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Protein

Probable ATP-dependent Clp protease proteolytic subunit 3

Gene

clpP3

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.UniRule annotation

Catalytic activityi

Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec; and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei101 – 1011NucleophileUniRule annotation
Active sitei126 – 1261UniRule annotation

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS14.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ATP-dependent Clp protease proteolytic subunit 3 (EC:3.4.21.92UniRule annotation)
Alternative name(s):
Endopeptidase Clp 3UniRule annotation
Gene namesi
Name:clpP3UniRule annotation
Ordered Locus Names:slr0165
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
ProteomesiUP000001425: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 202202Probable ATP-dependent Clp protease proteolytic subunit 3PRO_0000179696Add
BLAST

Proteomic databases

PaxDbiP74467.

Interactioni

Subunit structurei

Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.UniRule annotation

Protein-protein interaction databases

IntActiP74467. 3 interactions.
STRINGi1148.slr0165.

Structurei

3D structure databases

ProteinModelPortaliP74467.
SMRiP74467. Positions 15-194.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S14 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0740.
HOGENOMiHOG000285833.
InParanoidiP74467.
KOiK01358.
OMAiQTLCMGL.
OrthoDBiEOG6Z3KQ0.
PhylomeDBiP74467.

Family and domain databases

Gene3Di3.90.226.10. 1 hit.
HAMAPiMF_00444. ClpP.
InterProiIPR001907. ClpP.
IPR029045. ClpP/crotonase-like_dom.
IPR023562. ClpP/TepA.
IPR018215. ClpP_AS.
[Graphical view]
PANTHERiPTHR10381. PTHR10381. 1 hit.
PfamiPF00574. CLP_protease. 1 hit.
[Graphical view]
PRINTSiPR00127. CLPPROTEASEP.
SUPFAMiSSF52096. SSF52096. 1 hit.
PROSITEiPS00382. CLP_PROTEASE_HIS. 1 hit.
PS00381. CLP_PROTEASE_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P74467-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPIGVPSVPF RLPGSQYERW IDIYTRLSQE RIIFLGQEVN DSIANRIVAF
60 70 80 90 100
LLYLDSDDPS KPIYLYINSP GGSVTAGMAI YDTMQYIKAE VITICVGLAA
110 120 130 140 150
SMGAFLLASG APGKRLALPH ARIMIHQPMG GTGRRQATDI DIEAREILRI
160 170 180 190 200
RQQLNEIMAQ RTGQTVEKIA KDTDRDYFLS AAEAKEYGLI DKVIENSTMG

NN
Length:202
Mass (Da):22,397
Last modified:February 1, 1997 - v1
Checksum:iAAC31B70F5ACBAC8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA18568.1.
PIRiS76439.
RefSeqiNP_441890.1. NC_000911.1.
YP_005651949.1. NC_017277.1.
YP_007451770.1. NC_020286.1.

Genome annotation databases

EnsemblBacteriaiBAA18568; BAA18568; BAA18568.
GeneIDi954955.
KEGGisyn:slr0165.
PATRICi23841315. VBISynSp132158_2207.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA18568.1.
PIRiS76439.
RefSeqiNP_441890.1. NC_000911.1.
YP_005651949.1. NC_017277.1.
YP_007451770.1. NC_020286.1.

3D structure databases

ProteinModelPortaliP74467.
SMRiP74467. Positions 15-194.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP74467. 3 interactions.
STRINGi1148.slr0165.

Protein family/group databases

MEROPSiS14.001.

Proteomic databases

PaxDbiP74467.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA18568; BAA18568; BAA18568.
GeneIDi954955.
KEGGisyn:slr0165.
PATRICi23841315. VBISynSp132158_2207.

Phylogenomic databases

eggNOGiCOG0740.
HOGENOMiHOG000285833.
InParanoidiP74467.
KOiK01358.
OMAiQTLCMGL.
OrthoDBiEOG6Z3KQ0.
PhylomeDBiP74467.

Family and domain databases

Gene3Di3.90.226.10. 1 hit.
HAMAPiMF_00444. ClpP.
InterProiIPR001907. ClpP.
IPR029045. ClpP/crotonase-like_dom.
IPR023562. ClpP/TepA.
IPR018215. ClpP_AS.
[Graphical view]
PANTHERiPTHR10381. PTHR10381. 1 hit.
PfamiPF00574. CLP_protease. 1 hit.
[Graphical view]
PRINTSiPR00127. CLPPROTEASEP.
SUPFAMiSSF52096. SSF52096. 1 hit.
PROSITEiPS00382. CLP_PROTEASE_HIS. 1 hit.
PS00381. CLP_PROTEASE_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
    Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
    , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 6803 / Kazusa.

Entry informationi

Entry nameiCLPP3_SYNY3
AccessioniPrimary (citable) accession number: P74467
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: January 7, 2015
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.