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P74576

- SPEA1_SYNY3

UniProt

P74576 - SPEA1_SYNY3

Protein

Biosynthetic arginine decarboxylase 1

Gene

speA1

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Catalyzes the biosynthesis of agmatine from arginine.By similarity

    Catalytic activityi

    L-arginine = agmatine + CO2.

    Cofactori

    Magnesium.By similarity
    Pyridoxal phosphate.By similarity

    GO - Molecular functioni

    1. arginine decarboxylase activity Source: UniProtKB-HAMAP
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. arginine catabolic process Source: InterPro
    2. spermidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Biological processi

    Polyamine biosynthesis, Spermidine biosynthesis

    Keywords - Ligandi

    Magnesium, Metal-binding, Pyridoxal phosphate

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Biosynthetic arginine decarboxylase 1 (EC:4.1.1.19)
    Short name:
    ADC 1
    Gene namesi
    Name:speA1
    Synonyms:speA
    Ordered Locus Names:slr0662
    OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
    Taxonomic identifieri1111708 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
    ProteomesiUP000001425: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 695695Biosynthetic arginine decarboxylase 1PRO_0000149981Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei141 – 1411N6-(pyridoxal phosphate)lysineBy similarity

    Interactioni

    Protein-protein interaction databases

    IntActiP74576. 2 interactions.
    STRINGi1148.slr0662.

    Structurei

    3D structure databases

    ProteinModelPortaliP74576.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni332 – 34211Substrate-bindingSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1166.
    HOGENOMiHOG000029191.
    KOiK01585.
    OMAiDSEDMVE.
    OrthoDBiEOG676Z0R.
    PhylomeDBiP74576.

    Family and domain databases

    Gene3Di2.40.37.10. 2 hits.
    3.20.20.10. 1 hit.
    HAMAPiMF_01417. SpeA.
    InterProiIPR009006. Ala_racemase/Decarboxylase_C.
    IPR002985. Arg_decrbxlase.
    IPR022643. De-COase2_C.
    IPR022657. De-COase2_CS.
    IPR022644. De-COase2_N.
    IPR022653. De-COase2_pyr-phos_BS.
    IPR000183. Orn/DAP/Arg_de-COase.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF02784. Orn_Arg_deC_N. 1 hit.
    PF00278. Orn_DAP_Arg_deC. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001336. Arg_decrbxlase. 1 hit.
    PRINTSiPR01180. ARGDCRBXLASE.
    PR01179. ODADCRBXLASE.
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR01273. speA. 1 hit.
    PROSITEiPS00878. ODR_DC_2_1. 1 hit.
    PS00879. ODR_DC_2_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P74576-1 [UniParc]FASTAAdd to Basket

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    MEGQSIELEL SVMAMPELID STEAGHTAGV KTDSNPQAIA QDRRWTIDDS    50
    ENLYRITGWG EPYFSINAAG HVTVSPQADH GGALDLYELV KGLRQRNIGL 100
    PLLLRFSDIL ADRINRLNAA FARGIARYRY PNTYRGVYPI KCNQHRHIVE 150
    SLVRYGTPYN FGLEAGSKPE LMIALAMLQP QENPEPDQQN QPLLICNGYK 200
    DREYIETALL ARRLGHRPII VVEQVAEVAL AIEISSNLGI KPILGVRAKL 250
    STQGMGRWGI STGDRAKFGL TIPEMLTAIE QLRRADMLDS LQLLHFHIGS 300
    QISSISVIKE AMTEASQIFV QLAKLGANMR YLDVGGGLGV DYDGSKTNFY 350
    ASKNYNIQNY VNDVISAVQD ACVAAEVPCP VLISESGRAI ASHQSVLIFD 400
    VVATNDINPP LPKVKGKDHA ILRNLMETWE TITVDNYQEA YHDVEQFKTE 450
    AISLFNFGYL GLKERAKAEE LYWACCRKIL QICRQQEYVP DDLENLEVNL 500
    ASIYYANMSV FQSAPDSWAI DQLFPIMPIH RLDEEPTQRG ILADITCDSD 550
    GKIDQFIDLR DVKSVLELHP LIEVHQPGTP PRVEPYYLGM FLVGAYQEIM 600
    GNLHNLFGDI NVVHIQMNPK GYQIEHLVRG DTIAEVLGYV QYDPEDLLEN 650
    MRRYCEQAME DKRMSLEEAQ LLLENYERSL LQYTYLKPTS GIHTS 695
    Length:695
    Mass (Da):78,239
    Last modified:February 1, 1997 - v1
    Checksum:iE90EB699D666320D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000022 Genomic DNA. Translation: BAA18683.1.
    PIRiS76771.
    RefSeqiNP_442871.1. NC_000911.1.
    YP_005652932.1. NC_017277.1.
    YP_007452747.1. NC_020286.1.

    Genome annotation databases

    EnsemblBacteriaiBAA18683; BAA18683; BAA18683.
    GeneIDi953209.
    KEGGisyn:slr0662.
    syy:SYNGTS_2979.
    syz:MYO_130130.
    PATRICi23843536. VBISynSp132158_3299.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000022 Genomic DNA. Translation: BAA18683.1 .
    PIRi S76771.
    RefSeqi NP_442871.1. NC_000911.1.
    YP_005652932.1. NC_017277.1.
    YP_007452747.1. NC_020286.1.

    3D structure databases

    ProteinModelPortali P74576.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P74576. 2 interactions.
    STRINGi 1148.slr0662.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAA18683 ; BAA18683 ; BAA18683 .
    GeneIDi 953209.
    KEGGi syn:slr0662.
    syy:SYNGTS_2979.
    syz:MYO_130130.
    PATRICi 23843536. VBISynSp132158_3299.

    Phylogenomic databases

    eggNOGi COG1166.
    HOGENOMi HOG000029191.
    KOi K01585.
    OMAi DSEDMVE.
    OrthoDBi EOG676Z0R.
    PhylomeDBi P74576.

    Family and domain databases

    Gene3Di 2.40.37.10. 2 hits.
    3.20.20.10. 1 hit.
    HAMAPi MF_01417. SpeA.
    InterProi IPR009006. Ala_racemase/Decarboxylase_C.
    IPR002985. Arg_decrbxlase.
    IPR022643. De-COase2_C.
    IPR022657. De-COase2_CS.
    IPR022644. De-COase2_N.
    IPR022653. De-COase2_pyr-phos_BS.
    IPR000183. Orn/DAP/Arg_de-COase.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF02784. Orn_Arg_deC_N. 1 hit.
    PF00278. Orn_DAP_Arg_deC. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001336. Arg_decrbxlase. 1 hit.
    PRINTSi PR01180. ARGDCRBXLASE.
    PR01179. ODADCRBXLASE.
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR01273. speA. 1 hit.
    PROSITEi PS00878. ODR_DC_2_1. 1 hit.
    PS00879. ODR_DC_2_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
      Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
      , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
      DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 6803 / Kazusa.

    Entry informationi

    Entry nameiSPEA1_SYNY3
    AccessioniPrimary (citable) accession number: P74576
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 14, 2001
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Synechocystis PCC 6803
      Synechocystis (strain PCC 6803): entries and gene names

    External Data

    Dasty 3