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Protein

Probable ATP-dependent Clp protease proteolytic subunit 3

Gene

clpP3

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.UniRule annotation

Catalytic activityi

Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec; and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei101NucleophileUniRule annotation1
Active sitei126UniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS14.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ATP-dependent Clp protease proteolytic subunit 3 (EC:3.4.21.92UniRule annotation)
Alternative name(s):
Endopeptidase Clp 3UniRule annotation
Gene namesi
Name:clpP3UniRule annotation
Ordered Locus Names:slr0165
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesMerismopediaceaeSynechocystis
Proteomesi
  • UP000001425 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001796961 – 202Probable ATP-dependent Clp protease proteolytic subunit 3Add BLAST202

Interactioni

Subunit structurei

Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.UniRule annotation

Protein-protein interaction databases

IntActiP74467. 3 interactors.
STRINGi1148.SYNGTS_1996.

Structurei

3D structure databases

ProteinModelPortaliP74467.
SMRiP74467.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S14 family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000285833.
InParanoidiP74467.
KOiK01358.
OMAiYERWIDI.
PhylomeDBiP74467.

Family and domain databases

CDDicd07017. S14_ClpP_2. 1 hit.
HAMAPiMF_00444. ClpP. 1 hit.
InterProiView protein in InterPro
IPR001907. ClpP.
IPR029045. ClpP/crotonase-like_dom.
IPR023562. ClpP/TepA.
IPR033135. ClpP_His_AS.
IPR018215. ClpP_Ser_AS.
PANTHERiPTHR10381. PTHR10381. 1 hit.
PfamiView protein in Pfam
PF00574. CLP_protease. 1 hit.
PRINTSiPR00127. CLPPROTEASEP.
SUPFAMiSSF52096. SSF52096. 1 hit.
PROSITEiView protein in PROSITE
PS00382. CLP_PROTEASE_HIS. 1 hit.
PS00381. CLP_PROTEASE_SER. 1 hit.

Sequencei

Sequence statusi: Complete.

P74467-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPIGVPSVPF RLPGSQYERW IDIYTRLSQE RIIFLGQEVN DSIANRIVAF
60 70 80 90 100
LLYLDSDDPS KPIYLYINSP GGSVTAGMAI YDTMQYIKAE VITICVGLAA
110 120 130 140 150
SMGAFLLASG APGKRLALPH ARIMIHQPMG GTGRRQATDI DIEAREILRI
160 170 180 190 200
RQQLNEIMAQ RTGQTVEKIA KDTDRDYFLS AAEAKEYGLI DKVIENSTMG

NN
Length:202
Mass (Da):22,397
Last modified:February 1, 1997 - v1
Checksum:iAAC31B70F5ACBAC8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA18568.1.
PIRiS76439.

Genome annotation databases

EnsemblBacteriaiBAA18568; BAA18568; BAA18568.
KEGGisyn:slr0165.

Similar proteinsi

Entry informationi

Entry nameiCLPP3_SYNY3
AccessioniPrimary (citable) accession number: P74467
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: August 30, 2017
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names