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Protein

Threonine synthase

Gene

thrC

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.By similarity

Catalytic activityi

O-phospho-L-homoserine + H2O = L-threonine + phosphate.

Cofactori

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei119 – 1191Pyridoxal phosphateBy similarity
Binding sitei347 – 3471Pyridoxal phosphateBy similarity

GO - Molecular functioni

  1. pyridoxal phosphate binding Source: InterPro
  2. threonine synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. threonine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Threonine biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00050; UER00065.

Names & Taxonomyi

Protein namesi
Recommended name:
Threonine synthase (EC:4.2.3.1)
Short name:
TS
Gene namesi
Name:thrC
Ordered Locus Names:sll1172
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
ProteomesiUP000001425 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 382382Threonine synthasePRO_0000185641Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei93 – 931N6-(pyridoxal phosphate)lysineBy similarity

Proteomic databases

PaxDbiP74193.

Interactioni

Protein-protein interaction databases

IntActiP74193. 1 interaction.
STRINGi1148.sll1172.

Structurei

3D structure databases

ProteinModelPortaliP74193.
SMRiP74193. Positions 36-382.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni219 – 2235Pyridoxal phosphate bindingBy similarity

Sequence similaritiesi

Belongs to the threonine synthase family.Curated

Phylogenomic databases

eggNOGiCOG0498.
HOGENOMiHOG000076503.
InParanoidiP74193.
KOiK01733.
OMAiTHLECAM.
OrthoDBiEOG6HMX9M.
PhylomeDBiP74193.

Family and domain databases

InterProiIPR000634. Ser/Thr_deHydtase_PyrdxlP-BS.
IPR026260. Thr_Synthase_bac/arc.
IPR004450. Thr_synthase_like.
IPR001926. TrpB-like_PLP-dep.
[Graphical view]
PfamiPF00291. PALP. 1 hit.
[Graphical view]
PIRSFiPIRSF038945. Thr_synthase. 1 hit.
SUPFAMiSSF53686. SSF53686. 1 hit.
TIGRFAMsiTIGR00260. thrC. 1 hit.
PROSITEiPS00165. DEHYDRATASE_SER_THR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P74193-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISCHSFTMT PSAPNSTVLP SATPVCPQSS ACRWRGLIET YRPYLPVSDQ
60 70 80 90 100
TPVVTLLEGN TPLIPAPAIA KRIGKDVRVF VKYDGLNPTG SFKDRGMTMA
110 120 130 140 150
ISKAKEAGAK AVICASTGNT SAAAAAYARR AGLRAFVIIP DGYVALGKLG
160 170 180 190 200
QALIYGAEVI AIDGNFDDAL TTVRQLSEHY PVTLVNSVNP YRLEGQKTAA
210 220 230 240 250
FEIVDVLGQA PDWLCIPVGN AGNITAYWMG FCQYKELGKG DRLPRMMGFQ
260 270 280 290 300
AAGSAPFIQG QPISHPETLA TAIRIGNPAN WDKAWAASRE SNGEFHPVTD
310 320 330 340 350
AEILEAYRIL AAEEGVFCEP ASAASVAGLL KQKDQVPAGA TVVCVLTGNG
360 370 380
LKDPDCAVQN SGNQVKAGLK PDLEIVAKAM GF
Length:382
Mass (Da):40,414
Last modified:January 31, 1997 - v1
Checksum:iFBC9AEEC2B7F6F35
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA18282.1.
PIRiS75823.
RefSeqiNP_441602.1. NC_000911.1.
YP_005651660.1. NC_017277.1.
YP_007451484.1. NC_020286.1.

Genome annotation databases

EnsemblBacteriaiBAA18282; BAA18282; BAA18282.
KEGGisyn:sll1172.
PATRICi23840641. VBISynSp132158_1875.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA18282.1.
PIRiS75823.
RefSeqiNP_441602.1. NC_000911.1.
YP_005651660.1. NC_017277.1.
YP_007451484.1. NC_020286.1.

3D structure databases

ProteinModelPortaliP74193.
SMRiP74193. Positions 36-382.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP74193. 1 interaction.
STRINGi1148.sll1172.

Proteomic databases

PaxDbiP74193.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA18282; BAA18282; BAA18282.
KEGGisyn:sll1172.
PATRICi23840641. VBISynSp132158_1875.

Phylogenomic databases

eggNOGiCOG0498.
HOGENOMiHOG000076503.
InParanoidiP74193.
KOiK01733.
OMAiTHLECAM.
OrthoDBiEOG6HMX9M.
PhylomeDBiP74193.

Enzyme and pathway databases

UniPathwayiUPA00050; UER00065.

Family and domain databases

InterProiIPR000634. Ser/Thr_deHydtase_PyrdxlP-BS.
IPR026260. Thr_Synthase_bac/arc.
IPR004450. Thr_synthase_like.
IPR001926. TrpB-like_PLP-dep.
[Graphical view]
PfamiPF00291. PALP. 1 hit.
[Graphical view]
PIRSFiPIRSF038945. Thr_synthase. 1 hit.
SUPFAMiSSF53686. SSF53686. 1 hit.
TIGRFAMsiTIGR00260. thrC. 1 hit.
PROSITEiPS00165. DEHYDRATASE_SER_THR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
    Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
    , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    DNA Res. 3:109-136(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 6803 / Kazusa.

Entry informationi

Entry nameiTHRC_SYNY3
AccessioniPrimary (citable) accession number: P74193
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 14, 1998
Last sequence update: January 31, 1997
Last modified: March 31, 2015
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.