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P74741

- PUR9_SYNY3

UniProt

P74741 - PUR9_SYNY3

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Protein

Bifunctional purine biosynthesis protein PurH

Gene
purH, slr0597
Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurH
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
Alternative name(s):
AICAR transformylase
IMP cyclohydrolase (EC:3.5.4.10)
Alternative name(s):
ATIC
IMP synthase
Inosinicase
Gene namesi
Name:purH
Ordered Locus Names:slr0597
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
ProteomesiUP000001425: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 511511Bifunctional purine biosynthesis protein PurHUniRule annotationPRO_0000192141Add
BLAST

Proteomic databases

PaxDbiP74741.

Interactioni

Protein-protein interaction databases

IntActiP74741. 2 interactions.
STRINGi1148.slr0597.

Structurei

3D structure databases

ProteinModelPortaliP74741.

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
KOiK00602.
OMAiIRASSKN.
OrthoDBiEOG6QCDFF.
PhylomeDBiP74741.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

P74741-1 [UniParc]FASTAAdd to Basket

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MARLALLSVS DKSGIVELAQ RLVNEFQFDL ISSGGTAKTL KEAGVPVTKV    50
SDYTGAPEIL GGRVKTLHPR IHGGILARRD LPSDQADLEA NDIRPLDLVV 100
VNLYPFEQTI AKPGVTVAEA VEQIDIGGPA MIRATAKNFA HTTVLTNPNQ 150
YEAYLQALQE QGEIPLALRQ QFAGEAFALT NAYDQAIANY FSGLSGDSAN 200
QFGLSGTLRQ PLRYGENPHQ SAGWYQTGRE ATGWAKAEKL QGKELSYNNL 250
VDLEAARRII NEFDVREPAA VILKHTNPCG VALAPTLVEA YQKAFNADAT 300
SAFGGIVALN QPLDGPTAAA MVKTFLECIV APGCDAEAQE ILAKKNNLRV 350
LILPDLATGP SQTIKAIAGG FLVQSADDER EDPSTWQVVT EKQPSGEELA 400
ELAFAWKVCK HVKSNAITIT KNKTTLGVGA GQMNRVGSVE IALKQAGTEA 450
QGACLASDAF FPFDDSVRTA AAAGITTIIQ PGGSMRDQDS IQAANELGLV 500
MIFTGVRHFL H 511
Length:511
Mass (Da):54,565
Last modified:June 20, 2003 - v2
Checksum:i05C33DFF36E3BABF
GO

Sequence cautioni

The sequence BAA18861.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000022 Genomic DNA. Translation: BAA18861.1. Different initiation.
PIRiS76949.
RefSeqiNP_443049.1. NC_000911.1.
YP_007452924.1. NC_020286.1.

Genome annotation databases

EnsemblBacteriaiBAA18861; BAA18861; BAA18861.
GeneIDi953289.
KEGGisyn:slr0597.
syz:MYO_131910.
PATRICi23843956. VBISynSp132158_3508.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000022 Genomic DNA. Translation: BAA18861.1 . Different initiation.
PIRi S76949.
RefSeqi NP_443049.1. NC_000911.1.
YP_007452924.1. NC_020286.1.

3D structure databases

ProteinModelPortali P74741.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P74741. 2 interactions.
STRINGi 1148.slr0597.

Proteomic databases

PaxDbi P74741.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAA18861 ; BAA18861 ; BAA18861 .
GeneIDi 953289.
KEGGi syn:slr0597.
syz:MYO_131910.
PATRICi 23843956. VBISynSp132158_3508.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230373.
KOi K00602.
OMAi IRASSKN.
OrthoDBi EOG6QCDFF.
PhylomeDBi P74741.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
    Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
    , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 6803 / Kazusa.

Entry informationi

Entry nameiPUR9_SYNY3
AccessioniPrimary (citable) accession number: P74741
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 20, 2003
Last modified: July 9, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

External Data

Dasty 3

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