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P75039

- PTF3A_MYCPN

UniProt

P75039 - PTF3A_MYCPN

Protein

PTS system fructose-specific EIIABC component

Gene

fruA

Organism
Mycoplasma pneumoniae (strain ATCC 29342 / M129)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in fructose transport By similarity.By similarity

    Catalytic activityi

    Protein EIIA N(pi)-phospho-L-histidine + protein EIIB = protein EIIA + protein EIIB N(pi)-phospho-L-histidine/cysteine.PROSITE-ProRule annotation
    Protein EIIB N(pi)-phospho-L-histidine/cysteine + sugar = protein EIIB + sugar phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei68 – 681Tele-phosphohistidine intermediate; for EIIA activityPROSITE-ProRule annotation
    Active sitei185 – 1851Phosphocysteine intermediate; for EIIB activityBy similarity

    GO - Molecular functioni

    1. kinase activity Source: UniProtKB-KW
    2. protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity Source: InterPro
    3. sugar:proton symporter activity Source: InterPro

    GO - Biological processi

    1. phosphoenolpyruvate-dependent sugar phosphotransferase system Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Phosphotransferase system, Sugar transport, Transport

    Enzyme and pathway databases

    BioCyciMPNE272634:GJ6Z-81-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    PTS system fructose-specific EIIABC component
    Alternative name(s):
    EIIABC-Fru
    Including the following 3 domains:
    Fructose-specific phosphotransferase enzyme IIA component (EC:2.7.1.-)
    Alternative name(s):
    EII-Fru
    PTS system fructose-specific EIIA component
    Fructose-specific phosphotransferase enzyme IIB component (EC:2.7.1.69)
    Alternative name(s):
    EIII-Fru
    PTS system fructose-specific EIIB component
    Fructose permease IIC component
    Alternative name(s):
    PTS system fructose-specific EIIC component
    Gene namesi
    Name:fruA
    Ordered Locus Names:MPN_078
    ORF Names:MP077
    OrganismiMycoplasma pneumoniae (strain ATCC 29342 / M129)
    Taxonomic identifieri272634 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
    ProteomesiUP000000808: Chromosome

    Subcellular locationi

    Cell membrane PROSITE-ProRule annotation; Multi-pass membrane protein PROSITE-ProRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 694694PTS system fructose-specific EIIABC componentPRO_0000186511Add
    BLAST

    Proteomic databases

    PaxDbiP75039.

    Interactioni

    Protein-protein interaction databases

    STRINGi272634.MPN078.

    Structurei

    3D structure databases

    ProteinModelPortaliP75039.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei318 – 33821HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei364 – 38421HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei390 – 41021HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei422 – 44221HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei461 – 48121HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei502 – 52221HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei542 – 56221HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei576 – 59621HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei602 – 62221HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei655 – 67521HelicalPROSITE-ProRule annotationAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 149146PTS EIIA type-2PROSITE-ProRule annotationAdd
    BLAST
    Domaini179 – 27597PTS EIIB type-2PROSITE-ProRule annotationAdd
    BLAST
    Domaini310 – 687378PTS EIIC type-2PROSITE-ProRule annotationAdd
    BLAST

    Domaini

    The EIIA domain is phosphorylated by phospho-HPr on a histidyl residue. Then, it transfers the phosphoryl group to the EIIB domain.
    The EIIB domain is phosphorylated by phospho-EIIA on a cysteinyl or histidyl residue, depending on the transported sugar. Then, it transfers the phosphoryl group to the sugar substrate concomitantly with the sugar uptake processed by the EIIC domain.
    The EIIC domain forms the PTS system translocation channel and contains the specific substrate-binding site.

    Sequence similaritiesi

    Contains 1 PTS EIIA type-2 domain.PROSITE-ProRule annotation
    Contains 1 PTS EIIB type-2 domain.PROSITE-ProRule annotation
    Contains 1 PTS EIIC type-2 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1445.
    KOiK02768.
    K02769.
    K02770.
    OMAiYDMANGW.
    OrthoDBiEOG6XDGX2.

