ID SIGA_SYNY3 Reviewed; 425 AA. AC P74565; Q55351; DT 24-MAY-2004, integrated into UniProtKB/Swiss-Prot. DT 01-FEB-1997, sequence version 1. DT 27-MAR-2024, entry version 145. DE RecName: Full=RNA polymerase sigma factor SigA {ECO:0000255|HAMAP-Rule:MF_00963}; GN Name=sigA {ECO:0000255|HAMAP-Rule:MF_00963}; Synonyms=rpoD, rpoD1; GN OrderedLocusNames=slr0653; OS Synechocystis sp. (strain PCC 6803 / Kazusa). OC Bacteria; Cyanobacteriota; Cyanophyceae; Synechococcales; Merismopediaceae; OC Synechocystis. OX NCBI_TaxID=1111708; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=PCC 6803 / Kazusa; RX PubMed=8905231; DOI=10.1093/dnares/3.3.109; RA Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., RA Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., RA Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S., RA Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.; RT "Sequence analysis of the genome of the unicellular cyanobacterium RT Synechocystis sp. strain PCC6803. II. Sequence determination of the entire RT genome and assignment of potential protein-coding regions."; RL DNA Res. 3:109-136(1996). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 211-396. RC STRAIN=559; RA Asayama M., Yamada A., Tanaka K., Takahashi H., Shirai M.; RT "A new set of PCR primers for specific detection of the gene encoding the RT principal sigma factor in cyanobacteria."; RL J. Gen. Appl. Microbiol. 42:511-515(1996). CC -!- FUNCTION: Sigma factors are initiation factors that promote the CC attachment of RNA polymerase to specific initiation sites and are then CC released. This sigma factor is the primary sigma factor during CC exponential growth. {ECO:0000255|HAMAP-Rule:MF_00963}. CC -!- SUBUNIT: Interacts transiently with the RNA polymerase catalytic core. CC {ECO:0000255|HAMAP-Rule:MF_00963}. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00963}. CC -!- SIMILARITY: Belongs to the sigma-70 factor family. RpoD/SigA subfamily. CC {ECO:0000255|HAMAP-Rule:MF_00963}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BA000022; BAA18672.1; -; Genomic_DNA. DR EMBL; D86213; BAA13043.1; -; Genomic_DNA. DR PIR; S76760; S76760. DR PDB; 8GZG; EM; 3.13 A; F=1-425. DR PDB; 8GZH; EM; 2.96 A; F=1-425. DR PDBsum; 8GZG; -. DR PDBsum; 8GZH; -. DR AlphaFoldDB; P74565; -. DR SMR; P74565; -. DR IntAct; P74565; 42. DR STRING; 1148.gene:10500438; -. DR PaxDb; 1148-1653761; -. DR EnsemblBacteria; BAA18672; BAA18672; BAA18672. DR KEGG; syn:slr0653; -. DR eggNOG; COG0568; Bacteria. DR InParanoid; P74565; -. DR PhylomeDB; P74565; -. DR Proteomes; UP000001425; Chromosome. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule. DR GO; GO:0016987; F:sigma factor activity; IEA:UniProtKB-UniRule. DR GO; GO:0006352; P:DNA-templated transcription initiation; IEA:UniProtKB-UniRule. DR CDD; cd06171; Sigma70_r4; 1. DR Gene3D; 1.20.120.1810; -; 1. DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2. DR HAMAP; MF_00963; Sigma70_RpoD_SigA; 1. DR InterPro; IPR014284; RNA_pol_sigma-70_dom. DR InterPro; IPR000943; RNA_pol_sigma70. DR InterPro; IPR009042; RNA_pol_sigma70_r1_2. DR InterPro; IPR007627; RNA_pol_sigma70_r2. DR InterPro; IPR007624; RNA_pol_sigma70_r3. DR InterPro; IPR007630; RNA_pol_sigma70_r4. DR InterPro; IPR013325; RNA_pol_sigma_r2. DR InterPro; IPR013324; RNA_pol_sigma_r3/r4-like. DR InterPro; IPR017848; RNA_pol_sigma_RpoD/SigA_cyanob. DR InterPro; IPR012760; RNA_pol_sigma_RpoD_C. DR InterPro; IPR028630; Sigma70_RpoD. DR InterPro; IPR036388; WH-like_DNA-bd_sf. DR NCBIfam; TIGR02393; RpoD_Cterm; 1. DR NCBIfam; TIGR02997; Sig70-cyanoRpoD; 1. DR NCBIfam; TIGR02937; sigma70-ECF; 1. DR PANTHER; PTHR30603; RNA POLYMERASE SIGMA FACTOR RPO; 1. DR PANTHER; PTHR30603:SF62; RNA POLYMERASE SIGMA FACTOR SIGA; 1. DR Pfam; PF00140; Sigma70_r1_2; 1. DR Pfam; PF04542; Sigma70_r2; 1. DR Pfam; PF04539; Sigma70_r3; 1. DR Pfam; PF04545; Sigma70_r4; 1. DR PRINTS; PR00046; SIGMA70FCT. DR SUPFAM; SSF88946; Sigma2 domain of RNA polymerase sigma factors; 1. DR SUPFAM; SSF88659; Sigma3 and sigma4 domains of RNA polymerase sigma factors; 2. DR PROSITE; PS00715; SIGMA70_1; 1. DR PROSITE; PS00716; SIGMA70_2; 1. PE 1: Evidence at protein level; KW 3D-structure; Cytoplasm; DNA-binding; Reference proteome; Sigma factor; KW Transcription; Transcription regulation. FT CHAIN 1..425 FT /note="RNA polymerase sigma factor SigA" FT /id="PRO_0000093928" FT DNA_BIND 386..405 FT /note="H-T-H motif" FT /evidence="ECO:0000255|HAMAP-Rule:MF_00963" FT REGION 193..263 FT /note="Sigma-70 factor domain-2" FT /evidence="ECO:0000255|HAMAP-Rule:MF_00963" FT REGION 272..347 FT /note="Sigma-70 factor domain-3" FT /evidence="ECO:0000255|HAMAP-Rule:MF_00963" FT REGION 360..413 FT /note="Sigma-70 factor domain-4" FT /evidence="ECO:0000255|HAMAP-Rule:MF_00963" FT MOTIF 217..220 FT /note="Interaction with polymerase core subunit RpoC" FT HELIX 72..81 FT /evidence="ECO:0007829|PDB:8GZH" FT HELIX 88..115 FT /evidence="ECO:0007829|PDB:8GZH" FT HELIX 174..195 FT /evidence="ECO:0007829|PDB:8GZH" FT HELIX 198..205 FT /evidence="ECO:0007829|PDB:8GZH" FT STRAND 211..213 FT /evidence="ECO:0007829|PDB:8GZH" FT HELIX 215..230 FT /evidence="ECO:0007829|PDB:8GZH" FT HELIX 235..237 FT /evidence="ECO:0007829|PDB:8GZH" FT HELIX 241..259 FT /evidence="ECO:0007829|PDB:8GZH" FT HELIX 268..287 FT /evidence="ECO:0007829|PDB:8GZH" FT HELIX 294..301 FT /evidence="ECO:0007829|PDB:8GZH" FT HELIX 305..314 FT /evidence="ECO:0007829|PDB:8GZH" FT STRAND 325..330 FT /evidence="ECO:0007829|PDB:8GZH" FT HELIX 333..336 FT /evidence="ECO:0007829|PDB:8GZH" FT HELIX 344..361 FT /evidence="ECO:0007829|PDB:8GZH" FT HELIX 366..376 FT /evidence="ECO:0007829|PDB:8GZH" FT STRAND 378..381 FT /evidence="ECO:0007829|PDB:8GZH" FT HELIX 386..392 FT /evidence="ECO:0007829|PDB:8GZH" FT STRAND 393..395 FT /evidence="ECO:0007829|PDB:8GZH" FT HELIX 397..411 FT /evidence="ECO:0007829|PDB:8GZH" FT STRAND 413..416 FT /evidence="ECO:0007829|PDB:8GZG" FT HELIX 420..423 FT /evidence="ECO:0007829|PDB:8GZH" SQ SEQUENCE 425 AA; 49936 MW; 4043FEA859B442D7 CRC64; MTQTKEPLTK AESAELEQEI ELSQYINTDD IDDDDIDVED LEQEVAATEG KEKKVRKIRK DAVKKKPYTE DSIRIYLQEI GRIRLLRAEE EIELARQIAD LLELELIRDN LTLQLERQPS ELEWGKQVWK LETAKQRLVG DKKKEPKKKD IDSYLANPDN ELSLENEWSQ QPNKNFAAFR RRLFLDRRAK DKMVQSNLRL VVSIAKKYMN RGLSFQDLIQ EGSLGLIRAA EKFDHEKGYK FSTYATWWIR QAITRAIADQ SRTIRLPVHL YETISRIKKT TKLLSQEMRR KPTEEEIAEK MEMTIEKLRF IAKSAQLPIS LETPIGKEED SRLGDFIEAD GETPEDEVSK NLLREDLENV LDTLSPRERD VLRLRYGLDD GRMKTLEEIG QIFNVTRERI RQIEAKALRK LRHPNRNSIL KEYIR //