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Protein

Aspartate carbamoyltransferase regulatory chain

Gene

pyrI

Organism
Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Involved in allosteric regulation of aspartate carbamoyltransferase.By similarity

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi113ZincBy similarity1
Metal bindingi118ZincBy similarity1
Metal bindingi142ZincBy similarity1
Metal bindingi145ZincBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Pyrimidine biosynthesis

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartate carbamoyltransferase regulatory chain
Gene namesi
Name:pyrI
Ordered Locus Names:Saci_1595
OrganismiSulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Taxonomic identifieri330779 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001018 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001423421 – 164Aspartate carbamoyltransferase regulatory chainAdd BLAST164

Interactioni

Subunit structurei

Contains catalytic and regulatory chains.By similarity

Protein-protein interaction databases

IntActiP74766. 1 interactor.
STRINGi330779.Saci_1595.

Structurei

Secondary structure

1164
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi16 – 25Combined sources10
Helixi29 – 35Combined sources7
Beta strandi46 – 54Combined sources9
Turni55 – 57Combined sources3
Beta strandi58 – 66Combined sources9
Helixi72 – 78Combined sources7
Turni79 – 81Combined sources3
Beta strandi86 – 91Combined sources6
Beta strandi94 – 99Combined sources6
Beta strandi105 – 111Combined sources7
Helixi119 – 121Combined sources3
Beta strandi129 – 134Combined sources6
Turni135 – 138Combined sources4
Beta strandi139 – 142Combined sources4
Turni143 – 145Combined sources3
Beta strandi148 – 150Combined sources3
Helixi151 – 158Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PG5X-ray2.60B1-164[»]
2BE9X-ray2.60B1-164[»]
ProteinModelPortaliP74766.
SMRiP74766.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP74766.

Family & Domainsi

Sequence similaritiesi

Belongs to the PyrI family.Curated

Phylogenomic databases

eggNOGiarCOG04229. Archaea.
COG1781. LUCA.
HOGENOMiHOG000113530.
KOiK00610.
OMAiMNVPSDR.

Family and domain databases

Gene3Di2.30.30.20. 1 hit.
3.30.70.140. 1 hit.
HAMAPiMF_00002. Asp_carb_tr_reg. 1 hit.
InterProiIPR020545. Asp_carbamoyltransf_reg_N.
IPR002801. Asp_carbamoylTrfase_reg.
IPR020542. Asp_carbamoyltrfase_reg_C.
[Graphical view]
PfamiPF01948. PyrI. 1 hit.
PF02748. PyrI_C. 1 hit.
[Graphical view]
ProDomiPD006194. Asp_carbamoylTrfase_reg. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF54893. SSF54893. 1 hit.
SSF57825. SSF57825. 1 hit.
TIGRFAMsiTIGR00240. ATCase_reg. 1 hit.

Sequencei

Sequence statusi: Complete.

P74766-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEIQGNRKEL MVSKIKNGTV IDHIPAGRAF AVLNVLGIKG HEGFRIALVI
60 70 80 90 100
NVDSKKMGKK DIVKIEDKEI SDTEANLITL IAPTATINIV REYEVVKKTK
110 120 130 140 150
LEVPKVVKGI LKCPNPYCIT SNDVEAIPTF KTLTEKPLKM RCEYCETIID
160
ENEIMSQILG ANNK
Length:164
Mass (Da):18,280
Last modified:February 1, 1997 - v1
Checksum:iBA71887C47FCD75B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08309 Genomic DNA. Translation: CAA69618.1.
AJ459777 Genomic DNA. Translation: CAD31977.1.
CP000077 Genomic DNA. Translation: AAY80908.1.
RefSeqiWP_011278410.1. NC_007181.1.

Genome annotation databases

EnsemblBacteriaiAAY80908; AAY80908; Saci_1595.
GeneIDi3474278.
KEGGisai:Saci_1595.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08309 Genomic DNA. Translation: CAA69618.1.
AJ459777 Genomic DNA. Translation: CAD31977.1.
CP000077 Genomic DNA. Translation: AAY80908.1.
RefSeqiWP_011278410.1. NC_007181.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PG5X-ray2.60B1-164[»]
2BE9X-ray2.60B1-164[»]
ProteinModelPortaliP74766.
SMRiP74766.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP74766. 1 interactor.
STRINGi330779.Saci_1595.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAY80908; AAY80908; Saci_1595.
GeneIDi3474278.
KEGGisai:Saci_1595.

Phylogenomic databases

eggNOGiarCOG04229. Archaea.
COG1781. LUCA.
HOGENOMiHOG000113530.
KOiK00610.
OMAiMNVPSDR.

Miscellaneous databases

EvolutionaryTraceiP74766.

Family and domain databases

Gene3Di2.30.30.20. 1 hit.
3.30.70.140. 1 hit.
HAMAPiMF_00002. Asp_carb_tr_reg. 1 hit.
InterProiIPR020545. Asp_carbamoyltransf_reg_N.
IPR002801. Asp_carbamoylTrfase_reg.
IPR020542. Asp_carbamoyltrfase_reg_C.
[Graphical view]
PfamiPF01948. PyrI. 1 hit.
PF02748. PyrI_C. 1 hit.
[Graphical view]
ProDomiPD006194. Asp_carbamoylTrfase_reg. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF54893. SSF54893. 1 hit.
SSF57825. SSF57825. 1 hit.
TIGRFAMsiTIGR00240. ATCase_reg. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPYRI_SULAC
AccessioniPrimary (citable) accession number: P74766
Secondary accession number(s): Q4J8H2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: November 2, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.