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P74741

- PUR9_SYNY3

UniProt

P74741 - PUR9_SYNY3

Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 2 (20 Jun 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.
    IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.

    Pathwayi

    GO - Molecular functioni

    1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
    2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase, Transferase

    Keywords - Biological processi

    Purine biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00074; UER00133.
    UPA00074; UER00135.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional purine biosynthesis protein PurH
    Including the following 2 domains:
    Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
    Alternative name(s):
    AICAR transformylase
    IMP cyclohydrolase (EC:3.5.4.10)
    Alternative name(s):
    ATIC
    IMP synthase
    Inosinicase
    Gene namesi
    Name:purH
    Ordered Locus Names:slr0597
    OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
    Taxonomic identifieri1111708 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
    ProteomesiUP000001425: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 511511Bifunctional purine biosynthesis protein PurHPRO_0000192141Add
    BLAST

    Proteomic databases

    PaxDbiP74741.

    Interactioni

    Protein-protein interaction databases

    IntActiP74741. 2 interactions.
    STRINGi1148.slr0597.

    Structurei

    3D structure databases

    ProteinModelPortaliP74741.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domaini

    The IMP cyclohydrolase activity resides in the N-terminal region.By similarity

    Sequence similaritiesi

    Belongs to the PurH family.Curated

    Phylogenomic databases

    eggNOGiCOG0138.
    HOGENOMiHOG000230373.
    KOiK00602.
    OMAiIRASSKN.
    OrthoDBiEOG6QCDFF.
    PhylomeDBiP74741.

    Family and domain databases

    Gene3Di3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPiMF_00139. PurH.
    InterProiIPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view]
    PANTHERiPTHR11692. PTHR11692. 1 hit.
    PfamiPF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsiTIGR00355. purH. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P74741-1 [UniParc]FASTAAdd to Basket

    « Hide

    MARLALLSVS DKSGIVELAQ RLVNEFQFDL ISSGGTAKTL KEAGVPVTKV    50
    SDYTGAPEIL GGRVKTLHPR IHGGILARRD LPSDQADLEA NDIRPLDLVV 100
    VNLYPFEQTI AKPGVTVAEA VEQIDIGGPA MIRATAKNFA HTTVLTNPNQ 150
    YEAYLQALQE QGEIPLALRQ QFAGEAFALT NAYDQAIANY FSGLSGDSAN 200
    QFGLSGTLRQ PLRYGENPHQ SAGWYQTGRE ATGWAKAEKL QGKELSYNNL 250
    VDLEAARRII NEFDVREPAA VILKHTNPCG VALAPTLVEA YQKAFNADAT 300
    SAFGGIVALN QPLDGPTAAA MVKTFLECIV APGCDAEAQE ILAKKNNLRV 350
    LILPDLATGP SQTIKAIAGG FLVQSADDER EDPSTWQVVT EKQPSGEELA 400
    ELAFAWKVCK HVKSNAITIT KNKTTLGVGA GQMNRVGSVE IALKQAGTEA 450
    QGACLASDAF FPFDDSVRTA AAAGITTIIQ PGGSMRDQDS IQAANELGLV 500
    MIFTGVRHFL H 511
    Length:511
    Mass (Da):54,565
    Last modified:June 20, 2003 - v2
    Checksum:i05C33DFF36E3BABF
    GO

    Sequence cautioni

    The sequence BAA18861.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000022 Genomic DNA. Translation: BAA18861.1. Different initiation.
    PIRiS76949.
    RefSeqiNP_443049.1. NC_000911.1.
    YP_007452924.1. NC_020286.1.

    Genome annotation databases

    EnsemblBacteriaiBAA18861; BAA18861; BAA18861.
    GeneIDi953289.
    KEGGisyn:slr0597.
    syz:MYO_131910.
    PATRICi23843956. VBISynSp132158_3508.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000022 Genomic DNA. Translation: BAA18861.1 . Different initiation.
    PIRi S76949.
    RefSeqi NP_443049.1. NC_000911.1.
    YP_007452924.1. NC_020286.1.

    3D structure databases

    ProteinModelPortali P74741.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P74741. 2 interactions.
    STRINGi 1148.slr0597.

    Proteomic databases

    PaxDbi P74741.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAA18861 ; BAA18861 ; BAA18861 .
    GeneIDi 953289.
    KEGGi syn:slr0597.
    syz:MYO_131910.
    PATRICi 23843956. VBISynSp132158_3508.

    Phylogenomic databases

    eggNOGi COG0138.
    HOGENOMi HOG000230373.
    KOi K00602.
    OMAi IRASSKN.
    OrthoDBi EOG6QCDFF.
    PhylomeDBi P74741.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00133 .
    UPA00074 ; UER00135 .

    Family and domain databases

    Gene3Di 3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPi MF_00139. PurH.
    InterProi IPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view ]
    PANTHERi PTHR11692. PTHR11692. 1 hit.
    Pfami PF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsi TIGR00355. purH. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
      Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
      , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
      DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 6803 / Kazusa.

    Entry informationi

    Entry nameiPUR9_SYNY3
    AccessioniPrimary (citable) accession number: P74741
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: June 20, 2003
    Last modified: October 1, 2014
    This is version 97 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families
    3. Synechocystis PCC 6803
      Synechocystis (strain PCC 6803): entries and gene names

    External Data

    Dasty 3