Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P74936

- PROB_TREPA

UniProt

P74936 - PROB_TREPA

Protein

Glutamate 5-kinase

Gene

proB

Organism
Treponema pallidum (strain Nichols)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.UniRule annotation

    Catalytic activityi

    ATP + L-glutamate = ADP + L-glutamate 5-phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei15 – 151ATPUniRule annotation
    Binding sitei55 – 551SubstrateUniRule annotation
    Binding sitei159 – 1591SubstrateUniRule annotation
    Binding sitei186 – 1861Substrate; via amide nitrogenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi206 – 2072ATPUniRule annotation
    Nucleotide bindingi248 – 2547ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. glutamate 5-kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. L-proline biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Proline biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciTPAL243276:GC1H-376-MONOMER.
    UniPathwayiUPA00098; UER00359.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate 5-kinaseUniRule annotation (EC:2.7.2.11UniRule annotation)
    Alternative name(s):
    Gamma-glutamyl kinaseUniRule annotation
    Short name:
    GKUniRule annotation
    Gene namesi
    Name:proBUniRule annotation
    Ordered Locus Names:TP_0351
    OrganismiTreponema pallidum (strain Nichols)
    Taxonomic identifieri243276 [NCBI]
    Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
    ProteomesiUP000000811: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 296296Glutamate 5-kinasePRO_0000109750Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    IntActiP74936. 5 interactions.
    STRINGi243276.TP0351.

    Structurei

    3D structure databases

    ProteinModelPortaliP74936.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glutamate 5-kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0263.
    KOiK00931.
    OMAiQENEEFA.
    OrthoDBiEOG6PGK7G.

    Family and domain databases

    Gene3Di3.40.1160.10. 1 hit.
    HAMAPiMF_00456. ProB.
    InterProiIPR001048. Asp/Glu/Uridylate_kinase.
    IPR001057. Glu/AcGlu_kinase.
    IPR011529. Glu_5kinase.
    IPR005715. Glu_5kinase/COase_Synthase.
    IPR019797. Glutamate_5-kinase_CS.
    [Graphical view]
    PfamiPF00696. AA_kinase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000729. GK. 1 hit.
    PRINTSiPR00474. GLU5KINASE.
    SUPFAMiSSF53633. SSF53633. 1 hit.
    TIGRFAMsiTIGR01027. proB. 1 hit.
    PROSITEiPS00902. GLUTAMATE_5_KINASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P74936-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIRALFAAAK KIVIKIGSNT LAQADGTPDE EFLAECARAC AALMRDGKQI    50
    VVVSSGAQVA GISALHCLSS PPQGAGLERH ESRGVIPGDG ASCKQALCAV 100
    GQAELISRWR SAFAAHQQCV GQFLCTKEDF TDSDRAAQVR YTLSFLLERR 150
    VVPILNENDA LCCSDVPSVP ADRRVSLSPQ KRIGDNDSLS AFVALLWQAD 200
    LLLLLSDIDG VYDKDPKAHT DAQHVPLVTD VSALVGKTSM GSSNVFGTGG 250
    IATKLDAARL VTRAGIPLVL ANGRHLDPIL SLMRGDARGT LFVPVS 296
    Length:296
    Mass (Da):31,315
    Last modified:February 1, 1997 - v1
    Checksum:i4276927F287E4F14
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U61535 Genomic DNA. Translation: AAB39981.1.
    AE000520 Genomic DNA. Translation: AAC65336.1.
    PIRiF71336.
    RefSeqiNP_218791.1. NC_000919.1.
    WP_010881799.1. NC_021490.2.
    YP_008091203.1. NC_021490.2.

    Genome annotation databases

    EnsemblBacteriaiAAC65336; AAC65336; TP_0351.
    GeneIDi15851642.
    2611465.
    KEGGitpa:TP0351.
    tpw:TPANIC_0351.
    PATRICi20530695. VBITrePal57110_0368.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U61535 Genomic DNA. Translation: AAB39981.1 .
    AE000520 Genomic DNA. Translation: AAC65336.1 .
    PIRi F71336.
    RefSeqi NP_218791.1. NC_000919.1.
    WP_010881799.1. NC_021490.2.
    YP_008091203.1. NC_021490.2.

    3D structure databases

    ProteinModelPortali P74936.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P74936. 5 interactions.
    STRINGi 243276.TP0351.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC65336 ; AAC65336 ; TP_0351 .
    GeneIDi 15851642.
    2611465.
    KEGGi tpa:TP0351.
    tpw:TPANIC_0351.
    PATRICi 20530695. VBITrePal57110_0368.

    Phylogenomic databases

    eggNOGi COG0263.
    KOi K00931.
    OMAi QENEEFA.
    OrthoDBi EOG6PGK7G.

    Enzyme and pathway databases

    UniPathwayi UPA00098 ; UER00359 .
    BioCyci TPAL243276:GC1H-376-MONOMER.

    Family and domain databases

    Gene3Di 3.40.1160.10. 1 hit.
    HAMAPi MF_00456. ProB.
    InterProi IPR001048. Asp/Glu/Uridylate_kinase.
    IPR001057. Glu/AcGlu_kinase.
    IPR011529. Glu_5kinase.
    IPR005715. Glu_5kinase/COase_Synthase.
    IPR019797. Glutamate_5-kinase_CS.
    [Graphical view ]
    Pfami PF00696. AA_kinase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000729. GK. 1 hit.
    PRINTSi PR00474. GLU5KINASE.
    SUPFAMi SSF53633. SSF53633. 1 hit.
    TIGRFAMsi TIGR01027. proB. 1 hit.
    PROSITEi PS00902. GLUTAMATE_5_KINASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequences of the proA and proB genes of Treponema pallidum, the syphilis agent."
      Stamm L.V., Barnes N.Y.
      DNA Seq. 8:63-70(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Nichols.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Nichols.

    Entry informationi

    Entry nameiPROB_TREPA
    AccessioniPrimary (citable) accession number: P74936
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3