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P74416 (GCSP_SYNY3) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:slr0293
OrganismSynechocystis sp. (strain PCC 6803 / Kazusa) [Reference proteome] [HAMAP]
Taxonomic identifier1111708 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis

Protein attributes

Sequence length983 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 983983Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_0000166942

Amino acid modifications

Modified residue7261N6-(pyridoxal phosphate)lysine By similarity

Secondary structure

............................................................................................................................................................................. 983
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P74416 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: 4009367B62A2936F

FASTA983107,322
        10         20         30         40         50         60 
MPNLEPAVVV PTSEAIAVDL TKLEEKLAPA DSFLDRHLGP GETEQRQMLQ TLGFDTLGDL 

        70         80         90        100        110        120 
IDQAVPPAIR FPRSLQLPAS QSEYGAIAQL KSIASKNQVF RSYIGMGYYD TITPPVIQRN 

       130        140        150        160        170        180 
ILENPGWYTA YTPYQAEIAQ GRLEALLNFQ TMVMDLTGLE IANASLLDEG TAAAEAMALS 

       190        200        210        220        230        240 
YGVSKSKANA FFVAQDCHPQ TIEVIKTRAN PLGIEVIVGD HHTFSFSTSI FGALLQYPAT 

       250        260        270        280        290        300 
DGAVYDYRSF IDKAHQHQAL VTLAADPLSL TLLTPPGELG ADIAVGSTQR FGIPLGYGGP 

       310        320        330        340        350        360 
HAAYFATKAE YQRKMPGRIV GVSKDAHGNP ALRLALQTRE QHIRRDKATS NICTAQVLLA 

       370        380        390        400        410        420 
VMASMYGVYH GSTGLKNIAL RIHQLTVLLA IGLKRLNYSL NNDYFFDTLR VGVGEQSAPA 

       430        440        450        460        470        480 
ILKAAEGRGI NLRPLVPGEV GISLDETVTV QDLLDLWQVF AGKDNLPFTP EELWSEVKTS 

       490        500        510        520        530        540 
FPADLTRQSL YLQDAVFNQY HSETELLRYL HQLESKDLAL NTSMIPLGSC TMKLNATAEM 

       550        560        570        580        590        600 
MPVTWPEFGK IHPFAPAGQT EGYQILFAQL EAWLGEITGF DAISLQPNAG SQGEYAGLQV 

       610        620        630        640        650        660 
IRQYHLSRGE EQRNICLIPE SAHGTNPASA VMCGMQVVPV KCDGEGNIDV EDLTSKAEKY 

       670        680        690        700        710        720 
GDRLAALMVT YPSTHGVFEA TIGTICDIVH RFGGEVYMDG ANMNAQVGLC RPADFGADVC 

       730        740        750        760        770        780 
HLNLHKTFCI PHGGGGPGMG PIGVKSHLQA FLPRTSLNST AELQAEDQSI GMISAAPYGS 

       790        800        810        820        830        840 
ASILVISWMY IAMMGPQGLT KATEVAILSA NYMAKRLENY YPILFRGNNE LVAHECILDL 

       850        860        870        880        890        900 
RPLKKQAAIE VEDVAKRLMD FGFHAPTVSW PVLGTMMVEP TESESLGELD RFCDAMIAIY 

       910        920        930        940        950        960 
QEAQAITHGE IDPADNPLKN APHTAQSLIC GEWNHPYSQE EAAYPAPWTK QFKFWPAVGR 

       970        980 
INNTYGDRHL VCSCEGMEAY KEG 

« Hide

References

[1]"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. expand/collapse author list , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PCC 6803 / Kazusa.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000022 Genomic DNA. Translation: BAA18516.1.
PIRS76257.
RefSeqNP_441838.1. NC_000911.1.
YP_005651898.1. NC_017277.1.
YP_007451719.1. NC_020286.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4LGLX-ray2.00A/B1-983[»]
4LHCX-ray1.90A/B1-983[»]
4LHDX-ray1.80A/B1-983[»]
ProteinModelPortalP74416.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP74416. 2 interactions.
STRING1148.slr0293.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAA18516; BAA18516; BAA18516.
GeneID952059.
KEGGsyn:slr0293.
syy:SYNGTS_1945.
syz:MYO_119630.
PATRIC23841192. VBISynSp132158_2147.

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAFDSRPYS.
OrthoDBEOG6HMXDX.
PhylomeDBP74416.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_SYNY3
AccessionPrimary (citable) accession number: P74416
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: February 1, 1997
Last modified: July 9, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Synechocystis PCC 6803

Synechocystis (strain PCC 6803): entries and gene names

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references