P74667 (DAPF_SYNY3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Diaminopimelate epimerase
Short name=DAP epimerase
EC=5.1.1.7

Gene names

Name:	dapF
Ordered Locus Names:	slr1665

Organism

Synechocystis sp. (strain PCC 6803 / Kazusa)

Taxonomic identifier

1111708 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Synechocystis

Protein attributes

Sequence length	279 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	LL-2,6-diaminoheptanedioate = meso-diaminoheptanedioate. HAMAP MF_00197
Pathway	Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; DL-2,6-diaminopimelate from LL-2,6-diaminopimelate: step 1/1. HAMAP MF_00197
Subcellular location	Cytoplasm By similarity HAMAP MF_00197.
Sequence similarities	Belongs to the diaminopimelate epimerase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Lysine biosynthesis
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	lysine biosynthetic process via diaminopimelate Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	diaminopimelate epimerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 279	279	Diaminopimelate epimerase HAMAP MF_00197		PRO_0000149873
Sites
	Active site	75	1	By similarity
	Active site	222	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	P74667 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: 9E7EF1DEF5C63A02	FASTA	279	30,096
	10 20 30 40 50 60 MALSFSKYHG LGNDFILVDN RQSTEPCLTP DQAQQLCDRH FGIGADGVIF ALPGQGGTDY 70 80 90 100 110 120 TMRIFNSDGS EPEMCGNGIR CLAKFLADLE GVEEKTYRIH TLAGVITPQL LADGQVKVDM 130 140 150 160 170 180 GEPQLLAELI PTTLAPAGEK VVDLPLAVAG QTWAVTCVSM GNPHCLTFVD DVDSLNLTEI 190 200 210 220 230 240 GPLFEHHPQF SQRTNTEFIQ VLGSDRLKMR VWERGAGITL ACGTGACATV VAAVLTGRGD 250 260 270 RRCTVELPGG NLEIEWSAQD NRLYMTGPAQ RVFSGQAEI

References

[1]

"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions." Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S. DNA Res. 3:109-136(1996) [PubMed: 8905231] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 27184 / PCC 6803 / N-1.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000022 Genomic DNA. Translation: BAA18785.1.
PIR	S76873.
RefSeq	NP_442973.1. NC_000911.1.
3D structure databases
ProteinModelPortal	P74667.
ModBase	Search...
Protein-protein interaction databases
STRING	P74667.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	951942.
GenomeReviews	Gene locus slr1665 in contig BA000022_GR.
KEGG	syn:slr1665.
NMPDR	fig|1148.1.peg.3074.
PATRIC	23843780. VBISynSp132158_3420.
Phylogenomic databases
eggNOG	COG0253.
HOGENOM	HBG399442.
OMA	FMTGPAT.
PhylomeDB	P74667.
ProtClustDB	PRK00450.
Enzyme and pathway databases
BioCyc	SSP1148:SLR1665-MONOMER.
Family and domain databases
HAMAP	MF_00197. DAP_epimerase. [Tree]
InterPro	IPR018510. DAP_epimerase_AS. IPR001653. DAP_epimerase_DapF. [Graphical view]
KO	K01778.
Pfam	PF01678. DAP_epimerase. 2 hits. [Graphical view]
TIGRFAMs	TIGR00652. DapF. 1 hit.
PROSITE	PS01326. DAP_EPIMERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DAPF_SYNY3

Accession

Primary (citable) accession number: P74667

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	February 1, 1997
Last modified:	January 25, 2012
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program