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P74667

- DAPF_SYNY3

UniProt

P74667 - DAPF_SYNY3

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Protein

Diaminopimelate epimerase

Gene
dapF, slr1665
Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan By similarity.UniRule annotation

Catalytic activityi

LL-2,6-diaminoheptanedioate = meso-diaminoheptanedioate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei13 – 131Substrate By similarity
Binding sitei47 – 471Substrate By similarity
Binding sitei66 – 661Substrate By similarity
Active sitei75 – 751Proton donor/acceptor By similarity
Binding sitei162 – 1621Substrate By similarity
Sitei164 – 1641Important for catalytic activity By similarity
Binding sitei195 – 1951Substrate By similarity
Sitei213 – 2131Important for catalytic activity By similarity
Active sitei222 – 2221Proton donor/acceptor By similarity

GO - Molecular functioni

  1. diaminopimelate epimerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. lysine biosynthetic process via diaminopimelate Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Amino-acid biosynthesis, Lysine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00034; UER00025.

Names & Taxonomyi

Protein namesi
Recommended name:
Diaminopimelate epimerase (EC:5.1.1.7)
Short name:
DAP epimerase
Gene namesi
Name:dapF
Ordered Locus Names:slr1665
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
ProteomesiUP000001425: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 279279Diaminopimelate epimeraseUniRule annotationPRO_0000149873Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi75 ↔ 222UniRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP74667.

Interactioni

Protein-protein interaction databases

STRINGi1148.slr1665.

Structurei

3D structure databases

ProteinModelPortaliP74667.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni10 – 112Substrate binding By similarity
Regioni75 – 773Substrate binding By similarity
Regioni213 – 2142Substrate binding By similarity
Regioni223 – 2242Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0253.
HOGENOMiHOG000220467.
KOiK01778.
OMAiKMRIFNN.
OrthoDBiEOG6ND0M5.
PhylomeDBiP74667.

Family and domain databases

HAMAPiMF_00197. DAP_epimerase.
InterProiIPR018510. DAP_epimerase_AS.
IPR001653. DAP_epimerase_DapF.
[Graphical view]
PANTHERiPTHR31689. PTHR31689. 1 hit.
PfamiPF01678. DAP_epimerase. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00652. DapF. 1 hit.
PROSITEiPS01326. DAP_EPIMERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P74667-1 [UniParc]FASTAAdd to Basket

« Hide

MALSFSKYHG LGNDFILVDN RQSTEPCLTP DQAQQLCDRH FGIGADGVIF    50
ALPGQGGTDY TMRIFNSDGS EPEMCGNGIR CLAKFLADLE GVEEKTYRIH 100
TLAGVITPQL LADGQVKVDM GEPQLLAELI PTTLAPAGEK VVDLPLAVAG 150
QTWAVTCVSM GNPHCLTFVD DVDSLNLTEI GPLFEHHPQF SQRTNTEFIQ 200
VLGSDRLKMR VWERGAGITL ACGTGACATV VAAVLTGRGD RRCTVELPGG 250
NLEIEWSAQD NRLYMTGPAQ RVFSGQAEI 279
Length:279
Mass (Da):30,096
Last modified:February 1, 1997 - v1
Checksum:i9E7EF1DEF5C63A02
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000022 Genomic DNA. Translation: BAA18785.1.
PIRiS76873.
RefSeqiNP_442973.1. NC_000911.1.
YP_005653032.1. NC_017277.1.
YP_007452848.1. NC_020286.1.

Genome annotation databases

EnsemblBacteriaiBAA18785; BAA18785; BAA18785.
GeneIDi951942.
KEGGisyn:slr1665.
syy:SYNGTS_3079.
syz:MYO_131150.
PATRICi23843780. VBISynSp132158_3420.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000022 Genomic DNA. Translation: BAA18785.1 .
PIRi S76873.
RefSeqi NP_442973.1. NC_000911.1.
YP_005653032.1. NC_017277.1.
YP_007452848.1. NC_020286.1.

3D structure databases

ProteinModelPortali P74667.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 1148.slr1665.

Proteomic databases

PaxDbi P74667.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAA18785 ; BAA18785 ; BAA18785 .
GeneIDi 951942.
KEGGi syn:slr1665.
syy:SYNGTS_3079.
syz:MYO_131150.
PATRICi 23843780. VBISynSp132158_3420.

Phylogenomic databases

eggNOGi COG0253.
HOGENOMi HOG000220467.
KOi K01778.
OMAi KMRIFNN.
OrthoDBi EOG6ND0M5.
PhylomeDBi P74667.

Enzyme and pathway databases

UniPathwayi UPA00034 ; UER00025 .

Family and domain databases

HAMAPi MF_00197. DAP_epimerase.
InterProi IPR018510. DAP_epimerase_AS.
IPR001653. DAP_epimerase_DapF.
[Graphical view ]
PANTHERi PTHR31689. PTHR31689. 1 hit.
Pfami PF01678. DAP_epimerase. 2 hits.
[Graphical view ]
TIGRFAMsi TIGR00652. DapF. 1 hit.
PROSITEi PS01326. DAP_EPIMERASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
    Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
    , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 6803 / Kazusa.

Entry informationi

Entry nameiDAPF_SYNY3
AccessioniPrimary (citable) accession number: P74667
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: July 9, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

External Data

Dasty 3

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