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Protein

2,3-bisphosphoglycerate-independent phosphoglycerate mutase

Gene

gpmI

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.UniRule annotation

Catalytic activityi

2-phospho-D-glycerate = 3-phospho-D-glycerate.UniRule annotation

Cofactori

Mn2+UniRule annotationNote: Binds 2 manganese ions per subunit.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 3 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Glyceraldehyde-3-phosphate dehydrogenase 1 (gap1), Glyceraldehyde-3-phosphate dehydrogenase 2 (gap2)
  2. Phosphoglycerate kinase (pgk)
  3. 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (gpmI)
  4. Enolase (eno)
  5. Pyruvate kinase 1 (pyk1), Pyruvate kinase 2 (pyk2)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi15Manganese 2UniRule annotation1
Active sitei65Phosphoserine intermediateUniRule annotation1
Metal bindingi65Manganese 2UniRule annotation1
Binding sitei126SubstrateUniRule annotation1
Binding sitei188SubstrateUniRule annotation1
Binding sitei194SubstrateUniRule annotation1
Binding sitei331SubstrateUniRule annotation1
Metal bindingi398Manganese 1UniRule annotation1
Metal bindingi402Manganese 1UniRule annotation1
Metal bindingi439Manganese 2UniRule annotation1
Metal bindingi440Manganese 2UniRule annotation1
Metal bindingi457Manganese 1UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processGlycolysis
LigandManganese, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00109; UER00186

Names & Taxonomyi

Protein namesi
Recommended name:
2,3-bisphosphoglycerate-independent phosphoglycerate mutaseUniRule annotation (EC:5.4.2.12UniRule annotation)
Short name:
BPG-independent PGAMUniRule annotation
Short name:
PhosphoglyceromutaseUniRule annotation
Short name:
iPGMUniRule annotation
Gene namesi
Name:gpmIUniRule annotation
Synonyms:pgm
Ordered Locus Names:slr1945
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesMerismopediaceaeSynechocystis
Proteomesi
  • UP000001425 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002122221 – 5322,3-bisphosphoglycerate-independent phosphoglycerate mutaseAdd BLAST532

Proteomic databases

PaxDbiP74507
PRIDEiP74507

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

IntActiP74507, 1 interactor
STRINGi1148.SYNGTS_2040

Structurei

3D structure databases

ProteinModelPortaliP74507
SMRiP74507
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni156 – 157Substrate bindingUniRule annotation2
Regioni258 – 261Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the BPG-independent phosphoglycerate mutase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000223664
InParanoidiP74507
KOiK15633
OMAiFMDGRDT
PhylomeDBiP74507

Family and domain databases

CDDicd16010 iPGM, 1 hit
Gene3Di3.40.1450.10, 1 hit
3.40.720.10, 2 hits
HAMAPiMF_01038 GpmI, 1 hit
InterProiView protein in InterPro
IPR017849 Alkaline_Pase-like_a/b/a
IPR017850 Alkaline_phosphatase_core_sf
IPR011258 BPG-indep_PGM_N
IPR006124 Metalloenzyme
IPR036646 PGAM_B_sf
IPR005995 Pgm_bpd_ind
PANTHERiPTHR31637 PTHR31637, 1 hit
PfamiView protein in Pfam
PF06415 iPGM_N, 1 hit
PF01676 Metalloenzyme, 1 hit
PIRSFiPIRSF001492 IPGAM, 1 hit
SUPFAMiSSF53649 SSF53649, 2 hits
SSF64158 SSF64158, 1 hit
TIGRFAMsiTIGR01307 pgm_bpd_ind, 1 hit

Sequencei

Sequence statusi: Complete.

P74507-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEAPIAPVV LVILDGWGYR PDTRANAIAQ ANTPIMDSLI AAYPNTLVNT
60 70 80 90 100
SGKDVGLPKG QMGNSEVGHL NLGAGRVVPQ ELVRISDAIE DGTFFDNQAL
110 120 130 140 150
IEVCQRVRDR RGKLHLIGLC SDGGVHSHID HLLGLIDLAK LQGISQLCIH
160 170 180 190 200
AITDGRDTPT NEGAHFVQQI QAHLEKIGLG RIVSVSGRYY ALDRDRRWDR
210 220 230 240 250
VEKAYRVMTE DGVGDGRSAA QVIKDYYASD ITDEFIPPTR IGAGAIASGD
260 270 280 290 300
GVIFYNFRPD RARQLCYALV NPSFDGFPRE RIQPLDFVTF TQYDPALPVV
310 320 330 340 350
VAFEPQNLNN ILGEIISRQG MKQFRTAETE KYPHVTYFFN GGLEQPFAGE
360 370 380 390 400
DRELIQSPMV STYDKAPQMS AKAVTDAVCR AMEKGIYSLV VVNYANPDMV
410 420 430 440 450
GHTGKLKEAI QAIETVDLNL GRLLASAAKV GGTVLITADH GNAEYMSDES
460 470 480 490 500
GNPWTAHTTN PVPFILVEGE GRKIPGHGGE VKLREGGKLA DIAPTILDIL
510 520 530
QLPVPAEMTG KTLIDQPLVE IKANRTPVNL SR
Length:532
Mass (Da):57,982
Last modified:February 1, 1997 - v1
Checksum:i936D8E4E5256C6C0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA Translation: BAA18611.1
PIRiS76482

Genome annotation databases

EnsemblBacteriaiBAA18611; BAA18611; BAA18611
KEGGisyn:slr1945

Similar proteinsi

Entry informationi

Entry nameiGPMI_SYNY3
AccessioniPrimary (citable) accession number: P74507
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: February 1, 1997
Last modified: May 23, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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