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P74851

- SPTP_SALTI

UniProt

P74851 - SPTP_SALTI

Protein

Secreted effector protein SptP

Gene

sptP

Organism
Salmonella typhi
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein includes tyrosine phosphatase and GTPase activating protein (GAP) activities. After bacterial internalization, GAP mediates the reversal of the cytoskeletal changes induced by SopE. This function is independent of its tyrosine phosphatase activity, which remains unclear By similarity.By similarity

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei481 – 4811Phosphocysteine intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. GTPase activator activity Source: UniProtKB-KW
    2. protein tyrosine phosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. pathogenesis Source: UniProtKB-KW

    Keywords - Molecular functioni

    GTPase activation, Hydrolase, Protein phosphatase

    Keywords - Biological processi

    Virulence

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Secreted effector protein SptP
    Including the following 2 domains:
    GTPase-activating protein
    Short name:
    GAP
    Tyrosine-protein phosphatase (EC:3.1.3.48)
    Gene namesi
    Name:sptP
    Synonyms:stpA
    Ordered Locus Names:STY3001, t2780
    OrganismiSalmonella typhi
    Taxonomic identifieri90370 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
    ProteomesiUP000000541: Chromosome, UP000002670: Chromosome

    Subcellular locationi

    Secreted By similarity. Host cytoplasm By similarity
    Note: Secreted via type III secretion system 1 (SPI-1 TTSS), and delivered into the host cytoplasm.By similarity

    GO - Cellular componenti

    1. extracellular space Source: InterPro
    2. host cell cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host cytoplasm, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 543543Secreted effector protein SptPPRO_0000094865Add
    BLAST

    Interactioni

    Subunit structurei

    Forms a complex with SicP.By similarity

    Protein-protein interaction databases

    STRINGi220341.STY3001.

    Structurei

    3D structure databases

    ProteinModelPortaliP74851.
    SMRiP74851. Positions 36-139, 167-539.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini280 – 543264Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni35 – 139105Chaperone-bindingBy similarityAdd
    BLAST
    Regioni167 – 290124GAPBy similarityAdd
    BLAST

    Sequence similaritiesi

    In the N-terminal section; belongs to the YopE family.Curated
    Contains 1 tyrosine-protein phosphatase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG74835.
    HOGENOMiHOG000028733.
    KOiK13740.
    OMAiWIDKAST.
    OrthoDBiEOG6423BT.

    Family and domain databases

    Gene3Di1.20.120.260. 1 hit.
    3.90.190.10. 2 hits.
    InterProiIPR011070. Globular_prot_asu/bsu.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR015203. SicP-binding.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    IPR003546. Tyr_Pase_SptP/YopH.
    IPR014773. Uncharacterised_dom_YopE.
    [Graphical view]
    PfamiPF09119. SicP-binding. 1 hit.
    PF00102. Y_phosphatase. 1 hit.
    PF03545. YopE. 1 hit.
    [Graphical view]
    PRINTSiPR01371. BACYPHPHTASE.
    SMARTiSM00194. PTPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF47233. SSF47233. 1 hit.
    SSF52799. SSF52799. 1 hit.
    SSF56568. SSF56568. 1 hit.
    PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P74851-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLRYDERKLN NLTLSSFSKS GVSSDTRLYI AKENTDKAYV APEKFSSKVL    50
    TWLGKMPLFK NTEVVQKHTE NIRVQNQKIL QTFLQALTEK YGEKAVNNAL 100
    YMSSINMNKP LTQRLVVQIT ECVKGADGGF INLIKNKDNV GVMNAALVIK 150
    GGDTKVTEQN NDVGAESKQP LLDIALKGLK RTIPQLEQMD GNSLRENFQE 200
    MASGNGPLRS LMTNLQSLNK IPEAKQLNDY VTTLKNIQIG ADRFSQWGTC 250
    GGEVERWIDK ASTHELTQAV KKIHVIAKEL KNVTAELEKI KAGASMPQTM 300
    SGPTLGLARF AVSSIPINQQ TQVKLSDGMP VPVNTLTFDG KPVALAGSCP 350
    KNTPDALEAH MKMLLEKECS CLVVLTSEDQ MQAKQLPAYF RGSYTFGEVH 400
    TNSQKVSSAS QGGAIDQYNM QLSCGEKRYT IPVLHVKNWP DHQPLPSTDQ 450
    LEYLADRVKN SNQNGAPGRS SSDKHLPMIH CLGGVGRTGT MAAALVLKDN 500
    PHSNLEQVRA DFRNSRNNRM LEDASQFVQL KAMQAQLLMT TAS 543
    Length:543
    Mass (Da):59,898
    Last modified:February 1, 1997 - v1
    Checksum:i72E8DAA70ABD9E00
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X92546 Genomic DNA. Translation: CAA63304.1.
    AL513382 Genomic DNA. Translation: CAD05985.1.
    AE014613 Genomic DNA. Translation: AAO70341.1.
    RefSeqiNP_457272.1. NC_003198.1.
    NP_806481.1. NC_004631.1.

