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Protein

UDP-N-acetylenolpyruvoylglucosamine reductase

Gene

murB

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cell wall formation.By similarity

Catalytic activityi

UDP-N-acetyl-alpha-D-muramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine + NADPH.

Cofactori

FADBy similarity

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei185By similarity1
Active sitei238Proton donorBy similarity1
Active sitei308By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis
LigandFAD, Flavoprotein, NADP

Enzyme and pathway databases

UniPathwayiUPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylenolpyruvoylglucosamine reductase (EC:1.3.1.98)
Alternative name(s):
UDP-N-acetylmuramate dehydrogenase
Gene namesi
Name:murB
Ordered Locus Names:slr1424
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesMerismopediaceaeSynechocystis
Proteomesi
  • UP000001425 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001792791 – 317UDP-N-acetylenolpyruvoylglucosamine reductaseAdd BLAST317

Proteomic databases

PaxDbiP74529

Interactioni

Protein-protein interaction databases

STRINGi1148.SYNGTS_2931

Structurei

3D structure databases

ProteinModelPortaliP74529
SMRiP74529
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 208FAD-binding PCMH-typeAdd BLAST170

Sequence similaritiesi

Belongs to the MurB family.Curated

Phylogenomic databases

HOGENOMiHOG000284355
InParanoidiP74529
KOiK00075
OMAiIGNAGSF
PhylomeDBiP74529

Family and domain databases

Gene3Di3.30.43.10, 1 hit
3.90.78.10, 1 hit
HAMAPiMF_00037 MurB, 1 hit
InterProiView protein in InterPro
IPR016166 FAD-bd_2
IPR036318 FAD-bd_2-like_sf
IPR016167 FAD-bd_2_sub1
IPR003170 MurB
IPR011601 MurB_C
IPR036635 MurB_C_sf
IPR006094 Oxid_FAD_bind_N
PANTHERiPTHR21071 PTHR21071, 1 hit
PfamiView protein in Pfam
PF01565 FAD_binding_4, 1 hit
PF02873 MurB_C, 1 hit
SUPFAMiSSF56176 SSF56176, 1 hit
SSF56194 SSF56194, 1 hit
TIGRFAMsiTIGR00179 murB, 1 hit
PROSITEiView protein in PROSITE
PS51387 FAD_PCMH, 1 hit

Sequencei

Sequence statusi: Complete.

P74529-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIISPATRPT PMETPAIALA GTGTIIQPET SLAEFTTYRV GGKAEWYAAP
60 70 80 90 100
RCLEDLVAVL DWFQGQDLPL TFLGAGSNLL ISDQGLAGLV LSTRYLRQSK
110 120 130 140 150
FDEEQGLITV AAGEPIAKVG WQAAKRGWQG LEWAVGIPGT VGGAVVMNAG
160 170 180 190 200
AHNQCTAETL VEATVMRPDG GLEVLTNEQL GFSYRTSNLQ KHLGDRLVVD
210 220 230 240 250
ATFKLTPGFT REEIMGCTTR NLHQRKSTQP YDKPNCGSVF RNPTPLYSAR
260 270 280 290 300
LIEELGLKGY RIGGAEVSQR HANFIVNIDN AKAQDVFNLI FHVQGEVEKH
310
YGILLEPEVK MLGEFAR
Length:317
Mass (Da):34,586
Last modified:February 1, 1997 - v1
Checksum:iCE06A98956B5172B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA Translation: BAA18635.1
PIRiS76723

Genome annotation databases

EnsemblBacteriaiBAA18635; BAA18635; BAA18635
KEGGisyn:slr1424

Similar proteinsi

Entry informationi

Entry nameiMURB_SYNY3
AccessioniPrimary (citable) accession number: P74529
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: February 1, 1997
Last modified: March 28, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health