ID YIDC_SYNY3 Reviewed; 384 AA. AC P74155; DT 21-NOV-2003, integrated into UniProtKB/Swiss-Prot. DT 01-FEB-1997, sequence version 1. DT 27-MAR-2024, entry version 125. DE RecName: Full=Membrane protein insertase YidC; DE AltName: Full=Alb3; DE AltName: Full=Foldase YidC; DE AltName: Full=Membrane integrase YidC; DE AltName: Full=Membrane protein YidC; DE AltName: Full=Oxa1; DE AltName: Full=SynYidC; GN Name=yidC; Synonyms=alb3; OrderedLocusNames=slr1471; OS Synechocystis sp. (strain PCC 6803 / Kazusa). OC Bacteria; Cyanobacteriota; Cyanophyceae; Synechococcales; Merismopediaceae; OC Synechocystis. OX NCBI_TaxID=1111708; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=PCC 6803 / Kazusa; RX PubMed=8905231; DOI=10.1093/dnares/3.3.109; RA Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., RA Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., RA Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S., RA Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.; RT "Sequence analysis of the genome of the unicellular cyanobacterium RT Synechocystis sp. strain PCC6803. II. Sequence determination of the entire RT genome and assignment of potential protein-coding regions."; RL DNA Res. 3:109-136(1996). RN [2] RP FUNCTION, AND DISRUPTION PHENOTYPE. RX PubMed=15498761; DOI=10.1074/jbc.m411041200; RA Spence E., Bailey S., Nenninger A., Moller S.G., Robinson C.; RT "A homolog of Albino3/OxaI is essential for thylakoid biogenesis in the RT cyanobacterium Synechocystis sp. PCC6803."; RL J. Biol. Chem. 279:55792-55800(2004). RN [3] RP FUNCTION IN ASSEMBLY OF D1, INTERACTION WITH D1, AND SUBCELLULAR LOCATION. RC STRAIN=ATCC 27184 / PCC 6803 / N-1; RX PubMed=16905652; DOI=10.1105/tpc.106.043646; RA Ossenbuhl F., Inaba-Sulpice M., Meurer J., Soll J., Eichacker L.A.; RT "The synechocystis sp PCC 6803 oxa1 homolog is essential for membrane RT integration of reaction center precursor protein pD1."; RL Plant Cell 18:2236-2246(2006). RN [4] RP SUBCELLULAR LOCATION. RC STRAIN=ATCC 27184 / PCC 6803 / N-1; RX PubMed=18600052; RA Sven G., Eva R., Uwe K., Schneider D.; RT "A conserved structure and function of the YidC homologous protein Slr1471 RT from Synechocystis sp. PCC 6803."; RL J. Microbiol. Biotechnol. 18:1090-1094(2008). RN [5] RP INTERACTION WITH CYANOP; FTHS2; FTSH3; PHB1; YCF39 AND YCF48, AND SUBUNIT. RC STRAIN=PCC 6803 / Kazusa; RX PubMed=30061392; DOI=10.1073/pnas.1800609115; RA Yu J., Knoppova J., Michoux F., Bialek W., Cota E., Shukla M.K., RA Straskova A., Pascual Aznar G., Sobotka R., Komenda J., Murray J.W., RA Nixon P.J.; RT "Ycf48 involved in the biogenesis of the oxygen-evolving photosystem II RT complex is a seven-bladed beta-propeller protein."; RL Proc. Natl. Acad. Sci. U.S.A. 115:E7824-E7833(2018). CC -!- FUNCTION: Required for the insertion of integral membrane proteins into CC the membrane. Probably plays an essential role in the integration of CC proteins of the respiratory chain complexes. Involved in integration of CC membrane proteins that insert dependently and independently of the Sec CC translocase complex (By similarity). Addition of green fluorescent CC protein (GFP) to the C-terminus leads to photoinhibition at 80 CC umol/m(2)/s light intensity, reduced amounts of pigment, altered energy CC transfer between the antenna systems and the reaction centers of PSI CC and PSII, and impaired integration of PSII reaction center protein D1 CC (psbA) into membranes, suggesting it probably also aids protein CC insertion, folding and/or assembly of membrane complexes destined for CC the thylakoid (PubMed:15498761, PubMed:16905652). CC {ECO:0000250|UniProtKB:P25714, ECO:0000269|PubMed:15498761, CC ECO:0000269|PubMed:16905652}. CC -!