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Protein

PTS system fructose-specific EIIABC component

Gene

fruA

Organism
Mycoplasma pneumoniae (strain ATCC 29342 / M129)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in fructose transport.By similarity

Catalytic activityi

[Protein]-N(pi)-phospho-L-histidine + D-fructose(Side 1) = [protein]-L-histidine + D-fructose 1-phosphate(Side 2).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei68Tele-phosphohistidine intermediate; for EIIA activityPROSITE-ProRule annotation1
Active sitei185Phosphocysteine intermediate; for EIIB activityCurated1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processPhosphotransferase system, Sugar transport, Transport

Enzyme and pathway databases

BioCyciMPNE272634:G1GJ3-122-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
PTS system fructose-specific EIIABC componentBy similarity
Alternative name(s):
EIIABC-FruBy similarity
Including the following 3 domains:
PTS system fructose-specific EIIA componentBy similarity
Alternative name(s):
EII-FruBy similarity
Fructose-specific phosphotransferase enzyme IIA componentBy similarity
PTS system fructose-specific EIIB componentBy similarity (EC:2.7.1.202By similarity)
Alternative name(s):
EIII-FruBy similarity
Fructose-specific phosphotransferase enzyme IIB componentBy similarity
PTS system fructose-specific EIIC componentBy similarity
Alternative name(s):
Fructose permease IIC componentBy similarity
Gene namesi
Name:fruABy similarity
Ordered Locus Names:MPN_078
ORF Names:MP077
OrganismiMycoplasma pneumoniae (strain ATCC 29342 / M129)
Taxonomic identifieri272634 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
Proteomesi
  • UP000000808 Componenti: Chromosome

Subcellular locationi

  • Cell membrane PROSITE-ProRule annotation; Multi-pass membrane protein PROSITE-ProRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei318 – 338HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei364 – 384HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei390 – 410HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei422 – 442HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei461 – 481HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei502 – 522HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei542 – 562HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei576 – 596HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei602 – 622HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei655 – 675HelicalPROSITE-ProRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001865111 – 694PTS system fructose-specific EIIABC componentAdd BLAST694

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei68Phosphohistidine; by HPrCurated1
Modified residuei185Phosphocysteine; by EIIAPROSITE-ProRule annotation1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP75039

Structurei

3D structure databases

ProteinModelPortaliP75039
SMRiP75039
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 149PTS EIIA type-2PROSITE-ProRule annotationAdd BLAST146
Domaini179 – 275PTS EIIB type-2PROSITE-ProRule annotationAdd BLAST97
Domaini310 – 687PTS EIIC type-2PROSITE-ProRule annotationAdd BLAST378

Domaini

The PTS EIIA type-2 domain is phosphorylated by phospho-HPr on a histidyl residue. Then, it transfers the phosphoryl group to the PTS EIIB type-2 domain.PROSITE-ProRule annotation
The PTS EIIB type-2 domain is phosphorylated by phospho-EIIA on a cysteinyl residue. Then, it transfers the phosphoryl group to the sugar substrate concomitantly with the sugar uptake processed by the PTS EIIC type-2 domain.PROSITE-ProRule annotation
The EIIC type-2 domain forms the PTS system translocation channel and contains the specific substrate-binding site.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK02768
K02769
K02770
OMAiEGMKPML

Family and domain databases

CDDicd05569 PTS_IIB_fructose, 1 hit
Gene3Di3.40.930.10, 1 hit
InterProiView protein in InterPro
IPR016152 PTrfase/Anion_transptr
IPR002178 PTS_EIIA_type-2_dom
IPR036095 PTS_EIIB-like_sf
IPR013011 PTS_EIIB_2
IPR003501 PTS_EIIB_2/3
IPR003352 PTS_EIIC
IPR013014 PTS_EIIC_2
IPR004715 PTS_IIA_fruc
IPR003353 PTS_IIB_fruc
IPR006327 PTS_IIC_fruc
PfamiView protein in Pfam
PF00359 PTS_EIIA_2, 1 hit
PF02378 PTS_EIIC, 1 hit
PF02302 PTS_IIB, 1 hit
SUPFAMiSSF52794 SSF52794, 1 hit
SSF55804 SSF55804, 1 hit
TIGRFAMsiTIGR00829 FRU, 1 hit
TIGR00848 fruA, 1 hit
TIGR01427 PTS_IIC_fructo, 1 hit
PROSITEiView protein in PROSITE
PS51094 PTS_EIIA_TYPE_2, 1 hit
PS51099 PTS_EIIB_TYPE_2, 1 hit
PS51104 PTS_EIIC_TYPE_2, 1 hit

Sequencei

Sequence statusi: Complete.

P75039-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFKPLLSAEL FFNWTAKDFK DKTSFLKQAC RVLQDKNCIK EEQIALTALK
60 70 80 90 100
EREAQITTGI MSKLALPHMQ SATVLKPFVA VFKVNNVDWQ SLDNQPVKLI
110 120 130 140 150
FLIGVPKDQG NLHLEFISQF SKLMLQDEFA NKVPNIRSFN GLINLIDSFQ
160 170 180 190 200
QTAVASQPVV NEAAAQTEEP KDTNTQYDFV AVTACPTGIA HTFMAKEALE
210 220 230 240 250
KFARDHNLKV KVETQGTDGI QNQLTESDLN NTKGIILACD RLIDLTRFYG
260 270 280 290 300
HANVVEVSTT KAIKTPQTVY DQVVKKEGKL LGNKSSDSAS QTELKETTEQ
310 320 330 340 350
LSFKDFHKRI YRAILSGVSY MLPFVVFGGI LIAIAFLIDI NNAGNAGKQF
360 370 380 390 400
GSKDPIANWF KTLGGLSFGL IVPILSAYIA FALVGRQGLL PGFIVGLISA
410 420 430 440 450
GKFLLNIDIV TGKIDWATES KVSSGFFGAI FGGLLAAVLI IVQQRYIYRK
460 470 480 490 500
LPQALQGIKN ILFIPLLGTL VTAALFWVIN IPLIYLNYGL SKFLQIMDKP
510 520 530 540 550
YLAPLLGLVI GLMMCFDLGG PVNKAAYVFG VVSLESQNSG TVAMASAILS
560 570 580 590 600
GMVPPLGIAI AATIRKQCFD KEELPAAYAC YVMGLSFISE GAIPFVAKRP
610 620 630 640 650
KIMLAANLIG GAVCGVLTGA FALTIRAPHG GVFVFALLKT NLEGIAGNTL
660 670 680 690
QIGAGVGLAL LALIVSSFIS AGIIIGHNLL VVRKKTKQLV NTNA
Length:694
Mass (Da):75,164
Last modified:February 1, 1997 - v1
Checksum:i919E12BFBCC5FF6A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00089 Genomic DNA Translation: AAB95725.1
PIRiS73403
RefSeqiNP_109766.1, NC_000912.1
WP_010874435.1, NC_000912.1

Genome annotation databases

EnsemblBacteriaiAAB95725; AAB95725; MPN_078
GeneIDi877051
KEGGimpn:MPN078
PATRICifig|272634.6.peg.79

Similar proteinsi

Entry informationi

Entry nameiPTF3A_MYCPN
AccessioniPrimary (citable) accession number: P75039
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: May 23, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycoplasma pneumoniae
    Mycoplasma pneumoniae (strain M129): entries and gene names

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