Reviewed, UniProtKB/Swiss-Prot P74497 (MTNA_SYNY3)

Names and origin

Protein names

Recommended name:
    Methylthioribose-1-phosphate isomerase
      Short name=MTR-1-P isomerase
      Short name=M1Pi
    EC=5.3.1.23
Alternative name(s):
    S-methyl-5-thioribose-1-phosphate isomerase

Gene names

Name:	mtnA
Ordered Locus Names:	slr1938

Organism

Synechocystis sp. (strain PCC 6803) [Complete proteome] [HAMAP]

Taxonomic identifier

1148 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Synechocystis

Protein attributes

Sequence length	351 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) By similarity.
Catalytic activity	S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate. HAMAP MF_01678
Pathway	Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from (S)-methyl-5-thio-alpha-D-ribose 1-phosphate: step 1/6. HAMAP MF_01678
Sequence similarities	Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Methionine biosynthesis
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	methionine biosynthetic process from S-adenosylmethionine Inferred from electronic annotation. Source: HAMAP
Molecular function	S-methyl-5-thioribose-1-phosphate isomerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 351	351	Methylthioribose-1-phosphate isomerase HAMAP MF_01678		PRO_0000156093
Regions
	Region	53 – 55	3	Substrate binding By similarity
	Region	256 – 257	2	Substrate binding By similarity
Sites
	Active site	246	1	Proton donor By similarity
	Binding site	96	1	Substrate By similarity
	Binding site	205	1	Substrate By similarity
	Site	166	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	P74497-1 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: 8EF513650BE5A3C3	FASTA	351	38,282
	10 20 30 40 50 60 MTQSTNFDDV YPVQWRDDQV ILIDQTRLPL EYKEVAIADY EAMGHAIKSM VVRGAPAIGV 70 80 90 100 110 120 AAAYGMYLGA RRIQTTELRE FVVQLEFVAD QLRQTRPTAV NLFWAIDQML NVAYHSGENV 130 140 150 160 170 180 EQIKANLLSQ AQQIQLDDLR TCQAIGAAGL EVLPREPHQL TILTHCNAGA LATAGYGTAI 190 200 210 220 230 240 GVIRAAWSAG RLARVYADET RPRLQGAKLT VWECVQAGIP VTLITDNMAA HCMQQQRIDA 250 260 270 280 290 300 VVVGADRIAR NGDIANKIGT YGLAVLAKMH AIPFFVAAPL STVDFALDDG SQIPIEERDP 310 320 330 340 350 VEIYQPEGNR ITPEGAEFYN PAFDVTPASL ITAIITEQGA IAPEKLADLQ A

References

[1]

"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions." Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S. DNA Res. 3:109-136(1996) [PubMed: 8905231] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000022 Genomic DNA. Translation: BAA18601.1.
PIR	S76472.
RefSeq	NP_441923.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	P74497. 2 interactions.
Genome annotation databases
GeneID	953317.
GenomeReviews	Gene locus slr1938 in contig BA000022_GR.
KEGG	syn:slr1938.
NMPDR	fig|1148.1.peg.2024.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P74497.
OMA	P74497. NAGWLAT.
Enzyme and pathway databases
BioCyc	SSP1148:SLR1938-MON.
Family and domain databases
HAMAP	MF_01678. [Tree]
InterPro	IPR000649. IF-2B_related. IPR005251. IF-2BI_MTNA. IPR011559. Initiation_fac_2B_a/b/d. [Graphical view]
PANTHER	PTHR10233. IF-2B_related. 1 hit.
Pfam	PF01008. IF-2B. 1 hit. [Graphical view]
TIGRFAMs	TIGR00524. eIF-2B_rel. 1 hit. TIGR00512. salvage_mtnA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MTNA_SYNY3

Accession

Primary (citable) accession number: P74497

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	February 1, 1997
Last modified:	June 16, 2009
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)