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Reviewed, UniProtKB/Swiss-Prot P74956 (LON_VIBPA)

Last modified June 16, 2009. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    ATP-dependent protease La
    EC=3.4.21.53
Gene names
Name: lon
Synonyms: lonS
Ordered Locus Names: VP0919
OrganismVibrio parahaemolyticus [Complete proteome] [HAMAP]
Taxonomic identifier670 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio

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Protein attributes

Sequence length783 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Degrades short-lived regulatory and abnormal proteins in the presence of ATP. Hydrolyzes two ATP for each peptide bond cleaved in the protein substrate By similarity. Regulates swarmer cell differentiation of V.parahaemolyticus.

Catalytic activity

Hydrolysis of proteins in presence of ATP.

Subunit structure

Homotetramer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the peptidase S16 family.

Contains 1 Lon domain.

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Ontologies

Keywords
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionHydrolase
Protease
Serine protease
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processproteolysis

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

ATP-dependent peptidase activity

Inferred from electronic annotation. Source: InterPro

serine-type endopeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 783783ATP-dependent protease La
PRO_0000076147

Regions

Domain10 – 201192Lon
Nucleotide binding355 – 3628ATP Potential

Sites

Active site6781 By similarity
Active site7211 By similarity

Experimental info

Sequence conflict1361Q → P in AAC44747. Ref.1
Sequence conflict1631R → P in AAC44747. Ref.1
Sequence conflict7601Q → R in AAC44747. Ref.1

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Sequences

Sequence LengthMass (Da)Tools
P74956-1 [UniParc].

Last modified April 4, 2003. Version 2.
Checksum: 723A8A81BC501778

FASTA78387,812
        10         20         30         40         50         60 
MNLERSERIE IPVLPLRDVV VYPHMVIPLF VGREKSISCL ETAMETNKQV LLVAQKQADT 

        70         80         90        100        110        120 
DEPTVDDLFE VGTVATILQL LKLPDGTVKV LVEGQQRAKI NHFKESDFFL AEAEFIVTPE 

       130        140        150        160        170        180 
LDEREQEVIV RSAINQFEGF IKLNKKIPPE VLTSLNGIDE AARLADTIAA HMPLKLVDKQ 

       190        200        210        220        230        240 
QVLEIIDVTE RLEFLMGQME SEIDLLQVEK RIRGRVKKQM EKSQREYYLN EQMKAIQKEL 

       250        260        270        280        290        300 
GEMEDAPDEF ETLQKKIDES KMPQEAREKT EQELQKLKMM SPMSAEATVV RSYIDWMVSV 

       310        320        330        340        350        360 
PWTKRSKVKK NLAKAEEILN EDHYGLERVK ERILEYLAVQ NRINKLKGPI LCLVGPPGVG 

       370        380        390        400        410        420 
KTSLGRSIAS ATGRKYVRMA LGGVRDEAEI RGHRRTYIGS LPGKLIQKMS KVGVKNPLFL 

       430        440        450        460        470        480 
LDEIDKMSSD MRGDPASALL EVLDPEQNNS FNDHYLEVDY DLSDVMFVAT SNSMNIPGPL 

       490        500        510        520        530        540 
LDRMEVIRLS GYTEDEKLNI AKRHLVEKQV QRNGLKPNEI VIEDSAIIGI IRYYTREAGV 

       550        560        570        580        590        600 
RGLEREISKI CRKAVKNILL DKDIKSVTVT MDNLKEYLGV QRFDYGKADE SNRIGQVTGL 

       610        620        630        640        650        660 
AWTEVGGDLL TIETQSMPGK GKLTQTGSLG DVMQESIQAA MTVVRSRADK LGINSDFYEK 

       670        680        690        700        710        720 
KDIHVHVPEG ATPKDGPSAG TAMCTALVSA LTGNPVKAEV AMTGEITLRG EVLPIGGLKE 

       730        740        750        760        770        780 
KLLAAHRGGI KTVLIPKDNE RDLEEIPENV IADLQVIPVQ WIDEVLKVAL ERDPTGVEFE 


AKK

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References

« Hide 'large scale' references
[1]"The lonS gene regulates swarmer cell differentiation of Vibrio parahaemolyticus."
Stewart B.J., Enos-Berlage J.L., McCarter L.L.
J. Bacteriol. 179:107-114(1997) [PubMed: 8981986] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: BB22.
[2]"Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism distinct from that of V. cholerae."
Makino K., Oshima K., Kurokawa K., Yokoyama K., Uda T., Tagomori K., Iijima Y., Najima M., Nakano M., Yamashita A., Kubota Y., Kimura S., Yasunaga T., Honda T., Shinagawa H., Hattori M., Iida T.
Lancet 361:743-749(2003) [PubMed: 12620739] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: RIMD 2210633 / Serotype O3:K6.

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Cross-references

Sequence databases

U66708 Genomic DNA. Translation: AAC44747.1.
BA000031 Genomic DNA. Translation: BAC59182.1.
RefSeqNP_797298.1.

3D structure databases

SMRP74956. Positions 490-583, 593-783.
ModBaseSearch...

Protein family/group databases

MEROPSS16.001.

Genome annotation databases

GeneID1188417.
GenomeReviewsGene locus VP0919 in contig BA000031_GR.
KEGGvpa:VP0919.
NMPDRfig|223926.1.peg.919.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMP74956.
OMAP74956. VMKESIQ.

Enzyme and pathway databases

BioCycVPAR223926:VP0919-MON.
BRENDA3.4.21.53. 3063.

Family and domain databases

InterProIPR003593. ATPase_AAA+_core.
IPR003959. ATPase_AAA_core.
IPR008269. Pept_S16_C.
IPR004815. Pept_S16_lon.
IPR003111. Pept_S16_N.
IPR008268. Peptidase_S16_AS.
IPR001984. Peptidase_S16_C.
[Graphical view]
PfamPF00004. AAA. 1 hit.
PF02190. LON. 1 hit.
PF05362. Lon_C. 1 hit.
[Graphical view]
PRINTSPR00830. ENDOLAPTASE.
SMARTSM00382. AAA. 1 hit.
SM00464. LON. 1 hit.
[Graphical view]
TIGRFAMsTIGR00763. lon. 1 hit.
PROSITEPS01046. LON_SER. False negative.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameLON_VIBPA
AccessionPrimary (citable) accession number: P74956
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: April 4, 2003
Last modified: June 16, 2009
This is version 69 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

Peptidase families

Classification of peptidase families and list of entries

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents