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P74739

- FUR_SYNY3

UniProt

P74739 - FUR_SYNY3

Protein

Ferric uptake regulation protein

Gene

fur

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Acts as a global negative controlling element, employing Fe2+ as a cofactor to bind the operator of the repressed genes.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi38 – 381ZincBy similarity
    Metal bindingi86 – 861ZincBy similarity
    Metal bindingi94 – 941IronBy similarity
    Metal bindingi96 – 961IronBy similarity
    Metal bindingi97 – 971ZincBy similarity
    Metal bindingi100 – 1001ZincBy similarity
    Metal bindingi103 – 1031ZincBy similarity
    Metal bindingi108 – 1081ZincBy similarity

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Iron, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ferric uptake regulation protein
    Short name:
    Ferric uptake regulator
    Gene namesi
    Name:fur
    Ordered Locus Names:sll0567
    OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
    Taxonomic identifieri1111708 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
    ProteomesiUP000001425: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 165165Ferric uptake regulation proteinPRO_0000095583Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi1148.sll0567.

    Structurei

    3D structure databases

    ProteinModelPortaliP74739.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 9191DNA-bindingBy similarityAdd
    BLAST
    Regioni92 – 16574DimerizationBy similarityAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi93 – 975His-rich

    Sequence similaritiesi

    Belongs to the Fur family.Curated

    Phylogenomic databases

    eggNOGiCOG0735.
    HOGENOMiHOG000014143.
    KOiK03711.
    OMAiESPGIAS.
    OrthoDBiEOG6J48SS.
    PhylomeDBiP74739.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR002481. FUR.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF01475. FUR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P74739-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSYTADSLKA ELNARGWRLT PQREKILTIF QNLPEGEHLS AEELHHRLEE    50
    EREKISLSTV YRSVKLMSRM GILRELELAE GHKHYELQQA SPHHHHHVVC 100
    VQCNRTIEFK NDSILKQSLK QCEKEGFQLI DCQLTVTTIC PEAIRMGWPS 150
    TLPSNWACTR SISLA 165
    Length:165
    Mass (Da):19,072
    Last modified:February 1, 1997 - v1
    Checksum:i5F1A54D89336BA14
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000022 Genomic DNA. Translation: BAA18859.1.
    PIRiS76947.
    RefSeqiNP_443047.1. NC_000911.1.
    YP_005653106.1. NC_017277.1.
    YP_007452922.1. NC_020286.1.

    Genome annotation databases

    EnsemblBacteriaiBAA18859; BAA18859; BAA18859.
    GeneIDi952481.
    KEGGisyn:sll0567.
    syy:SYNGTS_3153.
    syz:MYO_131890.
    PATRICi23843952. VBISynSp132158_3506.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000022 Genomic DNA. Translation: BAA18859.1 .
    PIRi S76947.
    RefSeqi NP_443047.1. NC_000911.1.
    YP_005653106.1. NC_017277.1.
    YP_007452922.1. NC_020286.1.

    3D structure databases

    ProteinModelPortali P74739.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 1148.sll0567.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAA18859 ; BAA18859 ; BAA18859 .
    GeneIDi 952481.
    KEGGi syn:sll0567.
    syy:SYNGTS_3153.
    syz:MYO_131890.
    PATRICi 23843952. VBISynSp132158_3506.

    Phylogenomic databases

    eggNOGi COG0735.
    HOGENOMi HOG000014143.
    KOi K03711.
    OMAi ESPGIAS.
    OrthoDBi EOG6J48SS.
    PhylomeDBi P74739.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR002481. FUR.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF01475. FUR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
      Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
      , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
      DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 6803 / Kazusa.

    Entry informationi

    Entry nameiFUR_SYNY3
    AccessioniPrimary (citable) accession number: P74739
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Synechocystis PCC 6803
      Synechocystis (strain PCC 6803): entries and gene names

    External Data

    Dasty 3