Reviewed, UniProtKB/Swiss-Prot P74984 (ARSC_YEREN)

Names and origin

Protein names

Recommended name:
    Arsenate reductase
    EC=1.20.4.1
Alternative name(s):
    Arsenical pump modifier

Gene names

Name:

arsC

Encoded on

Plasmid pYV Ref.1
Plasmid pYVe227 Ref.2

Organism

Yersinia enterocolitica

Taxonomic identifier

630 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Yersinia

Protein attributes

Sequence length	141 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Reduction of arsenate [As(V)] to arsenite [As(III)]. This protein expands the substrate specificity of arsAB pump which can extrude arsenite and antimonite to allow for arsenate pumping and resistance By similarity.
Catalytic activity	Arsenate + glutaredoxin = arsenite + glutaredoxin disulfide + H2O.
Sequence similarities	Belongs to the arsC family.

Ontologies

Keywords
Biological process	Arsenical resistance
Molecular function	Oxidoreductase
Technical term	Plasmid Transposable element
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW response to arsenic Inferred from electronic annotation. Source: UniProtKB-KW transposition Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	arsenate reductase (glutaredoxin) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 141	141	Arsenate reductase		PRO_0000162544

Sequences

	Sequence		Length	Mass (Da)
	P74984-1 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: EE6481F5E8897CC7	FASTA	141	15,805
	10 20 30 40 50 60 MSNITIYHNP TCGTSRNTLE MIRNSGNEPT VIYYLETPPT HDELVKLIAD MGITVRALLR 70 80 90 100 110 120 KNVEPYEELG LAEGTFSDEQ LIGFMLEHPI LINRPIVVTP LGTRLCRPSE VVLDILPEPQ 130 140 QGAFTKEDGE KITDESGKRL K

References

[1]	"Virulence and arsenic resistance in Yersiniae." Neyt C., Iriarte M., Thi V.H., Cornelis G.R. J. Bacteriol. 179:612-619(1997) [PubMed: 9006011] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 439-80 / Serotype O:9. Transposon: Tn2502.
[2]	"Detailed genetic map of the pYVe227 plasmid of Yersinia enterocolitica serotype O:9." Iriarte M., Lambermont I., Kerbourch C., Cornelis G.R. Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: W22703 / Serotype O:9 / Biotype 2.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U58366 Genomic DNA. Translation: AAB42203.1. AF102990 Genomic DNA. Translation: AAD16858.1.
RefSeq	NP_052438.1.
3D structure databases
HSSP	HSSP built from PDB template 1I9D based on UniProtKB P08692.
SMR	P74984. Positions 3-140.
ModBase	Search...
Genome annotation databases
GeneID	1239164.
Enzyme and pathway databases
BRENDA	1.20.4.1. 74505.
Family and domain databases
InterPro	IPR006659. Arsenate_reductase. IPR006660. Arsenate_reductase-like. IPR012335. Thioredoxin_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
Pfam	PF03960. ArsC. 1 hit. [Graphical view]
TIGRFAMs	TIGR00014. arsC. 1 hit.
PROSITE	PS51353. ARSC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARSC_YEREN

Accession

Primary (citable) accession number: P74984

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	February 1, 1997
Last modified:	June 16, 2009
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)