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P75039

- PTF3A_MYCPN

UniProt

P75039 - PTF3A_MYCPN

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Protein

PTS system fructose-specific EIIABC component

Gene
fruA, MPN_078, MP077
Organism
Mycoplasma pneumoniae (strain ATCC 29342 / M129)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in fructose transport By similarity.

Catalytic activityi

Protein EIIA N(pi)-phospho-L-histidine + protein EIIB = protein EIIA + protein EIIB N(pi)-phospho-L-histidine/cysteine.
Protein EIIB N(pi)-phospho-L-histidine/cysteine + sugar = protein EIIB + sugar phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei68 – 681Tele-phosphohistidine intermediate; for EIIA activity By similarity
Active sitei185 – 1851Phosphocysteine intermediate; for EIIB activity By similarity

GO - Molecular functioni

  1. kinase activity Source: UniProtKB-KW
  2. protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity Source: InterPro
  3. sugar:proton symporter activity Source: InterPro

GO - Biological processi

  1. phosphoenolpyruvate-dependent sugar phosphotransferase system Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Phosphotransferase system, Sugar transport, Transport

Enzyme and pathway databases

BioCyciMPNE272634:GJ6Z-81-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
PTS system fructose-specific EIIABC component
Alternative name(s):
EIIABC-Fru
Including the following 3 domains:
Fructose-specific phosphotransferase enzyme IIA component (EC:2.7.1.-)
Alternative name(s):
EII-Fru
PTS system fructose-specific EIIA component
Fructose-specific phosphotransferase enzyme IIB component (EC:2.7.1.69)
Alternative name(s):
EIII-Fru
PTS system fructose-specific EIIB component
Fructose permease IIC component
Alternative name(s):
PTS system fructose-specific EIIC component
Gene namesi
Name:fruA
Ordered Locus Names:MPN_078
ORF Names:MP077
OrganismiMycoplasma pneumoniae (strain ATCC 29342 / M129)
Taxonomic identifieri272634 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000000808: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei318 – 33821Helical; Reviewed predictionAdd
BLAST
Transmembranei364 – 38421Helical; Reviewed predictionAdd
BLAST
Transmembranei390 – 41021Helical; Reviewed predictionAdd
BLAST
Transmembranei422 – 44221Helical; Reviewed predictionAdd
BLAST
Transmembranei461 – 48121Helical; Reviewed predictionAdd
BLAST
Transmembranei502 – 52221Helical; Reviewed predictionAdd
BLAST
Transmembranei542 – 56221Helical; Reviewed predictionAdd
BLAST
Transmembranei576 – 59621Helical; Reviewed predictionAdd
BLAST
Transmembranei602 – 62221Helical; Reviewed predictionAdd
BLAST
Transmembranei655 – 67521Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 694694PTS system fructose-specific EIIABC componentPRO_0000186511Add
BLAST

Proteomic databases

PaxDbiP75039.

Interactioni

Protein-protein interaction databases

STRINGi272634.MPN078.

Structurei

3D structure databases

ProteinModelPortaliP75039.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 149146PTS EIIA type-2Add
BLAST
Domaini179 – 27597PTS EIIB type-2Add
BLAST
Domaini310 – 687378PTS EIIC type-2Add
BLAST

Domaini

The EIIA domain is phosphorylated by phospho-HPr on a histidyl residue. Then, it transfers the phosphoryl group to the EIIB domain.
The EIIB domain is phosphorylated by phospho-EIIA on a cysteinyl or histidyl residue, depending on the transported sugar. Then, it transfers the phosphoryl group to the sugar substrate concomitantly with the sugar uptake processed by the EIIC domain.
The EIIC domain forms the PTS system translocation channel and contains the specific substrate-binding site.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1445.
KOiK02768.
K02769.
K02770.
OMAiYDMANGW.
OrthoDBiEOG6XDGX2.

Family and domain databases

Gene3Di3.40.930.10. 1 hit.
InterProiIPR016152. PTrfase/Anion_transptr.
IPR002178. PTS_EIIA_type-2_dom.
IPR013011. PTS_EIIB_2.
IPR003501. PTS_EIIB_2/3.
IPR003352. PTS_EIIC.
IPR013014. PTS_EIIC_2.
IPR004715. PTS_IIA_fruc.
IPR003353. PTS_IIB_fruc.
IPR006327. PTS_IIC_fruc.
[Graphical view]
PfamiPF00359. PTS_EIIA_2. 1 hit.
PF02378. PTS_EIIC. 1 hit.
PF02302. PTS_IIB. 1 hit.
[Graphical view]
SUPFAMiSSF52794. SSF52794. 1 hit.
SSF55804. SSF55804. 1 hit.
TIGRFAMsiTIGR00829. FRU. 1 hit.
TIGR00848. fruA. 1 hit.
TIGR01427. PTS_IIC_fructo. 1 hit.
PROSITEiPS51094. PTS_EIIA_TYPE_2. 1 hit.
PS51099. PTS_EIIB_TYPE_2. 1 hit.
PS51104. PTS_EIIC_TYPE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P75039-1 [UniParc]FASTAAdd to Basket

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MFKPLLSAEL FFNWTAKDFK DKTSFLKQAC RVLQDKNCIK EEQIALTALK    50
EREAQITTGI MSKLALPHMQ SATVLKPFVA VFKVNNVDWQ SLDNQPVKLI 100
FLIGVPKDQG NLHLEFISQF SKLMLQDEFA NKVPNIRSFN GLINLIDSFQ 150
QTAVASQPVV NEAAAQTEEP KDTNTQYDFV AVTACPTGIA HTFMAKEALE 200
KFARDHNLKV KVETQGTDGI QNQLTESDLN NTKGIILACD RLIDLTRFYG 250
HANVVEVSTT KAIKTPQTVY DQVVKKEGKL LGNKSSDSAS QTELKETTEQ 300
LSFKDFHKRI YRAILSGVSY MLPFVVFGGI LIAIAFLIDI NNAGNAGKQF 350
GSKDPIANWF KTLGGLSFGL IVPILSAYIA FALVGRQGLL PGFIVGLISA 400
GKFLLNIDIV TGKIDWATES KVSSGFFGAI FGGLLAAVLI IVQQRYIYRK 450
LPQALQGIKN ILFIPLLGTL VTAALFWVIN IPLIYLNYGL SKFLQIMDKP 500
YLAPLLGLVI GLMMCFDLGG PVNKAAYVFG VVSLESQNSG TVAMASAILS 550
GMVPPLGIAI AATIRKQCFD KEELPAAYAC YVMGLSFISE GAIPFVAKRP 600
KIMLAANLIG GAVCGVLTGA FALTIRAPHG GVFVFALLKT NLEGIAGNTL 650
QIGAGVGLAL LALIVSSFIS AGIIIGHNLL VVRKKTKQLV NTNA 694
Length:694
Mass (Da):75,164
Last modified:February 1, 1997 - v1
Checksum:i919E12BFBCC5FF6A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00089 Genomic DNA. Translation: AAB95725.1.
PIRiS73403.
RefSeqiNP_109766.1. NC_000912.1.

Genome annotation databases

EnsemblBacteriaiAAB95725; AAB95725; MPN_078.
GeneIDi877051.
KEGGimpn:MPN078.
PATRICi20021437. VBIMycPne110_0079.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00089 Genomic DNA. Translation: AAB95725.1 .
PIRi S73403.
RefSeqi NP_109766.1. NC_000912.1.

3D structure databases

ProteinModelPortali P75039.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272634.MPN078.

Proteomic databases

PaxDbi P75039.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB95725 ; AAB95725 ; MPN_078 .
GeneIDi 877051.
KEGGi mpn:MPN078.
PATRICi 20021437. VBIMycPne110_0079.

Phylogenomic databases

eggNOGi COG1445.
KOi K02768.
K02769.
K02770.
OMAi YDMANGW.
OrthoDBi EOG6XDGX2.

Enzyme and pathway databases

BioCyci MPNE272634:GJ6Z-81-MONOMER.

Family and domain databases

Gene3Di 3.40.930.10. 1 hit.
InterProi IPR016152. PTrfase/Anion_transptr.
IPR002178. PTS_EIIA_type-2_dom.
IPR013011. PTS_EIIB_2.
IPR003501. PTS_EIIB_2/3.
IPR003352. PTS_EIIC.
IPR013014. PTS_EIIC_2.
IPR004715. PTS_IIA_fruc.
IPR003353. PTS_IIB_fruc.
IPR006327. PTS_IIC_fruc.
[Graphical view ]
Pfami PF00359. PTS_EIIA_2. 1 hit.
PF02378. PTS_EIIC. 1 hit.
PF02302. PTS_IIB. 1 hit.
[Graphical view ]
SUPFAMi SSF52794. SSF52794. 1 hit.
SSF55804. SSF55804. 1 hit.
TIGRFAMsi TIGR00829. FRU. 1 hit.
TIGR00848. fruA. 1 hit.
TIGR01427. PTS_IIC_fructo. 1 hit.
PROSITEi PS51094. PTS_EIIA_TYPE_2. 1 hit.
PS51099. PTS_EIIB_TYPE_2. 1 hit.
PS51104. PTS_EIIC_TYPE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae."
    Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.
    Nucleic Acids Res. 24:4420-4449(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29342 / M129.

Entry informationi

Entry nameiPTF3A_MYCPN
AccessioniPrimary (citable) accession number: P75039
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: September 3, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycoplasma pneumoniae
    Mycoplasma pneumoniae (strain M129): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi