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P74741

- PUR9_SYNY3

UniProt

P74741 - PUR9_SYNY3

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Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurH
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
Alternative name(s):
AICAR transformylase
IMP cyclohydrolase (EC:3.5.4.10)
Alternative name(s):
ATIC
IMP synthase
Inosinicase
Gene namesi
Name:purH
Ordered Locus Names:slr0597
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
ProteomesiUP000001425: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 511511Bifunctional purine biosynthesis protein PurHPRO_0000192141Add
BLAST

Proteomic databases

PaxDbiP74741.

Interactioni

Protein-protein interaction databases

IntActiP74741. 2 interactions.
STRINGi1148.slr0597.

Structurei

3D structure databases

ProteinModelPortaliP74741.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region.By similarity

Sequence similaritiesi

Belongs to the PurH family.Curated

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
InParanoidiP74741.
KOiK00602.
OMAiIRASSKN.
OrthoDBiEOG6QCDFF.
PhylomeDBiP74741.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

P74741-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MARLALLSVS DKSGIVELAQ RLVNEFQFDL ISSGGTAKTL KEAGVPVTKV
60 70 80 90 100
SDYTGAPEIL GGRVKTLHPR IHGGILARRD LPSDQADLEA NDIRPLDLVV
110 120 130 140 150
VNLYPFEQTI AKPGVTVAEA VEQIDIGGPA MIRATAKNFA HTTVLTNPNQ
160 170 180 190 200
YEAYLQALQE QGEIPLALRQ QFAGEAFALT NAYDQAIANY FSGLSGDSAN
210 220 230 240 250
QFGLSGTLRQ PLRYGENPHQ SAGWYQTGRE ATGWAKAEKL QGKELSYNNL
260 270 280 290 300
VDLEAARRII NEFDVREPAA VILKHTNPCG VALAPTLVEA YQKAFNADAT
310 320 330 340 350
SAFGGIVALN QPLDGPTAAA MVKTFLECIV APGCDAEAQE ILAKKNNLRV
360 370 380 390 400
LILPDLATGP SQTIKAIAGG FLVQSADDER EDPSTWQVVT EKQPSGEELA
410 420 430 440 450
ELAFAWKVCK HVKSNAITIT KNKTTLGVGA GQMNRVGSVE IALKQAGTEA
460 470 480 490 500
QGACLASDAF FPFDDSVRTA AAAGITTIIQ PGGSMRDQDS IQAANELGLV
510
MIFTGVRHFL H
Length:511
Mass (Da):54,565
Last modified:June 20, 2003 - v2
Checksum:i05C33DFF36E3BABF
GO

Sequence cautioni

The sequence BAA18861.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA18861.1. Different initiation.
PIRiS76949.
RefSeqiNP_443049.1. NC_000911.1.
YP_007452924.1. NC_020286.1.

Genome annotation databases

EnsemblBacteriaiBAA18861; BAA18861; BAA18861.
GeneIDi953289.
KEGGisyn:slr0597.
PATRICi23843956. VBISynSp132158_3508.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA18861.1 . Different initiation.
PIRi S76949.
RefSeqi NP_443049.1. NC_000911.1.
YP_007452924.1. NC_020286.1.

3D structure databases

ProteinModelPortali P74741.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P74741. 2 interactions.
STRINGi 1148.slr0597.

Proteomic databases

PaxDbi P74741.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAA18861 ; BAA18861 ; BAA18861 .
GeneIDi 953289.
KEGGi syn:slr0597.
PATRICi 23843956. VBISynSp132158_3508.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230373.
InParanoidi P74741.
KOi K00602.
OMAi IRASSKN.
OrthoDBi EOG6QCDFF.
PhylomeDBi P74741.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
    Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
    , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 6803 / Kazusa.

Entry informationi

Entry nameiPUR9_SYNY3
AccessioniPrimary (citable) accession number: P74741
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 20, 2003
Last modified: November 26, 2014
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

External Data

Dasty 3