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P75039

- PTF3A_MYCPN

UniProt

P75039 - PTF3A_MYCPN

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Protein

PTS system fructose-specific EIIABC component

Gene

fruA

Organism
Mycoplasma pneumoniae (strain ATCC 29342 / M129)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in fructose transport (By similarity).By similarity

Catalytic activityi

Protein EIIA N(pi)-phospho-L-histidine + protein EIIB = protein EIIA + protein EIIB N(pi)-phospho-L-histidine/cysteine.PROSITE-ProRule annotation
Protein EIIB N(pi)-phospho-L-histidine/cysteine + sugar = protein EIIB + sugar phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei68 – 681Tele-phosphohistidine intermediate; for EIIA activityPROSITE-ProRule annotation
Active sitei185 – 1851Phosphocysteine intermediate; for EIIB activityBy similarity

GO - Molecular functioni

  1. kinase activity Source: UniProtKB-KW
  2. protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity Source: InterPro
  3. sugar:proton symporter activity Source: InterPro

GO - Biological processi

  1. phosphoenolpyruvate-dependent sugar phosphotransferase system Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Phosphotransferase system, Sugar transport, Transport

Enzyme and pathway databases

BioCyciMPNE272634:GJ6Z-81-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
PTS system fructose-specific EIIABC component
Alternative name(s):
EIIABC-Fru
Including the following 3 domains:
Fructose-specific phosphotransferase enzyme IIA component (EC:2.7.1.-)
Alternative name(s):
EII-Fru
PTS system fructose-specific EIIA component
Fructose-specific phosphotransferase enzyme IIB component (EC:2.7.1.69)
Alternative name(s):
EIII-Fru
PTS system fructose-specific EIIB component
Fructose permease IIC component
Alternative name(s):
PTS system fructose-specific EIIC component
Gene namesi
Name:fruA
Ordered Locus Names:MPN_078
ORF Names:MP077
OrganismiMycoplasma pneumoniae (strain ATCC 29342 / M129)
Taxonomic identifieri272634 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000000808: Chromosome

Subcellular locationi

Cell membrane PROSITE-ProRule annotation; Multi-pass membrane protein PROSITE-ProRule annotation

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 694694PTS system fructose-specific EIIABC componentPRO_0000186511Add
BLAST

Proteomic databases

PaxDbiP75039.

Interactioni

Protein-protein interaction databases

STRINGi272634.MPN078.

Structurei

3D structure databases

ProteinModelPortaliP75039.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei318 – 33821HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei364 – 38421HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei390 – 41021HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei422 – 44221HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei461 – 48121HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei502 – 52221HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei542 – 56221HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei576 – 59621HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei602 – 62221HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei655 – 67521HelicalPROSITE-ProRule annotationAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 149146PTS EIIA type-2PROSITE-ProRule annotationAdd
BLAST
Domaini179 – 27597PTS EIIB type-2PROSITE-ProRule annotationAdd
BLAST
Domaini310 – 687378PTS EIIC type-2PROSITE-ProRule annotationAdd
BLAST

Domaini

The EIIA domain is phosphorylated by phospho-HPr on a histidyl residue. Then, it transfers the phosphoryl group to the EIIB domain.
The EIIB domain is phosphorylated by phospho-EIIA on a cysteinyl or histidyl residue, depending on the transported sugar. Then, it transfers the phosphoryl group to the sugar substrate concomitantly with the sugar uptake processed by the EIIC domain.
The EIIC domain forms the PTS system translocation channel and contains the specific substrate-binding site.

Sequence similaritiesi

Contains 1 PTS EIIA type-2 domain.PROSITE-ProRule annotation
Contains 1 PTS EIIB type-2 domain.PROSITE-ProRule annotation
Contains 1 PTS EIIC type-2 domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1445.
KOiK02768.
K02769.
K02770.
OMAiYDMANGW.
OrthoDBiEOG6XDGX2.

