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P74467 (CLPP3_SYNY3) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable ATP-dependent Clp protease proteolytic subunit 3

EC=3.4.21.92
Alternative name(s):
Endopeptidase Clp 3
Gene names
Name:clpP3
Ordered Locus Names:slr0165
OrganismSynechocystis sp. (strain PCC 6803 / Kazusa) [Reference proteome] [HAMAP]
Taxonomic identifier1111708 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis

Protein attributes

Sequence length202 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins By similarity. HAMAP-Rule MF_00444

Catalytic activity

Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec; and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs). HAMAP-Rule MF_00444

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00444.

Sequence similarities

Belongs to the peptidase S14 family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionHydrolase
Protease
Serine protease
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processproteolysis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

serine-type endopeptidase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 202202Probable ATP-dependent Clp protease proteolytic subunit 3 HAMAP-Rule MF_00444
PRO_0000179696

Sites

Active site1011 By similarity
Active site1261 By similarity

Sequences

Sequence LengthMass (Da)Tools
P74467 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: AAC31B70F5ACBAC8

FASTA20222,397
        10         20         30         40         50         60 
MPIGVPSVPF RLPGSQYERW IDIYTRLSQE RIIFLGQEVN DSIANRIVAF LLYLDSDDPS 

        70         80         90        100        110        120 
KPIYLYINSP GGSVTAGMAI YDTMQYIKAE VITICVGLAA SMGAFLLASG APGKRLALPH 

       130        140        150        160        170        180 
ARIMIHQPMG GTGRRQATDI DIEAREILRI RQQLNEIMAQ RTGQTVEKIA KDTDRDYFLS 

       190        200 
AAEAKEYGLI DKVIENSTMG NN 

« Hide

References

[1]"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. expand/collapse author list , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PCC 6803 / Kazusa.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000022 Genomic DNA. Translation: BAA18568.1.
PIRS76439.
RefSeqNP_441890.1. NC_000911.1.
YP_005651949.1. NC_017277.1.
YP_007451770.1. NC_020286.1.

3D structure databases

ProteinModelPortalP74467.
SMRP74467. Positions 15-194.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP74467. 3 interactions.
STRING1148.slr0165.

Protein family/group databases

MEROPSS14.001.

Proteomic databases

PaxDbP74467.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAA18568; BAA18568; BAA18568.
GeneID12254608.
14617437.
954955.
KEGGsyn:slr0165.
syy:SYNGTS_1996.
syz:MYO_120150.
PATRIC23841315. VBISynSp132158_2207.

Phylogenomic databases

eggNOGCOG0740.
HOGENOMHOG000285833.
KOK01358.
OMADSTKPIY.
OrthoDBEOG6Z3KQ0.
PhylomeDBP74467.
ProtClustDBPRK00277.

Family and domain databases

HAMAPMF_00444. ClpP.
InterProIPR001907. ClpP.
IPR023562. ClpP/TepA.
IPR018215. ClpP_AS.
[Graphical view]
PANTHERPTHR10381. PTHR10381. 1 hit.
PfamPF00574. CLP_protease. 1 hit.
[Graphical view]
PRINTSPR00127. CLPPROTEASEP.
PROSITEPS00382. CLP_PROTEASE_HIS. 1 hit.
PS00381. CLP_PROTEASE_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCLPP3_SYNY3
AccessionPrimary (citable) accession number: P74467
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: April 16, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Synechocystis PCC 6803

Synechocystis (strain PCC 6803): entries and gene names

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries