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P74297

- SPKB_SYNY3

UniProt

P74297 - SPKB_SYNY3

Protein

Serine/threonine-protein kinase B

Gene

spkB

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Protein kinase required for cell motility, but not for phototaxis.

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei65 – 651ATPPROSITE-ProRule annotation
    Active sitei163 – 1631Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi40 – 489ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein serine/threonine kinase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein kinase B (EC:2.7.11.1)
    Gene namesi
    Name:spkB
    Ordered Locus Names:slr1697
    OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
    Taxonomic identifieri1111708 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
    ProteomesiUP000001425: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 574574Serine/threonine-protein kinase BPRO_0000171240Add
    BLAST

    Post-translational modificationi

    Autophosphorylated.

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiP74297.

    Interactioni

    Protein-protein interaction databases

    IntActiP74297. 4 interactions.
    STRINGi1148.slr1697.

    Structurei

    3D structure databases

    ProteinModelPortaliP74297.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini34 – 301268Protein kinasePROSITE-ProRule annotationAdd
    BLAST
    Domaini454 – 49340Pentapeptide repeat 1Add
    BLAST
    Domaini504 – 54340Pentapeptide repeat 2Add
    BLAST

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
    Contains 2 pentapeptide repeat domains.Curated
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000035219.
    KOiK08884.
    OMAiPRLLDYF.
    OrthoDBiEOG625JT5.
    PhylomeDBiP74297.

    Family and domain databases

    InterProiIPR001646. 5peptide_repeat.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR016252. Ser/Thr_kinase_SpkB.
    [Graphical view]
    PfamiPF00805. Pentapeptide. 2 hits.
    PF00069. Pkinase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000647. Ser/Thr_PK_SpkB. 1 hit.
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P74297-1 [UniParc]FASTAAdd to Basket

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    MSFCVNPNCP HPKNPNNVQV CQACGNSLRL NGRYQTLGLL GKGGFGATFA    50
    AADVALPGTP ICVVKQLRPQ TDDPNVFRMA KELFEREAQT LGRVGNHPQV 100
    PRLLDYFEDD HQFYLVQEYV KGHNLHQEVK KNGTFTEGSV KQFLTEILPI 150
    LDYIHSQKVI HRDIKPANLI RRQTDQKLVL IDFGAVKNQI DSVLSSNTSA 200
    QTALTAFAVG TAGFAPPEQM AMRPVYASDI YATGVTCLYL LTGKTPKEID 250
    CNSQTGEMDW EKHVTVSSKF AEVIRKMLEL SVRHRYKSAQ QVLDALEMPT 300
    YEDGMMQGMV STPFTTLTGA GDEPATGIRM GNSSSPDYGD PSTRFNTNVQ 350
    PRDPSSTSLN TGIKTRTAKP RQSPRDRATS NIESPTTRVR PASNMADGGS 400
    VGAGGIDYNM VNPKPFSRRE EEKQAIANQP ETKRWNGKTF LAEYAQGKRD 450
    FADQNLVGIV LAKAFVPGIN CYQANLTNAN FEQAELTRAD FGKARLKNVI 500
    FKGANLSDAY FGYADLRGAD LRGANLNGVN FKYANLQGAN FSGADLGSAK 550
    VSPEQLKLAK TNWRTVMPGS GRRR 574
    Length:574
    Mass (Da):63,079
    Last modified:February 1, 1997 - v1
    Checksum:iD96B2C5ABEE405A3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB046598 Genomic DNA. Translation: BAB17034.1.
    BA000022 Genomic DNA. Translation: BAA18391.1.
    PIRiS76132.
    RefSeqiNP_441711.1. NC_000911.1.
    YP_005651769.1. NC_017277.1.
    YP_007451593.1. NC_020286.1.

    Genome annotation databases

    EnsemblBacteriaiBAA18391; BAA18391; BAA18391.
    GeneIDi952988.
    KEGGisyn:slr1697.
    syy:SYNGTS_1816.
    syz:MYO_118340.
    PATRICi23840900. VBISynSp132158_2004.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB046598 Genomic DNA. Translation: BAB17034.1 .
    BA000022 Genomic DNA. Translation: BAA18391.1 .
    PIRi S76132.
    RefSeqi NP_441711.1. NC_000911.1.
    YP_005651769.1. NC_017277.1.
    YP_007451593.1. NC_020286.1.

    3D structure databases

    ProteinModelPortali P74297.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P74297. 4 interactions.
    STRINGi 1148.slr1697.

    Proteomic databases

    PaxDbi P74297.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAA18391 ; BAA18391 ; BAA18391 .
    GeneIDi 952988.
    KEGGi syn:slr1697.
    syy:SYNGTS_1816.
    syz:MYO_118340.
    PATRICi 23840900. VBISynSp132158_2004.

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000035219.
    KOi K08884.
    OMAi PRLLDYF.
    OrthoDBi EOG625JT5.
    PhylomeDBi P74297.

    Family and domain databases

    InterProi IPR001646. 5peptide_repeat.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR016252. Ser/Thr_kinase_SpkB.
    [Graphical view ]
    Pfami PF00805. Pentapeptide. 2 hits.
    PF00069. Pkinase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000647. Ser/Thr_PK_SpkB. 1 hit.
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Biochemical and functional characterization of a eukaryotic-type protein kinase, SpkB, in the cyanobacterium, Synechocystis sp. PCC 6803."
      Kamei A., Yoshihara S., Yuasa T., Geng X., Ikeuchi M.
      Curr. Microbiol. 46:296-301(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION.
    2. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
      Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
      , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
      DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 6803 / Kazusa.

    Entry informationi

    Entry nameiSPKB_SYNY3
    AccessioniPrimary (citable) accession number: P74297
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 14, 2001
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Synechocystis PCC 6803
      Synechocystis (strain PCC 6803): entries and gene names

    External Data

    Dasty 3