P74507 (GPMI_SYNY3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
2,3-bisphosphoglycerate-independent phosphoglycerate mutase
Short name=BPG-independent PGAM
Short name=Phosphoglyceromutase
Short name=iPGM
EC=5.4.2.1

Gene names

Name:	gpmI
Synonyms:	pgm
Ordered Locus Names:	slr1945

Organism

Synechocystis sp. (strain PCC 6803 / Kazusa) [Reference proteome] [HAMAP]

Taxonomic identifier

1111708 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Cyanobacteria › Oscillatoriophycideae › Chroococcales › Synechocystis › Synechocystis sp. PCC 6803

Protein attributes

Sequence length	532 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate By similarity. HAMAP-Rule MF_01038
Catalytic activity	2-phospho-D-glycerate = 3-phospho-D-glycerate. HAMAP-Rule MF_01038
Cofactor	Binds 2 manganese ions per subunit By similarity.
Pathway	Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5. HAMAP-Rule MF_01038
Subunit structure	Monomer By similarity.
Sequence similarities	Belongs to the BPG-independent phosphoglycerate mutase family.

Ontologies

Keywords
Biological process	Glycolysis
Ligand	Manganese Metal-binding
Molecular function	Isomerase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	glycolysis Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular_function	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity Inferred from electronic annotation. Source: HAMAP manganese ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 532	532	2,3-bisphosphoglycerate-independent phosphoglycerate mutase HAMAP-Rule MF_01038		PRO_0000212222
Sites
	Active site	65	1	Phosphoserine intermediate By similarity
	Metal binding	15	1	Manganese 2 By similarity
	Metal binding	65	1	Manganese 2 By similarity
	Metal binding	398	1	Manganese 1 By similarity
	Metal binding	402	1	Manganese 1 By similarity
	Metal binding	439	1	Manganese 2 By similarity
	Metal binding	440	1	Manganese 2 By similarity
	Metal binding	457	1	Manganese 1 By similarity

Sequences

	Sequence		Length	Mass (Da)
	P74507 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: 936D8E4E5256C6C0	FASTA	532	57,982
	10 20 30 40 50 60 MAEAPIAPVV LVILDGWGYR PDTRANAIAQ ANTPIMDSLI AAYPNTLVNT SGKDVGLPKG 70 80 90 100 110 120 QMGNSEVGHL NLGAGRVVPQ ELVRISDAIE DGTFFDNQAL IEVCQRVRDR RGKLHLIGLC 130 140 150 160 170 180 SDGGVHSHID HLLGLIDLAK LQGISQLCIH AITDGRDTPT NEGAHFVQQI QAHLEKIGLG 190 200 210 220 230 240 RIVSVSGRYY ALDRDRRWDR VEKAYRVMTE DGVGDGRSAA QVIKDYYASD ITDEFIPPTR 250 260 270 280 290 300 IGAGAIASGD GVIFYNFRPD RARQLCYALV NPSFDGFPRE RIQPLDFVTF TQYDPALPVV 310 320 330 340 350 360 VAFEPQNLNN ILGEIISRQG MKQFRTAETE KYPHVTYFFN GGLEQPFAGE DRELIQSPMV 370 380 390 400 410 420 STYDKAPQMS AKAVTDAVCR AMEKGIYSLV VVNYANPDMV GHTGKLKEAI QAIETVDLNL 430 440 450 460 470 480 GRLLASAAKV GGTVLITADH GNAEYMSDES GNPWTAHTTN PVPFILVEGE GRKIPGHGGE 490 500 510 520 530 VKLREGGKLA DIAPTILDIL QLPVPAEMTG KTLIDQPLVE IKANRTPVNL SR

References

[1]

"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions." Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S. DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PCC 6803 / Kazusa.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000022 Genomic DNA. Translation: BAA18611.1.
PIR	S76482.
RefSeq	NP_441933.1. NC_000911.1. YP_005651993.1. NC_017277.1. YP_007451813.1. NC_020286.1.
3D structure databases
ProteinModelPortal	P74507.
ModBase	Search...
Protein-protein interaction databases
IntAct	P74507. 1 interaction.
STRING	1148.slr1945.
Proteomic databases
PaxDb	P74507.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAA18611; BAA18611; BAA18611.
GeneID	12254653. 14617481. 955019.
KEGG	syn:slr1945. syy:SYNGTS_2040.
PATRIC	23841414. VBISynSp132158_2256.
Phylogenomic databases
eggNOG	COG0696.
HOGENOM	HOG000223664.
KO	K15633.
OMA	NAEQMTD.
ProtClustDB	PRK05434.
Enzyme and pathway databases
UniPathway	UPA00109; UER00186.
Family and domain databases
Gene3D	3.40.1450.10. 1 hit. 3.40.720.10. 2 hits.
HAMAP	MF_01038. GpmI.
InterPro	IPR017849. Alkaline_Pase-like_a/b/a. IPR017850. Alkaline_phosphatase_core. IPR011258. BPG-indep_PGM_N. IPR006124. Metalloenzyme. IPR005995. Pgm_bpd_ind. [Graphical view]
Pfam	PF06415. iPGM_N. 1 hit. PF01676. Metalloenzyme. 1 hit. [Graphical view]
PIRSF	PIRSF001492. IPGAM. 1 hit.
SUPFAM	SSF53649. Alkaline_phosphatase_core. 1 hit. SSF64158. BPG-indep_PGM_N. 1 hit.
TIGRFAMs	TIGR01307. pgm_bpd_ind. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GPMI_SYNY3

Accession

Primary (citable) accession number: P74507

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	February 1, 1997
Last modified:	May 1, 2013
This is version 93 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program