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P74851

- SPTP_SALTI

UniProt

P74851 - SPTP_SALTI

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Protein

Secreted effector protein SptP

Gene

sptP

Organism
Salmonella typhi
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein includes tyrosine phosphatase and GTPase activating protein (GAP) activities. After bacterial internalization, GAP mediates the reversal of the cytoskeletal changes induced by SopE. This function is independent of its tyrosine phosphatase activity, which remains unclear (By similarity).By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei481 – 4811Phosphocysteine intermediatePROSITE-ProRule annotation

GO - Molecular functioni

  1. GTPase activator activity Source: UniProtKB-KW
  2. protein tyrosine phosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. pathogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

GTPase activation, Hydrolase, Protein phosphatase

Keywords - Biological processi

Virulence

Names & Taxonomyi

Protein namesi
Recommended name:
Secreted effector protein SptP
Including the following 2 domains:
GTPase-activating protein
Short name:
GAP
Tyrosine-protein phosphatase (EC:3.1.3.48)
Gene namesi
Name:sptP
Synonyms:stpA
Ordered Locus Names:STY3001, t2780
OrganismiSalmonella typhi
Taxonomic identifieri90370 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000000541: Chromosome, UP000002670: Chromosome

Subcellular locationi

Secreted By similarity. Host cytoplasm By similarity
Note: Secreted via type III secretion system 1 (SPI-1 TTSS), and delivered into the host cytoplasm.By similarity

GO - Cellular componenti

  1. extracellular space Source: InterPro
  2. host cell cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Host cytoplasm, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 543543Secreted effector protein SptPPRO_0000094865Add
BLAST

Interactioni

Subunit structurei

Forms a complex with SicP.By similarity

Protein-protein interaction databases

STRINGi220341.STY3001.

Structurei

3D structure databases

ProteinModelPortaliP74851.
SMRiP74851. Positions 36-139, 167-539.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini280 – 543264Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni35 – 139105Chaperone-bindingBy similarityAdd
BLAST
Regioni167 – 290124GAPBy similarityAdd
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the YopE family.Curated
Contains 1 tyrosine-protein phosphatase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG74835.
HOGENOMiHOG000028733.
KOiK13740.
OMAiWIDKAST.
OrthoDBiEOG6423BT.

Family and domain databases

Gene3Di1.20.120.260. 1 hit.
3.90.190.10. 2 hits.
InterProiIPR011070. Globular_prot_asu/bsu.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR015203. SicP-binding.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
IPR003546. Tyr_Pase_SptP/YopH.
IPR014773. Uncharacterised_dom_YopE.
[Graphical view]
PfamiPF09119. SicP-binding. 1 hit.
PF00102. Y_phosphatase. 1 hit.
PF03545. YopE. 1 hit.
[Graphical view]
PRINTSiPR01371. BACYPHPHTASE.
SMARTiSM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMiSSF47233. SSF47233. 1 hit.
SSF52799. SSF52799. 1 hit.
SSF56568. SSF56568. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P74851-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLRYDERKLN NLTLSSFSKS GVSSDTRLYI AKENTDKAYV APEKFSSKVL
60 70 80 90 100
TWLGKMPLFK NTEVVQKHTE NIRVQNQKIL QTFLQALTEK YGEKAVNNAL
110 120 130 140 150
YMSSINMNKP LTQRLVVQIT ECVKGADGGF INLIKNKDNV GVMNAALVIK
160 170 180 190 200
GGDTKVTEQN NDVGAESKQP LLDIALKGLK RTIPQLEQMD GNSLRENFQE
210 220 230 240 250
MASGNGPLRS LMTNLQSLNK IPEAKQLNDY VTTLKNIQIG ADRFSQWGTC
260 270 280 290 300
GGEVERWIDK ASTHELTQAV KKIHVIAKEL KNVTAELEKI KAGASMPQTM
310 320 330 340 350
SGPTLGLARF AVSSIPINQQ TQVKLSDGMP VPVNTLTFDG KPVALAGSCP
360 370 380 390 400
KNTPDALEAH MKMLLEKECS CLVVLTSEDQ MQAKQLPAYF RGSYTFGEVH
410 420 430 440 450
TNSQKVSSAS QGGAIDQYNM QLSCGEKRYT IPVLHVKNWP DHQPLPSTDQ
460 470 480 490 500
LEYLADRVKN SNQNGAPGRS SSDKHLPMIH CLGGVGRTGT MAAALVLKDN
510 520 530 540
PHSNLEQVRA DFRNSRNNRM LEDASQFVQL KAMQAQLLMT TAS
Length:543
Mass (Da):59,898
Last modified:February 1, 1997 - v1
Checksum:i72E8DAA70ABD9E00
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X92546 Genomic DNA. Translation: CAA63304.1.
AL513382 Genomic DNA. Translation: CAD05985.1.
AE014613 Genomic DNA. Translation: AAO70341.1.
RefSeqiNP_457272.1. NC_003198.1.
NP_806481.1. NC_004631.1.

Genome annotation databases

EnsemblBacteriaiAAO70341; AAO70341; t2780.
CAD05985; CAD05985; CAD05985.
GeneIDi1249307.
KEGGisty:STY3001.
PATRICi18544050. VBISalEnt120419_3055.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X92546 Genomic DNA. Translation: CAA63304.1 .
AL513382 Genomic DNA. Translation: CAD05985.1 .
AE014613 Genomic DNA. Translation: AAO70341.1 .
RefSeqi NP_457272.1. NC_003198.1.
NP_806481.1. NC_004631.1.

3D structure databases

ProteinModelPortali P74851.
SMRi P74851. Positions 36-139, 167-539.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 220341.STY3001.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO70341 ; AAO70341 ; t2780 .
CAD05985 ; CAD05985 ; CAD05985 .
GeneIDi 1249307.
KEGGi sty:STY3001.
PATRICi 18544050. VBISalEnt120419_3055.

Phylogenomic databases

eggNOGi NOG74835.
HOGENOMi HOG000028733.
KOi K13740.
OMAi WIDKAST.
OrthoDBi EOG6423BT.

Family and domain databases

Gene3Di 1.20.120.260. 1 hit.
3.90.190.10. 2 hits.
InterProi IPR011070. Globular_prot_asu/bsu.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR015203. SicP-binding.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
IPR003546. Tyr_Pase_SptP/YopH.
IPR014773. Uncharacterised_dom_YopE.
[Graphical view ]
Pfami PF09119. SicP-binding. 1 hit.
PF00102. Y_phosphatase. 1 hit.
PF03545. YopE. 1 hit.
[Graphical view ]
PRINTSi PR01371. BACYPHPHTASE.
SMARTi SM00194. PTPc. 1 hit.
[Graphical view ]
SUPFAMi SSF47233. SSF47233. 1 hit.
SSF52799. SSF52799. 1 hit.
SSF56568. SSF56568. 1 hit.
PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular characterization of the Salmonella typhi StpA protein that is related to both Yersinia YopE cytotoxin and YopH tyrosine phosphatase."
    Arricau N., Hermant D., Waxin H., Popoff M.Y.
    Res. Microbiol. 148:21-26(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 700931 / Ty2.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CT18.
  3. "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and CT18."
    Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V., Kodoyianni V., Schwartz D.C., Blattner F.R.
    J. Bacteriol. 185:2330-2337(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700931 / Ty2.

Entry informationi

Entry nameiSPTP_SALTI
AccessioniPrimary (citable) accession number: P74851
Secondary accession number(s): Q7AME2, Q7C7N7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: February 1, 1997
Last modified: October 29, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Requires SicP as a chaperone for its stability and secretion.By similarity

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3