- SUBUNIT: Specifically interacts with transmembrane segments of nascent CC integral membrane proteins during membrane integration (By similarity). CC Interacts with the precursor of PSII reaction center D1 CC (PubMed:16905652). Coimmunoprecipitates with CyanoP (tlr2075), FtsH2, CC FtsH3, Phb1 (slr1106), Ycf39 and Ycf48 (PubMed:30061392). CC {ECO:0000250|UniProtKB:P25714, ECO:0000269|PubMed:16905652, CC ECO:0000269|PubMed:30061392}. CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000269|PubMed:16905652, CC ECO:0000269|PubMed:18600052}; Multi-pass membrane protein CC {ECO:0000269|PubMed:16905652, ECO:0000269|PubMed:18600052}. CC -!- DISRUPTION PHENOTYPE: Merodiplod cells have greatly altered thylakoid CC morphology, and about 40% photosynthetic pigements, photosynthetic CC electron transport and oxygen evolution. {ECO:0000269|PubMed:15498761}. CC -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily. CC {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BA000022; BAA18244.1; -; Genomic_DNA. DR PIR; S75683; S75683. DR AlphaFoldDB; P74155; -. DR IntAct; P74155; 19. DR STRING; 1148.gene:10499118; -. DR PaxDb; 1148-1653329; -. DR EnsemblBacteria; BAA18244; BAA18244; BAA18244. DR KEGG; syn:slr1471; -. DR eggNOG; COG0706; Bacteria. DR InParanoid; P74155; -. DR Proteomes; UP000001425; Chromosome. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0032977; F:membrane insertase activity; IBA:GO_Central. DR GO; GO:0051205; P:protein insertion into membrane; IBA:GO_Central. DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW. DR CDD; cd20070; 5TM_YidC_Alb3; 1. DR InterPro; IPR001708; YidC/ALB3/OXA1/COX18. DR InterPro; IPR028055; YidC/Oxa/ALB_C. DR InterPro; IPR047196; YidC_ALB_C. DR NCBIfam; TIGR03592; yidC_oxa1_cterm; 1. DR PANTHER; PTHR12428:SF65; INNER MEMBRANE PROTEIN ALBINO3, CHLOROPLASTIC; 1. DR PANTHER; PTHR12428; OXA1; 1. DR Pfam; PF02096; 60KD_IMP; 1. PE 1: Evidence at protein level; KW Cell inner membrane; Cell membrane; Chaperone; Membrane; Protein transport; KW Reference proteome; Transmembrane; Transmembrane helix; Transport. FT CHAIN 1..384 FT /note="Membrane protein insertase YidC" FT /id="PRO_0000124759" FT TRANSMEM 12..32 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 96..116 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 311..331 FT /note="Helical" FT /evidence="ECO:0000255" FT REGION 357..384 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 368..384 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 384 AA; 42627 MW; A90CEE83C43C12C0 CRC64; MDFGIGFIST NIMLPILDFF FGIVHSYGFA IIALTLVIRL GLYPLSAGQI RNMRKMRITQ PLMKERQEEI QKRYKDDPAK QQEEMAKVMK EFGNPLAGCL PLLLQMPILF ALFATLRGSP FSDINYTVDL QILPQEQVER IVPQTFSTKP QNIYVDEALH YPIAVFLPGG KMLGVGEKTQ LEIQSTEGKA FNQVIPEKNS QILTPTYSVT KGEDRISVNP DGTIEALVPG DATVQVTIPG IAARTGFLFI KALGQVGVTG ENGEINWDIL GMIVFFGFSI YLNQELSGAS GGGAPNAQAQ QQQTINKITP ILFSGMFLFF PLPAGVLMYI VMANVFQTIQ TLILMREPLP ENLQKLLDEQ QKATQGRESL PFEKKSSKKK EKTS //