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P74193

- THRC_SYNY3

UniProt

P74193 - THRC_SYNY3

Protein

Threonine synthase

Gene

thrC

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.By similarity

    Catalytic activityi

    O-phospho-L-homoserine + H2O = L-threonine + phosphate.

    Cofactori

    Pyridoxal phosphate.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei119 – 1191Pyridoxal phosphateBy similarity
    Binding sitei347 – 3471Pyridoxal phosphateBy similarity

    GO - Molecular functioni

    1. pyridoxal phosphate binding Source: InterPro
    2. threonine synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. threonine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Amino-acid biosynthesis, Threonine biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    UniPathwayiUPA00050; UER00065.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Threonine synthase (EC:4.2.3.1)
    Short name:
    TS
    Gene namesi
    Name:thrC
    Ordered Locus Names:sll1172
    OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
    Taxonomic identifieri1111708 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
    ProteomesiUP000001425: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 382382Threonine synthasePRO_0000185641Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei93 – 931N6-(pyridoxal phosphate)lysineBy similarity

    Proteomic databases

    PaxDbiP74193.

    Interactioni

    Protein-protein interaction databases

    IntActiP74193. 1 interaction.
    STRINGi1148.sll1172.

    Structurei

    3D structure databases

    ProteinModelPortaliP74193.
    SMRiP74193. Positions 36-382.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni219 – 2235Pyridoxal phosphate bindingBy similarity

    Sequence similaritiesi

    Belongs to the threonine synthase family.Curated

    Phylogenomic databases

    eggNOGiCOG0498.
    HOGENOMiHOG000076503.
    KOiK01733.
    OMAiRYASMLP.
    OrthoDBiEOG6HMX9M.
    PhylomeDBiP74193.

    Family and domain databases

    InterProiIPR000634. Ser/Thr_deHydtase_PyrdxlP-BS.
    IPR026260. Thr_Synthase_bac/arc.
    IPR004450. Thr_synthase_like.
    IPR001926. Trp_syn_b_sub_like_PLP_eny_SF.
    [Graphical view]
    PfamiPF00291. PALP. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038945. Thr_synthase. 1 hit.
    SUPFAMiSSF53686. SSF53686. 1 hit.
    TIGRFAMsiTIGR00260. thrC. 1 hit.
    PROSITEiPS00165. DEHYDRATASE_SER_THR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P74193-1 [UniParc]FASTAAdd to Basket

    « Hide

    MISCHSFTMT PSAPNSTVLP SATPVCPQSS ACRWRGLIET YRPYLPVSDQ    50
    TPVVTLLEGN TPLIPAPAIA KRIGKDVRVF VKYDGLNPTG SFKDRGMTMA 100
    ISKAKEAGAK AVICASTGNT SAAAAAYARR AGLRAFVIIP DGYVALGKLG 150
    QALIYGAEVI AIDGNFDDAL TTVRQLSEHY PVTLVNSVNP YRLEGQKTAA 200
    FEIVDVLGQA PDWLCIPVGN AGNITAYWMG FCQYKELGKG DRLPRMMGFQ 250
    AAGSAPFIQG QPISHPETLA TAIRIGNPAN WDKAWAASRE SNGEFHPVTD 300
    AEILEAYRIL AAEEGVFCEP ASAASVAGLL KQKDQVPAGA TVVCVLTGNG 350
    LKDPDCAVQN SGNQVKAGLK PDLEIVAKAM GF 382
    Length:382
    Mass (Da):40,414
    Last modified:February 1, 1997 - v1
    Checksum:iFBC9AEEC2B7F6F35
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000022 Genomic DNA. Translation: BAA18282.1.
    PIRiS75823.
    RefSeqiNP_441602.1. NC_000911.1.
    YP_005651660.1. NC_017277.1.
    YP_007451484.1. NC_020286.1.

    Genome annotation databases

    EnsemblBacteriaiBAA18282; BAA18282; BAA18282.
    GeneIDi953074.
    KEGGisyn:sll1172.
    syy:SYNGTS_1707.
    syz:MYO_117250.
    PATRICi23840641. VBISynSp132158_1875.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000022 Genomic DNA. Translation: BAA18282.1 .
    PIRi S75823.
    RefSeqi NP_441602.1. NC_000911.1.
    YP_005651660.1. NC_017277.1.
    YP_007451484.1. NC_020286.1.

    3D structure databases

    ProteinModelPortali P74193.
    SMRi P74193. Positions 36-382.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P74193. 1 interaction.
    STRINGi 1148.sll1172.

    Proteomic databases

    PaxDbi P74193.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAA18282 ; BAA18282 ; BAA18282 .
    GeneIDi 953074.
    KEGGi syn:sll1172.
    syy:SYNGTS_1707.
    syz:MYO_117250.
    PATRICi 23840641. VBISynSp132158_1875.

    Phylogenomic databases

    eggNOGi COG0498.
    HOGENOMi HOG000076503.
    KOi K01733.
    OMAi RYASMLP.
    OrthoDBi EOG6HMX9M.
    PhylomeDBi P74193.

    Enzyme and pathway databases

    UniPathwayi UPA00050 ; UER00065 .

    Family and domain databases

    InterProi IPR000634. Ser/Thr_deHydtase_PyrdxlP-BS.
    IPR026260. Thr_Synthase_bac/arc.
    IPR004450. Thr_synthase_like.
    IPR001926. Trp_syn_b_sub_like_PLP_eny_SF.
    [Graphical view ]
    Pfami PF00291. PALP. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038945. Thr_synthase. 1 hit.
    SUPFAMi SSF53686. SSF53686. 1 hit.
    TIGRFAMsi TIGR00260. thrC. 1 hit.
    PROSITEi PS00165. DEHYDRATASE_SER_THR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
      Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
      , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
      DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 6803 / Kazusa.

    Entry informationi

    Entry nameiTHRC_SYNY3
    AccessioniPrimary (citable) accession number: P74193
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families
    3. Synechocystis PCC 6803
      Synechocystis (strain PCC 6803): entries and gene names

    External Data

    Dasty 3