    Genome annotation databases

    EnsemblBacteriaiAAO70341; AAO70341; t2780.
    CAD05985; CAD05985; CAD05985.
    GeneIDi1249307.
    KEGGisty:STY3001.
    PATRICi18544050. VBISalEnt120419_3055.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X92546 Genomic DNA. Translation: CAA63304.1 .
    AL513382 Genomic DNA. Translation: CAD05985.1 .
    AE014613 Genomic DNA. Translation: AAO70341.1 .
    RefSeqi NP_457272.1. NC_003198.1.
    NP_806481.1. NC_004631.1.

    3D structure databases

    ProteinModelPortali P74851.
    SMRi P74851. Positions 36-139, 167-539.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 220341.STY3001.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO70341 ; AAO70341 ; t2780 .
    CAD05985 ; CAD05985 ; CAD05985 .
    GeneIDi 1249307.
    KEGGi sty:STY3001.
    PATRICi 18544050. VBISalEnt120419_3055.

    Phylogenomic databases

    eggNOGi NOG74835.
    HOGENOMi HOG000028733.
    KOi K13740.
    OMAi WIDKAST.
    OrthoDBi EOG6423BT.

    Family and domain databases

    Gene3Di 1.20.120.260. 1 hit.
    3.90.190.10. 2 hits.
    InterProi IPR011070. Globular_prot_asu/bsu.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR015203. SicP-binding.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    IPR003546. Tyr_Pase_SptP/YopH.
    IPR014773. Uncharacterised_dom_YopE.
    [Graphical view ]
    Pfami PF09119. SicP-binding. 1 hit.
    PF00102. Y_phosphatase. 1 hit.
    PF03545. YopE. 1 hit.
    [Graphical view ]
    PRINTSi PR01371. BACYPHPHTASE.
    SMARTi SM00194. PTPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47233. SSF47233. 1 hit.
    SSF52799. SSF52799. 1 hit.
    SSF56568. SSF56568. 1 hit.
    PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular characterization of the Salmonella typhi StpA protein that is related to both Yersinia YopE cytotoxin and YopH tyrosine phosphatase."
      Arricau N., Hermant D., Waxin H., Popoff M.Y.
      Res. Microbiol. 148:21-26(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 700931 / Ty2.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CT18.
    3. "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and CT18."
      Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V., Kodoyianni V., Schwartz D.C., Blattner F.R.
      J. Bacteriol. 185:2330-2337(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700931 / Ty2.

    Entry informationi

    Entry nameiSPTP_SALTI
    AccessioniPrimary (citable) accession number: P74851
    Secondary accession number(s): Q7AME2, Q7C7N7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2005
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Requires SicP as a chaperone for its stability and secretion.By similarity

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3