Family and domain databases

Gene3Di3.40.930.10. 1 hit.
InterProiIPR016152. PTrfase/Anion_transptr.
IPR002178. PTS_EIIA_type-2_dom.
IPR013011. PTS_EIIB_2.
IPR003501. PTS_EIIB_2/3.
IPR003352. PTS_EIIC.
IPR013014. PTS_EIIC_2.
IPR004715. PTS_IIA_fruc.
IPR003353. PTS_IIB_fruc.
IPR006327. PTS_IIC_fruc.
[Graphical view]
PfamiPF00359. PTS_EIIA_2. 1 hit.
PF02378. PTS_EIIC. 1 hit.
PF02302. PTS_IIB. 1 hit.
[Graphical view]
SUPFAMiSSF52794. SSF52794. 1 hit.
SSF55804. SSF55804. 1 hit.
TIGRFAMsiTIGR00829. FRU. 1 hit.
TIGR00848. fruA. 1 hit.
TIGR01427. PTS_IIC_fructo. 1 hit.
PROSITEiPS51094. PTS_EIIA_TYPE_2. 1 hit.
PS51099. PTS_EIIB_TYPE_2. 1 hit.
PS51104. PTS_EIIC_TYPE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P75039 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFKPLLSAEL FFNWTAKDFK DKTSFLKQAC RVLQDKNCIK EEQIALTALK
60 70 80 90 100
EREAQITTGI MSKLALPHMQ SATVLKPFVA VFKVNNVDWQ SLDNQPVKLI
110 120 130 140 150
FLIGVPKDQG NLHLEFISQF SKLMLQDEFA NKVPNIRSFN GLINLIDSFQ
160 170 180 190 200
QTAVASQPVV NEAAAQTEEP KDTNTQYDFV AVTACPTGIA HTFMAKEALE
210 220 230 240 250
KFARDHNLKV KVETQGTDGI QNQLTESDLN NTKGIILACD RLIDLTRFYG
260 270 280 290 300
HANVVEVSTT KAIKTPQTVY DQVVKKEGKL LGNKSSDSAS QTELKETTEQ
310 320 330 340 350
LSFKDFHKRI YRAILSGVSY MLPFVVFGGI LIAIAFLIDI NNAGNAGKQF
360 370 380 390 400
GSKDPIANWF KTLGGLSFGL IVPILSAYIA FALVGRQGLL PGFIVGLISA
410 420 430 440 450
GKFLLNIDIV TGKIDWATES KVSSGFFGAI FGGLLAAVLI IVQQRYIYRK
460 470 480 490 500
LPQALQGIKN ILFIPLLGTL VTAALFWVIN IPLIYLNYGL SKFLQIMDKP
510 520 530 540 550
YLAPLLGLVI GLMMCFDLGG PVNKAAYVFG VVSLESQNSG TVAMASAILS
560 570 580 590 600
GMVPPLGIAI AATIRKQCFD KEELPAAYAC YVMGLSFISE GAIPFVAKRP
610 620 630 640 650
KIMLAANLIG GAVCGVLTGA FALTIRAPHG GVFVFALLKT NLEGIAGNTL
660 670 680 690
QIGAGVGLAL LALIVSSFIS AGIIIGHNLL VVRKKTKQLV NTNA
Length:694
Mass (Da):75,164
Last modified:February 1, 1997 - v1
Checksum:i919E12BFBCC5FF6A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00089 Genomic DNA. Translation: AAB95725.1.
PIRiS73403.
RefSeqiNP_109766.1. NC_000912.1.

Genome annotation databases

EnsemblBacteriaiAAB95725; AAB95725; MPN_078.
GeneIDi877051.
KEGGimpn:MPN078.
PATRICi20021437. VBIMycPne110_0079.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00089 Genomic DNA. Translation: AAB95725.1 .
PIRi S73403.
RefSeqi NP_109766.1. NC_000912.1.

3D structure databases

ProteinModelPortali P75039.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272634.MPN078.

Proteomic databases

PaxDbi P75039.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB95725 ; AAB95725 ; MPN_078 .
GeneIDi 877051.
KEGGi mpn:MPN078.
PATRICi 20021437. VBIMycPne110_0079.

Phylogenomic databases

eggNOGi COG1445.
KOi K02768.
K02769.
K02770.
OMAi YDMANGW.
OrthoDBi EOG6XDGX2.

Enzyme and pathway databases

BioCyci MPNE272634:GJ6Z-81-MONOMER.

Family and domain databases

Gene3Di 3.40.930.10. 1 hit.
InterProi IPR016152. PTrfase/Anion_transptr.
IPR002178. PTS_EIIA_type-2_dom.
IPR013011. PTS_EIIB_2.
IPR003501. PTS_EIIB_2/3.
IPR003352. PTS_EIIC.
IPR013014. PTS_EIIC_2.
IPR004715. PTS_IIA_fruc.
IPR003353. PTS_IIB_fruc.
IPR006327. PTS_IIC_fruc.
[Graphical view ]
Pfami PF00359. PTS_EIIA_2. 1 hit.
PF02378. PTS_EIIC. 1 hit.
PF02302. PTS_IIB. 1 hit.
[Graphical view ]
SUPFAMi SSF52794. SSF52794. 1 hit.
SSF55804. SSF55804. 1 hit.
TIGRFAMsi TIGR00829. FRU. 1 hit.
TIGR00848. fruA. 1 hit.
TIGR01427. PTS_IIC_fructo. 1 hit.
PROSITEi PS51094. PTS_EIIA_TYPE_2. 1 hit.
PS51099. PTS_EIIB_TYPE_2. 1 hit.
PS51104. PTS_EIIC_TYPE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae."
    Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.
    Nucleic Acids Res. 24:4420-4449(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29342 / M129.

Entry informationi

Entry nameiPTF3A_MYCPN
AccessioniPrimary (citable) accession number: P75039
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: October 29, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycoplasma pneumoniae
    Mycoplasma pneumoniae (strain M129): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3