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P74576

- SPEA1_SYNY3

UniProt

P74576 - SPEA1_SYNY3

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Protein

Biosynthetic arginine decarboxylase 1

Gene

speA1

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the biosynthesis of agmatine from arginine.By similarity

Catalytic activityi

L-arginine = agmatine + CO2.

Cofactori

Protein has several cofactor binding sites:

GO - Molecular functioni

  1. arginine decarboxylase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. arginine catabolic process Source: InterPro
  2. spermidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Polyamine biosynthesis, Spermidine biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding, Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Biosynthetic arginine decarboxylase 1 (EC:4.1.1.19)
Short name:
ADC 1
Gene namesi
Name:speA1
Synonyms:speA
Ordered Locus Names:slr0662
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
ProteomesiUP000001425: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 695695Biosynthetic arginine decarboxylase 1PRO_0000149981Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei141 – 1411N6-(pyridoxal phosphate)lysineBy similarity

Interactioni

Protein-protein interaction databases

IntActiP74576. 2 interactions.
STRINGi1148.slr0662.

Structurei

3D structure databases

ProteinModelPortaliP74576.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni332 – 34211Substrate-bindingSequence AnalysisAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1166.
HOGENOMiHOG000029191.
InParanoidiP74576.
KOiK01585.
OMAiDSEDMVE.
OrthoDBiEOG676Z0R.
PhylomeDBiP74576.

Family and domain databases

Gene3Di2.40.37.10. 2 hits.
3.20.20.10. 1 hit.
HAMAPiMF_01417. SpeA.
InterProiIPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PIRSFiPIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSiPR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR01273. speA. 1 hit.
PROSITEiPS00878. ODR_DC_2_1. 1 hit.
PS00879. ODR_DC_2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P74576-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEGQSIELEL SVMAMPELID STEAGHTAGV KTDSNPQAIA QDRRWTIDDS
60 70 80 90 100
ENLYRITGWG EPYFSINAAG HVTVSPQADH GGALDLYELV KGLRQRNIGL
110 120 130 140 150
PLLLRFSDIL ADRINRLNAA FARGIARYRY PNTYRGVYPI KCNQHRHIVE
160 170 180 190 200
SLVRYGTPYN FGLEAGSKPE LMIALAMLQP QENPEPDQQN QPLLICNGYK
210 220 230 240 250
DREYIETALL ARRLGHRPII VVEQVAEVAL AIEISSNLGI KPILGVRAKL
260 270 280 290 300
STQGMGRWGI STGDRAKFGL TIPEMLTAIE QLRRADMLDS LQLLHFHIGS
310 320 330 340 350
QISSISVIKE AMTEASQIFV QLAKLGANMR YLDVGGGLGV DYDGSKTNFY
360 370 380 390 400
ASKNYNIQNY VNDVISAVQD ACVAAEVPCP VLISESGRAI ASHQSVLIFD
410 420 430 440 450
VVATNDINPP LPKVKGKDHA ILRNLMETWE TITVDNYQEA YHDVEQFKTE
460 470 480 490 500
AISLFNFGYL GLKERAKAEE LYWACCRKIL QICRQQEYVP DDLENLEVNL
510 520 530 540 550
ASIYYANMSV FQSAPDSWAI DQLFPIMPIH RLDEEPTQRG ILADITCDSD
560 570 580 590 600
GKIDQFIDLR DVKSVLELHP LIEVHQPGTP PRVEPYYLGM FLVGAYQEIM
610 620 630 640 650
GNLHNLFGDI NVVHIQMNPK GYQIEHLVRG DTIAEVLGYV QYDPEDLLEN
660 670 680 690
MRRYCEQAME DKRMSLEEAQ LLLENYERSL LQYTYLKPTS GIHTS
Length:695
Mass (Da):78,239
Last modified:February 1, 1997 - v1
Checksum:iE90EB699D666320D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA18683.1.
PIRiS76771.
RefSeqiNP_442871.1. NC_000911.1.
YP_005652932.1. NC_017277.1.
YP_007452747.1. NC_020286.1.

Genome annotation databases

EnsemblBacteriaiBAA18683; BAA18683; BAA18683.
GeneIDi953209.
KEGGisyn:slr0662.
PATRICi23843536. VBISynSp132158_3299.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA18683.1 .
PIRi S76771.
RefSeqi NP_442871.1. NC_000911.1.
YP_005652932.1. NC_017277.1.
YP_007452747.1. NC_020286.1.

3D structure databases

ProteinModelPortali P74576.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P74576. 2 interactions.
STRINGi 1148.slr0662.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAA18683 ; BAA18683 ; BAA18683 .
GeneIDi 953209.
KEGGi syn:slr0662.
PATRICi 23843536. VBISynSp132158_3299.

Phylogenomic databases

eggNOGi COG1166.
HOGENOMi HOG000029191.
InParanoidi P74576.
KOi K01585.
OMAi DSEDMVE.
OrthoDBi EOG676Z0R.
PhylomeDBi P74576.

Family and domain databases

Gene3Di 2.40.37.10. 2 hits.
3.20.20.10. 1 hit.
HAMAPi MF_01417. SpeA.
InterProi IPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view ]
PIRSFi PIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSi PR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR01273. speA. 1 hit.
PROSITEi PS00878. ODR_DC_2_1. 1 hit.
PS00879. ODR_DC_2_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
    Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
    , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 6803 / Kazusa.

Entry informationi

Entry nameiSPEA1_SYNY3
AccessioniPrimary (citable) accession number: P74576
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: February 1, 1997
Last modified: November 26, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

External Data

Dasty 3