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Protein

Transcriptional activator protein VanR

Gene

vanR

Organism
Vibrio anguillarum (Listonella anguillarum)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Probable transcriptional activator. Binds to autoinducer molecule ODHL.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi193 – 21220H-T-H motifPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • lactone biosynthetic process Source: CACAO
  • quorum sensing Source: UniProtKB-KW
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Quorum sensing, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional activator protein VanR
Gene namesi
Name:vanR
OrganismiVibrio anguillarum (Listonella anguillarum)
Taxonomic identifieri55601 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 240240Transcriptional activator protein VanRPRO_0000184195Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi882102.VAA_01245.

Structurei

3D structure databases

ProteinModelPortaliP74946.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini169 – 23466HTH luxR-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HTH luxR-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105VJY. Bacteria.
COG2771. LUCA.
KOiK15852.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.30.450.80. 1 hit.
InterProiIPR016032. Sig_transdc_resp-reg_C-effctor.
IPR005143. TF_LuxR_autoind-bd_dom.
IPR000792. Tscrpt_reg_LuxR_C.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF03472. Autoind_bind. 1 hit.
PF00196. GerE. 1 hit.
[Graphical view]
PRINTSiPR00038. HTHLUXR.
SMARTiSM00421. HTH_LUXR. 1 hit.
[Graphical view]
SUPFAMiSSF46894. SSF46894. 1 hit.
SSF75516. SSF75516. 1 hit.
PROSITEiPS50043. HTH_LUXR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P74946-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYKILRLIQE NQQITSHDDL ENVLNGLNNL IGHEFFLFGL SFQPTLKTSE
60 70 80 90 100
TLVTDNYPNS WRQQYDESGF MHIDPIVKYS ITNFLPIRWD DAKRVNNDGR
110 120 130 140 150
VIFEEARCNG LKAGFSIPIH GLRGEFGMIS FATSDTKSYD LNQQSIHTSQ
160 170 180 190 200
LIVPLLAHNI GNITRYHKDA KPRAVLTARE VQCLAWAAEG KSAWEIATII
210 220 230 240
NTSERTVKFH FSNACKKLGA TNRYQAITKA ILGGYINPYL
Length:240
Mass (Da):27,253
Last modified:February 1, 1997 - v1
Checksum:iBF9E0C40564C6663
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U69677 Genomic DNA. Translation: AAC45213.1.
RefSeqiWP_013868064.1. NZ_LK021129.1.

Genome annotation databases

GeneIDi10777015.
KEGGivau:VANGNB10_cII0861.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U69677 Genomic DNA. Translation: AAC45213.1.
RefSeqiWP_013868064.1. NZ_LK021129.1.

3D structure databases

ProteinModelPortaliP74946.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi882102.VAA_01245.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi10777015.
KEGGivau:VANGNB10_cII0861.

Phylogenomic databases

eggNOGiENOG4105VJY. Bacteria.
COG2771. LUCA.
KOiK15852.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.30.450.80. 1 hit.
InterProiIPR016032. Sig_transdc_resp-reg_C-effctor.
IPR005143. TF_LuxR_autoind-bd_dom.
IPR000792. Tscrpt_reg_LuxR_C.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF03472. Autoind_bind. 1 hit.
PF00196. GerE. 1 hit.
[Graphical view]
PRINTSiPR00038. HTHLUXR.
SMARTiSM00421. HTH_LUXR. 1 hit.
[Graphical view]
SUPFAMiSSF46894. SSF46894. 1 hit.
SSF75516. SSF75516. 1 hit.
PROSITEiPS50043. HTH_LUXR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Quorum sensing in Vibrio anguillarum: characterization of the vanI/vanR locus and identification of the autoinducer N-(3-oxodecanoyl)-L-homoserine lactone."
    Milton D.L., Hardman A., Camara M., Chhabra S.R., Bycroft B.W., Stewart G.S.A.B., Williams P.
    J. Bacteriol. 179:3004-3012(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: NB10 / Serotype O1.

Entry informationi

Entry nameiVANR_VIBAN
AccessioniPrimary (citable) accession number: P74946
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: February 1, 1997
Last modified: May 11, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.