    Family and domain databases

    Gene3Di3.40.930.10. 1 hit.
    InterProiIPR016152. PTrfase/Anion_transptr.
    IPR002178. PTS_EIIA_type-2_dom.
    IPR013011. PTS_EIIB_2.
    IPR003501. PTS_EIIB_2/3.
    IPR003352. PTS_EIIC.
    IPR013014. PTS_EIIC_2.
    IPR004715. PTS_IIA_fruc.
    IPR003353. PTS_IIB_fruc.
    IPR006327. PTS_IIC_fruc.
    [Graphical view]
    PfamiPF00359. PTS_EIIA_2. 1 hit.
    PF02378. PTS_EIIC. 1 hit.
    PF02302. PTS_IIB. 1 hit.
    [Graphical view]
    SUPFAMiSSF52794. SSF52794. 1 hit.
    SSF55804. SSF55804. 1 hit.
    TIGRFAMsiTIGR00829. FRU. 1 hit.
    TIGR00848. fruA. 1 hit.
    TIGR01427. PTS_IIC_fructo. 1 hit.
    PROSITEiPS51094. PTS_EIIA_TYPE_2. 1 hit.
    PS51099. PTS_EIIB_TYPE_2. 1 hit.
    PS51104. PTS_EIIC_TYPE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P75039-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFKPLLSAEL FFNWTAKDFK DKTSFLKQAC RVLQDKNCIK EEQIALTALK    50
    EREAQITTGI MSKLALPHMQ SATVLKPFVA VFKVNNVDWQ SLDNQPVKLI 100
    FLIGVPKDQG NLHLEFISQF SKLMLQDEFA NKVPNIRSFN GLINLIDSFQ 150
    QTAVASQPVV NEAAAQTEEP KDTNTQYDFV AVTACPTGIA HTFMAKEALE 200
    KFARDHNLKV KVETQGTDGI QNQLTESDLN NTKGIILACD RLIDLTRFYG 250
    HANVVEVSTT KAIKTPQTVY DQVVKKEGKL LGNKSSDSAS QTELKETTEQ 300
    LSFKDFHKRI YRAILSGVSY MLPFVVFGGI LIAIAFLIDI NNAGNAGKQF 350
    GSKDPIANWF KTLGGLSFGL IVPILSAYIA FALVGRQGLL PGFIVGLISA 400
    GKFLLNIDIV TGKIDWATES KVSSGFFGAI FGGLLAAVLI IVQQRYIYRK 450
    LPQALQGIKN ILFIPLLGTL VTAALFWVIN IPLIYLNYGL SKFLQIMDKP 500
    YLAPLLGLVI GLMMCFDLGG PVNKAAYVFG VVSLESQNSG TVAMASAILS 550
    GMVPPLGIAI AATIRKQCFD KEELPAAYAC YVMGLSFISE GAIPFVAKRP 600
    KIMLAANLIG GAVCGVLTGA FALTIRAPHG GVFVFALLKT NLEGIAGNTL 650
    QIGAGVGLAL LALIVSSFIS AGIIIGHNLL VVRKKTKQLV NTNA 694
    Length:694
    Mass (Da):75,164
    Last modified:February 1, 1997 - v1
    Checksum:i919E12BFBCC5FF6A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00089 Genomic DNA. Translation: AAB95725.1.
    PIRiS73403.
    RefSeqiNP_109766.1. NC_000912.1.

    Genome annotation databases

    EnsemblBacteriaiAAB95725; AAB95725; MPN_078.
    GeneIDi877051.
    KEGGimpn:MPN078.
    PATRICi20021437. VBIMycPne110_0079.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00089 Genomic DNA. Translation: AAB95725.1 .
    PIRi S73403.
    RefSeqi NP_109766.1. NC_000912.1.

    3D structure databases

    ProteinModelPortali P75039.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272634.MPN078.

    Proteomic databases

    PaxDbi P75039.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAB95725 ; AAB95725 ; MPN_078 .
    GeneIDi 877051.
    KEGGi mpn:MPN078.
    PATRICi 20021437. VBIMycPne110_0079.

    Phylogenomic databases

    eggNOGi COG1445.
    KOi K02768.
    K02769.
    K02770.
    OMAi YDMANGW.
    OrthoDBi EOG6XDGX2.

    Enzyme and pathway databases

    BioCyci MPNE272634:GJ6Z-81-MONOMER.

    Family and domain databases

    Gene3Di 3.40.930.10. 1 hit.
    InterProi IPR016152. PTrfase/Anion_transptr.
    IPR002178. PTS_EIIA_type-2_dom.
    IPR013011. PTS_EIIB_2.
    IPR003501. PTS_EIIB_2/3.
    IPR003352. PTS_EIIC.
    IPR013014. PTS_EIIC_2.
    IPR004715. PTS_IIA_fruc.
    IPR003353. PTS_IIB_fruc.
    IPR006327. PTS_IIC_fruc.
    [Graphical view ]
    Pfami PF00359. PTS_EIIA_2. 1 hit.
    PF02378. PTS_EIIC. 1 hit.
    PF02302. PTS_IIB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52794. SSF52794. 1 hit.
    SSF55804. SSF55804. 1 hit.
    TIGRFAMsi TIGR00829. FRU. 1 hit.
    TIGR00848. fruA. 1 hit.
    TIGR01427. PTS_IIC_fructo. 1 hit.
    PROSITEi PS51094. PTS_EIIA_TYPE_2. 1 hit.
    PS51099. PTS_EIIB_TYPE_2. 1 hit.
    PS51104. PTS_EIIC_TYPE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae."
      Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.
      Nucleic Acids Res. 24:4420-4449(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 29342 / M129.

    Entry informationi

    Entry nameiPTF3A_MYCPN
    AccessioniPrimary (citable) accession number: P75039
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Mycoplasma pneumoniae
      Mycoplasma pneumoniae (strain M129): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3