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P74933 (DPO1_TREPA) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
DNA polymerase I
Short name=POL I
EC=2.7.7.7
Gene names
Name:polA
Ordered Locus Names:TP_0105
OrganismTreponema pallidum (strain Nichols) [Complete proteome] [HAMAP]
Taxonomic identifier243276 [NCBI]
Taxonomic lineageBacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Treponema

Protein attributes

Sequence length997 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

In addition to polymerase activity, this DNA polymerase exhibits 3' to 5' and 5' to 3' exonuclease activity By similarity.

Catalytic activity

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

Sequence similarities

Belongs to the DNA polymerase type-A family.

Contains 1 3'-5' exonuclease domain.

Contains 1 5'-3' exonuclease domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 997997DNA polymerase I
PRO_0000101261

Experimental info

Sequence conflict7821V → A in AAB17467. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P74933 [UniParc].

Last modified December 15, 1998. Version 2.
Checksum: 764DE97E4CCD2054

FASTA997112,217
        10         20         30         40         50         60 
MQEKKTLYLL DAYGLIYRSY HAFARAPLIN DSGANVSAVY GFFRSLHTLL CHYRPRYFVA 

        70         80         90        100        110        120 
VFDSLTPTFR HVQYPAYKAK RDKTSAELYA QIPLIEEILC ALGITVLRHD GFEADDLIAT 

       130        140        150        160        170        180 
LAKRVAAEHC HVVIISSDKD VLQLVCDTVQ VLRLDIDHKW TCCDAAYVQQ RWTVMPTQLL 

       190        200        210        220        230        240 
DLFSLMGDSS DNVPGVRGIG PKTAAHLLHC FGTLDGIYRH TYSLKEALRT KIVCGKKDAF 

       250        260        270        280        290        300 
FSRSLIELRD DVPCVFSLED SCCIPLDVTS AARIFVREGL HALAQQYRAC VQEIDTEATN 

       310        320        330        340        350        360 
DTLQMTESSV LTSGRCANEC FLSQVEGRAS TPEVNSVLKS ELKTSAVSGA IPIENRDLRQ 

       370        380        390        400        410        420 
DVMLARSAGH YRGVTDPVEL KRIIDCACAN GVVAFDCETD GLHPHDTRLV GFSICFQEAE 

       430        440        450        460        470        480 
AFYVPLIVPD VSLHTESTQC TCARSTNVET EKECTEQHGV SASAVQDPAY VQAVMHQLRR 

       490        500        510        520        530        540 
LWNDETLTLV MHNGKFDYHV MHRAGVFEHC ACNIFDTMVA AWLLDPDRGT YGMDVLAASF 

       550        560        570        580        590        600 
FQIRTITFEE VVAKGQTFAH VPYECAVRYA AEDADITFRL YHYLKLRLET AGLLSVFETI 

       610        620        630        640        650        660 
EMPLLPILAR MEEVGIFLRK DVVQQLTRSF SDLIQQYEHD IFSLAGHEFN IGSPKQLQTV 

       670        680        690        700        710        720 
LFQELHLPPG KKNTQGYSTD HSVLKKLARK HPIAEKILLF RDLSKLRSTY TESLAKLADQ 

       730        740        750        760        770        780 
TGRVHTSFVQ IGTATGRLSS RNPNLQNIPI KSTEGRKIRQ AFQATVGHEL ISADYTQIEL 

       790        800        810        820        830        840 
VVLAHLSQDR NLLNAFRQHI DIHALTAAYI FNVSIDDVQP AMRRIAKTIN FGIVYGMSAF 

       850        860        870        880        890        900 
RLSDELKISQ KEAQSFIYRY FETYPGVYAF STQVAEQTRK TGYVTSLAGR RRYIRTIDSR 

       910        920        930        940        950        960 
NTLERARAER MALNTQIQSS AADIVKIAMI AIQRAFARRP LRAQLLLQVH DELIFEAPAA 

       970        980        990 
ETAIVKEILF AEMEHAVELS IPLRIHVESG NSWGDFH

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning of a gene (polA) coding for an unusual DNA polymerase I from Treponema pallidum."
Rodes B., Liu H., Johnson S., George R., Steiner B.M.
J. Med. Microbiol. 49:657-667(2000) [PubMed: 10882092] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Nichols.
[2]"Complete genome sequence of Treponema pallidum, the syphilis spirochete."
Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G., Dodson R.J., Gwinn M.L., Hickey E.K., Clayton R.A., Ketchum K.A., Sodergren E., Hardham J.M., McLeod M.P., Salzberg S.L., Peterson J.D., Khalak H.G., Richardson D.L., Howell J.K. expand/collapse author list , Chidambaram M., Utterback T.R., McDonald L.A., Artiach P., Bowman C., Cotton M.D., Fujii C., Garland S.A., Hatch B., Horst K., Roberts K.M., Sandusky M., Weidman J.F., Smith H.O., Venter J.C.
Science 281:375-388(1998) [PubMed: 9665876] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Nichols.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U57757 Genomic DNA. Translation: AAB17467.1.
AE000520 Genomic DNA. Translation: AAC26553.1.
PIRF71365.
RefSeqNP_218545.1. NC_000919.1.

3D structure databases

ProteinModelPortalP74933.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2610831.
GenomeReviewsGene locus TP_0105 in contig AE000520_GR.
KEGGtpa:TP0105.
NMPDRfig|243276.1.peg.104.
PATRIC20530159. VBITrePal57110_0116.
TIGRTP_0105.

Phylogenomic databases

HOGENOMHBG284758.
OMAPKGAPST.
ProtClustDBPRK05755.

Enzyme and pathway databases

BioCycTPAL243276:TP_0105-MONOMER.

Family and domain databases

InterProIPR002562. 3'-5'_exonuclease_dom.
IPR020046. 5-3_exonucl_a-hlix_arch_N.
IPR020045. 5-3_exonuclease_C.
IPR002421. 5-3_exonuclease_N.
IPR019760. DNA-dir_DNA_pol_A_CS.
IPR001098. DNA-dir_DNA_pol_A_palm_dom.
IPR018320. DNA_polymerase_1.
IPR002298. DNA_polymerase_A.
IPR008918. HhH2.
IPR012337. RNaseH-like_dom.
[Graphical view]
KOK02335.
PfamPF01367. 5_3_exonuc. 1 hit.
PF02739. 5_3_exonuc_N. 1 hit.
PF00476. DNA_pol_A. 1 hit.
PF01612. DNA_pol_A_exo1. 2 hits.
[Graphical view]
PRINTSPR00868. DNAPOLI.
SMARTSM00474. 35EXOc. 1 hit.
SM00475. 53EXOc. 1 hit.
SM00279. HhH2. 1 hit.
SM00482. POLAc. 1 hit.
[Graphical view]
SUPFAMSSF47807. 5_3_exo_C. 1 hit.
SSF53098. RNaseH_fold. 1 hit.
TIGRFAMsTIGR00593. Pola. 1 hit.
PROSITEPS00447. DNA_POLYMERASE_A. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDPO1_TREPA
AccessionPrimary (citable) accession number: P74933
Secondary accession number(s): O83143
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: December 15, 1998
Last modified: January 25, 2012
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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