P74572 (P5CR_SYNY3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pyrroline-5-carboxylate reductase
Short name=P5C reductase
Short name=P5CR
EC=1.5.1.2

Gene names

Name:	proC
Ordered Locus Names:	slr0661

Organism

Synechocystis sp. (strain PCC 6803 / Kazusa)

Taxonomic identifier

1111708 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Synechocystis

Protein attributes

Sequence length	267 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	L-proline + NAD(P)+ = 1-pyrroline-5-carboxylate + NAD(P)H.
Pathway	Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the pyrroline-5-carboxylate reductase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Proline biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	proline biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	nucleotide binding Inferred from electronic annotation. Source: InterPro oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Inferred from electronic annotation. Source: InterPro pyrroline-5-carboxylate reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 267	267	Pyrroline-5-carboxylate reductase		PRO_0000187308

Sequences

	Sequence		Length	Mass (Da)
	P74572 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: FD9C428047F391B0	FASTA	267	27,883
	10 20 30 40 50 60 MSIQLGIIGG GVMAEAILAR LIAEKTYAPE EIIVGEPHGA RRDYLQKTYQ VRVSPDNQEA 70 80 90 100 110 120 ANVSEVLLLA VKPQVLDRVL ASLAGGANRP LVISILAGVS LQRIQKGFPD HAIIRAMPNT 130 140 150 160 170 180 PATVGAGMTA IAANKMVEPD QLAKAKAIFS AVGNVVEVPE NLMDAVTGVS GSGPAYVALM 190 200 210 220 230 240 IEALADGGVL AGLPRAIAQK LALQTVLGTA ELIKETEEHP AQIKDKVTSP GGTTIAGVAV 250 260 LEKMGFRSAI IEAVRAAYRR SQELGKK

References

[1]

"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions." Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S. DNA Res. 3:109-136(1996) [PubMed: 8905231] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 27184 / PCC 6803 / N-1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000022 Genomic DNA. Translation: BAA18679.1.
PIR	S76767.
RefSeq	NP_442867.1. NC_000911.1.
3D structure databases
ProteinModelPortal	P74572.
ModBase	Search...
Protein-protein interaction databases
IntAct	P74572. 1 interaction.
STRING	P74572.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	952360.
GenomeReviews	Gene locus slr0661 in contig BA000022_GR.
KEGG	syn:slr0661.
NMPDR	fig|1148.1.peg.2968.
PATRIC	23843528. VBISynSp132158_3295.
Phylogenomic databases
eggNOG	COG0345.
HOGENOM	HBG726602.
OMA	RTFNEHQ.
PhylomeDB	P74572.
ProtClustDB	PRK11880.
Enzyme and pathway databases
BioCyc	SSP1148:SLR0661-MONOMER.
Family and domain databases
InterPro	IPR008927. 6-PGluconate_DH_C-like. IPR016040. NAD(P)-bd_dom. IPR004455. NADP_OxRdtase_F420. IPR000304. Pyrroline-COOH_reductase. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00286.
PANTHER	PTHR11645. P5CR. 1 hit.
Pfam	PF03807. F420_oxidored. 1 hit. [Graphical view]
PIRSF	PIRSF000193. Pyrrol-5-carb_rd. 1 hit.
SUPFAM	SSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMs	TIGR00112. ProC. 1 hit.
PROSITE	PS00521. P5CR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

P5CR_SYNY3

Accession

Primary (citable) accession number: P74572

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	February 1, 1997
Last modified:	January 25, 2012
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program