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Protein

2,3-bisphosphoglycerate-independent phosphoglycerate mutase

Gene

gpmI

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.By similarity

Catalytic activityi

2-phospho-D-glycerate = 3-phospho-D-glycerate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi15 – 151Manganese 2By similarity
Active sitei65 – 651Phosphoserine intermediateBy similarity
Metal bindingi65 – 651Manganese 2By similarity
Metal bindingi398 – 3981Manganese 1By similarity
Metal bindingi402 – 4021Manganese 1By similarity
Metal bindingi439 – 4391Manganese 2By similarity
Metal bindingi440 – 4401Manganese 2By similarity
Metal bindingi457 – 4571Manganese 1By similarity

GO - Molecular functioni

  1. 2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity Source: UniProtKB-HAMAP
  2. manganese ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. glucose catabolic process Source: InterPro
  2. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00109; UER00186.

Names & Taxonomyi

Protein namesi
Recommended name:
2,3-bisphosphoglycerate-independent phosphoglycerate mutase (EC:5.4.2.12)
Short name:
BPG-independent PGAM
Short name:
Phosphoglyceromutase
Short name:
iPGM
Gene namesi
Name:gpmI
Synonyms:pgm
Ordered Locus Names:slr1945
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
ProteomesiUP000001425 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 5325322,3-bisphosphoglycerate-independent phosphoglycerate mutasePRO_0000212222Add
BLAST

Proteomic databases

PaxDbiP74507.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

IntActiP74507. 1 interaction.
STRINGi1148.slr1945.

Structurei

3D structure databases

ProteinModelPortaliP74507.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0696.
HOGENOMiHOG000223664.
InParanoidiP74507.
KOiK15633.
OMAiDEFIMPA.
OrthoDBiEOG6HJ22X.
PhylomeDBiP74507.

Family and domain databases

Gene3Di3.40.1450.10. 1 hit.
3.40.720.10. 2 hits.
HAMAPiMF_01038. GpmI.
InterProiIPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core.
IPR011258. BPG-indep_PGM_N.
IPR006124. Metalloenzyme.
IPR005995. Pgm_bpd_ind.
[Graphical view]
PfamiPF06415. iPGM_N. 1 hit.
PF01676. Metalloenzyme. 1 hit.
[Graphical view]
PIRSFiPIRSF001492. IPGAM. 1 hit.
SUPFAMiSSF53649. SSF53649. 2 hits.
SSF64158. SSF64158. 1 hit.
TIGRFAMsiTIGR01307. pgm_bpd_ind. 1 hit.

Sequencei

Sequence statusi: Complete.

P74507-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEAPIAPVV LVILDGWGYR PDTRANAIAQ ANTPIMDSLI AAYPNTLVNT
60 70 80 90 100
SGKDVGLPKG QMGNSEVGHL NLGAGRVVPQ ELVRISDAIE DGTFFDNQAL
110 120 130 140 150
IEVCQRVRDR RGKLHLIGLC SDGGVHSHID HLLGLIDLAK LQGISQLCIH
160 170 180 190 200
AITDGRDTPT NEGAHFVQQI QAHLEKIGLG RIVSVSGRYY ALDRDRRWDR
210 220 230 240 250
VEKAYRVMTE DGVGDGRSAA QVIKDYYASD ITDEFIPPTR IGAGAIASGD
260 270 280 290 300
GVIFYNFRPD RARQLCYALV NPSFDGFPRE RIQPLDFVTF TQYDPALPVV
310 320 330 340 350
VAFEPQNLNN ILGEIISRQG MKQFRTAETE KYPHVTYFFN GGLEQPFAGE
360 370 380 390 400
DRELIQSPMV STYDKAPQMS AKAVTDAVCR AMEKGIYSLV VVNYANPDMV
410 420 430 440 450
GHTGKLKEAI QAIETVDLNL GRLLASAAKV GGTVLITADH GNAEYMSDES
460 470 480 490 500
GNPWTAHTTN PVPFILVEGE GRKIPGHGGE VKLREGGKLA DIAPTILDIL
510 520 530
QLPVPAEMTG KTLIDQPLVE IKANRTPVNL SR
Length:532
Mass (Da):57,982
Last modified:February 1, 1997 - v1
Checksum:i936D8E4E5256C6C0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA18611.1.
PIRiS76482.
RefSeqiNP_441933.1. NC_000911.1.
YP_005651993.1. NC_017277.1.
YP_007451813.1. NC_020286.1.

Genome annotation databases

EnsemblBacteriaiBAA18611; BAA18611; BAA18611.
KEGGisyn:slr1945.
PATRICi23841414. VBISynSp132158_2256.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA18611.1.
PIRiS76482.
RefSeqiNP_441933.1. NC_000911.1.
YP_005651993.1. NC_017277.1.
YP_007451813.1. NC_020286.1.

3D structure databases

ProteinModelPortaliP74507.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP74507. 1 interaction.
STRINGi1148.slr1945.

Proteomic databases

PaxDbiP74507.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA18611; BAA18611; BAA18611.
KEGGisyn:slr1945.
PATRICi23841414. VBISynSp132158_2256.

Phylogenomic databases

eggNOGiCOG0696.
HOGENOMiHOG000223664.
InParanoidiP74507.
KOiK15633.
OMAiDEFIMPA.
OrthoDBiEOG6HJ22X.
PhylomeDBiP74507.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00186.

Family and domain databases

Gene3Di3.40.1450.10. 1 hit.
3.40.720.10. 2 hits.
HAMAPiMF_01038. GpmI.
InterProiIPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core.
IPR011258. BPG-indep_PGM_N.
IPR006124. Metalloenzyme.
IPR005995. Pgm_bpd_ind.
[Graphical view]
PfamiPF06415. iPGM_N. 1 hit.
PF01676. Metalloenzyme. 1 hit.
[Graphical view]
PIRSFiPIRSF001492. IPGAM. 1 hit.
SUPFAMiSSF53649. SSF53649. 2 hits.
SSF64158. SSF64158. 1 hit.
TIGRFAMsiTIGR01307. pgm_bpd_ind. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
    Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
    , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    DNA Res. 3:109-136(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 6803 / Kazusa.

Entry informationi

Entry nameiGPMI_SYNY3
AccessioniPrimary (citable) accession number: P74507
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: February 1, 1997
Last modified: April 1, 2015
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.