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P74689 (ILVD_SYNY3) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Dihydroxy-acid dehydratase
Short name=DAD
EC=4.2.1.9
Gene names
Name:ilvD
Ordered Locus Names:slr0452
OrganismSynechocystis sp. (strain PCC 6803 / Kazusa) [Reference proteome] [HAMAP]
Taxonomic identifier1111708 [NCBI]
Taxonomic lineageBacteria › Cyanobacteria › Oscillatoriophycideae › Chroococcales › Synechocystis ›

Protein attributes

Sequence length561 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O. HAMAP-Rule MF_00012

Cofactor

Binds 1 4Fe-4S cluster Potential.

Pathway

Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4. HAMAP-Rule MF_00012

Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4. HAMAP-Rule MF_00012

Sequence similarities

Belongs to the IlvD/Edd family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 561561Dihydroxy-acid dehydratase HAMAP-Rule MF_00012
PRO_0000103520

Sites

Metal binding1231Iron-sulfur (4Fe-4S) Potential
Metal binding1951Iron-sulfur (4Fe-4S) Potential

Sequences

Sequence LengthMass (Da)Tools
P74689 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: 10A36D9EC02EAF4C

FASTA56158,646
        10         20         30         40         50         60 
MSNNPRSQVI TQGTQRSPNR AMLRAVGFGD DDFTKPIVGI ANGYSTITPC NMGINDLALR 

        70         80         90        100        110        120 
AEAGLRTAGA MPQLFGTITI SDGISMGTEG MKYSLVSREV IADSIETVCN GQRMDGVLAI 

       130        140        150        160        170        180 
GGCDKNMPGA MIAMARLNIP SIFVYGGTIK PGHYAGEDLT VVSAFEAVGQ YSAGKIDEET 

       190        200        210        220        230        240 
LYGIERNACP GAGSCGGMFT ANTMSSAFEA MGMSLPYSST MAAVDGEKAD STEESAKVLV 

       250        260        270        280        290        300 
EAIKKQILPS QILTRKAFEN AIAVIMAVGG STNAVLHLLA IANTIGVPLS LDDFETIRHK 

       310        320        330        340        350        360 
VPVLCDLKPS GKYVTTNLHA AGGIPQVMKI LLVNGILHGD ALTITGQTIA EVLADIPDQP 

       370        380        390        400        410        420 
PAGQDVIHSW DDPVYQEGHL AVLKGNLATE GSVAKISGVK KPVITGPAKV FESEEDCLEA 

       430        440        450        460        470        480 
ILAGKIQAGD VVVVRYEGPK GGPGMREMLA PTSAIIGAGL GDSVGLITDG RFSGGTYGLV 

       490        500        510        520        530        540 
VGHVAPEAYV GGAIALVQEG DQITIDAGKR LLQLNISEEE LAQRRAQWTP PQPRYPRGIL 

       550        560 
AKYAKLVSSS SLGAVTDIDL F

« Hide

References

[1]"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. expand/collapse author list , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PCC 6803 / Kazusa.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BA000022 Genomic DNA. Translation: BAA18807.1.
PIRS76895.
RefSeqNP_442995.1. NC_000911.1.
YP_005653054.1. NC_017277.1.
YP_007452870.1. NC_020286.1.

3D structure databases

ProteinModelPortalP74689.
ModBaseSearch...

Protein-protein interaction databases

IntActP74689. 6 interactions.
STRING1148.slr0452.

Proteomic databases

PaxDbP74689.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAA18807; BAA18807; BAA18807.
GeneID12255585.
14618562.
951849.
KEGGsyn:slr0452.
syy:SYNGTS_3101.
PATRIC23843834. VBISynSp132158_3447.

Phylogenomic databases

eggNOGCOG0129.
HOGENOMHOG000173155.
KOK01687.
OMANMPGAMI.
ProtClustDBPRK00911.

Enzyme and pathway databases

UniPathwayUPA00047; UER00057.
UPA00049; UER00061.

Family and domain databases

HAMAPMF_00012. IlvD.
InterProIPR015928. Aconitase/3IPM_dehydase_swvl.
IPR004404. DihydroxyA_deHydtase.
IPR000581. DiOHA_6PGluconate_deHydtase.
IPR020558. DiOHA_6PGluconate_deHydtase_CS.
[Graphical view]
PANTHERPTHR21000. PTHR21000. 1 hit.
PfamPF00920. ILVD_EDD. 1 hit.
[Graphical view]
SUPFAMSSF52016. Aconitase/3IPM_dehydase_swvl. 1 hit.
TIGRFAMsTIGR00110. ilvD. 1 hit.
PROSITEPS00886. ILVD_EDD_1. 1 hit.
PS00887. ILVD_EDD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameILVD_SYNY3
AccessionPrimary (citable) accession number: P74689
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: February 1, 1997
Last modified: May 1, 2013
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Synechocystis PCC 6803

Synechocystis (strain PCC 6803): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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