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Protein

Ferric uptake regulation protein

Gene

fur

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Acts as a global negative controlling element, employing Fe2+ as a cofactor to bind the operator of the repressed genes.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi38ZincBy similarity1
Metal bindingi86ZincBy similarity1
Metal bindingi94IronBy similarity1
Metal bindingi96IronBy similarity1
Metal bindingi97ZincBy similarity1
Metal bindingi100ZincBy similarity1
Metal bindingi103ZincBy similarity1
Metal bindingi108ZincBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Iron, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Ferric uptake regulation protein
Short name:
Ferric uptake regulator
Gene namesi
Name:fur
Ordered Locus Names:sll0567
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesMerismopediaceaeSynechocystis
Proteomesi
  • UP000001425 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000955831 – 165Ferric uptake regulation proteinAdd BLAST165

Proteomic databases

PRIDEiP74739.

Expressioni

Gene expression databases

CollecTFiEXPREG_00000c10.

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP74739.
SMRiP74739.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 91DNA-bindingBy similarityAdd BLAST91
Regioni92 – 165DimerizationBy similarityAdd BLAST74

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi93 – 97His-rich5

Sequence similaritiesi

Belongs to the Fur family.Curated

Phylogenomic databases

HOGENOMiHOG000014143.
InParanoidiP74739.
KOiK03711.
OMAiHIVCIQC.
PhylomeDBiP74739.

Family and domain databases

CDDicd07153. Fur_like. 1 hit.
Gene3Di1.10.10.10. 1 hit.
InterProiIPR002481. FUR.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF01475. FUR. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.

Sequencei

Sequence statusi: Complete.

P74739-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYTADSLKA ELNARGWRLT PQREKILTIF QNLPEGEHLS AEELHHRLEE
60 70 80 90 100
EREKISLSTV YRSVKLMSRM GILRELELAE GHKHYELQQA SPHHHHHVVC
110 120 130 140 150
VQCNRTIEFK NDSILKQSLK QCEKEGFQLI DCQLTVTTIC PEAIRMGWPS
160
TLPSNWACTR SISLA
Length:165
Mass (Da):19,072
Last modified:February 1, 1997 - v1
Checksum:i5F1A54D89336BA14
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA18859.1.
PIRiS76947.

Genome annotation databases

EnsemblBacteriaiBAA18859; BAA18859; BAA18859.
KEGGisyn:sll0567.
PATRICi23843952. VBISynSp132158_3506.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA18859.1.
PIRiS76947.

3D structure databases

ProteinModelPortaliP74739.
SMRiP74739.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP74739.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA18859; BAA18859; BAA18859.
KEGGisyn:sll0567.
PATRICi23843952. VBISynSp132158_3506.

Phylogenomic databases

HOGENOMiHOG000014143.
InParanoidiP74739.
KOiK03711.
OMAiHIVCIQC.
PhylomeDBiP74739.

Gene expression databases

CollecTFiEXPREG_00000c10.

Family and domain databases

CDDicd07153. Fur_like. 1 hit.
Gene3Di1.10.10.10. 1 hit.
InterProiIPR002481. FUR.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF01475. FUR. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFUR_SYNY3
AccessioniPrimary (citable) accession number: P74739
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: February 1, 1997
Last modified: November 2, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.