Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Aspartate carbamoyltransferase regulatory chain

Gene

pyrI

Organism
Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Involved in allosteric regulation of aspartate carbamoyltransferase.By similarity

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi113 – 1131ZincBy similarity
Metal bindingi118 – 1181ZincBy similarity
Metal bindingi142 – 1421ZincBy similarity
Metal bindingi145 – 1451ZincBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Pyrimidine biosynthesis

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciSACI330779:GH9J-1567-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartate carbamoyltransferase regulatory chain
Gene namesi
Name:pyrI
Ordered Locus Names:Saci_1595
OrganismiSulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Taxonomic identifieri330779 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001018 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 164164Aspartate carbamoyltransferase regulatory chainPRO_0000142342Add
BLAST

Interactioni

Subunit structurei

Contains catalytic and regulatory chains.By similarity

Protein-protein interaction databases

IntActiP74766. 1 interaction.
STRINGi330779.Saci_1595.

Structurei

Secondary structure

1
164
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi16 – 2510Combined sources
Helixi29 – 357Combined sources
Beta strandi46 – 549Combined sources
Turni55 – 573Combined sources
Beta strandi58 – 669Combined sources
Helixi72 – 787Combined sources
Turni79 – 813Combined sources
Beta strandi86 – 916Combined sources
Beta strandi94 – 996Combined sources
Beta strandi105 – 1117Combined sources
Helixi119 – 1213Combined sources
Beta strandi129 – 1346Combined sources
Turni135 – 1384Combined sources
Beta strandi139 – 1424Combined sources
Turni143 – 1453Combined sources
Beta strandi148 – 1503Combined sources
Helixi151 – 1588Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1PG5X-ray2.60B1-164[»]
2BE9X-ray2.60B1-164[»]
ProteinModelPortaliP74766.
SMRiP74766. Positions 11-160.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP74766.

Family & Domainsi

Sequence similaritiesi

Belongs to the PyrI family.Curated

Phylogenomic databases

eggNOGiarCOG04229. Archaea.
COG1781. LUCA.
HOGENOMiHOG000113530.
KOiK00610.
OMAiMNVPSDR.

Family and domain databases

Gene3Di2.30.30.20. 1 hit.
3.30.70.140. 1 hit.
HAMAPiMF_00002. Asp_carb_tr_reg.
InterProiIPR020545. Asp_carbamoyltransf_reg_N.
IPR002801. Asp_carbamoylTrfase_reg.
IPR020542. Asp_carbamoyltrfase_reg_C.
[Graphical view]
PfamiPF01948. PyrI. 1 hit.
PF02748. PyrI_C. 1 hit.
[Graphical view]
ProDomiPD006194. Asp_carbamoylTrfase_reg. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF54893. SSF54893. 1 hit.
SSF57825. SSF57825. 1 hit.
TIGRFAMsiTIGR00240. ATCase_reg. 1 hit.

Sequencei

Sequence statusi: Complete.

P74766-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEIQGNRKEL MVSKIKNGTV IDHIPAGRAF AVLNVLGIKG HEGFRIALVI
60 70 80 90 100
NVDSKKMGKK DIVKIEDKEI SDTEANLITL IAPTATINIV REYEVVKKTK
110 120 130 140 150
LEVPKVVKGI LKCPNPYCIT SNDVEAIPTF KTLTEKPLKM RCEYCETIID
160
ENEIMSQILG ANNK
Length:164
Mass (Da):18,280
Last modified:February 1, 1997 - v1
Checksum:iBA71887C47FCD75B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08309 Genomic DNA. Translation: CAA69618.1.
AJ459777 Genomic DNA. Translation: CAD31977.1.
CP000077 Genomic DNA. Translation: AAY80908.1.
RefSeqiWP_011278410.1. NC_007181.1.

Genome annotation databases

EnsemblBacteriaiAAY80908; AAY80908; Saci_1595.
GeneIDi3474278.
KEGGisai:Saci_1595.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08309 Genomic DNA. Translation: CAA69618.1.
AJ459777 Genomic DNA. Translation: CAD31977.1.
CP000077 Genomic DNA. Translation: AAY80908.1.
RefSeqiWP_011278410.1. NC_007181.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1PG5X-ray2.60B1-164[»]
2BE9X-ray2.60B1-164[»]
ProteinModelPortaliP74766.
SMRiP74766. Positions 11-160.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP74766. 1 interaction.
STRINGi330779.Saci_1595.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAY80908; AAY80908; Saci_1595.
GeneIDi3474278.
KEGGisai:Saci_1595.

Phylogenomic databases

eggNOGiarCOG04229. Archaea.
COG1781. LUCA.
HOGENOMiHOG000113530.
KOiK00610.
OMAiMNVPSDR.

Enzyme and pathway databases

BioCyciSACI330779:GH9J-1567-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP74766.

Family and domain databases

Gene3Di2.30.30.20. 1 hit.
3.30.70.140. 1 hit.
HAMAPiMF_00002. Asp_carb_tr_reg.
InterProiIPR020545. Asp_carbamoyltransf_reg_N.
IPR002801. Asp_carbamoylTrfase_reg.
IPR020542. Asp_carbamoyltrfase_reg_C.
[Graphical view]
PfamiPF01948. PyrI. 1 hit.
PF02748. PyrI_C. 1 hit.
[Graphical view]
ProDomiPD006194. Asp_carbamoylTrfase_reg. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF54893. SSF54893. 1 hit.
SSF57825. SSF57825. 1 hit.
TIGRFAMsiTIGR00240. ATCase_reg. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Durbecq V., Thia-Toong T.-L., Roovers M., Legrain C., Glansdorff N., Charlier D.R.M.
    Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770.
  2. "Genes of de novo pyrimidine biosynthesis from the hyperthermoacidophilic crenarchaeote Sulfolobus acidocaldarius: novel organization in a bipolar operon."
    Thia-Toong T.-L., Roovers M., Durbecq V., Gigot D., Glansdorff N., Charlier D.R.M.
    J. Bacteriol. 184:4430-4441(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770.
  3. "The genome of Sulfolobus acidocaldarius, a model organism of the Crenarchaeota."
    Chen L., Bruegger K., Skovgaard M., Redder P., She Q., Torarinsson E., Greve B., Awayez M., Zibat A., Klenk H.-P., Garrett R.A.
    J. Bacteriol. 187:4992-4999(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770.

Entry informationi

Entry nameiPYRI_SULAC
AccessioniPrimary (citable) accession number: P74766
Secondary accession number(s): Q4J8H2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: November 11, 2015
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.