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P74297

- SPKB_SYNY3

UniProt

P74297 - SPKB_SYNY3

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Protein

Serine/threonine-protein kinase B

Gene

spkB

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Protein kinase required for cell motility, but not for phototaxis.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei65 – 651ATPPROSITE-ProRule annotation
Active sitei163 – 1631Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi40 – 489ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein serine/threonine kinase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase B (EC:2.7.11.1)
Gene namesi
Name:spkB
Ordered Locus Names:slr1697
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
ProteomesiUP000001425: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 574574Serine/threonine-protein kinase BPRO_0000171240Add
BLAST

Post-translational modificationi

Autophosphorylated.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP74297.

Interactioni

Protein-protein interaction databases

IntActiP74297. 4 interactions.
STRINGi1148.slr1697.

Structurei

3D structure databases

ProteinModelPortaliP74297.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 301268Protein kinasePROSITE-ProRule annotationAdd
BLAST
Domaini454 – 49340Pentapeptide repeat 1Add
BLAST
Domaini504 – 54340Pentapeptide repeat 2Add
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 2 pentapeptide repeat domains.Curated
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000035219.
InParanoidiP74297.
KOiK08884.
OMAiPRLLDYF.
OrthoDBiEOG625JT5.
PhylomeDBiP74297.

Family and domain databases

InterProiIPR001646. 5peptide_repeat.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR016252. Ser/Thr_kinase_SpkB.
[Graphical view]
PfamiPF00805. Pentapeptide. 2 hits.
PF00069. Pkinase. 1 hit.
[Graphical view]
PIRSFiPIRSF000647. Ser/Thr_PK_SpkB. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P74297-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSFCVNPNCP HPKNPNNVQV CQACGNSLRL NGRYQTLGLL GKGGFGATFA
60 70 80 90 100
AADVALPGTP ICVVKQLRPQ TDDPNVFRMA KELFEREAQT LGRVGNHPQV
110 120 130 140 150
PRLLDYFEDD HQFYLVQEYV KGHNLHQEVK KNGTFTEGSV KQFLTEILPI
160 170 180 190 200
LDYIHSQKVI HRDIKPANLI RRQTDQKLVL IDFGAVKNQI DSVLSSNTSA
210 220 230 240 250
QTALTAFAVG TAGFAPPEQM AMRPVYASDI YATGVTCLYL LTGKTPKEID
260 270 280 290 300
CNSQTGEMDW EKHVTVSSKF AEVIRKMLEL SVRHRYKSAQ QVLDALEMPT
310 320 330 340 350
YEDGMMQGMV STPFTTLTGA GDEPATGIRM GNSSSPDYGD PSTRFNTNVQ
360 370 380 390 400
PRDPSSTSLN TGIKTRTAKP RQSPRDRATS NIESPTTRVR PASNMADGGS
410 420 430 440 450
VGAGGIDYNM VNPKPFSRRE EEKQAIANQP ETKRWNGKTF LAEYAQGKRD
460 470 480 490 500
FADQNLVGIV LAKAFVPGIN CYQANLTNAN FEQAELTRAD FGKARLKNVI
510 520 530 540 550
FKGANLSDAY FGYADLRGAD LRGANLNGVN FKYANLQGAN FSGADLGSAK
560 570
VSPEQLKLAK TNWRTVMPGS GRRR
Length:574
Mass (Da):63,079
Last modified:February 1, 1997 - v1
Checksum:iD96B2C5ABEE405A3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB046598 Genomic DNA. Translation: BAB17034.1.
BA000022 Genomic DNA. Translation: BAA18391.1.
PIRiS76132.
RefSeqiNP_441711.1. NC_000911.1.
YP_005651769.1. NC_017277.1.
YP_007451593.1. NC_020286.1.

Genome annotation databases

EnsemblBacteriaiBAA18391; BAA18391; BAA18391.
GeneIDi952988.
KEGGisyn:slr1697.
PATRICi23840900. VBISynSp132158_2004.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB046598 Genomic DNA. Translation: BAB17034.1 .
BA000022 Genomic DNA. Translation: BAA18391.1 .
PIRi S76132.
RefSeqi NP_441711.1. NC_000911.1.
YP_005651769.1. NC_017277.1.
YP_007451593.1. NC_020286.1.

3D structure databases

ProteinModelPortali P74297.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P74297. 4 interactions.
STRINGi 1148.slr1697.

Proteomic databases

PaxDbi P74297.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAA18391 ; BAA18391 ; BAA18391 .
GeneIDi 952988.
KEGGi syn:slr1697.
PATRICi 23840900. VBISynSp132158_2004.

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000035219.
InParanoidi P74297.
KOi K08884.
OMAi PRLLDYF.
OrthoDBi EOG625JT5.
PhylomeDBi P74297.

Family and domain databases

InterProi IPR001646. 5peptide_repeat.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR016252. Ser/Thr_kinase_SpkB.
[Graphical view ]
Pfami PF00805. Pentapeptide. 2 hits.
PF00069. Pkinase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000647. Ser/Thr_PK_SpkB. 1 hit.
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Biochemical and functional characterization of a eukaryotic-type protein kinase, SpkB, in the cyanobacterium, Synechocystis sp. PCC 6803."
    Kamei A., Yoshihara S., Yuasa T., Geng X., Ikeuchi M.
    Curr. Microbiol. 46:296-301(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION.
  2. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
    Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
    , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 6803 / Kazusa.

Entry informationi

Entry nameiSPKB_SYNY3
AccessioniPrimary (citable) accession number: P74297
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: February 1, 1997
Last modified: November 26, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

External Data

Dasty 3