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Protein

Probable propionate kinase

Gene

pduW

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + propanoate = ADP + propanoyl phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSENT99287:GCTI-2069-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable propionate kinaseUniRule annotation (EC:2.7.2.15UniRule annotation)
Gene namesi
Name:pduWUniRule annotation
Ordered Locus Names:STM2057
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001014 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 404404Probable propionate kinasePRO_0000107651Add
BLAST

Proteomic databases

PaxDbiP74879.

Expressioni

Inductioni

By propanediol.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi99287.STM2057.

Structurei

3D structure databases

ProteinModelPortaliP74879.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetokinase family. PduW subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C6H. Bacteria.
COG0282. LUCA.
HOGENOMiHOG000288398.
KOiK19697.
OMAiKWQETLP.
PhylomeDBiP74879.

Family and domain databases

HAMAPiMF_00020. Acetate_kinase. 1 hit.
MF_01882. Propion_kin_subfam2. 1 hit.
InterProiIPR004372. Ac/propionate_kinase.
IPR000890. Aliphatic_acid_kin_short-chain.
IPR023865. Aliphatic_acid_kinase_CS.
IPR024896. Propionate_kinase_PduW.
[Graphical view]
PANTHERiPTHR21060. PTHR21060. 1 hit.
PfamiPF00871. Acetate_kinase. 1 hit.
[Graphical view]
PIRSFiPIRSF000722. Acetate_prop_kin. 1 hit.
PRINTSiPR00471. ACETATEKNASE.
TIGRFAMsiTIGR00016. ackA. 1 hit.
PROSITEiPS01075. ACETATE_KINASE_1. 1 hit.
PS01076. ACETATE_KINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P74879-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYKIMAINA GSSSLKFQLL EMPQGDMLCQ GLIERIGMAD AQVTIKTHSQ
60 70 80 90 100
KWQETVPVAD HRDAVTLLLE KLLGYQIINS LRDIDGVGHR VAHGGEFFKD
110 120 130 140 150
STLVTDETLA QIERLAELAP LHNPVNALGI HVFRQLLPDA PSVAVFDTAF
160 170 180 190 200
HQTLDEPAYI YPLPWHYYAE LGIRRYGFHG TSHKYVSGVL AEKLGVPLSA
210 220 230 240 250
LRVICCHLGN GSSICAIKNG RSVNTSMGFT PQSGVMMGTR SGDIDPSILP
260 270 280 290 300
WIAQRESKTP QQLNQLLNNE SGLLGVSGVS SDYRDVEQAA NTGNRQAKLA
310 320 330 340 350
LTLFAERIRA TIGSYIMQMG GLDALVFTGG IGENSARARS AVCHNLQFLG
360 370 380 390 400
LAVDEEKNQR NATFIQTENA LVKVAVINTN EELMIAQDVM RIALPATEGL

CVPA
Length:404
Mass (Da):43,995
Last modified:May 30, 2000 - v2
Checksum:iE236F981EAFBB304
GO

Sequence cautioni

The sequence AAD39021 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti25 – 251G → R in AAB09552 (Ref. 1) Curated
Sequence conflicti60 – 678DHRDAVTL → RSSRCVNW in AAB09552 (Ref. 1) Curated
Sequence conflicti92 – 921A → R in AAB09552 (Ref. 1) Curated
Sequence conflicti212 – 2121S → T in AAB09552 (Ref. 1) Curated
Sequence conflicti247 – 26115SILPW…SKTPQ → HSAVDSPARNENAE in AAB09552 (Ref. 1) CuratedAdd
BLAST
Sequence conflicti300 – 30910ALTLFAERIR → RSHSVCRTHS in AAB09552 (Ref. 1) Curated
Sequence conflicti342 – 35211VCHNLQFLGLA → CAIISIFGLS in AAB09552 (Ref. 1) CuratedAdd
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U67435 Genomic DNA. Translation: AAB09552.1.
AF026270 Genomic DNA. Translation: AAD39021.1. Different initiation.
AE006468 Genomic DNA. Translation: AAL20961.1.
RefSeqiNP_461002.1. NC_003197.1.
WP_000120647.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL20961; AAL20961; STM2057.
GeneIDi1253578.
KEGGistm:STM2057.
PATRICi32382697. VBISalEnt20916_2179.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U67435 Genomic DNA. Translation: AAB09552.1.
AF026270 Genomic DNA. Translation: AAD39021.1. Different initiation.
AE006468 Genomic DNA. Translation: AAL20961.1.
RefSeqiNP_461002.1. NC_003197.1.
WP_000120647.1. NC_003197.1.

3D structure databases

ProteinModelPortaliP74879.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi99287.STM2057.

Proteomic databases

PaxDbiP74879.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL20961; AAL20961; STM2057.
GeneIDi1253578.
KEGGistm:STM2057.
PATRICi32382697. VBISalEnt20916_2179.

Phylogenomic databases

eggNOGiENOG4105C6H. Bacteria.
COG0282. LUCA.
HOGENOMiHOG000288398.
KOiK19697.
OMAiKWQETLP.
PhylomeDBiP74879.

Enzyme and pathway databases

BioCyciSENT99287:GCTI-2069-MONOMER.

Family and domain databases

HAMAPiMF_00020. Acetate_kinase. 1 hit.
MF_01882. Propion_kin_subfam2. 1 hit.
InterProiIPR004372. Ac/propionate_kinase.
IPR000890. Aliphatic_acid_kin_short-chain.
IPR023865. Aliphatic_acid_kinase_CS.
IPR024896. Propionate_kinase_PduW.
[Graphical view]
PANTHERiPTHR21060. PTHR21060. 1 hit.
PfamiPF00871. Acetate_kinase. 1 hit.
[Graphical view]
PIRSFiPIRSF000722. Acetate_prop_kin. 1 hit.
PRINTSiPR00471. ACETATEKNASE.
TIGRFAMsiTIGR00016. ackA. 1 hit.
PROSITEiPS01075. ACETATE_KINASE_1. 1 hit.
PS01076. ACETATE_KINASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPDUW_SALTY
AccessioniPrimary (citable) accession number: P74879
Secondary accession number(s): Q9XDM5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: September 7, 2016
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

Was originally (Ref. 1) thought to be AckA.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.