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P74309 (ALF1_SYNY3) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Fructose-bisphosphate aldolase class 1

EC=4.1.2.13
Alternative name(s):
Fructose-bisphosphate aldolase class I
Short name=FBP aldolase
Gene names
Name:fda
Synonyms:fbaB
Ordered Locus Names:slr0943
OrganismSynechocystis sp. (strain PCC 6803 / Kazusa) [Reference proteome] [HAMAP]
Taxonomic identifier1111708 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis

Protein attributes

Sequence length300 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate. HAMAP-Rule MF_00729

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4. HAMAP-Rule MF_00729

Sequence similarities

Belongs to the class I fructose-bisphosphate aldolase family.

Ontologies

Keywords
   Biological processGlycolysis
   LigandSchiff base
   Molecular functionLyase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processglycolysis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionfructose-bisphosphate aldolase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 300300Fructose-bisphosphate aldolase class 1 HAMAP-Rule MF_00729
PRO_0000216913

Sites

Active site1811Proton acceptor By similarity
Active site2181Schiff-base intermediate with dihydroxyacetone-P By similarity

Sequences

Sequence LengthMass (Da)Tools
P74309 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: EDAE4D24F58FE667

FASTA30033,149
        10         20         30         40         50         60 
MMTLEPNQEQ LKKMKSHPGF IAALDQSGGS TPGALADYGI EPNTYSGDDQ MFALVHQMRT 

        70         80         90        100        110        120 
RIMTSPGFTG DRILAAILFE DTMNREVDGE PTANYLWQNK QIVPILKVDK GLAQEKDGSQ 

       130        140        150        160        170        180 
LMKPIPQLDS LLMKAKKKGI FGTKMRSFIK HANPAGIEAI VDQQFELAQQ IIAAGLVPII 

       190        200        210        220        230        240 
EPEVDIHCSE KAQAEALLKQ AMLKHLNQLP KGQWVMLKLT LPEQDNLYSN CIEHANVLRV 

       250        260        270        280        290        300 
VALSGGYSQA EANERLSRNH GVIASFSRAL TEGLTAQQTD AEFNTMLDES IEKIYQASIT 

« Hide

References

[1]"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. expand/collapse author list , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PCC 6803 / Kazusa.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000022 Genomic DNA. Translation: BAA18403.1.
PIRS76144.
RefSeqNP_441723.1. NC_000911.1.
YP_005651782.1. NC_017277.1.
YP_007451605.1. NC_020286.1.

3D structure databases

ProteinModelPortalP74309.
SMRP74309. Positions 6-300.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP74309. 1 interaction.
STRING1148.slr0943.

Proteomic databases

PaxDbP74309.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAA18403; BAA18403; BAA18403.
GeneID12254437.
14617268.
952985.
KEGGsyn:slr0943.
syy:SYNGTS_1829.
syz:MYO_118460.
PATRIC23840928. VBISynSp132158_2018.

Phylogenomic databases

eggNOGCOG3588.
HOGENOMHOG000073502.
KOK01623.
OMAGTKMRSV.
OrthoDBEOG6M6JJT.
PhylomeDBP74309.
ProtClustDBPRK05377.

Enzyme and pathway databases

SABIO-RKP74309.
UniPathwayUPA00109; UER00183.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_00729. FBP_aldolase_1.
InterProIPR000741. Aldolase_I.
IPR013785. Aldolase_TIM.
IPR023014. FBP_aldolase_I_bac.
[Graphical view]
PfamPF00274. Glycolytic. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameALF1_SYNY3
AccessionPrimary (citable) accession number: P74309
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: February 1, 1997
Last modified: April 16, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Synechocystis PCC 6803

Synechocystis (strain PCC 6803): entries and gene names

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways