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P74562 (NADB_SYNY3) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
L-aspartate oxidase
Short name=LASPO
EC=1.4.3.16
Alternative name(s):
Quinolinate synthase B
Gene names
Name:nadB
Ordered Locus Names:sll0631
OrganismSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifier1111708 [NCBI]
Taxonomic lineageBacteria › Cyanobacteria › Chroococcales › Synechocystis

Protein attributes

Sequence length553 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidation of L-aspartate to iminoaspartate.

Catalytic activity

L-aspartate + O2 = iminosuccinate + H2O2.

Cofactor

FAD.

Pathway

Cofactor biosynthesis; NAD(+) biosynthesis; iminoaspartate from L-aspartate (oxidase route): step 1/1.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.

Ontologies

Keywords
   Biological processPyridine nucleotide biosynthesis
   Cellular componentCytoplasm
   LigandFAD
Flavoprotein
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processNAD biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionL-aspartate oxidase activity

Inferred from electronic annotation. Source: EC

L-aspartate:fumarate oxidoreductase activity

Inferred from electronic annotation. Source: EC

electron carrier activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 553553L-aspartate oxidase
PRO_0000184402

Regions

Nucleotide binding9 – 2315FAD Potential

Sites

Active site2291 By similarity
Active site2481 By similarity

Sequences

Sequence LengthMass (Da)Tools
P74562 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: 0ABCE7366B9940CC

FASTA55360,498
        10         20         30         40         50         60 
MGANQFDVVV VGSGAAGLYA CLCLPGHYRV ALVTKAELKT GASDWAQGGI AAAIAPTDSP 

        70         80         90        100        110        120 
QSHYEDTLAA GAGLCDGEAV DFLVNHAPQA IAELVQFGVS FDRHGQHLAL TLEAAHSQPR 

       130        140        150        160        170        180 
VLHAADTTGR AIVSTLMGQV QARPNVEIFS QAIALSLNIE PTTGHCRGIQ VFVNQTIETF 

       190        200        210        220        230        240 
HSRAVLLATG GGGQVFAQTT NPKVSTGDGI ALAWRSGAQV RDLEFFQFHP TALTKPGVPH 

       250        260        270        280        290        300 
FLISEAVRGE GAHLLDRQGK RFAFDYHPRG ELAPRDVVSR AIFQHLANTE KDPTQATVFL 

       310        320        330        340        350        360 
DLSPIEPERI QRRFPNIIRR CLHWGVDIFR EPIPVAPAAH YWMGGITTDI NCQTTIPGLY 

       370        380        390        400        410        420 
ALGETASTGV HGANRLASNS LLECIVFASQ LRNLSLPPLA SSDSNVNQSI KEIRLDTTND 

       430        440        450        460        470        480 
LALLNHWRSE LPRLMWQTAG ICRQAETLQM AIAKLEQWQE QWQQLSSSKL LAHLPEDQKI 

       490        500        510        520        530        540 
SLSGPGLNEF MQLWAETHNL LDIAQLILTS ALFREESRGG HYRLDCPDTK REWQSHTVIE 

       550 
GTRVFLQPSQ SQD

« Hide

References

[1]"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. expand/collapse author list , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
DNA Res. 3:109-136(1996) [PubMed: 8905231] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 27184 / PCC 6803 / N-1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BA000022 Genomic DNA. Translation: BAA18669.1.
PIRS76757.
RefSeqNP_442857.1. NC_000911.1.

3D structure databases

ProteinModelPortalP74562.
ModBaseSearch...

Protein-protein interaction databases

IntActP74562. 6 interactions.
STRINGP74562.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID952038.
GenomeReviewsGene locus sll0631 in contig BA000022_GR.
KEGGsyn:sll0631.
NMPDRfig|1148.1.peg.2958.
PATRIC23843496. VBISynSp132158_3283.

Phylogenomic databases

eggNOGCOG0029.
HOGENOMHBG293998.
OMAGAYIWNR.
PhylomeDBP74562.
ProtClustDBPRK07395.

Enzyme and pathway databases

BioCycSSP1148:SLL0631-MONOMER.

Family and domain databases

InterProIPR003953. FAD_bind2_N.
IPR013027. FAD_pyr_nucl-diS_OxRdtase.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR004112. Fum_Rdtase/Succ_DH_flav_C.
IPR005288. NadB.
[Graphical view]
Gene3DG3DSA:1.20.58.100. Fum_Rdtase/Succ_DH_flav-like_C. 1 hit.
KOK00278.
PfamPF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view]
PRINTSPR00368. FADPNR.
SUPFAMSSF46977. Succ_DH_flav_C. 1 hit.
TIGRFAMsTIGR00551. NadB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNADB_SYNY3
AccessionPrimary (citable) accession number: P74562
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: January 25, 2012
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Synechocystis PCC 6803

Synechocystis (strain PCC 6803): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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