Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P74297 (SPKB_SYNY3) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein kinase B

EC=2.7.11.1
Gene names
Name:spkB
Ordered Locus Names:slr1697
OrganismSynechocystis sp. (strain PCC 6803 / Kazusa) [Reference proteome] [HAMAP]
Taxonomic identifier1111708 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis

Protein attributes

Sequence length574 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Protein kinase required for cell motility, but not for phototaxis.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Post-translational modification

Autophosphorylated.

Sequence similarities

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.

Contains 2 pentapeptide repeat domains.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 574574Serine/threonine-protein kinase B
PRO_0000171240

Regions

Domain34 – 301268Protein kinase
Domain454 – 49340Pentapeptide repeat 1
Domain504 – 54340Pentapeptide repeat 2
Nucleotide binding40 – 489ATP By similarity

Sites

Active site1631Proton acceptor By similarity
Binding site651ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
P74297 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: D96B2C5ABEE405A3

FASTA57463,079
        10         20         30         40         50         60 
MSFCVNPNCP HPKNPNNVQV CQACGNSLRL NGRYQTLGLL GKGGFGATFA AADVALPGTP 

        70         80         90        100        110        120 
ICVVKQLRPQ TDDPNVFRMA KELFEREAQT LGRVGNHPQV PRLLDYFEDD HQFYLVQEYV 

       130        140        150        160        170        180 
KGHNLHQEVK KNGTFTEGSV KQFLTEILPI LDYIHSQKVI HRDIKPANLI RRQTDQKLVL 

       190        200        210        220        230        240 
IDFGAVKNQI DSVLSSNTSA QTALTAFAVG TAGFAPPEQM AMRPVYASDI YATGVTCLYL 

       250        260        270        280        290        300 
LTGKTPKEID CNSQTGEMDW EKHVTVSSKF AEVIRKMLEL SVRHRYKSAQ QVLDALEMPT 

       310        320        330        340        350        360 
YEDGMMQGMV STPFTTLTGA GDEPATGIRM GNSSSPDYGD PSTRFNTNVQ PRDPSSTSLN 

       370        380        390        400        410        420 
TGIKTRTAKP RQSPRDRATS NIESPTTRVR PASNMADGGS VGAGGIDYNM VNPKPFSRRE 

       430        440        450        460        470        480 
EEKQAIANQP ETKRWNGKTF LAEYAQGKRD FADQNLVGIV LAKAFVPGIN CYQANLTNAN 

       490        500        510        520        530        540 
FEQAELTRAD FGKARLKNVI FKGANLSDAY FGYADLRGAD LRGANLNGVN FKYANLQGAN 

       550        560        570 
FSGADLGSAK VSPEQLKLAK TNWRTVMPGS GRRR 

« Hide

References

« Hide 'large scale' references
[1]"Biochemical and functional characterization of a eukaryotic-type protein kinase, SpkB, in the cyanobacterium, Synechocystis sp. PCC 6803."
Kamei A., Yoshihara S., Yuasa T., Geng X., Ikeuchi M.
Curr. Microbiol. 46:296-301(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION.
[2]"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. expand/collapse author list , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PCC 6803 / Kazusa.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB046598 Genomic DNA. Translation: BAB17034.1.
BA000022 Genomic DNA. Translation: BAA18391.1.
PIRS76132.
RefSeqNP_441711.1. NC_000911.1.
YP_005651769.1. NC_017277.1.
YP_007451593.1. NC_020286.1.

3D structure databases

ProteinModelPortalP74297.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP74297. 4 interactions.
STRING1148.slr1697.

Proteomic databases

PaxDbP74297.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAA18391; BAA18391; BAA18391.
GeneID12254424.
14617256.
952988.
KEGGsyn:slr1697.
syy:SYNGTS_1816.
syz:MYO_118340.
PATRIC23840900. VBISynSp132158_2004.

Phylogenomic databases

eggNOGCOG0515.
HOGENOMHOG000035219.
KOK08884.
OMAPPEQMAM.
OrthoDBEOG625JT5.
PhylomeDBP74297.
ProtClustDBCLSK893249.

Family and domain databases

InterProIPR001646. 5peptide_repeat.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR016252. Ser/Thr_kinase_SpkB.
[Graphical view]
PfamPF00805. Pentapeptide. 2 hits.
PF00069. Pkinase. 1 hit.
[Graphical view]
PIRSFPIRSF000647. Ser/Thr_PK_SpkB. 1 hit.
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSPKB_SYNY3
AccessionPrimary (citable) accession number: P74297
Entry history
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: February 1, 1997
Last modified: April 16, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Synechocystis PCC 6803

Synechocystis (strain PCC 6803): entries and gene names

SIMILARITY comments

Index of protein domains and families