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P74193

- THRC_SYNY3

UniProt

P74193 - THRC_SYNY3

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Protein

Threonine synthase

Gene

thrC

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.By similarity

Catalytic activityi

O-phospho-L-homoserine + H2O = L-threonine + phosphate.

Cofactori

Pyridoxal phosphate.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei119 – 1191Pyridoxal phosphateBy similarity
Binding sitei347 – 3471Pyridoxal phosphateBy similarity

GO - Molecular functioni

  1. pyridoxal phosphate binding Source: InterPro
  2. threonine synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. threonine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Threonine biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00050; UER00065.

Names & Taxonomyi

Protein namesi
Recommended name:
Threonine synthase (EC:4.2.3.1)
Short name:
TS
Gene namesi
Name:thrC
Ordered Locus Names:sll1172
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
ProteomesiUP000001425: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 382382Threonine synthasePRO_0000185641Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei93 – 931N6-(pyridoxal phosphate)lysineBy similarity

Proteomic databases

PaxDbiP74193.

Interactioni

Protein-protein interaction databases

IntActiP74193. 1 interaction.
STRINGi1148.sll1172.

Structurei

3D structure databases

ProteinModelPortaliP74193.
SMRiP74193. Positions 36-382.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni219 – 2235Pyridoxal phosphate bindingBy similarity

Sequence similaritiesi

Belongs to the threonine synthase family.Curated

Phylogenomic databases

eggNOGiCOG0498.
HOGENOMiHOG000076503.
InParanoidiP74193.
KOiK01733.
OMAiRYASMLP.
OrthoDBiEOG6HMX9M.
PhylomeDBiP74193.

Family and domain databases

InterProiIPR000634. Ser/Thr_deHydtase_PyrdxlP-BS.
IPR026260. Thr_Synthase_bac/arc.
IPR004450. Thr_synthase_like.
IPR001926. TrpB-like_PLP-dep.
[Graphical view]
PfamiPF00291. PALP. 1 hit.
[Graphical view]
PIRSFiPIRSF038945. Thr_synthase. 1 hit.
SUPFAMiSSF53686. SSF53686. 1 hit.
TIGRFAMsiTIGR00260. thrC. 1 hit.
PROSITEiPS00165. DEHYDRATASE_SER_THR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P74193-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MISCHSFTMT PSAPNSTVLP SATPVCPQSS ACRWRGLIET YRPYLPVSDQ
60 70 80 90 100
TPVVTLLEGN TPLIPAPAIA KRIGKDVRVF VKYDGLNPTG SFKDRGMTMA
110 120 130 140 150
ISKAKEAGAK AVICASTGNT SAAAAAYARR AGLRAFVIIP DGYVALGKLG
160 170 180 190 200
QALIYGAEVI AIDGNFDDAL TTVRQLSEHY PVTLVNSVNP YRLEGQKTAA
210 220 230 240 250
FEIVDVLGQA PDWLCIPVGN AGNITAYWMG FCQYKELGKG DRLPRMMGFQ
260 270 280 290 300
AAGSAPFIQG QPISHPETLA TAIRIGNPAN WDKAWAASRE SNGEFHPVTD
310 320 330 340 350
AEILEAYRIL AAEEGVFCEP ASAASVAGLL KQKDQVPAGA TVVCVLTGNG
360 370 380
LKDPDCAVQN SGNQVKAGLK PDLEIVAKAM GF
Length:382
Mass (Da):40,414
Last modified:February 1, 1997 - v1
Checksum:iFBC9AEEC2B7F6F35
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000022 Genomic DNA. Translation: BAA18282.1.
PIRiS75823.
RefSeqiNP_441602.1. NC_000911.1.
YP_005651660.1. NC_017277.1.
YP_007451484.1. NC_020286.1.

Genome annotation databases

EnsemblBacteriaiBAA18282; BAA18282; BAA18282.
GeneIDi953074.
KEGGisyn:sll1172.
syy:SYNGTS_1707.
syz:MYO_117250.
PATRICi23840641. VBISynSp132158_1875.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000022 Genomic DNA. Translation: BAA18282.1 .
PIRi S75823.
RefSeqi NP_441602.1. NC_000911.1.
YP_005651660.1. NC_017277.1.
YP_007451484.1. NC_020286.1.

3D structure databases

ProteinModelPortali P74193.
SMRi P74193. Positions 36-382.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P74193. 1 interaction.
STRINGi 1148.sll1172.

Proteomic databases

PaxDbi P74193.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAA18282 ; BAA18282 ; BAA18282 .
GeneIDi 953074.
KEGGi syn:sll1172.
syy:SYNGTS_1707.
syz:MYO_117250.
PATRICi 23840641. VBISynSp132158_1875.

Phylogenomic databases

eggNOGi COG0498.
HOGENOMi HOG000076503.
InParanoidi P74193.
KOi K01733.
OMAi RYASMLP.
OrthoDBi EOG6HMX9M.
PhylomeDBi P74193.

Enzyme and pathway databases

UniPathwayi UPA00050 ; UER00065 .

Family and domain databases

InterProi IPR000634. Ser/Thr_deHydtase_PyrdxlP-BS.
IPR026260. Thr_Synthase_bac/arc.
IPR004450. Thr_synthase_like.
IPR001926. TrpB-like_PLP-dep.
[Graphical view ]
Pfami PF00291. PALP. 1 hit.
[Graphical view ]
PIRSFi PIRSF038945. Thr_synthase. 1 hit.
SUPFAMi SSF53686. SSF53686. 1 hit.
TIGRFAMsi TIGR00260. thrC. 1 hit.
PROSITEi PS00165. DEHYDRATASE_SER_THR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
    Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
    , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 6803 / Kazusa.

Entry informationi

Entry nameiTHRC_SYNY3
AccessioniPrimary (citable) accession number: P74193
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: February 1, 1997
Last modified: October 29, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

External Data

Dasty 3