P74181 (GGT_SYNY3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Gamma-glutamyltranspeptidase
EC=2.3.2.2

Cleaved into the following 2 chains:

1. Gamma-glutamyltranspeptidase large chain
2. Gamma-glutamyltranspeptidase small chain

Gene names

Name:	ggt
Ordered Locus Names:	slr1269

Organism

Synechocystis sp. (strain PCC 6803 / Kazusa)

Taxonomic identifier

1111708 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Synechocystis

Protein attributes

Sequence length	518 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl amino acid. Glutathione + H2O = L-cysteinylglycine + L-glutamate.
Pathway	Sulfur metabolism; glutathione metabolism.
Subunit structure	This enzyme consists of two polypeptide chains, which are synthesized in precursor form from a single polypeptide.
Sequence similarities	Belongs to the gamma-glutamyltransferase family.

Ontologies

Keywords
Biological process	Glutathione biosynthesis
Domain	Signal
Molecular function	Acyltransferase Transferase
PTM	Zymogen
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	glutathione biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	gamma-glutamyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – ?		Potential
	Chain	? – 336		Gamma-glutamyltranspeptidase large chain By similarity		PRO_0000011056
	Chain	337 – 518	182	Gamma-glutamyltranspeptidase small chain By similarity		PRO_0000011057

Sequences

	Sequence		Length	Mass (Da)
	P74181 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: 4FDA234F16C66540	FASTA	518	55,988
	10 20 30 40 50 60 MAGKTTGVVA AGHAQTAEAG KCMLEEGGNA FDAAIASVLA ACVVESSLTS LGGGGFLLAQ 70 80 90 100 110 120 TAAKKSYLFD FFCQTPQVNP GEKAVDFYPV ALNFGGAWQT FHIGKGAIAV PGMVAGLFAA 130 140 150 160 170 180 HRKLGQLPFK VLIEPAVAYA RQGFTLNRFN DFTNGLLEPI LTQQEEGRKF YAPQGKILRQ 190 200 210 220 230 240 GEKAYLPQFA DVLEQLARHG PDWFYRGELT EWVLESLGEA SALTAKDWAD YQVEIRLPLR 250 260 270 280 290 300 AQYRQRQLLT NPPPSAGGIL IAFALQLLEK YDLSQYPLGS AAQIQLFSQV MALSNQARRQ 310 320 330 340 350 360 YLDGNLHCGD IEAKFLGGDR LASELGQSKF INKLGSTTHI SVLDGEGNAA SLTSSNGEGS 370 380 390 400 410 420 GHFIPGTGIM LNNMLGEEDL NPQGFYQWPP GQRLSSMMAP TILLDQEQPR LVLGSGGSNR 430 440 450 460 470 480 IRSAILQVVC HHLDYQLPLA EAVGRERIHW EAHKLDLEPT SVADILAQLR FDDGTQGTLW 490 500 510 TEQNMFFGGV HGVATTTAGT MEGVGDPRRS GAVAYSLE

References

[1]

"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions." Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S. DNA Res. 3:109-136(1996) [PubMed: 8905231] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 27184 / PCC 6803 / N-1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000022 Genomic DNA. Translation: BAA18270.1.
PIR	S75811.
RefSeq	NP_441590.1. NC_000911.1.
3D structure databases
ProteinModelPortal	P74181.
ModBase	Search...
Protein-protein interaction databases
STRING	P74181.
Protein family/group databases
MEROPS	T03.013.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	953078.
GenomeReviews	Gene locus slr1269 in contig BA000022_GR.
KEGG	syn:slr1269.
NMPDR	fig|1148.1.peg.1691.
PATRIC	23840617. VBISynSp132158_1863.
Phylogenomic databases
eggNOG	COG0405.
HOGENOM	HBG738311.
OMA	NSTHENT.
PhylomeDB	P74181.
ProtClustDB	CLSK893193.
Enzyme and pathway databases
BioCyc	SSP1148:SLR1269-MONOMER.
Family and domain databases
InterPro	IPR000101. GGT_peptidase. [Graphical view]
KO	K00681.
PANTHER	PTHR11686. GGT_peptidase. 1 hit.
Pfam	PF01019. G_glu_transpept. 1 hit. [Graphical view]
PRINTS	PR01210. GGTRANSPTASE.
TIGRFAMs	TIGR00066. G_glut_trans. 1 hit.
PROSITE	PS00462. G_GLU_TRANSPEPTIDASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GGT_SYNY3

Accession

Primary (citable) accession number: P74181

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	February 1, 1997
Last modified:	January 25, 2012
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program