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P74565

- SIGA_SYNY3

UniProt

P74565 - SIGA_SYNY3

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Protein

RNA polymerase sigma factor SigA

Gene

sigA

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi386 – 40520H-T-H motifUniRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-HAMAP
  2. sequence-specific DNA binding transcription factor activity Source: InterPro
  3. sigma factor activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. transcription initiation from bacterial-type RNA polymerase promoter Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Sigma factor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase sigma factor SigAUniRule annotation
Gene namesi
Name:sigAUniRule annotation
Synonyms:rpoD, rpoD1
Ordered Locus Names:slr0653
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
ProteomesiUP000001425: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 425425RNA polymerase sigma factor SigAPRO_0000093928Add
BLAST

Proteomic databases

PaxDbiP74565.

Interactioni

Subunit structurei

Interacts transiently with the RNA polymerase catalytic core.UniRule annotation

Protein-protein interaction databases

IntActiP74565. 42 interactions.
STRINGi1148.slr0653.

Structurei

3D structure databases

ProteinModelPortaliP74565.
SMRiP74565. Positions 187-260, 347-424.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni193 – 26371Sigma-70 factor domain-2UniRule annotationAdd
BLAST
Regioni272 – 34776Sigma-70 factor domain-3UniRule annotationAdd
BLAST
Regioni360 – 41354Sigma-70 factor domain-4UniRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi217 – 2204Interaction with polymerase core subunit RpoC

Sequence similaritiesi

Belongs to the sigma-70 factor family. RpoD/SigA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0568.
HOGENOMiHOG000270273.
InParanoidiP74565.
KOiK03086.
OMAiIVEDGEM.
OrthoDBiEOG6XHC70.
PhylomeDBiP74565.

Family and domain databases

Gene3Di1.10.10.10. 2 hits.
HAMAPiMF_00963. Sigma70_RpoD_SigA.
InterProiIPR014284. RNA_pol_sigma-70_dom.
IPR000943. RNA_pol_sigma70.
IPR009042. RNA_pol_sigma70_r1_2.
IPR007627. RNA_pol_sigma70_r2.
IPR007624. RNA_pol_sigma70_r3.
IPR007630. RNA_pol_sigma70_r4.
IPR013325. RNA_pol_sigma_r2.
IPR013324. RNA_pol_sigma_r3_r4.
IPR012760. RNA_pol_sigma_RpoD_C.
IPR017848. RNA_pol_sigma_RpoD_cyanobac.
IPR028630. Sigma70_RpoD.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00140. Sigma70_r1_2. 1 hit.
PF04542. Sigma70_r2. 1 hit.
PF04539. Sigma70_r3. 1 hit.
PF04545. Sigma70_r4. 1 hit.
[Graphical view]
PRINTSiPR00046. SIGMA70FCT.
SUPFAMiSSF88659. SSF88659. 2 hits.
SSF88946. SSF88946. 2 hits.
TIGRFAMsiTIGR02393. RpoD_Cterm. 1 hit.
TIGR02997. Sig70-cyanoRpoD. 1 hit.
TIGR02937. sigma70-ECF. 1 hit.
PROSITEiPS00715. SIGMA70_1. 1 hit.
PS00716. SIGMA70_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P74565-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTQTKEPLTK AESAELEQEI ELSQYINTDD IDDDDIDVED LEQEVAATEG
60 70 80 90 100
KEKKVRKIRK DAVKKKPYTE DSIRIYLQEI GRIRLLRAEE EIELARQIAD
110 120 130 140 150
LLELELIRDN LTLQLERQPS ELEWGKQVWK LETAKQRLVG DKKKEPKKKD
160 170 180 190 200
IDSYLANPDN ELSLENEWSQ QPNKNFAAFR RRLFLDRRAK DKMVQSNLRL
210 220 230 240 250
VVSIAKKYMN RGLSFQDLIQ EGSLGLIRAA EKFDHEKGYK FSTYATWWIR
260 270 280 290 300
QAITRAIADQ SRTIRLPVHL YETISRIKKT TKLLSQEMRR KPTEEEIAEK
310 320 330 340 350
MEMTIEKLRF IAKSAQLPIS LETPIGKEED SRLGDFIEAD GETPEDEVSK
360 370 380 390 400
NLLREDLENV LDTLSPRERD VLRLRYGLDD GRMKTLEEIG QIFNVTRERI
410 420
RQIEAKALRK LRHPNRNSIL KEYIR
Length:425
Mass (Da):49,936
Last modified:February 1, 1997 - v1
Checksum:i4043FEA859B442D7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000022 Genomic DNA. Translation: BAA18672.1.
D86213 Genomic DNA. Translation: BAA13043.1.
PIRiS76760.
RefSeqiNP_442860.1. NC_000911.1.
YP_005652921.1. NC_017277.1.
YP_007452736.1. NC_020286.1.

