P75046 (RSMI_MYCPN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ribosomal RNA small subunit methyltransferase I
EC=2.1.1.198

Alternative name(s):
16S rRNA 2'-O-ribose C1402 methyltransferase
rRNA (cytidine-2'-O-)-methyltransferase RsmI

Gene names

Name:	rsmI
Ordered Locus Names:	MPN_071
ORF Names:	D09_orf276, MP084

Organism

Mycoplasma pneumoniae (strain ATCC 29342 / M129) [Reference proteome] [HAMAP]

Taxonomic identifier

272634 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Tenericutes › Mollicutes › Mycoplasmatales › Mycoplasmataceae › Mycoplasma › Mycoplasma pneumoniae

Protein attributes

Sequence length	276 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA By similarity. HAMAP-Rule MF_01877
Catalytic activity	S-adenosyl-L-methionine + cytidine(1402) in 16S rRNA = S-adenosyl-L-homocysteine + 2'-O-methylcytidine(1402) in 16S rRNA. HAMAP-Rule MF_01877
Subcellular location	Cytoplasm Potential HAMAP-Rule MF_01877.
Sequence similarities	Belongs to the methyltransferase superfamily. RsmI family.

Ontologies

Keywords
Biological process	rRNA processing
Cellular component	Cytoplasm
Ligand	S-adenosyl-L-methionine
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	enzyme-directed rRNA 2'-O-methylation Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	rRNA (cytosine-2'-O-)-methyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 276	276	Ribosomal RNA small subunit methyltransferase I HAMAP-Rule MF_01877		PRO_0000211944

Sequences

	Sequence		Length	Mass (Da)
	P75046 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: 2A071E7A17FCD0CD	FASTA	276	31,062
	10 20 30 40 50 60 MPALKVIATP IGNIEEVSPR VKAALTKCEV LFCEDTRVTK KLLGLLGIDF SNKQFIINNE 70 80 90 100 110 120 FKEKQNLSKV ANLIHQYHCG LVSDAGYPSV SDPGHILVEY VRTQLPQIAI EVINGPSALV 130 140 150 160 170 180 CGLVTSGFPE SPLLFLGFLD HKPTQVTQTL KHYQNFQGTI VLFEAVHRLQ QTLEVIQTVF 190 200 210 220 230 240 SNTEVFVGRE LTKLHESHYW FNTSAPLPDI TLKGEFVIVI NNHHTQPVGQ YSDQLLKQEI 250 260 270 TQLVQMGVKV KDACHYLAKR LQLKSNKLYT LFHESD

References

[1]

"Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae." Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R. Nucleic Acids Res. 24:4420-4449(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 29342 / M129.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U00089 Genomic DNA. Translation: AAB95732.1.
PIR	S73410.
RefSeq	NP_109759.1. NC_000912.1.
3D structure databases
ProteinModelPortal	P75046.
ModBase	Search...
Protein-protein interaction databases
STRING	272634.MPN071.
Proteomic databases
PaxDb	P75046.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAB95732; AAB95732; MPN_071.
GeneID	877160.
KEGG	mpn:MPN071.
PATRIC	20021421. VBIMycPne110_0072.
Phylogenomic databases
eggNOG	COG0313.
KO	K07056.
OMA	GREMTKI.
ProtClustDB	CLSK542125.
Enzyme and pathway databases
BioCyc	MPNE272634:GJ6Z-73-MONOMER.
Family and domain databases
Gene3D	3.30.950.10. 1 hit. 3.40.1010.10. 1 hit.
HAMAP	MF_01877. 16SrRNA_methyltr_I.
InterPro	IPR000878. 4pyrrol_Mease. IPR014777. 4pyrrole_Mease_sub1. IPR014776. 4pyrrole_Mease_sub2. IPR008189. rRNA_ssu_MeTfrase_I. IPR018063. SAM_MeTrfase_RsmI_CS. [Graphical view]
PANTHER	PTHR21091:SF18. PTHR21091:SF18. 1 hit.
Pfam	PF00590. TP_methylase. 1 hit. [Graphical view]
PIRSF	PIRSF005917. MTase_YraL. 1 hit.
SUPFAM	SSF53790. Cor/por_Metransf. 1 hit.
TIGRFAMs	TIGR00096. TIGR00096. 1 hit.
PROSITE	PS01296. RSMI. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RSMI_MYCPN

Accession

Primary (citable) accession number: P75046

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	February 1, 1997
Last modified:	May 1, 2013
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program