P74309 (ALF1_SYNY3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Fructose-bisphosphate aldolase class 1
EC=4.1.2.13

Alternative name(s):
Fructose-biphosphate aldolase class I
Short name=FBP aldolase

Gene names

Name:	fda
Synonyms:	fbaB
Ordered Locus Names:	slr0943

Organism

Synechocystis sp. (strain PCC 6803 / Kazusa)

Taxonomic identifier

1111708 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Synechocystis

Protein attributes

Sequence length	300 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate. HAMAP MF_00729
Pathway	Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4. HAMAP MF_00729
Sequence similarities	Belongs to the class I fructose-bisphosphate aldolase family.

Ontologies

Keywords
Biological process	Glycolysis
Ligand	Schiff base
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	fructose-bisphosphate aldolase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 300	300	Fructose-bisphosphate aldolase class 1 HAMAP MF_00729		PRO_0000216913
Sites
	Active site	181	1	Proton acceptor By similarity
	Active site	218	1	Schiff-base intermediate with dihydroxyacetone-P By similarity

Sequences

	Sequence		Length	Mass (Da)
	P74309 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: EDAE4D24F58FE667	FASTA	300	33,149
	10 20 30 40 50 60 MMTLEPNQEQ LKKMKSHPGF IAALDQSGGS TPGALADYGI EPNTYSGDDQ MFALVHQMRT 70 80 90 100 110 120 RIMTSPGFTG DRILAAILFE DTMNREVDGE PTANYLWQNK QIVPILKVDK GLAQEKDGSQ 130 140 150 160 170 180 LMKPIPQLDS LLMKAKKKGI FGTKMRSFIK HANPAGIEAI VDQQFELAQQ IIAAGLVPII 190 200 210 220 230 240 EPEVDIHCSE KAQAEALLKQ AMLKHLNQLP KGQWVMLKLT LPEQDNLYSN CIEHANVLRV 250 260 270 280 290 300 VALSGGYSQA EANERLSRNH GVIASFSRAL TEGLTAQQTD AEFNTMLDES IEKIYQASIT

References

[1]

"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions." Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S. DNA Res. 3:109-136(1996) [PubMed: 8905231] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 27184 / PCC 6803 / N-1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000022 Genomic DNA. Translation: BAA18403.1.
PIR	S76144.
RefSeq	NP_441723.1. NC_000911.1.
3D structure databases
ProteinModelPortal	P74309.
SMR	P74309. Positions 6-300.
ModBase	Search...
Protein-protein interaction databases
IntAct	P74309. 1 interaction.
STRING	P74309.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	952985.
GenomeReviews	Gene locus slr0943 in contig BA000022_GR.
KEGG	syn:slr0943.
NMPDR	fig|1148.1.peg.1824.
PATRIC	23840928. VBISynSp132158_2018.
Phylogenomic databases
eggNOG	COG3588.
HOGENOM	HBG307137.
OMA	GTKMRSV.
PhylomeDB	P74309.
ProtClustDB	PRK05377.
Enzyme and pathway databases
BioCyc	SSP1148:SLR0943-MONOMER.
Family and domain databases
HAMAP	MF_00729. FBP_aldolase_1. [Tree]
InterPro	IPR000741. Aldolase_I. IPR013785. Aldolase_TIM. IPR023014. FBP_aldolase_I_bac. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01623.
Pfam	PF00274. Glycolytic. 1 hit. [Graphical view]
PROSITE	PS00158. ALDOLASE_CLASS_I. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ALF1_SYNY3

Accession

Primary (citable) accession number: P74309

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	February 1, 1997
Last modified:	January 25, 2012
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program