Genome annotation databases

EnsemblBacteriaiBAA18672; BAA18672; BAA18672.
GeneIDi953190.
KEGGisyn:slr0653.
syy:SYNGTS_2968.
syz:MYO_129970.
PATRICi23843506. VBISynSp132158_3288.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000022 Genomic DNA. Translation: BAA18672.1 .
D86213 Genomic DNA. Translation: BAA13043.1 .
PIRi S76760.
RefSeqi NP_442860.1. NC_000911.1.
YP_005652921.1. NC_017277.1.
YP_007452736.1. NC_020286.1.

3D structure databases

ProteinModelPortali P74565.
SMRi P74565. Positions 187-260, 347-424.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P74565. 42 interactions.
STRINGi 1148.slr0653.

Proteomic databases

PaxDbi P74565.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAA18672 ; BAA18672 ; BAA18672 .
GeneIDi 953190.
KEGGi syn:slr0653.
syy:SYNGTS_2968.
syz:MYO_129970.
PATRICi 23843506. VBISynSp132158_3288.

Phylogenomic databases

eggNOGi COG0568.
HOGENOMi HOG000270273.
InParanoidi P74565.
KOi K03086.
OMAi IVEDGEM.
OrthoDBi EOG6XHC70.
PhylomeDBi P74565.

Family and domain databases

Gene3Di 1.10.10.10. 2 hits.
HAMAPi MF_00963. Sigma70_RpoD_SigA.
InterProi IPR014284. RNA_pol_sigma-70_dom.
IPR000943. RNA_pol_sigma70.
IPR009042. RNA_pol_sigma70_r1_2.
IPR007627. RNA_pol_sigma70_r2.
IPR007624. RNA_pol_sigma70_r3.
IPR007630. RNA_pol_sigma70_r4.
IPR013325. RNA_pol_sigma_r2.
IPR013324. RNA_pol_sigma_r3_r4.
IPR012760. RNA_pol_sigma_RpoD_C.
IPR017848. RNA_pol_sigma_RpoD_cyanobac.
IPR028630. Sigma70_RpoD.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00140. Sigma70_r1_2. 1 hit.
PF04542. Sigma70_r2. 1 hit.
PF04539. Sigma70_r3. 1 hit.
PF04545. Sigma70_r4. 1 hit.
[Graphical view ]
PRINTSi PR00046. SIGMA70FCT.
SUPFAMi SSF88659. SSF88659. 2 hits.
SSF88946. SSF88946. 2 hits.
TIGRFAMsi TIGR02393. RpoD_Cterm. 1 hit.
TIGR02997. Sig70-cyanoRpoD. 1 hit.
TIGR02937. sigma70-ECF. 1 hit.
PROSITEi PS00715. SIGMA70_1. 1 hit.
PS00716. SIGMA70_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
    Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
    , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 6803 / Kazusa.
  2. "A new set of PCR primers for specific detection of the gene encoding the principal sigma factor in cyanobacteria."
    Asayama M., Yamada A., Tanaka K., Takahashi H., Shirai M.
    J. Gen. Appl. Microbiol. 42:511-515(1996)
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 211-396.
    Strain: 559.

Entry informationi

Entry nameiSIGA_SYNY3
AccessioniPrimary (citable) accession number: P74565
Secondary accession number(s): Q55351
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: February 1, 1997
Last modified: October 29, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

External Data

Dasty 3