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P74368

- RNC1_SYNY3

UniProt

P74368 - RNC1_SYNY3

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Protein

Ribonuclease 3 1

Gene

rnc1

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage to 5'-phosphomonoester.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi38 – 381MagnesiumUniRule annotation
Active sitei42 – 421UniRule annotation
Metal bindingi111 – 1111MagnesiumUniRule annotation
Active sitei114 – 1141UniRule annotation
Metal bindingi114 – 1141MagnesiumUniRule annotation

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. ribonuclease III activity Source: UniProtKB-HAMAP
  3. rRNA binding Source: UniProtKB-KW

GO - Biological processi

  1. mRNA processing Source: UniProtKB-HAMAP
  2. rRNA catabolic process Source: InterPro
  3. rRNA processing Source: UniProtKB-HAMAP
  4. tRNA processing Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Biological processi

mRNA processing, rRNA processing, tRNA processing

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding, rRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease 3 1UniRule annotation (EC:3.1.26.3UniRule annotation)
Alternative name(s):
Ribonuclease III 1UniRule annotation
Short name:
RNase III 1UniRule annotation
Gene namesi
Name:rnc1UniRule annotation
Ordered Locus Names:slr1646
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
ProteomesiUP000001425: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 231231Ribonuclease 3 1PRO_0000180447Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

IntActiP74368. 1 interaction.
STRINGi1148.slr1646.

Structurei

3D structure databases

ProteinModelPortaliP74368.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 125125RNase IIIUniRule annotationAdd
BLAST
Domaini160 – 22970DRBMUniRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 DRBM (double-stranded RNA-binding) domain.UniRule annotation
Contains 1 RNase III domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG0571.
HOGENOMiHOG000246808.
InParanoidiP74368.
KOiK03685.
OMAiEVECEER.
OrthoDBiEOG6T1WVS.
PhylomeDBiP74368.

Family and domain databases

Gene3Di1.10.1520.10. 1 hit.
3.30.160.20. 1 hit.
HAMAPiMF_00104. RNase_III.
InterProiIPR014720. dsRNA-bd_dom.
IPR011907. RNase_III.
IPR000999. RNase_III_dom.
[Graphical view]
PANTHERiPTHR11207. PTHR11207. 1 hit.
PfamiPF00035. dsrm. 1 hit.
PF00636. Ribonuclease_3. 1 hit.
[Graphical view]
SMARTiSM00358. DSRM. 1 hit.
SM00535. RIBOc. 1 hit.
[Graphical view]
SUPFAMiSSF69065. SSF69065. 1 hit.
TIGRFAMsiTIGR02191. RNaseIII. 1 hit.
PROSITEiPS50137. DS_RBD. 1 hit.
PS00517. RNASE_3_1. 1 hit.
PS50142. RNASE_3_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P74368-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNHPDFPPIG DPQLKLEALT HRSYCNEHPG TPSYDRLEFL GDAVLGFVVG
60 70 80 90 100
RILFERYPHF TEAELTRLRS QLVNQNQLAY LARFLHIAPE IRLSQSLARD
110 120 130 140 150
DGQSSPSILA DVFESLLGAA LLDRGLTAVE DFIQELFVPI LEQWEKSQDG
160 170 180 190 200
RSPKLVPTMD VKSMLQQWAL AKTKQLPEYE LINTSGPPHA QEFTFTVKVA
210 220 230
GKIHGQGSGP SKQIATKQAA LEALKSLGLL Q
Length:231
Mass (Da):25,712
Last modified:February 1, 1997 - v1
Checksum:i7638BC25E6B46D60
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA18463.1.
PIRiS76204.
RefSeqiNP_441783.1. NC_000911.1.
YP_005651842.1. NC_017277.1.
YP_007451664.1. NC_020286.1.

Genome annotation databases

EnsemblBacteriaiBAA18463; BAA18463; BAA18463.
GeneIDi952928.
KEGGisyn:slr1646.
PATRICi23841052. VBISynSp132158_2079.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA18463.1 .
PIRi S76204.
RefSeqi NP_441783.1. NC_000911.1.
YP_005651842.1. NC_017277.1.
YP_007451664.1. NC_020286.1.

3D structure databases

ProteinModelPortali P74368.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P74368. 1 interaction.
STRINGi 1148.slr1646.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAA18463 ; BAA18463 ; BAA18463 .
GeneIDi 952928.
KEGGi syn:slr1646.
PATRICi 23841052. VBISynSp132158_2079.

Phylogenomic databases

eggNOGi COG0571.
HOGENOMi HOG000246808.
InParanoidi P74368.
KOi K03685.
OMAi EVECEER.
OrthoDBi EOG6T1WVS.
PhylomeDBi P74368.

Family and domain databases

Gene3Di 1.10.1520.10. 1 hit.
3.30.160.20. 1 hit.
HAMAPi MF_00104. RNase_III.
InterProi IPR014720. dsRNA-bd_dom.
IPR011907. RNase_III.
IPR000999. RNase_III_dom.
[Graphical view ]
PANTHERi PTHR11207. PTHR11207. 1 hit.
Pfami PF00035. dsrm. 1 hit.
PF00636. Ribonuclease_3. 1 hit.
[Graphical view ]
SMARTi SM00358. DSRM. 1 hit.
SM00535. RIBOc. 1 hit.
[Graphical view ]
SUPFAMi SSF69065. SSF69065. 1 hit.
TIGRFAMsi TIGR02191. RNaseIII. 1 hit.
PROSITEi PS50137. DS_RBD. 1 hit.
PS00517. RNASE_3_1. 1 hit.
PS50142. RNASE_3_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
    Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
    , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 6803 / Kazusa.

Entry informationi

Entry nameiRNC1_SYNY3
AccessioniPrimary (citable) accession number: P74368
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: November 26, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

External Data

Dasty 3