P74193 (THRC_SYNY3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Threonine synthase
Short name=TS
EC=4.2.3.1

Gene names

Name:	thrC
Ordered Locus Names:	sll1172

Organism

Synechocystis sp. (strain PCC 6803 / Kazusa) [Reference proteome] [HAMAP]

Taxonomic identifier

1111708 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Cyanobacteria › Oscillatoriophycideae › Chroococcales › Synechocystis › Synechocystis sp. PCC 6803

Protein attributes

Sequence length	382 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine By similarity.
Catalytic activity	O-phospho-L-homoserine + H2O = L-threonine + phosphate.
Cofactor	Pyridoxal phosphate By similarity.
Pathway	Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 5/5.
Sequence similarities	Belongs to the threonine synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Threonine biosynthesis
Ligand	Pyridoxal phosphate
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	threonine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro threonine synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 382	382	Threonine synthase		PRO_0000185641
Regions
	Region	219 – 223	5	Pyridoxal phosphate binding By similarity
Sites
	Binding site	119	1	Pyridoxal phosphate By similarity
	Binding site	347	1	Pyridoxal phosphate By similarity
Amino acid modifications
	Modified residue	93	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P74193 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: FBC9AEEC2B7F6F35	FASTA	382	40,414
	10 20 30 40 50 60 MISCHSFTMT PSAPNSTVLP SATPVCPQSS ACRWRGLIET YRPYLPVSDQ TPVVTLLEGN 70 80 90 100 110 120 TPLIPAPAIA KRIGKDVRVF VKYDGLNPTG SFKDRGMTMA ISKAKEAGAK AVICASTGNT 130 140 150 160 170 180 SAAAAAYARR AGLRAFVIIP DGYVALGKLG QALIYGAEVI AIDGNFDDAL TTVRQLSEHY 190 200 210 220 230 240 PVTLVNSVNP YRLEGQKTAA FEIVDVLGQA PDWLCIPVGN AGNITAYWMG FCQYKELGKG 250 260 270 280 290 300 DRLPRMMGFQ AAGSAPFIQG QPISHPETLA TAIRIGNPAN WDKAWAASRE SNGEFHPVTD 310 320 330 340 350 360 AEILEAYRIL AAEEGVFCEP ASAASVAGLL KQKDQVPAGA TVVCVLTGNG LKDPDCAVQN 370 380 SGNQVKAGLK PDLEIVAKAM GF

References

[1]

"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions." Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S. DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PCC 6803 / Kazusa.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000022 Genomic DNA. Translation: BAA18282.1.
PIR	S75823.
RefSeq	NP_441602.1. NC_000911.1. YP_005651660.1. NC_017277.1. YP_007451484.1. NC_020286.1.
3D structure databases
ProteinModelPortal	P74193.
SMR	P74193. Positions 36-382.
ModBase	Search...
Protein-protein interaction databases
IntAct	P74193. 1 interaction.
STRING	1148.sll1172.
Proteomic databases
PaxDb	P74193.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAA18282; BAA18282; BAA18282.
GeneID	12254315. 14617147. 953074.
KEGG	syn:sll1172. syy:SYNGTS_1707.
PATRIC	23840641. VBISynSp132158_1875.
Phylogenomic databases
eggNOG	COG0498.
HOGENOM	HOG000076503.
KO	K01733.
OMA	KYAYPLN.
ProtClustDB	PRK07409.
Enzyme and pathway databases
UniPathway	UPA00050; UER00065.
Family and domain databases
InterPro	IPR000634. Ser/Thr_deHydtase_PyrdxlP-BS. IPR026260. Thr_Synthase. IPR004450. Thr_synthase_like. IPR001926. Trp_syn_b_sub_like_PLP_eny_SF. [Graphical view]
Pfam	PF00291. PALP. 1 hit. [Graphical view]
PIRSF	PIRSF038945. Thr_synthase. 1 hit.
SUPFAM	SSF53686. PyrdxlP-dep_enz_bsu. 1 hit.
TIGRFAMs	TIGR00260. thrC. 1 hit.
PROSITE	PS00165. DEHYDRATASE_SER_THR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

THRC_SYNY3

Accession

Primary (citable) accession number: P74193

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	February 1, 1997
Last modified:	May 1, 2013
This is version 88 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program