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P74467

- CLPP3_SYNY3

UniProt

P74467 - CLPP3_SYNY3

Protein

Probable ATP-dependent Clp protease proteolytic subunit 3

Gene

clpP3

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.UniRule annotation

    Catalytic activityi

    Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec; and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei101 – 1011NucleophileUniRule annotation
    Active sitei126 – 1261UniRule annotation

    GO - Molecular functioni

    1. serine-type endopeptidase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Protein family/group databases

    MEROPSiS14.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable ATP-dependent Clp protease proteolytic subunit 3 (EC:3.4.21.92UniRule annotation)
    Alternative name(s):
    Endopeptidase Clp 3UniRule annotation
    Gene namesi
    Name:clpP3UniRule annotation
    Ordered Locus Names:slr0165
    OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
    Taxonomic identifieri1111708 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
    ProteomesiUP000001425: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 202202Probable ATP-dependent Clp protease proteolytic subunit 3PRO_0000179696Add
    BLAST

    Proteomic databases

    PaxDbiP74467.

    Interactioni

    Subunit structurei

    Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.UniRule annotation

    Protein-protein interaction databases

    IntActiP74467. 3 interactions.
    STRINGi1148.slr0165.

    Structurei

    3D structure databases

    ProteinModelPortaliP74467.
    SMRiP74467. Positions 15-194.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S14 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0740.
    HOGENOMiHOG000285833.
    KOiK01358.
    OMAiGTQGKRL.
    OrthoDBiEOG6Z3KQ0.
    PhylomeDBiP74467.

    Family and domain databases

    Gene3Di3.90.226.10. 1 hit.
    HAMAPiMF_00444. ClpP.
    InterProiIPR001907. ClpP.
    IPR029045. ClpP/crotonase-like_dom.
    IPR023562. ClpP/TepA.
    IPR018215. ClpP_AS.
    [Graphical view]
    PANTHERiPTHR10381. PTHR10381. 1 hit.
    PfamiPF00574. CLP_protease. 1 hit.
    [Graphical view]
    PRINTSiPR00127. CLPPROTEASEP.
    SUPFAMiSSF52096. SSF52096. 1 hit.
    PROSITEiPS00382. CLP_PROTEASE_HIS. 1 hit.
    PS00381. CLP_PROTEASE_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P74467-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPIGVPSVPF RLPGSQYERW IDIYTRLSQE RIIFLGQEVN DSIANRIVAF    50
    LLYLDSDDPS KPIYLYINSP GGSVTAGMAI YDTMQYIKAE VITICVGLAA 100
    SMGAFLLASG APGKRLALPH ARIMIHQPMG GTGRRQATDI DIEAREILRI 150
    RQQLNEIMAQ RTGQTVEKIA KDTDRDYFLS AAEAKEYGLI DKVIENSTMG 200
    NN 202
    Length:202
    Mass (Da):22,397
    Last modified:February 1, 1997 - v1
    Checksum:iAAC31B70F5ACBAC8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000022 Genomic DNA. Translation: BAA18568.1.
    PIRiS76439.
    RefSeqiNP_441890.1. NC_000911.1.
    YP_005651949.1. NC_017277.1.
    YP_007451770.1. NC_020286.1.

    Genome annotation databases

    EnsemblBacteriaiBAA18568; BAA18568; BAA18568.
    GeneIDi954955.
    KEGGisyn:slr0165.
    syy:SYNGTS_1996.
    syz:MYO_120150.
    PATRICi23841315. VBISynSp132158_2207.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000022 Genomic DNA. Translation: BAA18568.1 .
    PIRi S76439.
    RefSeqi NP_441890.1. NC_000911.1.
    YP_005651949.1. NC_017277.1.
    YP_007451770.1. NC_020286.1.

    3D structure databases

    ProteinModelPortali P74467.
    SMRi P74467. Positions 15-194.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P74467. 3 interactions.
    STRINGi 1148.slr0165.

    Protein family/group databases

    MEROPSi S14.001.

    Proteomic databases

    PaxDbi P74467.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAA18568 ; BAA18568 ; BAA18568 .
    GeneIDi 954955.
    KEGGi syn:slr0165.
    syy:SYNGTS_1996.
    syz:MYO_120150.
    PATRICi 23841315. VBISynSp132158_2207.

    Phylogenomic databases

    eggNOGi COG0740.
    HOGENOMi HOG000285833.
    KOi K01358.
    OMAi GTQGKRL.
    OrthoDBi EOG6Z3KQ0.
    PhylomeDBi P74467.

    Family and domain databases

    Gene3Di 3.90.226.10. 1 hit.
    HAMAPi MF_00444. ClpP.
    InterProi IPR001907. ClpP.
    IPR029045. ClpP/crotonase-like_dom.
    IPR023562. ClpP/TepA.
    IPR018215. ClpP_AS.
    [Graphical view ]
    PANTHERi PTHR10381. PTHR10381. 1 hit.
    Pfami PF00574. CLP_protease. 1 hit.
    [Graphical view ]
    PRINTSi PR00127. CLPPROTEASEP.
    SUPFAMi SSF52096. SSF52096. 1 hit.
    PROSITEi PS00382. CLP_PROTEASE_HIS. 1 hit.
    PS00381. CLP_PROTEASE_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
      Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
      , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
      DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 6803 / Kazusa.

    Entry informationi

    Entry nameiCLPP3_SYNY3
    AccessioniPrimary (citable) accession number: P74467
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families
    3. Synechocystis PCC 6803
      Synechocystis (strain PCC 6803): entries and gene names

    External Data

    Dasty 3