutase_a/b/a-II.
IPR005846. A-D-PHexomutase_a/b/a-III.
IPR005843. A-D-PHexomutase_C.
IPR016066. A-D-PHexomutase_CS.
[Graphical view]
PfamPF02878. PGM_PMM_I. 1 hit.
PF02879. PGM_PMM_II. 1 hit.
PF02880. PGM_PMM_III. 1 hit.
PF00408. PGM_PMM_IV. 1 hit.
[Graphical view]
SUPFAMSSF53738. SSF53738. 3 hits.
SSF55957. SSF55957. 1 hit.
PROSITEPS00710. PGM_PMM. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMANB_MYCPN
AccessionPrimary (citable) accession number: P75050
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: April 16, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Mycoplasma pneumoniae

Mycoplasma pneumoniae (strain M129): entries and gene names